Patents Examined by Maris R Kessel
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Patent number: 12145150Abstract: Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.Type: GrantFiled: May 8, 2023Date of Patent: November 19, 2024Assignee: Overture Life, Inc.Inventors: Santiago Munne, Jose Antonio Horcajadas Almansa, Lionel Matthys, Joana Alexandra Sales Fidalgo, Pablo Carasa Ruiz, David Cancio Villalonga, Daniel Garcia Alonso, Cristina Dosda Munuera, Sara Alvarez Arguelles
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Patent number: 12135270Abstract: Modular flow cytometry systems and methods for processing samples are described herein. The systems include automated or semi-automated modules that are replaceable and removable. A sample pathway module may be removed and placed in a microfluidic device cleaning module for cleaning, and then reinstalled or stored for later use. The systems further include optical modules, electronics modules, and mixing and collection modules. The optical module includes a photo-damaging assembly and detection laser assembly that may be on the same side relative to a plane or surface of a flow cytometry device and opposite of a detection assembly. The laser beam may have a beam waist that is wider in a direction perpendicular to a flow direction than in the flow direction. The mixing and collection module can automatically mix a sample being collected in a sample tube and switch to another sample tube when the other tube is full.Type: GrantFiled: November 12, 2021Date of Patent: November 5, 2024Assignee: ABS GLOBAL, INC.Inventors: Gary Klas, Daniel McAda, Zheng Xia, Matthew Ebersole, Brian Lena, David Appleyard, Richard Lu, Scott Buckley, Mark Abermoske
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Patent number: 12128159Abstract: An illumination lamp system having automatic switching function for sterilization is disclosed. It contains a plurality of germicidal lighting lamp assemblies, a personnel counter, a data receiving indicator, and an ultraviolet indicator. Each germicidal lighting lamp assembly includes a lamp panel, an infrared human body sensor and a control module. The control module includes a power conversion unit, a synchronization interface, a startup circuit, a first microcontroller, and an output and input connection interface. Because the infrared human body sensor can detect the appearance of people in real time, with a synchronous voltage to switch emitting between illumination LED strips and ultraviolet germicidal light sources, in addition to effectively expanding the disinfection area, it can also safely adjust the type of light to achieve the automatic switching function for sterilization.Type: GrantFiled: April 1, 2021Date of Patent: October 29, 2024Inventors: Shih Fong Lin, Wu Yi Hsu, Chia-Hsien Chou
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Patent number: 12115291Abstract: An electric heating fragrance diffuser includes a hollow body and a fragrance diffusing device. A power source and an electric wire are arranged in the body. The fragrance diffusing device includes a fragrance holder, a fragrance box, and an electric heating plate. The fragrance holder is disposed in the body and provided with a first hole communicating with upper and lower edges of the fragrance holder in a vertical direction. The upper edge of the fragrance holder is recessed with a fragrance groove surrounding the first hole. The fragrance box is detachably arranged in the fragrance groove. The electric heating plate is connected to the lower edge of the fragrance holder and provided with a second hole aligned with the first hole.Type: GrantFiled: July 22, 2021Date of Patent: October 15, 2024Assignee: PRO-IRODA INDUSTRIES, INC.Inventor: Wei Cheng Wu
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Patent number: 12097494Abstract: This document provides methods, devices, and systems for detecting the presence, absence, or amount of two or more analytes present within a small volume (e.g., less than 10 ?L) of a sample (e.g., a blood sample) obtained from a mammal (e.g., a human such as a human neonate). For example, methods and materials for using plasma separation and multiplex analyte detection to detect two or more analytes (e.g., proteins, carbohydrates, lipids, nucleic acids, intact cells, intact viruses, intact microorganisms, and/or chemicals) within a small volume of a blood sample are provided.Type: GrantFiled: September 17, 2021Date of Patent: September 24, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Alan M. Gonzalez Suarez, Alexander Revzin
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Patent number: 12070747Abstract: The present invention provides a discrete microenvironment chamber (DIMIC) configured to accurately mimics the microenvironment of poorly perfused tissue. In one embodiment, the DIMIC of the present invention is further designed to allow the extraction of cells and media from different local environments for any type of biochemical analysis.Type: GrantFiled: December 17, 2021Date of Patent: August 27, 2024Assignee: New York UniversityInventor: Carlos Carmona-Fontaine
