Patents Examined by Lezah Roberts
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Patent number: 12268766Abstract: The present invention relates to formulations with active oxygen compounds that include active oxygen and other active ingredients for the purposes of care for and/or maintaining and preserving a healthy condition of skin and integumentary systems on the surface of the body of the organism and in the ears, healthy condition of finger- and toenails and of oral cavity, including its mucous membranes, teeth, interdental spaces and periodontal tissues (gingiva) in the oral cavity, i.e. the target areas of the organism. The formulation for skin and integumentary systems on the surface of the body and in the ears and for the finger- and toenails is in the form of a solution, gel, emulsion, lotion, milk, spray, cream, film dressing, liposomes and/or mycelia. The formulation for the oral cavity and related systems and structures, including teeth, interdental spaces and periodontal tissues (gingiva) is in the form of a solution, mouthwash, spray, gel, paste, emulsion, film dressing, liposomes and/or mycelia.Type: GrantFiled: January 14, 2020Date of Patent: April 8, 2025Inventor: Dominika Tompa Majcen
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Patent number: 12263274Abstract: The present invention provides surface-modified medical implants having one of more layer of gold nanoparticles, wherein, for example, the surface of a medical implant body could be immobilized with a single of double layers of GNPs. The implants could have a superior biocompatibility and superior osteogenic differentiation.Type: GrantFiled: November 8, 2020Date of Patent: April 1, 2025Assignee: SELJIN CO.LTD.Inventors: Seil Sohn, Wan Kyu Ko, Seong Jun Kim
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Patent number: 12257341Abstract: The present invention relates to an injectable pharmaceutical composition containing a prodrug of caspase inhibitors, and a preparation method therefor. More specifically, the present invention relates to an injectable pharmaceutical composition, and a preparation method therefor, the composition comprising, as an active ingredient, (2S,3S)-2-(fluoromethyl)-3-((R)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydroisoxazole-5-carboxamido)-5-oxotetrahydrofuran-2-yl acetate, which is a prodrug of caspase inhibitors, or a pharmaceutically acceptable salt or isomer thereof, and comprising, as a biocompatible polymer, microspheres containing poly(lactide-co-glycolide).Type: GrantFiled: May 29, 2020Date of Patent: March 25, 2025Assignee: LG CHEM, LTD.Inventors: Sung Won Kim, Jae Uk Baek, Hyun Seo Park, Myung Won Jin, Jung Gyu Park, Bok Tae Kim, Sei Hyun Choi
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Patent number: 12257329Abstract: An aqueous composition for removing oral malodor caused by volatile gaseous compounds present in the oral cavity is disclosed herein. The aqueous oral composition comprises one or more of metals selected from the group consisting of Silver, Gold, Zinc, Aluminum, Magnesium and Tin, wherein the metals are present as a stable aqueous nanoparticulate dispersion or a colloid, having an average metal particle size of 1-1000 nm. at a concentration between 1 to 100 ppm. The aqueous oral composition may also include metal particles that may be partially oxidized, by reaction with oxygen including that from air during manufacture or storage. The aqueous oral composition may also include a mucoadhesive polymer selected from a group of water-soluble polymers having an affinity to keratin. The aqueous oral composition may be a synergistic mixture of two or more metal nanoparticulate colloids.Type: GrantFiled: September 21, 2022Date of Patent: March 25, 2025Assignee: Helix Science LLCInventors: Anthony Andrady, Milroy Codipilly
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Patent number: 12251460Abstract: Kits comprising unit-dose oral care compositions with two or more flavors. Kits comprising unit-dose oral care compositions with two or more benefit agents. An oral care regimen comprising applying water to a toothbrush and picking up a unit-dose oral care composition without the consumer having to handle the unit-dose oral care composition.Type: GrantFiled: June 11, 2020Date of Patent: March 18, 2025Assignee: The Procter and Gamble CompanyInventors: Paul Albert Sagel, Gregory T. Jones, Min Mao, Peter Middleton, Natosha Parnell, Melissa Cherie Payne, Jeanette Marie Swartz
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Patent number: 12246078Abstract: An oral care product comprising at least one of phytomenadione (vitamin K1), menaquinone (vitamin K2), vitamin C, selenium, ubiquinone (Coenzyme Q10), Astragalus, Ginseng, Schisandra, adaptogenic herbs, cannabidiol, or the like. An oral care product directed toward rebalancing micro-bacterial homeostasis in the mouth, or establishing and maintaining a healthy oral microbiome.Type: GrantFiled: September 6, 2018Date of Patent: March 11, 2025Inventor: Gerald P. Curatola
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Patent number: 12239725Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.Type: GrantFiled: November 27, 2019Date of Patent: March 4, 2025Inventor: Michael Arnold
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Patent number: 12239723Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.Type: GrantFiled: January 4, 2023Date of Patent: March 4, 2025Assignee: The University of MelbourneInventor: Eric Charles Reynolds
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Patent number: 12220677Abstract: The present invention relates to a process for the preparation of microcapsules, in particular isocyanate-based microcapsules with improved stability to carboxylic acid and aldehyde-containing active ingredients as core material. In addition, the present invention relates to microcapsules obtainable by the process according to the invention. In addition, the present invention relates to microcapsules, suspensions of such microcapsules, and the use of the microcapsules and suspensions as a component in detergents, fabric softeners, cleaning products, scent boosters (fragrance enhancers) in liquid or solid form, cosmetics, personal care products, agricultural products, or pharmaceutical products.Type: GrantFiled: February 13, 2019Date of Patent: February 11, 2025Assignee: SYMRISE AGInventors: Julian Alexander Georgi, Benjamin Rost, Diane Dröge, Ralf Bertram, Thorsten Böddeker
