Patents Examined by Maris R Kessel
  • Patent number: 10890559
    Abstract: An ITP-based system and a method are provided. ITP is used to focus a sample of interest and deliver a high concentration target to a pre-functionalized surface comprising immobilized probes, thus enabling rapid reaction at the sensor site.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: January 12, 2021
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Moran Bercovici, Merav Karsenty
  • Patent number: 10888863
    Abstract: This disclosure provides an apparatus and a method for quickly, efficiently and continuously fractionating biomolecules, such as DNAs and proteins based on size and other factors, while allowing imaging of the separated biomolecules as they are processed within the apparatus. The apparatus employs angled nanochannels to first preconcentrate and then separate like molecules. Its embodiments offer improved detection sensitivity and separation resolution over existing technologies and multiplexing capabilities.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 12, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Sung Hee Ko, Jongyoon Han
  • Patent number: 10883958
    Abstract: A liquid electrolyte, for an electrochemical gas sensor for detecting NH3 or gas mixtures containing NH3, contains at least one solvent, one conductive salt and/or one organic mediator. The conductive salt is an ionic liquid, an inorganic salt, an organic salt or a mixture thereof. The electrolyte preferably is comprised of (I) water, propylene carbonate, ethylene carbonate or a mixture thereof as solvent; (ii) LiCl, KCl, tetrabutylammonium toluenesulphonate or 1-hexyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate as conductive salt; and (iii) tert-butylhydroquinone or anthraquinone-2-sulphonate as organic mediator.
    Type: Grant
    Filed: September 1, 2014
    Date of Patent: January 5, 2021
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Andreas Nauber, Michael Sick, Gregor Steiner, Marie-Isabell Mattern-Frühwald, Rigobert Chrzan, Sabrina Sommer, Frank Mett, Andreas Hengstenberg
  • Patent number: 10877005
    Abstract: An analyte concentration can be measured at an electrochemical detector using a waveform that includes a reductive voltage. The waveform may include three or four different voltages, in which at least one of the voltage values is reductive. One or more current or charge values can be measured during at least part of a reductive voltage portion of the waveform. The analyte concentration can be calculated based on the measured one or more current or charge values.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: December 29, 2020
    Assignee: Dionex Corporation
    Inventors: Jun Cheng, Yan Liu
  • Patent number: 10876994
    Abstract: A sensor element includes an element body having an elongate rectangular parallelepiped shape and including solid electrolyte layers with oxygen ion conductivity, an outer pump electrode disposed on a first surface of the element body, and a protective layer covering at least a part of a second surface of the element body on a side opposite to the first surface and including one or more exposed spaces (a lower space) to which the second surface is exposed.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 29, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventors: Takashi Hino, Mika Murakami, Koichi Masuda, Hironori Sakakibara
  • Patent number: 10870113
    Abstract: Methods, devices, and systems for performing isoelectric focusing reactions are described. The systems or devices disclosed herein may comprise fixtures that have a membrane. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: December 22, 2020
    Assignee: INTABIO, INC.
    Inventors: Erik Gentalen, Scott Mack, Eric Gwerder, Luc Bousse
  • Patent number: 10866206
    Abstract: A sensor element includes an element body having an elongate rectangular parallelepiped shape and including solid electrolyte layers with oxygen ion conductivity, an outer pump electrode disposed on a first surface of the element body, and a protective layer covering at least a part of the first surface of the element body and including one or more exposed spaces (an upper space) to which the first surface is exposed.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 15, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventors: Takashi Hino, Mika Murakami, Koichi Masuda, Hironori Sakakibara
  • Patent number: 10866246
    Abstract: Devices and methods for characterization of samples are provided. Samples may comprise one or more analytes. Some methods described herein include performing enrichment steps on a device. Some methods described herein include performing mobilization of analytes. Analytes may then be further processed and characterized.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: December 15, 2020
    Assignee: INTABIO, INC.
