Abstract: A combination flush catheter and selective catheter as one convertible catheter and methods of using the same. The selective catheter may be a reverse curve or guide catheter. The additional steps of removal of the flush catheter and re-insertion of the selective catheter may be eliminated, reducing the possibility of errors and making the procedure smoother and shorter.

Abstract: An obstruction detection system for a robotic catheter system including a robotic catheter manipulator assembly including one or more catheter manipulation bases and one or more sheath manipulation bases. Each manipulation base may be generally linearly movable on one or more tracks relative to the robotic catheter manipulator assembly. The obstruction detection system may include one or more obstruction detection sensors disposed on the track or on the manipulation bases to detect an obstruction along a path of motion of one or more manipulation bases. A software system may be provided for monitoring movement of the catheter and sheath manipulation bases, and/or a status of the obstruction detection sensors.

Abstract: This disclosure relates to a medical device including, a hard part, a converter, and a conductive path. The hard part has fluid paths for guiding a medical fluid, in particular blood, through the hard part. The converter is arranged to measure a characteristic of the medical fluid while the fluid is present in one of the fluid paths. At least a first section of the converter or of the conductive path is applied to or superimposed on the hard part by a first additive application method. At least a second section of the converter or of the conductive path is applied to the hard part by a second application method. The first and the second additive application methods differ from each other.

Abstract: A first tube connector and a second tube connector are to be automatically and mechanically attached to and detached from each other. Provided is an attaching/detaching device (100) including: a fixing portion (104) configured to fix a first tube connector (105); a holding portion (107) configured to hold a second tube connector (106); a moving portion configured to move the holding portion (107), which holds the second tube connector (106), in a direction of approaching the first tube connector (105) to connect the second tube connector (106) to the first tube connector (105), and move the second tube connector (106) after the connection in a direction of separating from the first tube connector (105) to release the connection of the second tube connector (106) and the first tube connector (105).

Abstract: A plunger gasket with reduced surface contact area including a body, a first side defining a first side surface, a second side defining a second side surface, and at least one surface feature projecting outwardly from at least one of the first or second side surfaces. In example embodiments, at least one surface feature projects outwardly from both the first and second side surfaces. By reducing the surface areas of contact between gaskets during manufacture and processing, the incidence of unintentional cohesion may be reduced or eliminated.

Abstract: A gas mixing system for providing mixed gas for intraocular injection. In some embodiments, a first fixed-volume chamber is automatically purged and filled with gas from a first gas supply input, to a first predetermined pressure. A second fixed-volume chamber is purged and filled with gas from a second gas supply input, to a second predetermined pressure. The first and second predetermined pressures are determined based on a desired concentration of gases in the final mix, and the respective volumes of the first and second fixed-volume chambers and of a third fixed-volume chamber. Gas from the first fixed-volume chamber is then allowed to mix with gas in the third fixed-volume chamber, which was previously purged. Next, gas from the second fixed-volume chamber is allowed to mix with gas in the third fixed-volume chamber. Finally, the mixture of gases in the third fixed-volume chamber is expressed into an intraocular syringe.

Abstract: Methods, systems, and kits are provided for performing hemodialysis, hemodiafiltration, and peritoneal dialysis on a portable machine suitable for both clinical and home use. Peritoneal dialysate can be flowed into and out of the peritoneal cavity, and can also be regenerated within the system, without the need for introducing fresh dialysate. Common hardware and software can be utilized for both peritoneal dialysis and other forms of dialysis such as hemodialysis, hemofiltration, and hemodiafiltration, allowing for facile transition between different dialysis modes using the same dialysis machine.

Abstract: A medication delivery apparatus for use with a medication container includes a housing, a fluid conduit at least partially extending within the housing and configured to deliver medication within the medication container to a patient, a medication port extending from the housing and configured to be coupled to a fluid outlet of the medication container, the medication port being fluidically coupled to the fluid conduit, and at least one sensor disposed within the housing to generate information characterizing administration of the medication for processing by a remote data collection system. The housing can have a size and shape that enables it to be supported by a first hand of a user while the user administers the medication from the medication container via the medication port using a second hand of the user. Related apparatus, systems, and techniques are also described.

Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Abstract: A medical valve can include a housing that includes a sidewall and defines a chamber. The medical valve can include a septum coupled to the housing. The septum can include a proximal surface and a selectively openable closure positioned within the chamber. The medical valve can further include a plurality of projections that extend away from the sidewall and are configured to contact the proximal surface of the septum to oppose movement of a restricted portion of the septum in a proximal direction such that an aspiration cracking pressure required to open the closure to permit fluid flow through the septum in the proximal direction exceeds an infusion cracking pressure required to open the closure to permit fluid flow through the septum in the distal direction.

