Abstract: The non-invasive biolipid concentration meter comprises: an irradiator (2) that emits light at a given intensity toward the inside of a living body from outside; a light intensity detector (3) that is disposed at a given distance from a position (21) irradiated with the light from the irradiator (2) and that determines the intensity of light emitted from the living body; a scattering coefficient calculator (4) that calculates the coefficient of light scattering within the living body on the basis of the light intensity determined with the light intensity detector (3); and a lipid concentration calculator (5) that calculates the lipid concentration in the living body on the basis of the coefficient of light scattering.

Abstract: A physiological parameter sensor system includes a housing with a first cell and a plurality of second cells. A first sensor system element (either an emitter or a detector) resides in the first cell. Second sensor system elements reside in at least some of the second cells. If the first sensor system element is an emitter, each second sensor system element is a detector, and vice versa. The housing is conformable to the contours of a patient to ensure that the sensor system elements are closely coupled to the patient's skin. The system identifies the emitter which yields the best quality signal at the detector (or the detector which receives the best quality signal from the emitter). The system then uses only the identified emitter/detector pair. The system is compact, places only modest demands on battery power, and tolerates being positioned at a nonoptimal locations on the patient's body.

Abstract: The invention provides a pulse oximetry sensor for attachment to the lower half of the palm or the ulnar edge of the palm. The sensor may be portable, untethered and in some instances, disposable. The features of the sensor make it effective in stable, chronic or emergency medical settings.

Abstract: Some embodiments described herein relate to a sensor that includes an analyte-sensing dye and a reference dye. The analyte-sensing dye can be configured to emit an analyte-dependent optical signal in the presence of an analyte. Similarly stated, the intensity and/or duration of the analyte-dependent optical signal can be modulated by a quantity and/or concentration of the analyte in the environment of the sensor. The reference dye can be configured to emit an analyte-independent optical signal. The analyte-dependent optical signal and the analyte-independent optical signal have an analyte-dependent spectrum and an analyte-independent spectrum, respectfully. The analyte-dependent optical spectrum and the analyte-independent spectrum can be the same, substantially the same, and/or overlapping. The analyte-dependent optical signal can have a duration of lifetime that is shorter than a duration or lifetime of the analyte-independent optical signal.

Abstract: An physiological measurement device provides a device body having a base, legs extending from the base and an optical housing disposed at ends of the legs opposite the base. An optical assembly is disposed in the housing. The device body is flexed so as to position the housing over a tissue site. The device body is unflexed so as to attach the housing to the tissue site and position the optical assembly to illuminate the tissue site. The optical assembly is configured to transmit optical radiation into tissue site tissue and receive the optical radiation after attenuation by pulsatile blood flow within the tissue.

Abstract: An endoscope system has an oxygen saturation calculation unit that calculates the oxygen saturation of an observation object, and includes an image acquisition unit that acquires a preliminarily captured image that is an image of the observation object, a correction unit that corrects an LUT that the oxygen saturation calculation unit uses for the calculation of the oxygen saturation, using the preliminarily captured image, a determination unit that determines a success or failure of the correction, and a warning unit that performs warning in a case where a determination result obtained by the determination unit is a failure.

Abstract: A sensor cartridge according to embodiments of the disclosure is capable of being used with a non-invasive physiological sensor. Certain embodiments of the sensor cartridge protect the sensor from damage, such as damage due to repeated use, reduce the need for sensor sanitization, or both. Further, embodiments of the sensor cartridge are positionable on the user before insertion in the sensor and allow for improved alignment of the treatment site with the sensor. In addition, the sensor cartridge of certain embodiments of the disclosure can be configured to allow a single sensor to comfortably accommodate treatment sites of various sizes such as for both adult and pediatric applications.

Abstract: A pulse oximeter includes one or more processor and one or more memory storing instructions. When the instructions are executed by the one or more processor, the one or more processor causes the pulse oximeter to acquire a first signal corresponding to an intensity of first light having a first wavelength and a second signal corresponding to an intensity of second light having a second wavelength, set a presumptive value of an arterial oxygen saturation, acquire an arterial blood component signal and a venous blood component signal corresponding to the presumptive value from the first signal and the second signal, acquire an index value corresponding to a phase difference between the arterial blood component signal and the venous blood component signal, and calculate the arterial oxygen saturation based on a variation of the index value associated with a change of the presumptive value.

Abstract: Presented herein are devices for collecting and/or channeling a biofluid (e.g., sweat, tears, saliva) and detecting and/or quantifying one or more biomarkers in the biofluid. The one or more biomarkers may include, for example, ions, salts thereof, hormones and/or steroids, proteins, metabolites and organic compounds. In certain embodiments, the devices described herein include a specially designed interface and a zero-energy micro pump that allow the device to be comfortably affixed directly to the skin of a user while biofluid is efficiently and non-invasively collected from the skin of the user. In certain embodiments, the biofluid collection and sensing device is housed on or in another wearable device, such as a wrist band or a smart watch. In certain embodiments, the devices described herein are disposable (e.g., after a certain period of use and/or wear the device can be disposed and replaced with a low-cost replacement).