    Inventors: Scott Mack, Erik Gentalen
  • Patent number: 10852270
    Abstract: A sensor element includes an element body having an elongate rectangular parallelepiped shape and including solid electrolyte layers with oxygen ion conductivity, an outer pump electrode disposed on a first surface of the element body, and a protective layer covering at least a part of the first surface of the element body and including one or more spaces (an upper space) that are present apart from the first surface in a direction perpendicular to the first surface.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 1, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventors: Takashi Hino, Mika Murakami, Koichi Masuda, Hironori Sakakibara
  • Patent number: 10844712
    Abstract: Provided herein are devices and methods for reducing the negative effects of bubble formation on the detection, quantification and/or monitoring of analytes.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: November 24, 2020
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Richard Ferguson, Gary Martin Oddie, Nathan Lawrence, Andrew Meredith, Laurent Pirolli, Emma Irene Corcoran
  • Patent number: 10809220
    Abstract: The synthesis of silver nanoparticles (AgNPs)/meso-porous silicon (PSi) nanocomposite and its effective use as efficient chemical sensor and photocatalyst are described. The PSi was prepared via a simple stain etching of Si microparticles in HF/HNO3 aqueous solution, followed by the deposition of AgNPs onto stain etched PSi by the immersion plating technique. The resultant nanocomposite is used successfully for (i) enhanced electro-oxidation and quantification of ascorbic acid (AA) on modified glassy carbon electrode and (ii) for the photo-reduction of hexavalent chromium Cr(VI) to trivalent Cr(III) under direct visible light irradiation in the presence of citric acid.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 20, 2020
    Assignee: Najran University
    Inventors: Farid A Harraz, Mohd Faisal, Mohammad S Al-Assiri, Ahmed Mohamed El-Toni
  • Patent number: 10809227
    Abstract: A microcomputer calculates the concentration of ammonia contained in exhaust gas. The microcomputer repeatedly obtains from a first ammonia detection section a first ammonia electromotive force EMF1 whose value changes with both the concentrations of ammonia and a flammable gas contained in the exhaust gas. The microcomputer outputs, as ammonia concentration information at the present point in time, ammonia concentration information representing the ammonia concentration at the point 0.5 sec prior to the present point in time. The microcomputer sets a rich spike flag Fs when a first ammonia electromotive force change amount ?EMF1 is smaller than a value obtained by multiplying a start determination value by ?1. When the rich spike flag Fs is set, the microcomputer sets the ammonia concentration information at the present point in time to the value of the ammonia concentration information at the point immediately before the rich spike flag Fs is set.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 20, 2020
    Assignee: NGK Spark Plug Co., LTD.
    Inventors: Shinya Miyamoto, Yoshihiro Nakano
  • Patent number: 10801988
    Abstract: A gas sensor includes a sensor element having a detection section at a distal end portion thereof, and an element cover that surrounds a periphery of the sensor element. The sensor element includes electrodes and formed on a surface of a solid electrolyte body, a heater, and a porous protective layer formed on an outside of the detection section. The element cover includes a cover member with gas flow holes on a side surface and a gas passage is formed between the cover member and the sensor element. A distance between the cover member and the side surface of the sensor element in a direction perpendicular to an axis of the sensor element is in a range of 0.2 mm to 0.8 mm in the entire region of the gas passage leading from the gas flow holes to the detecting section.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: October 13, 2020
    Assignee: DENSO CORPORATION
    Inventors: Yota Iwamoto, Yasufumi Suzuki
  • Patent number: 10794895
    Abstract: A nanopore sensor is provided, including a nanopore disposed in a support structure. A fluidic passage is disposed between a first fluidic reservoir and the nanopore to fluidically connect the first fluidic reservoir to the nanopore through the fluidic passage. The fluidic passage has a passage length that is greater than the passage width. A second fluidic reservoir is fluidically connected to the nanopore, with the nanopore providing fluidic communication between the fluidic passage the second reservoir. Electrodes are connected to impose an electrical potential difference across the nanopore. At least one electrical transduction element is disposed in the nanopore sensor with a connection to measure the electrical potential that is local to the fluidic passage.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: October 6, 2020
    Assignee: President and Fellows of Harvard College
    Inventor: Ping Xie
  • Patent number: 10781469
    Abstract: The present disclosure provides, inter alia, mediator formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are reagent formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are methods and devices for the measurement of an analyte in a sample.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 22, 2020
    Assignee: Omni Biomedical, Inc.
