Patents Examined by M. C.
  • 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds
    Patent number: 4248883
    Abstract: 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives of the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group or a substituted phenyl-lower alkyl group, R.sub.1 represents a hydrogen atom, R.sub.4 CO--, R.sub.5 S--, or ##STR2## R.sub.2 represents a hydrogen atom or a lower alkyl group, R.sub.3 represents a hydrogen atom, a phenyl group, a lower alkyl group, or a substituted lower alkyl group, or R.sub.2 and R.sub.3 form a heterocyclic ring together with the nitrogen and carbon atoms to which they are respectively bonded; salts of these compounds; compositions comprising these compounds or salts; and processes for preparing these compounds or salts. These compounds and salts have excellent antihypertensive activity.
    Type: Grant
    Filed: June 29, 1979
    Date of Patent: February 3, 1981
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Tadahiro Sawayama, Hiroaki Kinugasa, Haruki Nishimura, Kunihiko Takeyama, Kanoo Hosoki
  • Liquid extraction method for recovering aromatic bisimides
    Patent number: 4247464
    Abstract: A liquid extraction method is provided for recovering aromatic bisimides from an organic solvent aromatic bisimide reaction mixture having a variety of reaction by-products. An organic solvent solution of the bisimide reaction mixture is extracted with water and/or an aqueous alkali metal hydroxide to effect removal of such reaction by-products, and provide an organic solvent phase of the aromatic bisimide which can be obtained in substantially pure form upon removal of the organic solvent.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: January 27, 1981
    Assignee: General Electric Company
    Inventors: Howard M. Relles, Frank J. Williams, III
  • Preparation of isocyanate derivatives of 1,3[oxazoles, oxazines, diazoles and diazines]
    Patent number: 4247689
    Abstract: The present invention relates to a new organic heterocyclic isocyanate which is the reaction product of an organic diisocyanate and an amino or hydroxy nitrile. The invention also relates to a process of producing such isocyanates by reacting an excess of the diisocyanate with the nitrile under conditions under which the nitrile will not decompose and then maintaining the reaction mixture at an elevated temperature until the isocyanate nitrile adduct cyclizes. The reaction may be carried out in the presence of a catalyst for isocyanate addition reactions. Additionally, the invention relates to a process for the production of polyurethane by the reaction of the heterocyclic isocyanates with compounds carrying at least two isocyanate reactive hydrogen atoms per molecule.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: January 27, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Kurt Findeisen, Kuno Wagner, Walter Uerdingen
  • 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives
    Patent number: 4244966
    Abstract: Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: January 13, 1981
    Assignee: American Home Products Corporation
    Inventors: Wilbur Lippman, Christopher A. Demerson, Leslie G. Humber, Jean-Marie Ferland
  • Octahydro-1H-benzo[4,5]furo[3,2-e]-isoquinoline analgesic and narcotic antagonistic compounds
    Patent number: 4243668
    Abstract: Octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline compounds and processes for their manufacture are provided. The compounds correspond to the formula ##STR1## These compounds exhibit both analgesic and narcotic antagonistic properties, as well as low abuse liability.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: January 6, 1981
    Assignee: E. I. Du Pont De Nemours and Company
    Inventor: Engelbert Ciganek
  • Novel 2,6-dinitrophenyl selenium compounds and their use as epoxidation catalysts
    Patent number: 4242285
    Abstract: Novel unsubstituted and 4-substituted, 2,6-dinitrophenyl seleninic acids, selenium halides and diselenides are described. The above-described selenium compounds are particularly useful to catalyze the oxidation of olefins to the corresponding epoxide in the presence of hydrogen peroxide.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: December 30, 1980
    Assignee: The Dow Chemical Company
    Inventor: James M. Renga
  • Tricyclic imidyl derivatives
    Patent number: 4242264
    Abstract: Novel tricyclic imidyl derivatives, for example those of the formula ##STR1## [n=1 or 2, Y=a bridge member and X=a functional group] are described. The novel tricyclic imidyl derivatives are suitable for the preparation of photocrosslinkable polymers by incorporation into existing polymer chains or by building up the polymer chain from tricyclic imidyl derivatives, according to the definition, with suitable functional groups X by polymerization or polycondensation. The photocrosslinkable polymers obtained by this means can be used, for example, to produce printing plates for the offset printing process and especially as photoresists.
    Type: Grant
    Filed: February 6, 1979
    Date of Patent: December 30, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Zweifel, Walter Schilling, Angelo Storni, Daniel Bellus
  • Preparation of indolenines
    Patent number: 4240963
    Abstract: A process for the preparation of an indolenine of the general formula I ##STR1## where R, R.sup.1 and R.sup.2 are aliphatic radicals and R.sup.1 and R.sup.2 may also be linked and the ring A may be additionally substituted, wherein a compound of the formula II ##STR2## is heated in the presence of a Lewis acid and of a halide. The products are valuable starting compounds for the preparation of dyes.
    Type: Grant
    Filed: August 9, 1979
    Date of Patent: December 23, 1980
    Assignee: BASF Aktiengesellschaft
    Inventors: Harald Laas, Axel Nissen, Hans-Joachim Opgenorth, Horst Scheuermann, Hans-Richard Mueller, Wolfgang Schulte
  • Process for producing phthalimido derivatives
    Patent number: 4239686
    Abstract: A process for producing a 3-iminohaloisoindoline-1-one which comprises treating a halophthalodinitrile with ammonia and/or an organic amine together with hydrogen peroxide in a mixed reaction medium comprising water and an organic solvent.