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Patent number: 12072292Abstract: The present disclosure relates to an optochemical sensor element, comprising: a substrate layer having a first substrate side facing toward a measuring medium and a second substrate side opposite the first substrate side; a functional layer arranged on the first substrate side and is subdivided into functional segments separate from one another, wherein a first functional segment has a second reference dye and a second functional segment has an indicator dye, wherein the second reference dye comprises an organic material and is insensitive to oxygen, and is suitable to emit a second luminescence signal upon stimulation with a first stimulation signal, wherein the indicator dye comprises an organic material and is sensitive to oxygen, and is suitable to emit a third luminescence signal upon stimulation with the first stimulation signal, wherein the substrate layer is transparent to the stimulation signal and to the second and third luminescence signals.Type: GrantFiled: December 21, 2021Date of Patent: August 27, 2024Assignee: Endress+Hauser Conducta GmbH+Co. KGInventor: Andreas Löbbert
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Patent number: 12064758Abstract: Stabilized indicator compositions, and systems and methods using the same are described. In embodiments the stabilized indicator compositions include a solvent, an indicator, a stabilizer for the indicator, and optionally a buffer. In embodiments the indicator is or includes N, N-diethyl-p-phenylene diamine (DPD). Systems and methods utilizing the stabilized indicator composition to determine an amount of at least one constituent in a test sample (e.g., water) are also described. In embodiments, the systems and methods remove the stabilizer from the stabilized indicator composition to produce a fluid flow containing un stabilized indicator, which is then combined with a fluid from a sample source to form a test sample for analysis.Type: GrantFiled: August 20, 2021Date of Patent: August 20, 2024Assignee: WATTS REGULATOR CO.Inventor: Dorian Cauceglia
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Patent number: 12012580Abstract: An analyzing system for pesticide effectiveness includes a transparent container having an interior area, the transparent container having a port extending through a wall of the transparent container; a bracket positioned within the interior are of the transparent container; a dish having a dish interior area configured to hold a test insect, the dish to be supported by the bracket within the transparent container; an injection device to inject a test liquid into the interior area of the transparent container through the port; the dish is to hold the test insect a distance from an injected test liquid; and the transparent container provides for visual observations of an effect of the test liquid on the test insect.Type: GrantFiled: May 21, 2021Date of Patent: June 18, 2024Inventors: Peng Xu, Li Cheng
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Patent number: 11971415Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device comprising a sample mixture that comprises at least one sample flag compound for detecting the presence or non-presence of a patient's liquid test sample upon being interrogated by a pre-determined wavelength of light.Type: GrantFiled: June 20, 2019Date of Patent: April 30, 2024Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Aaron Kauffmann
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Patent number: 11951471Abstract: A pipette for use with a pipette tip or syringe including a piston positioned within a cylinder comprises a pipette housing extending between an upper end and a lower end. Two parallel rods are positioned in the pipette housing, wherein one of the two parallel rods is coupled to a lifting rod. An operating element is configured to protrude outwardly from the pipette housing and be displaced relative to the pipette housing. A gear mechanism is arranged in the pipette housing and comprises a drive comprising a moveable input member and configured to be driven by the operating element, and an output comprising at least one moveable output member and configured to drive the two parallel rods. Successive displacements of the input member by the operating element are configured to alternately displace one of the two parallel rods and then another of the two parallel rods by the output member.Type: GrantFiled: June 22, 2021Date of Patent: April 9, 2024Assignee: Eppendorf AGInventors: Marc Wilth, Dana Tuchscherer, Matthias Kunsch, Florian Tesch, Burghardt Reichmuth
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Patent number: 11846632Abstract: A sample measurement device including: a dispensing mechanism that includes a nozzle capable of penetrating through a plug body that closes a sample container and of aspirating and discharging a sample housed in the sample container, and that dispenses the sample into a disposable container from the sample container through the nozzle; a cleaning mechanism that cleans the nozzle; and a first measurement section that performs measurement for an immunological test of the sample dispensed by the dispensing mechanism.Type: GrantFiled: December 26, 2018Date of Patent: December 19, 2023Assignee: SYSMEX CORPORATIONInventors: Masaki Shiba, Hironori Katsumi, Tsuyoshi Fukuzaki
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Patent number: 11740203Abstract: A diagnostic system that includes a cartridge and a reader is discussed herein. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease, or infection of the patient.Type: GrantFiled: June 25, 2020Date of Patent: August 29, 2023Assignee: Hemex Health, Inc.Inventors: Peter Galen, Umut Atakan Gurkan, Muhammad Noman Hasan, James Daren Bledsoe, Tyler Witte
