Patents Examined by M. C.
  • Patent number: 4231932
    Abstract: Novel cyclopropane carboxylic acid esters of the formula ##STR1## wherein X.sub.1 is selected from the group consisting of hydrogen, fluorine, chlorine and bromine, X.sub.2 is selected from the group consisting of fluorine, chlorine and bromine, X.sub.3 is selected from the group consisting of chlorine, bromine and iodine and R is selected from the group consisting of ##STR2## and benzyl optionally substituted with at least one member of the group consisting of alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 2 to 6 carbon atoms, alkadienyl of 4 to 8 carbon atoms, methylenedioxy, benzyl and halogens, R.sub.1 is selected from the group consisting of hydrogen and methyl, R.sub.2 is selected from the group consisting of monocyclic aryl and --CH.sub.2 --C.tbd.CH,R.sub.3 is an aliphatic of 2 to 6 carbon atoms having at least one double bond, R.sub.4 is selected from the group consisting of hydrogen, --CN and --C.tbd.CH, R.sub.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: November 4, 1980
    Assignee: Roussel Uclaf
    Inventors: Jacques Martel, Jean Tessier, Jean-Pierre Demoute
  • Patent number: 4230691
    Abstract: An antibody is prepared from a stable new form of nerve growth factor having a molecular weight of about 116,000. The pure nerve growth factor is obtained from an extract of mouse submandibular gland or mouse saliva which is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The component rich in nerve growth factor is subjected to at least one additional chromatography step, usually two to four, to obtain pure nerve growth factor. The pure nerve growth factor then is injected into the blood system of an animal to form the antibody which is recovered from the animal's blood serum.
    Type: Grant
    Filed: May 23, 1978
    Date of Patent: October 28, 1980
    Assignee: The Massachusetts General Hospital
    Inventor: David M. Young
  • Patent number: 4228178
    Abstract: N-Sulphenylated carbamoyl compounds of the formula ##STR1## in which Z represents two adjacent C atoms of a bifunctional lower aliphatic radical, of a cycloaliphatic radical or of an optionally substituted aromatic radical,m denotes the number 0 or 1 andn denotes the number 0, 1, 2 or 3,which possess fungicidal properties.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: October 14, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Engelbert Kuhle, Wilhelm Brandes, Paul-Ernst Frohberger
  • Patent number: 4228183
    Abstract: A compound of the formula: ##STR1## wherein R is methyl or 2-methylthioethyl, is prepared by either (A) condensing a compound of the formula: ##STR2## wherein R is the same as above, or a reactive derivative thereof with 3,4-diethoxycarboxyphenethylamine, or (B) condensing the compound (II) or a reactive derivative thereof with dopamine, followed by reacting the resultant product with an ethoxycarbonyl halide. The compound (I) shows potent renal blood flow-increasing activity and is useful for the treatment of renal hypertension, congestive heart failure and other diseases due to renal blood flow disturbances.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: October 14, 1980
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tasaburo Kiguchi, Kimiaki Hayashi, Isao Yamaguchi
  • Patent number: 4226997
    Abstract: 8-Chloro-5,6,7,8-tetrahydro-2-quinolone and 8-bromo-5,6,7,8-tetrahydro-2-quinolone, the hydrochloride or hydrobromide thereof and their manufacture by reacting 3,4,5,6,7,8-hexahydro-2-quinolone with chlorine or bromine in an inert solvent at 10.degree. to 50.degree. C. with heating of the reaction mixture to 60.degree. to 80.degree. C. after the halogen addition.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: October 7, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Helmut Meidert, Werner H. Muller, Wilfried Pressler
  • Patent number: 4225488
    Abstract: In preparing organic sulfides by reacting olefins (e.g., butylenes) with a sulfur halide to form a sulfohalogenated intermediate which is subsequently sulfurized and dehalogenated by reaction with an aqueous solution of an alkali metal sulfide compound to form a noncorrosive organic sulfide product of high sulfur content, the copper strip corrosion activity is improved by resulfurizing the sulfurized olefin by contacting it with additional aqueous metal sulfide in the presence of a lower molecular weight alcohol, such as isopropanol.
