Patents Examined by Marianne Cintins
  • Patent number: 6124353
    Abstract: The present invention provides a method of treating ocular hypertension which comprises applying to the eye an amount sufficient to treat ocular hypertension of a compound of formula (I) ##STR1## wherein the wavy line attachments indicate either alpha (.alpha.) or beta (.beta.) configuration; hatched lines indicate .alpha. configuration, solid triangles are used to indicate .beta. configuration; the dashed bonds represent a single bond or a double bond which can be in the cis or trans configuration; X is selected from the group consisting of H, R or a pharmaceutically-acceptable cation, and R is an aliphatic hydrocarbon group of about 1 to about 6 carbon atoms; one of R.sub.1 and R.sub.2 is .dbd.O, --OH or an --O(CO)R.sub.4 group, and the other one is --OH or an --O(CO)R.sub.4 group or R.sub.1 is .dbd.O and R.sub.2 is H; R.sub.3 is --OH or --O(CO)R.sub.4, wherein R.sub.4 is a saturated or unsaturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or --(CH.sub.2).sub.n R.sub.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: September 26, 2000
    Assignee: Allergan Sales, Inc.
    Inventor: David F. Woodward
  • Patent number: 5618842
    Abstract: N-acyl derivatives of aminoalcohols with bicarboxylic or tricarboxylic acids able to modulate the degranulation process consequent to the mast cells activation in inflammatory processes caused by supramaximal stimuli of neurogenic and immunogenic origin.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: April 8, 1997
    Assignee: Lifegroup S.p.A.
    Inventors: Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo
  • Patent number: 5510387
    Abstract: An antimicrobial and interferon-inducing composition containing the crystalline gamma-modification of para-amino benzenesulfanilamide and a method for inducing interferon by administering a composition containing crystalline gamma-modification of para-amino benzenesulfanilamide.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: April 23, 1996
    Assignee: Nikolai Borisovich Leonidov
    Inventors: Nikolai B. Leonidov, Nikolai G. Seleznev
  • Patent number: 5354887
    Abstract: Hexene-1,6-dioic acids, e.g., hex-3-ene-l,6-dioic acid, are prepared by reacting carbon monoxide and water with at least one diacyloxylated butene in a polar, aprotic and basic solvent, in the presence of a catalytically effective amount of palladium values, optionally a halide, and at least one inorganic halide, the cation of which being an alkali or alkaline earth metal and the anion of which being a chloride or bromide.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: October 11, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventor: Philippe Denis
  • Patent number: 5189222
    Abstract: Process for the manufacture and recovery of alkali-metal tetraorganylborates. A mixed solvent and liquid/liquid contactor configuration is used in the system which aids in the recovery of the product.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: February 23, 1993
    Assignee: Optima Chemicals, Inc.
    Inventors: Eugene C. Ashby, Laurence L. Earnhart, Daniel W. Tedder, Jagvir Singh
  • Patent number: 5180842
    Abstract: Disclosed is a process for removing chlorine-containing impurities from quinone compounds such as p-bezonquinone. The process involves extracting a quinone compound containing 1000 ppm or more chlorine with heptane, cyclohexane or a mixture thereof and separating the quinone compound from the extraction mixture. The process provides a means for obtaining quinone compounds containing 50 ppm or less chlorine.
