Abstract: Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.

Abstract: A piston to be provided within an inner wall of a barrel of a pharmaceutical syringe for dispensing medicament retained in the barrel is described. The piston includes a body defining a central face, a cylindrical portion, and an annular curved portion between the cylindrical portion and the central face portion. The piston also includes an inert film enclosing the central face portion and at least a part of the annular curved portion. The cylindrical portion and the part of the annular curved portion are together configured to maintain a fluid-tight seal with the inner wall of the barrel. A pharmaceutical syringe is described for dispensing a medicament includes a barrel configured to retain the medicament and the piston.

Abstract: Surgical systems can include evacuation systems for evacuating smoke, fluid, and/or particulates from a surgical site. A surgical evacuation system can be intelligent and may include one or more sensors for detecting one or more properties of the surgical system, evacuation system, surgical procedure, surgical site, and/or patient tissue, for example.

Abstract: A tubing assembly includes a signal generating apparatus for a catheter placement system. The tubing assembly includes a catheter and a signal generating apparatus. The catheter includes an elongate shaft having a wall surrounding a lumen. The signal generating apparatus includes at least one electromagnetic coil and at least one electrically conductive polymer that is configured to electrically connect the at least one electromagnetic coil to a monitor unit.

Abstract: An injector includes an injector housing, an activation button assembly translatable from an unactuated position to an actuated position and a cartridge door movably mounted to the injector housing between an open position and a closed position. A deflectable interference member has a resting position configured to limit an insertion depth of a cartridge into an interior channel of the cartridge door to a sealed position, wherein the cartridge piercing needle does not fully penetrate a pierceable septum of the cartridge. Movement of the activation button assembly from the unactuated position to the actuated position thereof, in the closed position of the cartridge door, deflects the interference element out of the resting position thereof, thereby enabling further advancement of the cartridge into the interior channel of the cartridge door to an unsealed position, wherein the cartridge piercing needle fully penetrates the pierceable septum.

Abstract: A medicament delivery device comprises a needle configured to move between a retracted position and an inserted position; an insertion mechanism to move the needle from the retracted position to the inserted position when activated; a locking arm which, in a locked position, is engaged with the insertion mechanism to prevent activation of the insertion mechanism and, in an unlocked position, is disengaged from the insertion mechanism; a retraction mechanism to move the needle from the inserted position to the retracted position when activated; and a trigger configured to move between a disengaged position and an engaged position. On moving from the disengaged position to the engaged position, the trigger is configured to move the locking arm from the locked position to the unlocked position. On moving from the engaged position to the disengaged position, the trigger is configured to activate the retraction mechanism.

Abstract: A valve for sealing the hub of a sheath assembly is provided. The valve includes a valve body having a solid thickness extending between a proximal surface and a distal surface. A bisecting slot extends across the proximal surface of the valve body and terminates at a depth less than the thickness of the valve body such that a portion of the valve body distally of the slot defines a bridge extending between opposed halves of the valve body such that the distal surface of the valve body is substantially continuous and a central portion of the proximal surface of the valve body is concave and defines a concave proximal portion.

Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.

Abstract: Disclosed is a system for injecting a radioactive product to a patient, wherein the system includes: a first syringe containing the radioactive product, whose plunger cooperates with an injection mass, acting by gravity, associated with deactivatable holding element; a mobile stop arranged to constitute an end-of-travel stop for the retraction of the plunger, as a function of the volume of radioactive product to be injected to the patient; a second syringe containing a rinsing product, whose plunger cooperates with a rinsing mass, acting by gravity, associated with deactivatable holding element; a trigger control element for triggering the injection of the radioactive product to the patient; and a management element including a unit for displacing the mobile stop structure as a function of the prescribed activity to be injected to the patient, and a unit for controlling the deactivatable holding element of the masses.

Abstract: The disclosure provides a method for preventing infection and microbial ingress in medical device connections between tubing sets and medical devices. The tubing set includes a male connector with a distal tip and a recess at the distal tip configured to trap bacterial, and deliver and confine antimicrobial into solution within a cavity formed by the recess. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

Abstract: A needleless connector and methods for preventing microbial ingress in medical device connections are disclosed. Various examples provide a needleless connector including a male luer having a recessed distal tip surface containing a water-soluble antimicrobial composition. Further examples include a trap for retaining antimicrobial composition. As the needleless connector is inserted into a female connector, a tapered surface distal edge acts to push microorganisms, while the distal tip surface is configured to leave microorganisms undisturbed. After insertion of the needleless connector, microorganisms present on the female luer surface are biased to reside in the recess region. The recess, trap, and antimicrobial composition are configured to facilitate a long-lasting supply of antimicrobial solution within the fluid-filled recess, at the same time confining the antimicrobial solution inside the recess.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: Described herein is the use of CSF, more particularly external CSF or CSF-like compositions for the treatment and prevention of different diseases. More particularly, the application provides for the administration of CSF to the intrathecal space or the cerebral ventricles of a patient to increase intracranial pressure and/or CSF flow.

Abstract: Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula.

Abstract: The present disclosure is directed to a device for delivering an antimicrobial composition into an infusion device. The disclosure provides a method for preventing infection and microbial ingress in medical device connections. The device includes a male connector with a distal tip and a recess at the distal tip. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

Abstract: A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the overall plaque site.

Abstract: The invention provides an insufflation apparatus having a housing and a gas generator arranged to be, at least partially, mounted to the housing. The housing includes a gas outlet for delivering gas to a patient and a gas storage chamber arranged to store gas and deliver it to the gas outlet. The gas generator includes a cartridge mount on the housing adapted to receive a gas generating cartridge, the gas generating cartridge containing gas generating material that generates gas that is delivered to the gas storage chamber. The invention also provides alternative insufflation apparatus, a gas cartridge and a method of generating insufflation gas.

Abstract: Surgical systems can include evacuation systems for evacuating smoke, fluid, and/or particulates from a surgical site. A surgical evacuation system can be intelligent and may include one or more sensors for detecting one or more properties of the surgical system, evacuation system, surgical procedure, surgical site, and/or patient tissue, for example.

Abstract: A dosing mechanism for an injection device includes a dose-setting element with a first element coupled thereto, which, during dose setting, is rotatable relative to a second element about a main rotation axis in a first direction and, during dose discharge, is fixed in rotation relative to the second element. The first and the second elements are coupled via a sleeve-shaped stop element, which forms a stop abutment. The dosing mechanism includes a stop, and the stop abutment, during the rotation of the first element in the first direction, executes a movement to a stop position where the stop abutment strikes the stop and prevents rotation of the first element relative to the second element in the first direction of rotation. The sleeve-shaped stop element is rotatable about a secondary rotation axis, which is offset parallel to or offset at an angle to the main rotation axis.

Abstract: Examples herein provide a syringe comprising a fluid reservoir and a male connector comprising a fluid flow channel in fluid communication with the fluid reservoir. The male connector including a male luer having a tapered sealing surface configured to mate with a female tapered surface of a female connector to form a substantially fluid-tight seal. The male luer has a distal tip with a recess defined by a recess surface that is distal to the tapered sealing surface. A water-soluble antimicrobial composition is disposed on the recess surface. The male luer is configured such that, when the male connector is mated with a female connector to form a substantially fluid-tight seal, a cavity is formed between the female tapered surface and the recess surface.