Abstract: 1-Halo-2-alkylthioethyl and 1-halo-2-arylthioethyl sulfones, having algicidal and fungicidal activity, are prepared by the addition of arylsulfenyl or alkylsulfenyl halides to alkyl or aryl vinyl sulfones. The thioethyl sulfone products are treated with a base to produce 2-alkylthiovinyl or 2-arylthiovinyl sulfones, which also have algicidal and fungicidal activity. The vinyl sulfones are halogenated to produce 1,2-dihalothioethyl sulfones, which have superior fungicidal activity, especially for tomato and celery late blight.

Abstract: What is disclosed are 1,2,6,7-tetrahydroindolo[1,7-ab] [1,5]benzodiazepines of the formula ##STR1## wherein R is hydrogen, loweralkyl, or cycloalkyl; ##STR2## n is an integer from 1 to 3; R.sub.1 is hydrogen, loweralkyl, or phenylloweralkyl;R.sub.2 is hydrogen or loweralkyl;or R.sub.1 and R.sub.2 may be taken together with the nitrogen to which they are attached to form pyrrolidinyl, piperidino, morpholino, or phenylpiperazinyl; andR.sub.3 is loweralkyl; and the pharmaceutically acceptable acid addition salts thereof.These compounds are useful as antidepressants and as analgesic and anti-inflammatory agents.

Abstract: Catalytic aromatic carbonate process which comprises contacting a phenol, carbon monoxide, an oxidant, a base, and a Group VIIIB element selected from ruthenium, rhodium, palladium, osmium, iridium or platinum. The resulting aromatic mono- and polycarbonates are useful in the preparation of polycarbonates or as polycarbonates, per se, respectfully, which can be molded or formed into films, sheets, fibers, laminates or reinforced plastics by conventional techniques.

Abstract: An improved method is provided for the chemotherapy of leishmanial infections. The anti-leishmanial agent is encapsulated within liposomes and the liposome-encapsulated drug is injected into the body. Subject use of a liposome carrier has produced marked enhancement of the effectiveness and duration of anti-leishmanial action of meglumine antimoniate, and of sodium stibogluconate, drugs which are recommended widely for therapy of leishmaniasis.

Abstract: What is disclosed are ##STR1## wherein X is hydrogen, halogen or trifluoromethyl;Y is hydrogen, halogen or trifluoromethyl;R is hydrogen, loweralkyl, cycloalkyl, phenyl, halophenyl, furyl, pyridinyl, 4-methylpiperazin-1-ylethyl or phenylloweralkyl;R.sup.1 is hydrogen;n and m are independently 0 or 1, but n is not 0 when m is 1, and the bonds between ring positions 1 and 2 and between positions 6 and 7 are respectively saturated when n and m are 1 and are unsaturated when n and m are 0;pharmaceutically acceptable acid addition salts thereof; methods of preparing said compounds; pharmaceutical compositions including said compounds; methods of treatment using the compounds; and intermediates therefor.These compounds are useful as analgesic and anti-inflammatory agents, as well as intermediates for the preparation of other pharmaceutically active compounds.

Abstract: Amino- or guanidino-phenylpropionic ester derivatives represented by the formula: ##STR1## wherein R is --NH.sub.2 or ##STR2## R.sup.1 is hydrogen or a lower alkyl group, and R.sup.2 is an unsubstituted or a lower-alkyl-, carboxyalkyl-, lower-alkoxy-, lower-alkoxycarbonyl- or halogen-substituted phenyl group or an unsubstituted or a halogen-substituted naphthyl group, and acid addition salts thereof are novel compounds exhibiting a specific enzyme-inhibitory activity to proteolytic enzymes and, therefore, they are useful as the therapeutic agent of diseases induced by abnormal activation of these enzymes. The above-mentioned compounds can be produced by subjecting a nitrocinnamic acid derivative represented by the formula: ##STR3## and a phenol derivative or a naphthol derivative represented by the formula:HO--R.sup.

Abstract: An improved process for the preparation of a dialkyl carbonate by contacting a glycol carbonate with alcohol at an elevated temperature in the presence of an alkali metal or alkali metal compound, the improvement residing in employing less than 0.01 percent by weight of alkali metal and/or alkali metal compound, based upon the weight the reaction mixture.

Abstract: The invention relates to novel etherified cycloalkanols of the formula ##STR1## wherein X.sub.1 represents oxygen, sulphur or methylene, X.sub.2 represents oxygen or sulphur, A represents an unsubstituted or substituted phenyl radical and n is an integer from 1 to 10 inclusive, and processes for the production thereof.These compounds, especially 2-(4-phenoxyphenoxy)-cyclo-pentan-1-ol, effect a lowering of the lipid content in the blood serum. They are also intermediates for the production of insecticidal cyclopropanecarboxylic acid esters.

Abstract: The invention concerns the use of diphenylamine as a detoxicant for halogen-containing drugs administered to animals, such as carbon tetrachloride, hexachlorophene, bithionol sulfoxide, etc. The diphenylamine may be administered separately to the animal or simultaneously with the halogen-containing drug in the form of a therapeutic composition.

