Abstract: A system including a sensor interface coupled to a processor. The sensor interface is configured to receive and process an analog electrocardiogram signal of a subject and provide a digitized electrocardiogram signal sampled over a first time period and a second time period that is subsequent to the first time period. The processor is configured to receive the digitized electrocardiogram signal, to analyze a frequency domain transform of the digitized electrocardiogram signal sampled over the first and second time periods and determine first and second metrics indicative of metabolic state of a myocardium of the subject during the first and second time periods, respectively, to compare the first and second metrics to determine whether the metabolic state of the myocardium of the subject is improving, and to indicate administration of an intervention to the subject in response to a determination that the metabolic state is not improving.

Abstract: A cannula for moving fluids between a pump and the circulatory system of a patient. The cannula includes a liner having an intermediate portion between a proximal portion and a distal portion, and a lumen extending between the proximal and distal portions. At least the intermediate portion of the liner is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket surrounds at least part of the liner.

Abstract: A physiological detection system including an image sensor, a converting unit, a retrieving unit and a processing unit is provided. The image sensor includes a plurality of pixels respectively configured to output a PPG signal. The converting unit is configured to convert a plurality of PPG signals of a plurality of pixels regions to a plurality of frequency domain signals. The retrieving unit is configured to respectively retrieve a spectral energy of the frequency domain signals corresponding to each of the pixel regions. The processing unit is configured to construct a 3D energy distribution according to the spectral energies.

Abstract: A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces.

Abstract: Devices and methods for single therapy pulse (STP) therapy for tacharrythmia are disclosed. The STP therapy can be delivered from a far-field position to allow a “global” capture approach to pacing. Due to the global capture in STP, a series of pulses, which is indicative of conventional anti-tachycardia pacing (ATP) delivered by transvenous systems, becomes unnecessary. One to four pulses at most are needed for STP, and after delivery of the one to four pulses, therapy delivery can be interrupted to determine whether the previously delivered therapy has been successful.

Abstract: An apparatus is disclosed, configured to control transmission of wireless energy supplied to an electrically operable medical device adapted to be implanted in a mammal patient. The apparatus comprises an external energy source adapted to be located outside the mammal patient and comprising an external control unit, wherein the external energy source is adapted to transmit wireless energy. Further, the apparatus comprises an internal energy receiver located inside the patient and comprising an internal control unit, wherein the internal energy receiver is adapted to receive the wireless energy and to directly or indirectly supply wirelessly received energy to the electrically operable device. The apparatus further comprises at least one stabilizing unit adapted to stabilize the wirelessly received energy in the electrically operable medical device.

Abstract: A method and system for supplying energy to an electrically operable medical device (100) implanted in a patient. Wireless energy is transferred from an external energy source (104) located outside the patient to an internal energy receiver (102) located inside the patient and connected to the medical device. An internal control unit (108) determines an amount of energy currently required for the operation of said medical device. A control signal is transmitted to the external energy source, reflecting the required amount of energy. An external control unit (106) controls the amount of transferred energy in response to the control signal, by adjusting the energy transfer efficiency from the external energy source to the internal energy receiver. The energy transfer efficiency is adjusted by adjusting the position of a primary coil, serving as the external energy source, relative to an implanted secondary coil, serving as the internal energy source.

Abstract: A spindle assembly of a surgical instrument includes a body and a cutter pin. The body has at least one wall forming first and second channels therein. The cutter pin is disposed within the second channel and operably coupled to a knife rod extending therethrough and is operatively coupled at its distal end to a knife. When the knife rod is moved between a retracted position and a deployed position, the spindle assembly is moved between a first and a second position along the shaft. The cutter pin is configured to deform and exit the body when the knife is deployed and disposed in a trapped condition and in response to an applied force, thereby decoupling the knife from the spindle assembly.

Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Abstract: An insulative feedthrough attachable to an active implantable medical device includes a feedthrough body having a material which is both electrically insulative, biocompatible and separates a body fluid side from a device side. A passageway is disposed through the feedthrough body. A composite conductor is disposed within the passageway and has a body fluid side metallic wire electrically conductive to a device side metallic wire. The body fluid side metallic wire extends from a first end disposed inside the passageway to a second end on the body fluid side. The device side metallic wire extends from a first end disposed inside the passageway to a second end on the device side. The body fluid side metallic wire is hermetically sealed to the feedthrough body. The body fluid side metallic wire is biocompatible and is not the same material as the device side metallic wire.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example system for mapping the electrical activity of the heart includes a catheter shaft. The catheter shaft includes a plurality of electrodes including a first and a second electrode. The system also includes a processor. The processor is capable of collecting a first signal corresponding to a first electrode over a time period and generating a first time-frequency distribution corresponding to the first signal. The first time-frequency distribution includes a first dominant frequency value representation occurring at one or more first base frequencies. The processor is also capable of applying a filter to the first signal or derivatives thereof to determine whether the first dominant frequency value representation includes a single first dominant frequency value at a first base frequency or two or more first dominant frequency values at two or more base frequencies.