    Type: Grant
    Filed: November 21, 1978
    Date of Patent: December 16, 1980
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Teruyuki Misumi, Kyogo Tanaka, Osamu Okuno
  • Dimethyl 7-[.omega.-N-(phthalimido)alkyl]aminonaphthalene-1,2-dicarboxylates
    Patent number: 4238395
    Abstract: -Dimethyl 7-[.omega.-N-(phthalimido)alkyl]aminonaphthalene -1,2-dicarboxylates of the formula: ##STR1## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms and n=2-6. The compounds are intermediates in the synthesis of chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
    Type: Grant
    Filed: October 5, 1979
    Date of Patent: December 9, 1980
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert T. Buckler, Hartmut R. Schroeder
  • Dichloroacetylimino herbicide antagonists as plant protection agents
    Patent number: 4237302
    Abstract: New compounds which are herbicide antagonists that are useful for protection of plants from various herbicides are members of the group having the general structural formulas: ##STR1## in which R is hydrogen or C.sub.1 to C.sub.4 alkyl, alkenyl or alkynyl, branched or straight chain, R.sup.1 is C.sub.1 to C.sub.3 alkyl, alkenyl or alkynyl, branched or straight chain, with the total number of carbon atoms in R and R.sup.1 being less than six, preferably less than four, on compounds with both R and R.sup.1 substituents. The novel plant protection agents may be applied both to seeds and to the soil.
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: December 2, 1980
    Assignee: Gulf Oil Corporation
    Inventors: Otto L. Hoffman, Joel L. Kirkpatrick
  • Method of immunization against enterotoxogenic infection by Escherichia coli
    Patent number: 4237115
    Abstract: There is provided a vaccine material capable of providing a substantial level of protection against infection by enterotoxogenic organisms of Escherichia coli. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or to a pregnant female where protection of the newborn is desired. In the case of piglets, where there is substantially no transplacental transfer of immunity from mother to offspring, the pili are administered to mothers, who are then caused to feed the offspring to be protected, whereby the immunization is transferred via the colostrum of the mother.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: December 2, 1980
    Assignee: Bactex, Inc.
    Inventor: Charles C. Brinton, Jr.
  • Tetrahydro-2H-benzo[c]pyrroles
    Patent number: 4235776
    Abstract: Tetrahydro-2H-benzo[c]pyrroles, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinson's syndrome.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: November 25, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • Live Newcastle disease virus vaccine
    Patent number: 4235876
    Abstract: The invention relates to an avian vaccine and to the preparation thereof.The vaccine according to the invention is a Newcastle disease virus vaccine. Its active ingredient is the P/77/8 NDV strain.The vaccine of the invention is useful in the prevention of Newcastle disease by administration to chickens in the form of an aerosol.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 25, 1980
    Assignee: SmithKline-Rit
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Method of encapsulating biologically active materials in lipid vesicles
    Patent number: 4235871
    Abstract: The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.
    Type: Grant
    Filed: February 24, 1978
    Date of Patent: November 25, 1980
    Inventors: Demetrios P. Papahadjopoulos, Francis C. Szoka, Jr.
  • Substituted 5H-dibenz[b,f]azepine
    Patent number: 4235895
    Abstract: The substituted 5H-dibenz[b,f]azepine of the formula ##STR1## a process for its manufacture, pharmaceutical compositions which contain the novel compound, and a method of treating epilepsy which comprises the use thereof.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: November 25, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Blattner, Angelo Storni
  • Benzylpyrrolylmethyl esters of 3-(1,2-dibromo-2,2-dichloroethyl)-2,2-dimethylcyclopropanecarboxylic acid
    Patent number: 4235777
    Abstract: Benzylpyrrolylmethyl esters of 3-(1,2-dibromo-2,2-dichloroethyl)-2,2-dimethylcyclopropanecarboxylic acid, synthesis thereof and the use of said esters for the control of pests.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: November 25, 1980
    Assignee: Zoecon Corporation
    Inventor: Clive A. Henrick
  • Pyroglutamic acid derivatives and analogs
    Patent number: 4234489
    Abstract: Pyroglutamic acid derivatives and analogs having the formula ##STR1## and salts thereof, wherein R is hydrogen, alkyl or diphenylmethyl;R.sub.1 is hydrogen, alkyl or trifluoromethyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is hydrogen, alkyl, phenyl, or phenylalkyl; X is oxygen or sulfur; andn is 0 or 1;have useful hypotensive activity.
    Type: Grant
    Filed: June 25, 1979
    Date of Patent: November 18, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Eric M. Gordon, Denis E. Ryono
  • Carbonylation process
    Patent number: 4234504
    Abstract: A carbonylation process which comprises contacting a .beta.-fluoroalkanol, carbon monoxide, a base, and the Group IIB element mercury present in an oxidation state greater than zero. The resulting .beta.-fluoroaliphatic carbonates can be employed in combination with alkanols and/or phenols to prepare aliphatic and aromatic mono- and polycarbonates. The resulting carbonates are useful in a wide variety of applications, especially polycarbonates which can be molded or formed into films, sheets, fibers, laminates, or reinforced plastics by conventional techniques.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: November 18, 1980
    Assignee: General Electric Company
    Inventors: John E. Hallgren, William E. Smith
  • Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith
    Patent number: 4232004
    Abstract: An antibody-specific solid phase immunoadsorbent is prepared by adsorptively binding a lipid-containing viral antigen, such as hepatitis B surface antigen, to the surface of a porous glass carrier having an average pore diameter within the range of about 40-200 nm and an adsorptive surface which within the pH range of 2-8 is capable of selectively and stably binding lipid-containing materials, employing an adsorption buffer having a pH within such range. The high adsorptive selectivity of the carrier surface for the antigen under such conditions, enables preparation of the immunoadsorbent directly from whole human plasma containing the antigen, without the necessity for prior antigen purification.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: November 4, 1980
    Assignee: American National Red Cross
    Inventor: Roger Y. Dodd