    Type: Grant
    Filed: July 25, 1978
    Date of Patent: September 30, 1980
    Assignee: Mobil Oil Corporation
    Inventors: Andrew G. Horodysky, Phillip S. Landis
  • Patent number: 4224051
    Abstract: Plant growth-regulating compounds of the formula ##STR1## wherein X and Y are separately oxygen, sulfur, N-B where B is hydrogen, lower alkyl, or acyl; R and R' are separately lower alkyl, acyl, amido, or form a cycle with ##STR2## corresponding to the formula ##STR3## in which R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are separately hydrogen, lower alkyl, halogen-substituted lower alkyl, NO.sub.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: September 23, 1980
    Assignee: Philagro, service Brevets
    Inventors: Claude Clapot, Louis Dumont, Jean Vial
  • Patent number: 4224313
    Abstract: A material capable of forming hydrogen bonds or covalent bonds with loading materials incorporated in loaded cells is introduced into the cells with the loading materials to inhibit the destruction of the cell membranes by the loading material after the permeability of the membranes is brought back down to its normal value. In order to provide for the hydrogen bond formation with common loading materials, such as methotrexate, proteins such as albumin and sugars such as sucrose are effective. The time period during which these materials inhibit a destructive effect on the membranes of loaded cells is well defined.
    Type: Grant
    Filed: December 9, 1977
    Date of Patent: September 23, 1980
    Assignee: Kernforschungsanlage Julich Gesellschaft mit beschrankter Haftung
    Inventors: Ulrich Zimmermann, Gunter Pilwat, Karin Bock, Hermann-Josef Buers
  • Patent number: 4222954
    Abstract: Covers iodophore compounds prepared by reacting a polyether polycarbonate and and an iodine-supplying compound, preferably iodine itself.
    Type: Grant
    Filed: November 2, 1978
    Date of Patent: September 16, 1980
    Assignee: Texaco Development Corp.
    Inventors: Michael Cuscurida, George P. Speranza
  • Patent number: 4223014
    Abstract: A method for immunizing fish against disease by spraying with vaccine or bacterin.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: September 16, 1980
    Assignee: The United States of America as represented by the Secretary of the Interior
    Inventors: Robert L. Garrison, Rowan W. Gould, Patrick J. O'Leary, John L. Fryer
  • Patent number: 4222938
    Abstract: Thiolcarbamates are prepared from carbamoyl halides and xanthates.
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: September 16, 1980
    Assignee: Monsanto Company
    Inventor: John J. D'Amico
  • Patent number: 4223152
    Abstract: Isoindolinone pigments of an extremely high purity, which are represented by the following general formula: ##STR1## wherein R represents a carbocyclic bridge member such as:an unsubstituted phenylene or diphenylene group,a phenylene or diphenylene group substituted by chlorine atoms, methyl groups or methoxy groups, ora group expressed by the formula ##STR2## where X is oxygen or a methylene group; or R represents a heterocyclic bridge member such as: a pyridylene group; orR represents a direct bond,are prepared by a process wherein a crude isoindolinone pigment is dispersed in an aromatic hydrocarbon; (a) an alcoholate or hydroxide of an alkali metal and (b) a lower alcohol and/or water are incorporated in the crude isoindolinone pigment dispersion thereby forming an alkali metal salt of the isoindolinone pigment; and then, the so formed pigment salt is contacted with an acid thereby hydrolyzing the pigment salt into the free acid form.
    Type: Grant
    Filed: April 3, 1979
    Date of Patent: September 16, 1980
    Assignee: Toyo Soda Manufacturing Co., Ltd.
