Abstract: A process for producing 1,1-dichloro-1,2,2,2-tetrafluoroethane, which comprises isomerizing 1,1,2-trichloro-1,2,2-trifluoroethane to form 1,1,1-trichloro-2,2,2-trifluoroethane, followed by fluorination with hydrofluoric acid.

Abstract: The present invention provides a compound represented by the formula: ##STR1## wherein R.sub.1 denotes a hydrogen atom or a methyl group; R.sub.2 represents a 1-methyl-2-propenyl group, a 1-methyl-2-propynyl group, a 3,3-dihalogeno-1-methyl-2-propenyl group or a C.sub.1 -C.sub.6 alkyl group which may be substituted with at least one halogen atom; and A' represents a hydrogen atom or a protecting group for a hydroxyl group. The compound is useful in the preparation of esters which can be used to control insect pests.

Abstract: The present invention relates to a process for reducing the chlorine content of an organochlorine compound comprising: introducing into the organochlorine compound, at least one Lewis acid to form a mixture, and contacting the organochlorine compound with the Lewis acid in the mixture in the absence of elemental carbon for a sufficient amount of time to reduce the chlorine content of the organochlorine compound. In another embodiment, a process is described for reducing the chlorine content of an organochlorine compound comprising contacting the organochlorine compound with (a) at least one acid selected from the group consisting of Lewis acids, mineral acids other than hydriodic acid and hydrobromic acid, and organic acids having a pKa of less than about 2, and (b) a source of iodine or bromine in the absence of elemental carbon for a sufficient amount of time to reduce the chlorine content of the organochlorine compound.

Abstract: A process is disclosed for producing 1,1-difluoroethane (CH.sub.3 CHF.sub.2 or HFC-152a) in a two-step reaction in a manner that reduces formation of high boiling materials. The first step comprises adding at least one of HCl or HF to chloroethene (CH.sub.2 .dbd.CHCl) in order to obtain at least one of 1,1-dichloroethane (CH.sub.3 CHF.sub.2) or 1-chloro-1-fluoroethane (CH.sub.3 CHClF). The second step comprises converting 1,1-dichloroethane or 1-chloro-1-fluoroethane to 1,1-difluoroethane.

Abstract: Oxirane compounds are produced by molecular oxygen oxidation of an olefin in the presence of a platinum (II) dihalide catalyst.

Abstract: A class of chemical compounds comprising a 1-H-indazole moiety and a substituted heterocyclic moiety, linked via the 3-position of the indazole moiety by a methylene group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia. In formula (I) R represents hydrogen or C.sub.1-6 alkyl, Q represents a moiety of formula Qa, Qb, or Qc.

Abstract: A mixture of higher primary aliphatic alcohols of 22 to 38 carbon atoms can be obtained by saponifying and extracting steps with organic solvents from sugar cane wax. The mixture which contains tetracosanol, hexacosanol, heptacosanol, octacosanol, nonacosanol, triacontanol, dotriacontanol and tetratriacontanol can be used for the treatment of hypercholesterolemia, and atherosclerotic complications as platelet hyperaggregabiulity, ischemia and thrombosis, and prevents drug induced gastric ulcer and improves male sexual activity.

Abstract: Prochiral ethylenically unsaturated substrates are converted to chiral epoxides by reaction with optically active hydroperoxides in the presence of titanium-containing zeolites such as titanium zeolite beta. The method is particularly suitable for producing epoxides from unsubstituted aliphatic olefins which have exceptionally high optical purity as measured by enantiomeric excess.

Abstract: A process for making poly(2-methyl-1,3-propanediol) is disclosed. The process comprises heating 2-methyl-1,3-propanediol in the presence of an etherification catalyst at a temperature within the range of about 100.degree. C. to about 210.degree. C. The resulting poly(2-methyl-1,3-propanediol) has a degree of polymerization within the range of about 2 to about 20, and a number average molecular weight within the range of about 150 to about 2000. The process enables the synthesis of dimers and trimers of 2-methyl-1,3-propanediol, which are useful as reactive diluents or chain extenders for polyurethanes and as diol components for unsaturated polyester resins and thermoplastic polyesters.

Abstract: There are provided production methods of 1,1,1,3,3-pentafluoropropane characterized in that 1,1,1,3,3-pentafluoro-2,3-dichloropropane is reacted with hydrogen fluoride in the presence of a noble metal catalyst; of 1,1,1,3,3-pentafluoro-2-halogeno-3-chloropropane characterized in that the halogenated propene indicated as general formula I is fluorinated in the presence of antimony trihalogenide and/or antimony pentahalogenide by hydrogen fluoride of mole ratio of or over five times the said antimony halogenide in a liquid phase; and of 1,1,1,2,3,3-hexaohloropropene characterized in that 1,1,1,2,2,3,3-heptachloropropane is reacted with an aqueous solution of alkali metal hydroxide in the presence of a phase transfer catalyst. Therefore, an industrial manufacturing method which is possible to obtain the objective product easily at low cost and high yield can be provided.

