Abstract: A catheter lock solution which is a catheter lock preparation having a bacteriostatic property at physiological osmotic pressure without practically containing a bacteriostatic component such as a preservative, an antimicrobial agent, or an antibiotic and having high safety, characterized in that the preparation contains a weak acid having an acid dissociation constant (pKa) of 3.0 to 6.5 as a buffer, a pH of the solution is less than 6.0, preferably from 3.0 to about 5.5, an osmotic pressure ratio is from 0.5 to 3.0, and a pH change (variation) can be suppressed to less than the 6.0 with the weak acid, and a container containing the catheter lock solution.
Abstract: Thermally stable anhydrous Rebaudioside D can be provided by methods disclosed here and has been found to be more soluble in aqueous solutions than the previously known non-anhydrous Rebaudioside D. This physical property makes the anhydrous Reb D amenable to food and beverage manufacturing applications for which the non-anhydrous form is not suitable. Anhydrous Rebaudioside D is useful in sweeteners, and can be included in food and beverage products, which are also disclosed.
Abstract: A single phase preparation of free flowing, hydrophobic starches which comprises a starch treated with a siliconate and an acid in a single phase process, is described herein.
Type:
Grant
Filed:
January 6, 2012
Date of Patent:
April 22, 2014
Assignee:
Corn Products Development, Inc
Inventors:
Shawn R. Branning, Tracy M. John, Kamlesh K. Shah
Abstract: Compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal, where in the galectin is preferably a galectin-3.
Type:
Grant
Filed:
April 26, 2010
Date of Patent:
April 22, 2014
Assignee:
Galecto Biotech AB
Inventors:
Hakon Leffler, Ulf J. Nilsson, Henrik Von Wachenfeldt
Abstract: Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3?-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.
Abstract: A topical pharmaceutical gel includes flurbiprofen or a pharmaceutically acceptable salt of flurbiprofen, thiocolchicoside or a pharmaceutically acceptable salt of thiocolchicoside, and menthol. Pharmaceutical combinations of flurbiprofen, thiocolchicoside, and menthol in the form of topical gels with anti-inflammatory, analgesic, and myorelaxant activities are described.
Type:
Grant
Filed:
September 20, 2010
Date of Patent:
April 8, 2014
Assignee:
Sanovel Ilac Sanayi ve Ticaret Anonim Sirketi
Inventors:
Fatih Cakir, Ali Turkyilmaz, Umit Cifter
Abstract: The present invention relates to a composition for skin application, which has the effects of reducing skin wrinkles, enhancing skin elasticity and preventing skin aging, and more particularly, to a composition for skin application, which contains, as an active ingredient, a polysaccharide extract of red ginseng having a molecular weight of less than 10,000, in which the polysaccharide extract of red ginseng has the effect of increasing the expression of mitochondrial electron transport system enzymes in human skin keratinocytes to enhance the activity of the skin cells, thereby reducing skin wrinkles, increasing skin elasticity and preventing skin aging.
Type:
Grant
Filed:
November 23, 2010
Date of Patent:
April 8, 2014
Assignee:
Amorepacific Corporation
Inventors:
Ji Seong Kim, Myeong Hun Yeom, Sun Sang Kwon, Duck Hee Kim, Han Kon Kim
Abstract: Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.
Type:
Grant
Filed:
February 21, 2007
Date of Patent:
April 8, 2014
Assignee:
Korea Institute of Radiological & Medical Sciences
Inventors:
Chun-Ho Kim, Seung-Jae Lee, Jin-Ik Lim, Youngsook Son
Abstract: Methods for maintaining or improving the gastrointestinal health of animals susceptible to or suffering from poor gastrointestinal health by administering to the animal a gastrointestinal health maintaining or improving amount of a food composition comprising from about 1 to about 20% carbohydrate; from about 3 to about 10% total dietary fiber, wherein the total dietary fiber contains from about 10 to about 40% soluble fiber and from about 90 to about 60% insoluble fiber; and from about 0.1 to about 10% omega-3 fatty acids; wherein the composition has a digestibility coefficient of at least 80. Generally, the compositions are administered to the animal to prevent or treat diarrhea or to improve stool quality. Further, the compositions may be administered in conjunction with one or more probiotics, prebiotics, anti-gastritis drugs, anti-enteritis drugs, or anti-diarrhea drugs, microbial exopolysaccharides, or combinations thereof to maintain or improve gastrointestinal health.
Type:
Grant
Filed:
September 1, 2009
Date of Patent:
April 8, 2014
Assignee:
Nestec SA
Inventors:
Hui Xu, Dorothy Pauline LaFlamme, Carolyn Jean Cupp
Abstract: The present invention relates to a process for preparing a chemically modified polysaccharide, preferably starch, by using a microdevice. It further relates to the use of a microdevice for the chemical reactions of polysaccharides in heterogeneous mixtures. Examples of chemical modifications are acetylation, oxidation, hydroxypropylation and the like.
Type:
Grant
Filed:
August 19, 2010
Date of Patent:
April 1, 2014
Assignee:
Cargill, Incorporated
Inventors:
Marc Charles Florent Berckmans, Rita Maria Delrue, Bruno Frédéric Stengel
Abstract: A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural.
Type:
Grant
Filed:
October 30, 2012
Date of Patent:
March 25, 2014
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Joseph Bartholomew Binder, Ronald Thaddeus Raines
Abstract: Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.
Type:
Grant
Filed:
September 17, 2009
Date of Patent:
March 25, 2014
Assignee:
Nektar Therapeutics
Inventors:
Antoni Kozlowski, Samuel P. McManus, Xiaoming Shen
Abstract: The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.
Abstract: A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.
Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
May 1, 2012
Date of Patent:
March 18, 2014
Assignee:
Alchemia Limited
Inventors:
Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
Abstract: A pharmaceutical composition for use in the prevention and/or treatment of a neurodegenerative disorder comprising a compound comprised of one or more disaccharide units, the or each disaccharide unit comprising a uronate moiety linked to a glucosamine moiety, wherein the 2-O atom of the uronate moiety is substituted with a hydrogen atom, the 6-O atom of the glucosamine moiety is substituted with a sulphate group and the 2-N atom of the glucosamine moiety is substituted with an atom or group other than a sulphate group. The composition is particularly preferred for use in the prevention and/or treatment of Alzheimer's disease.
Type:
Grant
Filed:
May 23, 2007
Date of Patent:
March 18, 2014
Assignee:
The University Of Liverpool
Inventors:
Jeremy Turnbull, Edwin Yates, Susannah Patey
Abstract: The invention provides a method of treatment of a female human or non-human subject to enhance cervical mucus penetrability by spermatozoa, which method comprises vaginally applying to said subject an effective amount of a spermicide-free, physiologically tolerable oligouronate.
Type:
Grant
Filed:
October 6, 2006
Date of Patent:
March 18, 2014
Assignee:
NTNU Technology Transfer AS
Inventors:
Catherine Taylor, Kurt Ingar Draget, Olav Asmund Smidsrod
Abstract: A method of localizing reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.
Type:
Grant
Filed:
April 30, 2012
Date of Patent:
March 11, 2014
Assignee:
Kode Biotech Limited
Inventors:
Nicola Lewell Carter, Deborah Adella Blake, Nicolai Bovin, Stephen Michael Henry, Elena Yurievna Korchagina, Eleanor Christine Williams, Alexander Tuzikov
Abstract: The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.
Type:
Grant
Filed:
December 13, 2011
Date of Patent:
February 25, 2014
Inventors:
Shenda Baker, William P. Wiesmann, Shannon Ryan