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Patent number: 11730850Abstract: Provided is an indoor air cleaning device for a vehicle using a nonthermal plasma and an operation method thereof, and more particularly, to an indoor air cleaning device for a vehicle using a nonthermal plasma, in which ozone is generated by a nonthermal plasma through corona discharge and an air purifying filter is sterilized through strong oxidization action of ozone, achieving more hygienic and continuous management, static electricity of an electrostatic filter is recharged with the controlled magnitude of applied voltage to maintain the best purification performance of the filter, and negative ions beneficial for human body are generated, creating pleasant indoor air conditions.Type: GrantFiled: August 3, 2021Date of Patent: August 22, 2023Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Jingyu Kim, Jaeseung Jeong
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Patent number: 11719687Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.Type: GrantFiled: December 17, 2018Date of Patent: August 8, 2023Assignee: AgaMatrix, Inc.Inventors: Sridhar Iyengar, Ian Harding, Richard Williams, Kevin Cai
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Patent number: 11686705Abstract: Systems and methods for identifying DNA strand size and purifying the DNA based on strand size using electrophoresis. The methods include moving, via voltage, a plurality of DNA strands through a separation gel from an inlet of a capillary or passage to either a first outlet or a second outlet dependent on the DNA strand length. In some implementations, the system is a capillary electrophoresis system. In other implementations, the system is a microfluidic lab-on-a-chip.Type: GrantFiled: May 8, 2020Date of Patent: June 27, 2023Assignee: SEAGATE TECHNOLOGY LLCInventors: Gemma Mendonsa, Tim Rausch, Riyan Alex Mendonsa
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Patent number: 11679173Abstract: The Portable Sanitizer Spritzier Station as disclosed includes an undercarriage of frontward and backward motion rollers and sidewards rollers configured to ambulate the station in a first mode and to convey carts there through in a second mode and to collect used sanitizer for recycle and refuse. The disclosure also includes an upper structure of clear side panels and clear tarp ends and inside guide rails between conveyor belts and a sanitizer pipe network directing sanitizer upward from a floor thereof and downward from a ceiling thereof. The disclosure further includes a controller configured to determine one of the first and the second modes and to determine a time limit for the sanitizer to be sprayed through the sanitizer pipes and to control the rollers and conveyor belt.Type: GrantFiled: March 5, 2021Date of Patent: June 20, 2023Inventor: Traci Long
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Patent number: 11644434Abstract: Methods and biosensor systems for compensating an analyte measurement are provided. The methods and systems determine a secondary output signal based on the measured primary output signal in order to better approximate the effects of an extraneous stimulus on the primary output signal under actual measurement conditions. The methods and systems according to the present disclosure may provide a more accurate analyte measurement, and may be particularly useful in detecting and compensating an analyte measurement during an off-condition.Type: GrantFiled: May 13, 2016Date of Patent: May 9, 2023Assignee: Ascensia Diabetes Care Holdings AGInventor: Huan-Ping Wu
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Patent number: 11592418Abstract: A solid electrolyte includes partially stabilized zirconia in which a stabilizer forms a solid solution in zirconia. The partially stabilized zirconia includes at least monoclinic phase particles and cubic phase particles as crystal particles that configure the partially stabilized zirconia, and an abundance ratio of the monoclinic phase particle is 5 to 25% by volume. The partially stabilized zirconia includes stabilizer low-concentration phase particles of which concentration of the stabilizer at a particle center is equal to or less than 1 mol %, as the crystal particles. The stabilizer low-concentration phase particles have a particle-size distribution of number frequency thereof having a peak at which an average particle size is 0.6 to 1.0 ?m, and a particle size at 10% of a cumulative number is 0.5 ?m or greater, and of the overall low-concentration phase particles, 50% by volume or greater belong to the peak.Type: GrantFiled: May 1, 2020Date of Patent: February 28, 2023Assignee: DENSO CORPORATIONInventors: Mitsuhiro Yoshida, Satoshi Suzuki, Makoto Noguchi
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Patent number: 11579113Abstract: A sensor element includes: an element base made of an oxygen-ion conductive solid electrolyte; an internal space provided inside the element base; an electrochemical pump cell configured to pump oxygen in and out between the internal space and outside; a porous thermal shock resistant layer provided to an outermost peripheral part in a predetermined range at one end part of the element base, at which a gas inlet is provided; and a buffer layer adjacent to the thermal shock resistant layer on a pump surface and a heater surface. A thermal diffusion time in a thickness direction of the thermal shock resistant layer is 0.4 sec to 1.0 sec inclusive, and a total thermal diffusion time in a stacking direction of the thermal shock resistant layer and the buffer layer is 0.2 sec to 1.0 sec inclusive.Type: GrantFiled: March 28, 2018Date of Patent: February 14, 2023Assignee: NGK INSULATORS, LTD.Inventor: Takashi Hino