Patents Examined by Layla Bland
  • C-glycoside compounds, and method for preparing C-glycoside compounds
    Patent number: 8569467
    Abstract: The invention relates to C-glycose compounds of formula (I) where: S? is a monosaccharide radical or a polysaccharide radical derived from a monosaccharide or polysaccharide S; R is a linear or branched alkyl radical; and Z is an ethylenyl CH?CR1(R2) or an acetylenyl C?CR3 radical. The invention also relates to a method for preparing C-glycoside compounds of formula (III), characterized in that the method consists of a step of reacting a sugar (S), in an aqueous solvent or in the absence of a solvent and in the presence of an organic or mineral base (B), with a phosphonate of formula (II) according to the following reaction pattern: Formulas (II), (III).
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: October 29, 2013
    Assignees: Ecole Nationale Supérieure de Chimie de Rennes, Armor Proteines
    Inventors: Thierry Benvegnu, Loïc Lemlegre, Adeline Ranoux
  • Cross-linking of low-molecular weight and high-molecular weight polysaccharides, preparation of injectable monophase hydrogels, polysaccharides and hydrogels obtained
    Patent number: 8563532
    Abstract: A process for the crosslinking of at least one polymer selected from polysaccharides and derivatives thereof, which is carried out in an aqueous solvent by the action of an effective and non-excessive amount of at least one crosslinking agent, characterized in that it is carried out on a mixture containing at least one low-molecular weight polymer and at least one high-molecular weight polymer. A process for the preparation of an injectable monophase hydrogel of at least one crosslinked polymer selected from polysaccharides and derivatives thereof. Crosslinked polymers and injectable monophase hydrogels respectively obtainable by each of said processes.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 22, 2013
    Assignee: Allergan Industrie SAS
    Inventor: Pierre F. Lebreton
  • Composite fibre of alginate and chitosan
    Patent number: 8563702
    Abstract: There are provided composite fibers of alginate and chitosan. Also provided are fiber materials methods of producing composite fibers or films and composite films. In one embodiment there is provided a composite fiber of alginate and chitosan suitable for use in wound management products, wherein chitosan polymer is bonded to alginate polymer along the length of the fiber.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 22, 2013
    Assignee: The University of Bolton Education Corporation
    Inventors: Mohsen Miraftab, Gillian Mary Smart
  • Statin-carboxyalkylether combinations
    Patent number: 8557835
    Abstract: The invention is a pharmaceutical composition comprising a carboxyalkylether which lowers triglycerides and elevated HDL, and a statin which inhibits HMG-CoA reductase, thereby reducing LDL, said composition being useful for treating vascular diseases.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: October 15, 2013
    Assignee: Warner-Lambert Company, LLC
    Inventors: Charles Larry Bisgaier, Roger Schofield Newton
  • Anti-tumor agent comprising cytidine derivative and carboplatin
    Patent number: 8557791
    Abstract: Provision of a novel combined therapy with ECyd, which therapy exhibits remarkable antitumor effect and gives less adverse effects. The invention provides an antitumor agent containing, in combination, 1-(3-C-ethynyl-?-D-ribopentofuranosyl) cytosine or a salt thereof and carboplatin.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: October 15, 2013
    Assignees: Taiho Pharmaceutical Co., Ltd.
    Inventor: Hiromi Kazuno
  • Localized delivery of cardiac inotropic agents
    Patent number: 8551961
    Abstract: The present invention provides novel methods for the localized delivery of inotropic agents to the heart, including specific regions of the heart, such as the ventricles, for example in a subject undergoing cardiothoracic surgery, with the aim of supporting the myocardial contractile function of the heart.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: October 8, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Elazer Edelman, Mark Lovich
  • Saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions
    Patent number: 8552161
    Abstract: This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenyl, C6-10 aryl-C(O)—, C6-10 aryl-C1-4 alkyl-C(O)—, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel compounds and to a pharmaceutical composition containing these compounds.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: October 8, 2013
    Assignees: Uniwersytet W Bialymstoku, Univerzita Palackeho V Olomouci, Bioapex, S.R.O.
    Inventors: Jacek Witold Morzycki, Agnieszka Wojtkielewicz, Jana Oklestkova, Lucie Hoffmannova, Miroslav Strnad
  • Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives
    Patent number: 8552162
    Abstract: The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: October 8, 2013
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Guoyou Xu, Datong Tang, In Jong Kim, Ly Tam Phan, Yat Sun Or, Zhe Wang
  • Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-?-L-ribofuranosyl)-1H-benzimidazole
    Patent number: 8546344
    Abstract: The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(?-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 1, 2013
    Assignee: ViroPharma Incorporated
    Inventors: Gerard Coquerel, Guillaume Levilain, Marie-Noelle Petit, Servane Coste-Leconte
  • Modified galactomannan ethers
    Patent number: 8546559
    Abstract: Cationic hydrophobically modified galactomannan ethers having a cationic degree of substitution (DSC) from 0.01 to 0.5 and hydrophobic degree of substitution (DSH) below 0.001 are readily soluble in aqueous systems and useful to thicken, stabilize and condition cosmetics, detergent compositions and household cleaning products; they further improve the deposition of other ingredients on the treated surface (skin, hair or fabric).