    Type: Grant
    Filed: August 16, 1991
    Date of Patent: January 19, 1993
    Assignee: Eastman Kodak Company
    Inventors: Yeong-Jen Kuo, Michael Bellas
  • Patent number: 5162585
    Abstract: A process for preparing a dihydroxy bis-sulfide is disclosed, wherein a thiolate salt, a dihaloalkane, an ether solvent that is partially soluble in water and is substantially nonreactive with either said thiolate salt or said dehaloalkane; and water are contacted under reaction conditions sufficient to synthesize a dihydroxy bis-sulfide; to subsequently recover a dihydroxy bis-sulfide.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: November 10, 1992
    Assignee: Phillips Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 5159074
    Abstract: Aminomethanephosphonic acid aryl esters of the formula ##STR1## in which R.sup.1 is an aromatic radical and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently of one another represent hydrogen atoms, ##STR2## groups, an optionally substituted C.sub.1-10 alkyl radical or an optionally substituted aromatic ring, or salts thereof.These aminomethanephosphonic acid aryl esters are useful as flameproofing agents in foams, thermoplastics and thermosets and as a crosslinking component in oligo-and polycondensates based on monomers containing hydroxy groups.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: October 27, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Arndt, Hans-Dieter Block, Wolfgang-Hans Schulz-Schlitte
  • Patent number: 5159075
    Abstract: Substituted alkoxy- or alkylthiochlorotriazines wherein the substituents on the alkoxy groups are chlorine, bromine or dialkylphosphato are useful as capping agents for polyphenylene ethers. The capped polyphenylene ethers form copolymers with other polymers containing nucleophilic groups, including polyesters, polyamides and functionalized olefin polymers. Such copolymers serve as compatibilizers in the formation of blends having high impact strength.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: October 27, 1992
    Assignee: General Electric Company
    Inventors: Otto Phanstiel, Sterling B. Brown
  • Patent number: 5149878
    Abstract: Various 1,4-disubstituted-2,3,5,6-tetrahydroxy-1,4-diphosphorinanes, their oxides and sulfides, methods for the production thereof, flame-retarded compositions of matter containing them and froth flotation processes therewith, are disclosed.
    Type: Grant
    Filed: July 2, 1990
    Date of Patent: September 22, 1992
    Inventors: Allan J. Robertson, James B. Gallivan
  • Patent number: 5144065
    Abstract: In the process according to the invention for the preparation of aminoarylsulphonic acids by catalytic hydrogenation of nitroarylsulphonic acids, a substantial increase in the space-time yield in combination with reduced consumption of the catalyst is achieved by dispersing the hydrogen more finely and by limiting according to the invention the concentration of the nitroarylsulphonic acids to be hydrogenated.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: September 1, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventor: Guido Steffan
  • Patent number: 5144081
    Abstract: The invention relates to dialkoxybenzylidene-camphor derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2, in each case independently of one another, are a straight-chain or branched alkyl radical having 1 to 10 c atoms, andX is H or SO.sub.3 H,and to a process for their preparation and their use in cosmetic and pharmaceutical preparations.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: September 1, 1992
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ulrich Heywang, Roland Martin, Ingeborg Stein
  • Patent number: 5144083
    Abstract: A process for producing a p-hydroxyneophyl m-phenoxybenzyl ether represented by the general formula (II) ##STR1## (X.sub.1 and X.sub.2 are independently a hydrogen atom or a halogen atom) by subjecting a corresponding p-alkoxyneophyl m-phenoxybenzyl ether represented by the general formula (I) ##STR2## (R represents a lower alkyl group, and X.sub.1 and X.sub.2 have the same definitions as above) to ether cleavage, in which process the ether cleavage reaction is effected in an aprotic polar solvent, using a lower alkoxide of an alkali metal or an alkaline earth metal or using a metal hydroxide in the presence of a lower alcohol.