    Inventors: David Zhi Deng, Gary T. Neel
  • Patent number: 10775341
    Abstract: In a sensor element 101, oxygen contained in a gas to be measured introduced into a first internal space 20 through a first diffusion control part 11 is pumped out by applying voltage between an inner pump electrode 22 and an outer pump electrode 23. After the oxygen is pumped out, NOx in the gas to be measured generates oxygen by being reduced by a measurement electrode 44. This oxygen is pumped by applying voltage between the measurement electrode 44 and the outer pump electrode 23. On the basis of current generated according to the amount of oxygen thus pumped, the NOx gas concentration is calculated. A slit width of the first diffusion control part 11 on an entrance side is larger than a slit width on an exit side.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 15, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventors: Akari Tominaga, Hirohito Kiyota
  • Patent number: 10775340
    Abstract: An apparatus comprising first and second electrodes (201, 202) separated by an electrolyte (203), the first and second electrodes (201, 202) configured to exhibit a potential difference therebetween on interaction of the first electrode (201) with an analyte, wherein the first electrode (201) is configured such that its electrical conductance and electrochemical potential are dependent upon the amount of analyte present, the electrical conductance and electrochemical potential of the first electrode (201) affecting the potential difference between the first and second electrodes (201, 202), and wherein the apparatus comprises respective first and second terminals (204, 205) configured for electrical connection to a readout circuit to enable determination of the presence and/or amount of analyte based on the potential difference.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: September 15, 2020
    Assignee: Nokia Technologies Oy
    Inventors: Di Wei, Michael Astley, Stefano Borini, Jani Kivioja
  • Patent number: 10775331
    Abstract: In a biological information measurement device, the ingress of biological sample is detected even when a sensor is mounted, which reduces measurement error. The biological information measurement device comprises a voltage supply component that supplies voltage between first and second connectors, between second and third connectors, and between first and third connectors, a current measurement component that measures a first current that flows between the first and second connectors, a second current that flows between the second and third connectors, and a third current that flows between the first and third connectors, and a controller that is connected to the current measurement component and the voltage supply component. The controller compares two or more of the currents and thereby determines whether a foreign substance has adhered between two or more connectors out of the first, second, and third connectors.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: September 15, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Mamiko Ochi, Takashi Miki, Daiki Mizuoka
  • Patent number: 10775338
    Abstract: The invention relates to an electrochemical gas sensing apparatus for sensing one or more analytes, such as NO2 and/or O3, in a sample gas and a method of using same. The apparatus uses Mn2O3 as a filter for ozone. The Mn2O3 may take the form of a powder which may be unmixed, mixed with various PTFE particles sizes, formed into a solid layer deposited onto a membrane and/or pretreated with NO2.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: September 15, 2020
    Assignee: ALPHASENSE LIMITED
    Inventors: John Saffell, Ronan Baron, Marlene Hossain
  • Patent number: 10761053
    Abstract: Embodiments described herein relate generally to compositions that include a synthetic redox-active receptor, and in particular to compositions that include a boronic acid based synthetic redox-active receptor which can electrochemically sense a target analyte in a sample solution. In some embodiments, a synthetic redox-active receptor can have a composition of formula I: wherein the variables L, L?, R, R?, n and X? are described herein.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: September 1, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Jeff T. Suri