Patents Examined by Layla Bland
  • Ophthalmic composition with hyaluronic acid and polymeric biguanide
    Patent number: 8759321
    Abstract: An ophthalmic composition comprising 0.5 ppm to 3 ppm of poly(hexamethylene biguanide), and 0.002 wt. % to 0.03 wt. % of hyaluronic acid. The weight ratio of hyaluronic acid to poly(hexamethylene biguanide) in the composition is from 45:1 to 120:1. The invention is also directed to a method of cleaning, disinfecting or packaging contact lenses with the composition, or to a method of rewetting contact lenses with the composition.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: June 24, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Susan E. Burke, Srini Venkastesh
  • Oligosaccharides comprising an aminooxy group and conjugates thereof
    Patent number: 8759501
    Abstract: The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: June 24, 2014
    Assignee: Genzyme Corporation
    Inventors: Yunxiang Zhu, Seng H. Cheng, Canwen Jiang, Luis Z. Avila
  • Thermally inhibited polysaccharides and process of preparing
    Patent number: 8759511
    Abstract: This invention is directed to a process for making a thermally inhibited polysaccharide by dehydrating a polysaccharide to substantially anhydrous or anhydrous conditions and thermally inhibiting the substantially anhydrous or anhydrous polysaccharide at a temperature of 100° C. or greater for a time sufficient to inhibit the polysaccharide in an oxygen enriched concentration of at least 6.5 moles/m3.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: June 24, 2014
    Assignee: Corn Products Development, Inc.
    Inventors: Thomas J. English, Kamlesh Shah, James J. Kasica, Christopher C. Lane, Tushar Shah
  • Extract obtained by a commercially viable process for the extraction of furostanolic saponins from fenugreek seeds, in which one of the compounds in the extract is protodioscin
    Patent number: 8754205
    Abstract: Disclosed is an extract obtained by a commercially viable process for the extraction of furostanolic saponins from fenugreek seeds, in which one of the compounds in the extract is protodioscin. The process includes providing plurality of fenugreek seeds and crushing the same by milling and grinding; performing a primary extraction on the prepared fenugreek seeds using a first hydrophilic polar solvent which is a lower primary aliphatic alcohol followed by ion-exchange chromatography; performing a secondary extraction after ion-exchange chromatography using a composite solvent; and decolorizing the final extract by use of activated charcoal concentration of the extract by heating and vacuum drying sieving the final powdered product.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: June 17, 2014
    Inventor: Pawan Kumar Goel
  • Process for the preparation and purification of topiramate
    Patent number: 8748594
    Abstract: A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4,5-bis-O-{1-methylethylidene)-?-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4,5-bis-O-(1-methylethylidene)-?-D-fructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: June 10, 2014
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Lung-Hu Wang, Chun-Teng Huang
  • Synthesis of protected 3?-amino nucleoside monomers
    Patent number: 8748593
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: June 10, 2014
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Complex crystalline sugar comprising D-psicose and D-allose and process for production of the same
    Patent number: 8748589
    Abstract: A complex crystalline sugar comprising D-psicose and D-allose and a method for producing the same are disclosed. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: June 10, 2014
    Assignees: National University Corporation Kagawa University, Matsutani Chemical Industry Co., Ltd.
    Inventors: Ken Izumori, Masaaki Tokuda, Goro Takata, Kenji Morimoto
  • Mitochondria-targeting antioxidant therapeutics
    Patent number: 8741853
    Abstract: The instant invention constitutes an unique subject matter as a whole which has four individual aspects: (1) a class of chiral, non-racemic, synthetic carnitinoid analog carrier molecules which constitute biocompatible transport compounds not found in nature; (2) a subsequently formed, mitochondria-targeting, coupled antioxidant-carrier complex comprising an antioxidant reversibly attached to and releasable from the synthetic carrier molecule; (3) a method for introducing a biologically active antioxidant into the interior of mitochondria of a living cell for subsequent reaction with such reactive oxygen species may then be present; and (4) a system for delivering a biologically active antioxidant to the interior of mitochondria within a living cell.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: June 3, 2014
    Inventor: Kosta Steliou
  • Method of producing a bran product
    Patent number: 8742095
    Abstract: The present invention relates to a method of manufacturing a cereal bran product containing beta-glucan. According to the method, a plastic mass is formed from cereal bran by means of a thermo-mechanical treatment, and the mass is brought into contact with an enzyme that breaks up beta-glucan, with or without an enzyme that breaks up starch. After inactivating the enzyme, the bran is dried and, when so needed, ground. The cereal bran product manufactured according to the method has an essentially inextensible structure in a water environment. The product is suitable to be added to aqueous foodstuffs or to foodstuffs, the manufacture of which employs water.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: June 3, 2014
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Ilkka Lehtomäki, Olavi Myllymäki
  • Saccharide-containing protein conjugates and uses thereof
    Patent number: 8742079
    Abstract: Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: June 3, 2014
    Assignee: Protalix Ltd.