    Inventors: Osamu Fujii, Misao Takano, Takeshi Uotani, Eiji Iwamoto
  • Patent number: 4221716
    Abstract: A novel process for the preparation of 7-acylindolin-2-ones of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or trifluoromethyl; R.sup.1 is lower alkyl, alkylphenyl, cycloalkyl, or aryl; and R.sup.2 is hydrogen, lower alkyl or benzyl is provided. The compounds are useful as intermediates in the preparation of 2-amino-3-acylphenylacetic acid compounds which possess pharmaceutical properties.
    Type: Grant
    Filed: February 16, 1979
    Date of Patent: September 9, 1980
    Assignee: A. H. Robins Company, Inc.
    Inventors: Young S. Lo, David A. Walsh, William J. Welstead, Jr.
  • Patent number: 4220656
    Abstract: Novel compounds having the formula ##STR1## in which R is thio(halo-lower alkyl) or 3,4-dichlorophenyl, having bactericidal and/or fungicidal properties.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: September 2, 1980
    Assignee: Stauffer Chemical Company
    Inventor: Raymond A. Felix
  • Patent number: 4219481
    Abstract: New crosslinkable bis-imidyl derivatives are described which can be produced by reaction of imidylphthalic acid derivatives, such as maleimidyl-phthalic acid anhydrides, with monomeric, oligomeric or polymeric diamines. The new crosslinkable bis-imidyl derivatives can be used for producing crosslinked polymers wich are distnguished, in particular, by their stability to oxidation and to heat.
    Type: Grant
    Filed: September 7, 1978
    Date of Patent: August 26, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Roland Darms, Vratislav Kvita, Gerd Greber
  • Patent number: 4218391
    Abstract: Carbonic acid esters are prepared by reacting the alcohol concerned with oxygen and carbon monoxide in the presence of a catalyst which is a salt of a metal belonging to the Groups IB, IIB and VIII of the Periodic Table: the least possible number of inorganic anions is desirable in order to reduce the acidity of the environment as far as possible. The salts of monovalent copper are preferred and high yields and selectivities are obtained.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: August 19, 1980
    Assignee: Anic, S.p.A.
    Inventors: Ugo Romano, Renato Tesei, Gioacchino Cipriani, Lidio Micucci
  • Patent number: 4218464
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using novel 2,3-dihydro-1H-isoindole compounds having 4- and 5-substituents.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: August 19, 1980
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Robert G. Pendleton
  • Patent number: 4217298
    Abstract: A process for producing an organic carbonate, which comprises reacting an alkali metal carbonate, carbon dioxide gas, an alcohol and an organic halide in the presence of a catalyst.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: August 12, 1980
    Assignee: Tokuyama Soda Kabushiki Kaisha
    Inventors: Kazuo Shikata, Toshiaki Shigemune
  • Patent number: 4217459
    Abstract: Weeds are selectively controlled in soybean fields by post-emergent application of a compound having the structural formula ##STR1## in which X represents bromo, fluoro, cyano or trifluoromethyl and R is hydrogen or methyl.
    Type: Grant
    Filed: October 18, 1978
    Date of Patent: August 12, 1980
    Assignee: Gulf Oil Corporation
    Inventor: Joel L. Kirkpatrick
  • Patent number: 4217297
    Abstract: The present invention relates to a process for the preparation of bis-carbonic acid monoaryl esters of polyester-diols, lengthened via --OCOO-- groups, characterized in that polyester-diols with molecular weights Mn (number-average) of over 250, preferably over 600, are heated with carbonic acid bis-aryl esters at temperatures between about 100.degree. C. and 200.degree. C., preferably between about 110.degree. C. and 180.degree. C., in vacuo below about 35 mm Hg, preferably between about 25 and 1 mm Hg, in the presence of catalysts, less than one mol of carbonic acid bis-aryl ester being employed per mol of OH group of the polyester-diol and the hydroxyaryl compounds formed being distilled off.The invention further relates to the bis-carbonic acid aryl esters of polyester-diols lengthened via --OCOO-- groups.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: August 12, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christian Lindner, Carlhans Suling, Herbert Bartl, Manfred Schreckenberg, Dieter Freitag, Klaus Konig