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Patent number: 12220475Abstract: A cosmetic composition includes a firming system that includes: a pectin; at least one powder; water; at least one fatty compound; and at least one plasticizer. The firming system when is spreadable and wherein upon drying the firming system forms a firming film that exhibits cohesion and adhesion when applied to a substrate. The pectin may comprise low methoxyl pectin, and the firming system may further include at least one monosaccharide, disaccharide or combination thereof. The composition may include a cosmetic carrier system wherein the firming system and cosmetic carrier system is in the form of liquidous or creamy type emulsion or an oil free serum for application to skin to ameliorate the signs of aging or a viscous liquidous emulsion or suspension for application as a makeup to keratinous tissue selected from skin, lashes and hair to confer firming to the keratinous tissue.Type: GrantFiled: December 27, 2022Date of Patent: February 11, 2025Assignee: L'OREALInventors: Chunwei Wu, Hy Bui, Zhengzheng Liao
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Patent number: 12178907Abstract: Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.Type: GrantFiled: July 11, 2019Date of Patent: December 31, 2024Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Anu Puri, Mathias Viard
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Patent number: 12171865Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.Type: GrantFiled: November 5, 2020Date of Patent: December 24, 2024Assignee: Trimph IP Pty LtdInventors: Ali Fathi, Fariba Dehghani, Anthony Weiss, Suzanne Mithieux
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Patent number: 12171880Abstract: A metformin tablet, a metformin tablet for relieving pain and reducing inflammation, and a manufacturing method thereof. The tablet for relieving pain and reducing inflammation comprises: a filler, a diluent, an excipient, a binder, a slow-release agent, a sweetener, and a medicinal powder; the excipient comprises: at least one of PVP, PEG, and polymer; the medicinal powder comprises: at least one of metformin and the excipient. The metformin tablet comprises: a hollow part, a thick colloidal layer formed on an outer side of the hollow part, and a powder colloidal layer formed on an outer side of the thick colloidal layer. The tablet for relieving pain and reducing inflammation comprises: a thick colloidal layer, a powder colloidal layer formed on an outer side of the thick colloidal layer, and a hollow part located at a center of the tablet and on an inner side of the thick colloidal layer.Type: GrantFiled: September 8, 2022Date of Patent: December 24, 2024Assignee: Taiwan Mercury Medical CorporationInventors: Chao-Yi Chen, Chih-Chia Tsai
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Patent number: 12167731Abstract: A field of biological fungicides with a broad range of antifungal activity coming from plant extracts from the order of Brassicales or molecules revealing similar chemical structure. In particular, Applicants surprisingly provided a new usage of a combination of sulfonyl and sulfinyl containing aliphatic glucosinolates, their by-products and synthetic analogues as efficient antifungal compounds with broad spectrum of activity.Type: GrantFiled: July 9, 2019Date of Patent: December 17, 2024Assignee: UNIVERSITE DE LAUSANNEInventors: Olga Dubey, Edward Farmer, Christiane Nawrath, Katia Gindro, Sylvain Schnee, Sylvain Dubey
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Patent number: 12161747Abstract: A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.Type: GrantFiled: July 11, 2024Date of Patent: December 10, 2024Assignee: Imam Abdulrahman Bin Faisal UniversityInventor: Abdul Samad Khan
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Patent number: 12138349Abstract: The present invention relates to a process for spray drying of a feed solution comprising semaglutide, said process comprising introducing the feed solution comprising semaglutide in a solvent into a spray dryer and introducing an atomising gas and a drying gas, characterised in that the spray dryer comprises a gas heater for the drying gas with an inner surface comprising iron and less than 18.5% chromium.Type: GrantFiled: March 13, 2020Date of Patent: November 12, 2024Assignee: Novo Nordisk A/SInventors: Ole Vangsgaard, Marlene Hoerslev Hansen
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Patent number: 12133918Abstract: A hybrid composition of partially pre-gelatinized cassava starch powder is herein disclosed. The hybrid composition is obtained by a pre-compaction process and a wet-granulation process, and the partially pre-gelatinized cassava starch including birefringent portions and non-birefringent portions. The hybrid composition is formulated for use in, for example, tablets, and may be used as a multi-functional excipient in various powder formulations.Type: GrantFiled: July 8, 2022Date of Patent: November 5, 2024Assignee: Griffin Gamma, LLCInventor: Patrick Chukwuemeka Okoye
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Patent number: 12128156Abstract: The present invention generally relates to an orthopedic implant. Specifically, the present invention relates to an implant that incorporates a purposefully designed material that optimizes bony ingrowth combined with a support material configured to provide structural integrity.Type: GrantFiled: September 4, 2020Date of Patent: October 29, 2024Inventor: Bret Michael Berry
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Patent number: 12109284Abstract: The present invention relates to methods for preparing compositions comprising calcium and fluoride, and, in particular, to methods for preparing compositions comprising calcium that is stabilised with a stabilising agent and fluoride. For example, the method is for the preparation of compositions comprising amorphous calcium phosphate stabilised by phosphopeptides, and free fluoride. The invention also extends to various compositions produced by such methods, including oral care products.Type: GrantFiled: November 7, 2017Date of Patent: October 8, 2024Assignee: DENTHERAPY LTDInventors: David Andrew Smillie, Richard James Willson
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Patent number: 12102708Abstract: A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.Type: GrantFiled: March 9, 2024Date of Patent: October 1, 2024Assignee: Imam Abdulrahman Bin Faisal UniversityInventor: Abdul Samad Khan