Abstract: Systems and methods encourage users to rotate injection sites and avoid lipodystrophy. Sleeves and/or lost-tooth gear dials and/or microswitches in or on injection pens or their caps, on vials, and on other portable devices manually adjust an indicator before or after an injection to show a current or next injection site in accordance with a site rotation plan. Injected medicine packaging and related printed indicia encourage site rotation. Optical devices employing optical mouse or projection technology help locate and/or distribute injection sites within a body area. A mobile phone app tracks injections and locations to select next injection site, and can use imaging to locate a target injection site and optionally diagnose lipodystrophic conditions and record them. Tactile and print media educational tools are presented to help users palpate and identify lipos in body areas having injection sites.

Abstract: Methods and apparatus provide treatment with a first therapeutic agent and a second therapeutic agent for an extended time. The first therapeutic agent may comprise a VEGF inhibitor and the second therapeutic agent may comprise an antiinflammatory, such as a non-steroidal anti-inflammatory, for example a cyclooxygenase inhibitor. One or more of the first therapeutic agent or the second therapeutic agent can be injected into the eye, for example injected into a therapeutic device implanted into the eye to release the injected therapeutic agent for an extended time.

Abstract: A supplementary device configured to be releasably attached to a distal end of a drug delivery device. The supplementary device comprising primary electronics, a non-contact acceleration sensor and a low power processor. The non-contact acceleration sensor is directed towards a proximal end of the drug delivery device and the low power processor is configured to: receive the signals output from the non-contact acceleration sensor; determine based on the signals that an outer needle cap of the drug delivery device has been removed; and in response to determining that an outer needle cap of the drug delivery device has been removed, send a wake-up signal to the primary electronics of the supplementary device.

Abstract: A pen needle assembly apparatus (60) includes a housing (30), a movable support (40) for supporting a pen needle (18), an ejector (80) for ejecting a used pen needle from the support, and an actuator (56). The support (40) is rotated relative to the housing (30) to index the pen needles to a position where the pen needle can be accessed and coupled to a delivery device (10). The used pen needle (18) is returned to the well (42) in the support and the support rotated toward the ejector (80) where the used pen needle is ejected to a compartment (50) in the housing for disposal. A cover (60) on the housing includes at least one opening (65) for accessing the pen needle when the support is rotated to position a pen needle relative to the opening in the cover.

Abstract: Disclosed is a system that includes a sensor for acquiring a physiological bioelectrical impedance signal from a patient functionally connected to the computing device. The computing device preferably analyzes the physiological bioelectrical impedance signal and provides outputs an assessment of minute ventilation of the patient based on the analyzed bioelectrical impedance signal. Preferably, the system monitors the signal over time, provides a control signal to an IV pump that instructs the IV Pump to automatically adjust medication levels by automatically lowering medication levels when respiration levels fall or completely stopping flow of the medication.

Abstract: An injection device comprising a housing in which can be mounted a syringe comprising a barrel for holding a volume of medicament, a needle at one end of the barrel and a plunger axially-moveable in the barrel to a forwardmost position, the injection device further comprising a syringe support means for supporting the barrel at an axial location at or forward of the forwardmost position of the plunger and having a reaction surface for the syringe, whereby in use said reaction surface provides an axial compressive force on said barrel when a forward axial force is applied to the plunger.

Abstract: A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The stopper has a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition. The stopper has a circumferential surface partially contacting an inner surface of the barrel. A surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness.

Abstract: A syringe system, including a plunger, a microcontroller, a battery, and a coil. The syringe barrel having a proximal end, a distal end, and a cylindrical sidewall defining a longitudinal axis, the cylindrical sidewall extending longitudinally between the proximal and distal ends, the sidewall having an exterior surface and defining an internal volume, the plunger being positioned between the proximal and distal ends of the syringe barrel and being movable within the internal volume with respect to the syringe barrel in the longitudinal direction. The syringe barrel further includes a label disposed on the sidewall and having at least two conductive strips extending in a non-parallel direction with respect to the longitudinal axis and having unique lengths. The microcontroller is configured to determine a position of the plunger with respect to the syringe barrel by measuring a current induced in the coil by the at least two conductive strips.

Abstract: A catheter assembly may include a catheter adapter, which may include a proximal end, a distal end, and a lumen extending between the proximal end and the distal end. The distal end may include a catheter configured to be inserted into vasculature of a patient. The catheter assembly may also include a septum, which may be disposed within the lumen of the catheter adapter. The septum may be secured within the lumen in response to increased pressure by one or more of the following: one or more septum stoppers, a retention disc of a needle assembly, a U-shaped washer, and a conical washer.

Abstract: An automatic injection device including a housing element, at least one resilient element arranged to be located within the housing element, a syringe including at least one syringe piston, a needle guard adapted for selectable positioning with respect to the housing element and a selectable driving element adapted, when actuated, to be driven by the at least one resilient element for initially displacing the syringe relative to the housing element from a non-penetration position to a penetration position and thereafter displacing the at least one syringe piston in the syringe to effect drug delivery and displacing the needle guard into a needle guarding position.