Abstract: As placement of a physiological monitoring sensor is typically at a sensor site located at an extremity of the body, the state of microcirculation, such as whether vessels are blocked or open, can have a significant effect on the readings at the sensor site. It is therefore desirable to provide a patient monitor and/or physiological monitoring sensor capable of distinguishing the microcirculation state of blood vessels. In some embodiments, the patient monitor and/or sensor provide a warning and/or compensates a measurement based on the microcirculation state. In some embodiments, a microcirculation determination process implementable by the patient monitor and/or sensor is used to determine the state of microcirculation of the patient.

Abstract: A method or device for assaying physiological gas levels in a human, comprising: repeatedly measuring a gas in samples of breath or blood, or continuously measuring the gas through the skin or fingernail, while he or she holds his or her breath for a specified time interval (BHt) before each measurement, wherein these time intervals are selected from the group consisting of BHt=0, 4-6, 20-25 and 35-40 seconds, and recording the results to form a series of values including at least one measurement at BHt=35-40 which is treated as representing the average gas level in all the tissues of the body (T) at that time, to determine if the individual is net inhaling, net exhaling or in equilibrium with the gas.

Abstract: A method of detection of an analyte includes implementing a scan routine using a detector array that is electrically connected to a transmit circuit and electrically connected to a receive circuit, the detector array having at least three detector elements. In a first scan, a first combination of the detector elements is used to transmit a first transmit signal that is in a radio or microwave frequency or visible range of the electromagnetic spectrum into a target containing at least one analyte of interest and used to detect a response resulting from transmission of the first transmit signal into the target. In a second scan, a second combination of the detector elements, different from the first combination, is used to transmit a second transmit signal that is in a radio or microwave frequency or visible range of the electromagnetic spectrum into the target and is used to detect a response resulting from transmission of the second transmit signal into the target.

Abstract: A total hemoglobin index system derives total hemoglobin (tHb) index value utilizing a depopulated emitter with an index set of LEDs. A patient fails a tHb index test if tHb measurements are trending down and/or tHb values fall below a predefined index threshold. If a patient fails the tHb index test, a high resolution sensor derives a specific tHb measurement utilizing a high resolution set of LEDs. The number of high resolution set LEDs is greater than the number of index set LEDs.

Abstract: An optical proximity sensor assembly includes an optical proximity sensor with an IR LED emitting light having an infrared wavelength, an IR photo detector sensitive to the infrared wavelength, an optical barrier blocking direct light rays from the LED to the IR photo detector and permitting reflected light rays to reach the at least one photo detector; and an electronic integrated circuit with an amplifier for amplifying a signal detected by the photo detector, an analog to digital converter, LED drivers, noise reduction and ambient light cancellation circuitry, and a digital interface for communication with a microcontroller. The optical proximity sensor is accommodated on a wearable carrier. A single sensor may include a plurality of identical or different LEDs, a plurality of photodiodes, or both. Also, several sensors may be placed on a person's skin along a vascular path to obtain data relating to blood flow and artery stiffness.

Abstract: A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.

Abstract: A plethysmography (“PPG”) measurement system may include at least one source of PPG radiation and at least one auxiliary sensor for detection of PPG radiation. The radiation source emits a portion of the PPG radiation toward a subject and another portion along an optical path for direct communication between the PPG radiation source and the auxiliary sensor. The auxiliary sensor may develop a profile against which measurements from primary PPG sensors, which receive light returning from the subject, may be compared. From this comparison, new PPG signals may be generated that exhibit lower noise than the PPG signals output by PPG sensors. These noise mitigation techniques may be used advantageously by a PPG system to generate more accurate measurements and also to reduce power consumption by the radiation sources.

Abstract: An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

Abstract: An electroactive photonic polymer sensing device includes an imaging component that uses photonic energy to generate a photocurrent that represents a molecular parameter, wherein the imaging component includes a photosensitive material and at least one of a laser diode and/or photodiode; and a memory component that stores a representation of the molecular parameter, wherein the memory component includes at least one of a protein, vitamin, lipid, carbon allotrope, carbon tetra fluoride.

Abstract: The present invention relates to a method for estimating the relative orientation between a tibia (11a) and a femur (11b) of a lower limb (10) of a person (1), the method being characterised in that it comprises the steps of: (a) During at least one reference movement of said lower limb (10) from a reference position, acquiring by first inertial measuring means (20a) integral with the tibia (11a) and by second inertial measuring means (20b) integral with the femur (11b) reference accelerations and angular velocities; (b) Estimating a plurality of morphological parameters of said lower limb (10), as a function of said measured reference accelerations and angular velocities; (c) Determining a relative orientation in said initial position between said tibia (11a) and femur (11b), as a function of said estimated morphological parameters of said lower limb (10); (d) During a working movement of said lower limb (10) from an initial position, acquiring by the first inertial measuring means (20a) and the second in