    Type: Grant
    Filed: October 2, 1990
    Date of Patent: September 1, 1992
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Hideyuki Akieda, Naoki Sato, Koichi Morinaga, Yoshinori Ide, Ryuichi Mita, Mitsumasa Umemoto
  • Patent number: 5136097
    Abstract: The invention relates to a process for the synthesis of sulfonylmethanes and derivatives thereof of the formula M[(RSO.sub.2).sub.2 CH].sub.m (I), in which M represents H, an alkali metal or alkaline earth metal or NR'.sub.4, R' and R are monovalent organic radicals and m represents the valence of M.The process comprises reacting an ionic carbide with a sulfonyl halide, hydrolyzing the product obtained, adding a compound M.sub.y Y.sub.m, in which Y represents an anion capable of reacting with the cation of the ionic carbide to the reaction medium before or after hydrolysis to give a compound which can be separated from compound (I), and y represents the valence of Y.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: August 4, 1992
    Assignees: Centre National de la Recherche Scientifique, Hydro-Quebec
    Inventor: Michel Armand
  • Patent number: 5136106
    Abstract: Active-hydrogen compounds, for example, primary and secondary alcohols or diols, are alkoxylated, for example, ethoxylated, using solid anion-bound metal oxide catalysts, such as, zirconium oxysulfate catalyst. Hydrous zirconium oxide is treated with solutions of sulfate phosphate, nitrate or tetrafluoroborate and calcined in air at 300.degree. to 950.degree. C. to produce highly active heterogeneous alkoxylation catalysts. The amorphous catalysts afford narrow molecular weight products. The catalyst can be removed from the product by filtration and reused with no significant loss in activity. Reaction temperatures of 50.degree. to 140.degree. C. are employed for alkoxylation.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: August 4, 1992
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventor: Stephen W. King
  • Patent number: 5136095
    Abstract: Compounds and methods are disclosed for reversibly aggregating particles suspended in a liquid medium. The method comprises combining the liquid medium containing the particles with a polyionic polymer capable of aggregating the particles under conditions suitable for such aggregation. Thereafter, the particles are contacted with a chemical reagent capable of cleaving the polyionic polymer under conditions sufficient to reverse the aggregation. Optionally, magnetic particles are added to the liquid medium in the present method under conditions for non-specific binding and the medium including the aggregates is subjected to a magnetic field gradient to separate the aggregates from the medium. The compounds of the present invention are polyions. The aggregation of the particles is reversible upon contact with chemical agents which cleave at least some of the bonds within the polyionic polymer.
    Type: Grant
    Filed: December 1, 1988
    Date of Patent: August 4, 1992
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Thomas L. Tarnowski, Cheng-I Lin, Edwin F. Ullman
  • Patent number: 5135958
    Abstract: A process for converting synthesis gas to paraffin wax by conversion over a partially sulfided rhenium-aluminum borate catalyst containing an alkali metal or alkaline earth metal compound is disclosed. The inventive process and a catalyst provided highly efficient and selective conversion of synthesis gas to paraffin wax.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: August 4, 1992
    Assignee: Amoco Corporation
    Inventors: Cecelia A. Radlowski, Mark P. Kaminsky
  • Patent number: 5136098
    Abstract: Sulfonic acids are reacted with sodium nitrite to form new compositions specifically nitrosyl sulfonates. The nitrosyl sulfonates are useful in reacting with a dye base to form a diazo composition which can in turn react with a coupling agent to form a diazo dye. The nitrosyl sulfonate can also be used to react with an aromatic composition to nitrosoate an aromatic composition. These reactions are particularly useful in the formation of a dispersed dye because the dye can be formed directly in a nonpolar organic solvent and can be used without purification of the dye product. Particularly useful is the nitrosyl dodecyl benzene sulfonate since the formed product is soluble in nonpolar solvents and all reaction products remain in solution and aid with the dyeing of fabrics.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: August 4, 1992
    Inventor: Rodger L. Gamblin
  • Patent number: 5132472
    Abstract: Process is provided for oxidation of organic compounds in which a reaction zone is provided, containing an open space and a bed of solid granular catalyst, an organic feedstock and oxygen are passed in gas phase through the open space and then into contact with the catalyst bed, and reaction products are removed from the open space after relatively less contact with the catalyst, and from at least one other location after relatively greater contact with the catalyst. Greater yield of desired product may be obtained in such operation than in operation where all of the reaction products are removed after the greater contact with the catalyst.
    Type: Grant
    Filed: October 17, 1990
    Date of Patent: July 21, 1992
    Assignee: Sun Refining and Marketing Company
    Inventors: Vincent A. Durante, Darrell W. Walker, Steven M. Gussow, James E. Lyons, Robert C. Hayes
  • Patent number: 5132463
    Abstract: Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Donald W. Graham, John C. Chabala, Tesfaye Biftu, Michael N. Chang, Yuan-Ching P. Chiang, Shu S. Yang, Kathryn L. Thompson