Abstract: An improved vaccine and method for immunizing cattle to Shipping Fever Complex type Bovine Respiratory Disease (BRD) which employs an intradermally administered vaccine containing a live culture of Pasteurella sp., particularly, Pasteurella hemolytica. Innoculation is carried out before the animals are subjected to stress factors, including weaning and transportation to feedlots. Also described is a method for preparing the vaccine by incubation of P. hemolytica within an infusion broth.

Abstract: Freeze-drying of an aqueous solution of human native gamma globulin having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of a neutral inorganic salt for 1 part by weight of the gamma globulin gives an immunoactive lyophilized native gamma globulin preparation which has undergone neither increase in anticomplementary activity nor deterioration in antibody activity during the freeze-drying and is safe for use in intravenous administration.

Abstract: A method of controlling mosquito larvae, by using a spore-forming bacillus ONR-60A obtained from screening clonal isolates from soil samples of known mosquito larval breeding sites. A larvicide comprising the bacillus and a carrier is formulated as a buoyant colloidal suspension which stabilizes just under the surface of the water to concentrate in the feeding zone of many varieties of mosquito larvae.

Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: Isopropylphenyl esters are converted to di- or trihydric phenols via a novel autoxidation of the esters at high conversion rates to the corresponding hydroperoxyisopropylphenyl esters in the presence of a catalyst combination comprising at least two members selected from the group consisting of (i) a metal phthalocyanine; (ii) a di-tertiary alkyl peroxide; and (iii) a tertiary alkyl hydroperoxide.Rearrangement of the hydroperoxyisopropylphenyl esters to the corresponding hydroxyphenyl esters and the hydrolysis of the latter compounds provides the phenols in overall yields (from the starting esters) heretofore not obtainable. Novel bis(hydroperoxyisopropylphenyl)carbonates are described which are attractive intermediates for the intermediate bisphenol carbonate or the final hydroquinone hydrolysis product.

Abstract: In a process for producing 4,4'-dihydroxydiphenylsulfone by reacting phenol with sulfuric acid in the presence of a solvent, an improvement which comprises using at least a member selected from the group consisting of chlorobenzene, dichlorobenzene, trichlorobenzene, chlorotoluene, diethylbenzene, xylene, decalin, tetralin and tetrachloroethane as the solvent and removing said solvent progressively and finally substantially completely from the mixture while maintaining the reaction mixture at a temperature of about 160.degree. to about 200.degree. C. to effect precipitation of 4,4'-dihydroxydiphenylsulfone and isomerization of 2,4'-dihydroxydiphenylsulfone to 4,4'-dihydroxydiphenylsulfone.

Abstract: The invention concerns a new process for the production of primary and secondary mercaptans.The invention is based on the fact that it is possible to cause an hydrogen exchange between a thioaldehyde or a thioketone and a mercaptan with very good selectivity and conversion yields.

Abstract: Polyfluoroalkylthio alcohols and esters thereof are disclosed with utility as intermediates for the synthesis of fluorochemicals with low free surface energies having oil and water repellent properties. The novel alcohols and esters are obtained by a free radical catalyzed addition of polyfluoroalkylthiols to acetylenic alcohols or esters thereof. The alcohols are employed in preparation of fluorine containing polyurethanes which are useful as finishes to provide oil and water repellency to textiles and as additives to plastics to provide mold release and other desirable properties.

Abstract: A therapeutic chewing gum composition orally utilizable to maintain the minerals balance of human physiological fluids during strenuous activity comprising an insoluble gum base having bound therein from about 2 to about 6 percent by weight of sodium chloride and from about 0.1 to about 0.5 percent by weight of potassium chloride; wherein the relative weight ratio of sodium chloride to potassium chloride is at least about 3:1.

Abstract: A galenic immune-globulin preparation for the treatment of skin viruses, fungus and bacterial diseases, comprising about 1 to 30% by weight of immune-globulin prepared from human blood, and a carrier. The immune-globulin may be a standard gamma globulin, a chemically stabilized or an enzymatically or hydrolytically decomposed immuneglobulin, non-fractionated serum, etc., and the composition may be a salve with a conventional base.

Abstract: Compounds of the formula ##STR1## wherein N REPRESENTS THE NUMBERS 0 OR 1,Z represents oxygen, ##STR2## or sulphur R.sub.1 represents the groups ##STR3## wherein R.sub.5 represents hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, ethynyl, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.5 -alkoxy, C.sub.3 -C.sub.5 -alkenyloxy, C.sub.3 -C.sub.5 -haloalkenyloxy, C.sub.3 -C.sub.5 -alkynyloxy, nitro, cyano, C.sub.2 -C.sub.5 -alkoxycarbonyl, C.sub.3 -C.sub.5 -alkenyloxycarbonyl, C.sub.3 -C.sub.5 -alkynyloxycarbonyl, C.sub.1 -C.sub.3 -alkanoyl, C.sub.1 -C.sub.4 -alkylcarbamoyl, (di-C.sub.1 -C.sub.4 -alkyl)carbamoyl,R.sub.6 represents hydrogen, halogen, methyl, ethyl, isopropyl or methoxy, andR.sub.8 represents hydrogen or n-propyl,R.sub.2 represents hydrogen, methyl or ethyl,R.sub.3 and R.sub.4 each represent hydrogen, methyl, ethyl, methoxy, ethoxy, nitro or halogen, andR.sub.7 represents hydrogen or C.sub.1 -C.sub.2 -alkanoyl,And their use for combating insects and members of the order acarina are disclosed.