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: October 1, 2013
    Assignee: Lamberti SpA
    Inventors: Valentina Langella, Eva Baldaro, Giuseppe Li Bassi
  • Processes for the convergent synthesis of calicheamicin derivatives
    Patent number: 8546549
    Abstract: This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 1, 2013
    Assignee: Wyeth LLC
    Inventors: Keith Moran, Jianxin Gu
  • Method for removing impurities from biopolymer material
    Patent number: 8530644
    Abstract: The present invention relates to a method for removing impurities from biopolymer material, e.g. polysaccharides, polypeptides or polynucleotides. More particularly, the present invention provides a method of reducing lipopolysaccharide levels in a lipopolysaccharide containing biopolymer material, comprising the successive steps of: a) providing an aqueous solution containing 0.05-50 wt. % of dissolved lipopolysaccharide-containing biopolymer material; 0.001-10 wt.% of a surfactant; 0.05-15 wt. % of solid adsorbent; and at least 50 wt. % of water; b) allowing the adsorbent to adsorb lipopolysaccharides; c) separating the solid adsorbent containing adsorbed lipopolysaccharides from the remaining aqueous solution; and d) recovering the biopolymer material containing a reduced level of lipopolysaccharide from the separated aqueous solution.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: September 10, 2013
    Assignee: Bender Analytical Holding B.V.
    Inventors: Johannes Caspar Mathias Elizabeth Bender, Pieter Sebastiaan Vermeulen
  • Bicyclic cyclohexitol nucleic acid analogs
    Patent number: 8530640
    Abstract: The present disclosure provides bicyclic cyclohexitol nucleoside analogs of formula I and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are expected to be useful for enhancing properties of oligomeric compounds including for example nuclease resistance.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: September 10, 2013
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Punit P. Seth, Michael T. Migawa, Eric E. Swayze, Quanlai Song, Mingming Han, Bruce S. Ross
  • Chlorination of sucrose-6-esters
    Patent number: 8530643
    Abstract: A method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-?-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6? positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: September 10, 2013
    Assignee: Tate & Lyle Technology Ltd.
    Inventors: Wayne N. Boutzale, David A. Dentel, Mohamad R. Jaber
  • Method of producing D-psicose crystals
    Patent number: 8524888
    Abstract: The present invention relates to a method of producing D-psicose crystals from a D-psicose solution by using supersaturation.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: September 3, 2013
    Assignee: CJ Cheiljedang Corp.
    Inventors: Kang Pyo Lee, Sang Hoon Song, Seung Won Park, Sung Bo Kim, Young Ho Hong, Joo Hang Lee, Taek Beom Kim, Jun Gap An, Jung Hoon Kim
  • Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate
    Patent number: 8524687
    Abstract: This invention relates to ophthalmic wound-healing pharmaceutical compositions based on amino acids and sodium hyaluronate.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: September 3, 2013
    Assignee: Professional Dietetics S.R.L.
    Inventors: Francesco Saverio Dioguardi, Edoardo Carlo Maria Conti, Federico Giovanni Maria Conti, Isabella Arborio Mella
  • Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
    Patent number: 8518910
    Abstract: The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a ?-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: August 27, 2013
    Assignee: Curis, Inc.
    Inventors: Xiong Cai, Changgeng Qian, Haixiao Zhai, Rudi Bao
  • Method for the synthesis of anthocyanins
    Patent number: 8513395
    Abstract: The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: August 20, 2013
    Assignee: Biosynth AS
    Inventor: Einar Bakstad
  • Method for the treatment of type II diabetes
    Patent number: 8507451
    Abstract: A method of treating Type II diabetes utilizing two off-the-shelf drugs. Intravenous injection of one or both drugs, individually and in combination, can prevent and treat diabetes, restore damaged islet cell functions and reduce or stop the use of oral hypoglycemic agents and insulin.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: August 13, 2013
    Inventors: Zhili Wang, Renming Wang
  • Anti-cholesterolemic compounds and methods of use
    Patent number: 8492351
    Abstract: The present invention provides novel compounds with hypocholesteremic activity from crude Embilica officinialis (EO) extracts and methods of use. The invention also provides nutraceuticals.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: July 23, 2013
    Inventors: Subroto Chatterjee, Mark S. Butler, Brinda Somanadhan