Abstract: Methods and compositions for treating cancer and other diseases in which inhibition of telomerase activity can ameliorate disease symptoms or prevent or treat the disease relate to compounds characterized by the following structure: ##STR1## and its pharmaceutically acceptable salts. Z is selected from the group consisting of oxygen, sulfur, sulfone, sulfinyl and --NR--, where R selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. R.sub.1 is --Y.sub.n R.sub.6, where n is an integer between 0 and 10 and each Y.sub.n for n greater than 0 independently is methylene, methine, or quaternary carbon, and R.sub.

Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,R.sub.2 represents a hydrogen atom or a substituted or unsubstituted alkyl, substituted or unsubstituted phenyl, cycloalkyl, piperidino or substituted or unsubstituted amino group,X represents CO or SO.sub.2,R.sub.3 represents hydrogen or alkyl,R.sub.4 represents alkyl, substituted or unsubstituted phenyl or trihalomethyl, or else R.sub.3 and R.sub.4 form, together with the carbon atoms which carry them, cyclo(C.sub.3 -C.sub.7)alkenyl,A represents phenyl, naphthyl or pyridyl ring, each phenyl, naphthyl or pyridyl ring optionally being substituted,their isomers, the corresponding quaternary ammonium salts of the piperidine and their addition salts with a pharmaceutically acceptable acid, an medicinal products containing the same are useful as antagonists of NK.sub.1 receptors.

Abstract: The present invention relates to new compounds of formula ##STR1## wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole.B is a R.sup.2 substituted benzene ring or an unsubstituted pyridine or thiophene ring;R is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro, cyano, carboxy or a group NR.sup.3 R.sup.4 wherein each of R.sup.3 and R.sup.4 is independently hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkanoyl;R.sup.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro, cyano, carboxy, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkanoyloxy or a group NR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are as defined above;n is zero or an integer of 1 to 2;x is zero or an integer of 1 to 5;and the pharmaceutically acceptable salts thereof.The compounds of the invention are useful as tyrosine kinase inhibitors.

Abstract: A method of inhibiting cell proliferation or differentiation by exposing a cell to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. Q is selected from the group consisting of NH and S, n is 0 or 1; and R.sub.1-9 are independently selected from the group consisting of halo, trihalomethyl, alkyl, nitro, hydroxy, alkoxy, sulphoxy, sulphonyl, amide, sulfonamide, carboxamide, amino, and hydrogen.

Abstract: Compounds of formula (I): ##STR1## wherein: R is selected from the radicals: ##STR2## Y is selected from ##STR3## R.sub.1 represents the radical ##STR4## and A, B, C, D, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, and also the possible geometric isomers and/or diastereoisomers and/or enantiomers thereof in pure form or in the form of a mixture. The compounds of the present invention have a therapeutic use as a result of their angiogenesis-inhibiting activity.

Abstract: The selectivity of an olefin epoxidation process catalyzed by titanium silicalite is improved by performing the epoxidation in the presence of minor amounts of nonbasic salts such as lithium chloride, sodium nitrate, potassium sulfate, and ammonium dihydrogen phosphate. For example, when hydrogen peroxide is reacted with propylene to form propylene oxide, non-selective ring-opening reactions of the propylene oxide are suppressed when low concentrations of a nonbasic salt are added to the hydrogen peroxide feed.

Abstract: Process for synthesizing 1,1,1-trifluoroethane (143a) in the gaseous phase by reacting 1,1-defluoro-1-chloroethane in gaseous phase in the presence of a Cr catalyst. The process may be run isothermally or adiabatically, without co-feeding air or other oxygen containing gas, in the presence or absence of a Ni, Co, Zn or Mn cocatalyst for the Cr catalyst. The catalyst may be unsupported or supported with a support preferably selected from activated carbon, alumina and fluorided alumina. The formation of olefin byproduct can be kept to less than 10 ppm in accordance with the process of the invention.

Abstract: Intermediates for the preparation of benzothiazole derivatives useful for the prevention and treatment of diseases for which an inhibitory action against the production of leukotriene and thromboxane is efficacious, and industrially advantageous processes for the preparation of the intermediates.

Abstract: Method of preparing taxane derivatives of general formula (I) by esterification of protected baccatine III or 10-deacetyl-baccatine III by means of an acid of general formula (VII), deprotection of the side chain and elimination of the hydroxy function protection groupings. In general formulae (I) and (VII): Ar stands for aryl, R is hydrogen or acetyl, R.sub.1 is benzoyl or R.sub.2 --O--CO-- in which R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl, and R.sub.3 is hydrogen, alkoxy, optionally substituted aryl.

Abstract: A process for the epoxidation of olefins comprises contacting the olefin with bis(trimethylsilyl)peroxide in the presence of a rhenium catalyst in an organic solvent.