    Inventors: Avidor Shulman, Ilya Ruderfer
  • Method for the solid phase-based production of phosphate-bridged nucleoside conjugates
    Patent number: 8742094
    Abstract: The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: June 3, 2014
    Assignee: Universitaet Hamburg
    Inventors: Chris Meier, Viktoria Caroline Tonn
  • Composition, preparation, and use of dense chitosan membrane materials
    Patent number: 8735571
    Abstract: A composition of exceptionally dense chitosan and a novel method for producing the dense chitosan structure have been described. The novel production method employs coincident compression and vacuum on a neutralized chitosan polymer that results in an exceptionally dense chitosan film or membrane material. The dense chitosan film or membrane composition possesses multiple physical and clinically appealing qualities for a variety of medical applications on or in animals, mammals, or humans.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 27, 2014
    Assignee: Agenta Biotechnologies, Inc.
    Inventors: Arthur A. DeCarlo, April Ellis, Thomas P. Dooley, Maria Belousova
  • Glycosaminoglycan oral use and compositions
    Patent number: 8735373
    Abstract: The present invention concerns the use of a glycosaminoglycan association of hyaluronic acid and chondroitin sulfate for the preparation of oral compositions for the prevention or for the treatment of upper gastro-intestinal tract disorders and for the preparation of upper gastro-intestinal epithelial damage, as well as the oral compositions comprising said glycosaminoglycan association.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: May 27, 2014
    Assignee: Apharm S.R.L.
    Inventor: Angelo Pizzoni
  • Method to recover bioactive compounds
    Patent number: 8735573
    Abstract: The invention relates to a process for separating bioactive compounds obtained from vegetable materials. The invention also relates to a process for extracting bioactive compounds from vegetable material.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: May 27, 2014
    Assignee: Langtech International Pty Ltd.
    Inventors: Tim Lang, Wayne Simpkins
  • Tri- and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens
    Patent number: 8729051
    Abstract: Compositions which include a homotrimer, heterotrimer, homotetramer, and/or heterotetramer of a component such as pentose, hexose, an L or D isomer of a pentose or hexose, a ?-form of a pentose or hexose, oxidized derivatives and mixtures of such compounds are disclosed as agglutination agents. The disclosed compositions are useful for agglutination of enteric pathogens and may be used for selectively controlling and regulating the microbial ecosystem in the gastrointestinal tract of a subject.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: May 20, 2014
    Assignee: Nutrition Sciences N.V./S.A.
    Inventors: Geert Bruggeman, Katrien Deschepper
  • Isomerization of sugars
    Patent number: 8729256
    Abstract: Disclosed are processes for isomerizing saccharides. Also disclosed are processes for converting saccharides to furan derivatives. Also disclosed are processes for converting starch to furan derivatives.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: May 20, 2014
    Assignee: California Institute of Technology
    Inventors: Manuel Moliner-Marin, Yuriy Roman-Leshkov, Mark E. Davis, Eranda Nikolla
  • Use of iron(III) complex compounds
    Patent number: 8722101
    Abstract: The present invention relates to novel therapeutic uses of iron(III) complex compounds with carbohydrates or derivatives thereof, in the preparation of a medicament for improving immune defence and/or brain performance.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: May 13, 2014
    Assignee: Vifor (International) AG
    Inventors: Jessica Tanner-Baumgartner, Ranjeet Chandra, Peter Geisser
  • 7-deazapurine modulators of histone methyltransferase, and methods of use thereof
    Patent number: 8722877
    Abstract: Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: May 13, 2014
    Assignee: Epizyme, Inc.
    Inventors: Richard Chesworth, Kevin Wayne Kuntz, Edward James Olhava, Michael A. Patane
  • Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
    Patent number: 8722644
    Abstract: The present invention is related to a method of treating and preventing peptic ulcer and duodenal ulcer by administering hyaluronic acid composition with a binary mixture of hyaluronic acids having mainly different weight-average molecular weight and then different rheological, scaffold and degradation properties in aqueous solution. The resulted compositions have demonstrated an optimal balance between adhesion, tissue scaffold and treating time to the peptic and duodenal ulcer and bleeding. Thus, the present inventive binary mixture exhibits a quick and lasting effect on the treatment and prevention of duodenal or peptic ulcer and bleeding.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: May 13, 2014
    Assignee: Holy Stone Healthcare Co., Ltd.
    Inventor: Tsung-Chung Wu
  • Biomass hydrolysis
    Patent number: 8722878
    Abstract: High-yielding method for chemical hydrolysis of lignocellulose into monosaccharides. The process of the invention can additionally be applied to cellulose, xylan and related biomass polysaccharides, such as galactan, mannan, or arabinan. The method is employed for hydrolysis of a biomass polysaccharide substrate. The process is carried out in an ionic liquid in which cellulose is soluble in the presence of catalytic acid at a temperature sufficiently high to initiate hydrolysis. Water is added to the reaction mixture after initiation of hydrolysis at a rate controlled to avoid precipitation yet avoid undesired sugar dehydration products such ad HMF. Hydrolysis product is useful as feedstock for fermentations including fermentation processes for ethanol, butanol and other fuels.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: May 13, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Joseph B. Binder