Abstract: Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

Abstract: A centrifugal blood pump includes a housing that defines an inlet passage, a chamber, and an outlet passage. The pump includes an impeller rotatably positioned in the chamber to transfer blood from the inlet passage through the chamber and to the outlet passage and magnetic members embedded in the impeller such that the impeller and the magnetic members rotate together within the chamber. The pump includes a motor to control movement of the impeller in the chamber. The motor is adjacent the chamber and separated from the chamber by a partition member. The pump includes an inner annular magnetic member and an outer annular magnetic member embedded in a side of the housing opposite the partition member. A first net magnetic force between the inner annular magnetic member and the magnetic members exhibits greater attraction than a second net magnetic force between the outer annular member and the magnetic members.

Abstract: An example a system includes a neuromodulation generator that may be configured to use electrodes to generate a first modulation field over a test region of neural tissue along the electrodes to prime the neural tissue throughout the test region and a second modulation field to test targeted locations within the test region for therapeutic effectiveness. A memory may be configured to store a first modulation field parameter for generating the first modulation field and a second modulation field parameter set for generating the second modulation field to modulate a targeted location within the test region. The second modulation field parameter set is programmable for modulating other targeted locations. The controller may be configured to control the neuromodulation generator to use the first modulation field parameter set to deliver the first modulation field and to use the second modulation field parameter set to deliver the second modulation field.

Abstract: A skull-mountable medical device is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient. A light pipe is attached to the housing. The device is configured to be positioned on a patient's skull with the light pipe extending into the patient's brain, such that light from the light source can irradiate a target position within the patient's brain. Once so positioned, the housing may be affixed to the skull via bone screws. The device is powered and controlled by an implantable pulse generator (IPG) that may be implanted into a patient's tissue remotely from the device and connected to the device by wire leads.

Abstract: An electrosurgical device for directing energy to a target volume of tissue includes a coaxial feedline having an inner conductor, an outer conductor and a dielectric material disposed therebetween. A proximal cylindrical dielectric sleeve is coupled to the inner conductor at a distal end of the coaxial feedline. A distal cylindrical dielectric sleeve is coupled to the inner conductor. First and second dielectric segments are coupled to the inner conductor and disposed between the proximal cylindrical dielectric sleeve and the distal cylindrical dielectric sleeve. The device also includes an elongated shaft overlying the proximal cylindrical dielectric sleeve, the first dielectric segment, the second dielectric segment and the distal cylindrical dielectric sleeve. The elongated shaft includes an opening defined therethrough, wherein the opening is at least partially aligned with the first dielectric segment.

Abstract: Systems and methods of processing raw electrocardiogram (ECG) waveform data of a patient into estimated real-time ECG waveform data. The method includes sensing at least one physical non-cardiac influence on the raw ECG waveform data, constructing a time domain computer model of the at least one physical, non-cardiac influence on the raw ECG waveform data, and adaptively filtering the raw ECG waveform data in the time domain using the constructed time domain computer model of the at least one physical non-cardiac influence on the raw ECG waveform data to form the estimated real-time ECG waveform data. The system can include an ECG device for collecting raw ECG waveform data, at least two ECG electrodes positioned on the patient and electrically coupled to the ECG device, and a processor coupled to the ECG device and configured to compute a time domain model of an artifact created by chest compressions.

Abstract: A medical device, such as an intra-aortic balloon pump or carrier with an extendable wheel track and handle configured to be removably carried and integrated with a cart. The wheel track is configured to extend upon extension of the handle and to return to its original position upon retraction of the handle.

Abstract: Cannula assemblies and methods of manufacturing cannula assemblies are provided. The cannula assembly includes a cannula and a pigtail extension coupled to the cannula. The pigtail extension includes a proximal section having a first stiffness and a distal section having a second stiffness, the first stiffness greater than the second stiffness. The proximal section of the pigtail extension is positioned between the cannula and at least a portion of the distal section.

Abstract: The disclosure describes techniques for associating therapy adjustments with posture states using a timer. The techniques may include detecting a patient adjustment to electrical stimulation therapy delivered to the patient, sensing a posture state of the patient, and associating the detected adjustment with the sensed posture state if the sensed posture state is sensed within a first period following the detection of the adjustment and if the sensed posture state does not change during a second period following the sensing of the sensed posture state.