Abstract: An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and/or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.

Abstract: Embodiments concern coupling polarized light at two or more wavelengths across the aqueous humor of the eye (e.g., as part of a noninvasive glucose monitoring system). An approach discloses non-contact and minimal contact eye-coupling designs that are part of a system for providing glucose concentration levels via measurements acquired by passing two or more optical beams through the cornea/aqueous chamber in the eye. The approach provides for coupling the light to account for the index mismatch incurred while allowing for monitoring the light polarization. Specifically, in an embodiment the light transitions from the device, through the air, through the proximal side of the cornea, through the aqueous humor, through the medial side of the cornea, and through the air back into the device. Embodiments address the index of refraction mismatch and polarized light maintaining concerns with a coupling approach that can take the form of contact and non-contact mechanisms.

Abstract: A method for monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. The method can optionally include optically detecting glucose concentration as a function of polarimetry and/or fluorescence. A system for monitoring glucose concentration can include devices described herein.

Abstract: An apparatus for monitoring an oxygen saturation level of a wearer of the apparatus includes a processor, a memory operably coupled to the processor, a first housing portion, a second housing portion, and a connection member. The first housing portion includes at least one light-emitting diode (LED), and the second housing portion includes a photodetector. The connection member is mechanically coupled to each of the first housing portion and the second housing portion. The apparatus is sized and shaped to be worn about a portion of an ear of a wearer of the apparatus. During operation, the at least one LED emits light in a direction toward the photodetector. A portion of the emitted light passes through the portion of the ear prior to arriving at the photodetector. The photodetector detects a signal in response to the portion of the emitted light, and the memory stores instructions to cause the processor to calculate an oxygen saturation level of the wearer based on the detected signal.

Abstract: Apparatus configured to detect congenital heart disease (CHD) in newborns may comprise a body with a cavity configured to receive a hand or foot of a newborn. Sensor pairs of the apparatus may be configured scan such that the best signals can be selected, which can accommodate for movements of the newborn and/or facilitate impartialness as to which body part is inserted in the apparatus. Positions of the sensor pairs may be adjusted to ensure contact with the newborn's skin. A disposable cover may protect the newborn's skin from contacting the apparatus. The apparatus may include a pressure device so that CHD threshold values can be adjusted for different altitudes. The apparatus may integrate with electronic medical record (EMR) systems.

Abstract: Systems and methods to determine presence of an analyte using an implantable medical device are disclosed. In an embodiment, a medical system includes an implantable medical device, a light source, an optical sensor and a processor. The implantable medical device includes an indicator tag, which is responsive to an analyte. The light source is configured to emit light onto the indicator tag, where the emitted light comprises at least one wavelength of light, and where the indicator tag emanates light, in response to the emitted light, that corresponds to whether the indicator tag is exposed the analyte. The optical sensor is configured to receive at least a portion of the emanated light, which includes at least one wavelength of light. And, the processor is configured to determine whether the indicator tag is exposed to the analyte based on the received light.

Abstract: A method of extracting glucose feature, a method for monitoring glucose using near-infrared (NIR) spectroscopy and a glucose monitoring device are provided. The method comprising: removing noise from a near-infrared (NIR) data; extracting a glucose signal from the NIR data; and removing temporal drift components from the extracted glucose signal.

Abstract: A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Abstract: A used photoacoustic apparatus includes: a light source capable of individually emitting light having a first wavelength at which absorption coefficients of oxyhemoglobin and deoxyhemoglobin are equal and light having a second wavelength; an acoustic detector that receives acoustic waves generated when the light having the first and second wavelengths is absorbed by an object; an absorption coefficient distribution generator that determines absorption coefficient distributions of an object interior; a blood vessel position determining unit that determines a blood vessel position from an absorption coefficient distribution corresponding to the first wavelength; an organism characteristics distribution calculator that determines an organism characteristics distribution from the absorption coefficient distributions; and a trimming unit that trims the organism characteristics distribution in accordance with the blood vessel position.

Abstract: A multi-channel measurement device for measuring properties of human tissue, may comprise a microcontroller and first and second source/sensor complexes. The first source/sensor complex may include a first housing having a first measurement portion, a first light sensor coupled to the microcontroller and exposed to the first measurement portion, and a first plurality of light sources coupled to the microcontroller and exposed to the first measurement portion. The second source/sensor complex may include a second housing having a second measurement portion, a second light sensor coupled to the microcontroller and exposed to the second measurement portion, and a second plurality of light sources coupled to the microcontroller and exposed to the second measurement portion. The first and second source/sensor complexes are coupled to each other such that the first measurement portion is opposite the second measurement portion and human tissue may be placed between the the first and second measurement portions.

Abstract: A device to extract physiological information has at least one laser emitter. At least one optical detector is used to detect a change in optical power absorption. The laser emitter and optical detector are wire bonded into a chip scale module.

Abstract: A photoplethysmography (PPG) circuit obtains PPG signals at a plurality of wavelengths of light reflected from tissue of a user. A processing device generates parameters using the PPG signals to screen the user for an infection, such as sepsis, influenza and/or COVID-19. The processing device may also determine a severity level of the infection and a confidence level in the determination. The parameters may include a measurement of nitric oxide (NO) level, respiration rate, heart rate and/or oxygen saturation.

Abstract: The present disclosure includes a body-worn alcohol detection device. The device includes a housing comprising an electronics module and an alcohol detection module. The device further comprises a strap for securing the housing to a limb of the user. The electronics module includes a processor and a communication module, and the alcohol detection module includes an alcohol detection sensor, a sample collection device and a biometric camera for capturing an image of the inside of the user's mouth.

Abstract: The invention relates to a photoplethysmography apparatus (100), comprising a source of light (110) configured to provide source light (130) of at least a first and a second spectral position directed at a tissue (140); alight detector (120) configured to detect scattered source light, and to provide at least a first and a second sensor signal (127, 29) indicative of the scattered source light of the first and second spectral position; and a processing unit (150). The processing unit is configured to calculate a corrected sensor signal (160), indicative of a variation in blood absorbance within the tissue, by removing a tissue-path error signal component, indicative of a variation in optical path length through the tissue over time, and a light-coupling error signal component, indicative of a variation of source light intensity of the source light emitted at the tissue, from the at least first and second sensor signals.

Abstract: Technologies for measuring a hydration level of a user includes a hydration measurement device having an arm position sensor and one or more reflectance sensors. The hydration measurement device generates sensor data indicative of a position of a user's arm using the arm position sensor. The hydration measurement device performs reflectance measurements with the reflectance sensor(s) at a first position that is determined based on the sensor data and a second position that is raised relative to the first position that is also based on the sensor data. The hydration measurement device determines a hematocrit of the user's blood based on the reflectance measurements and determines a hydration level of the user based on the determined hematocrit. Other embodiments are described and claimed.

Abstract: A photoplethysmography (PPG) circuit obtains PPG signals at a plurality of wavelengths of light reflected from tissue of a user. A processing device generates parameters using the PPG signals to determine a glucose level in blood flow of the user. The parameters include one or more ratio values obtained using the plurality of PPG signals; a phase delay between the plurality of PPG signals; a correlation of phase shape between the plurality of PPG signals or a periodicity of one or more of the plurality of PPG signals.

Abstract: Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.

Abstract: An apparatus comprises an activity monitor for measuring physical activity of a subject. The activity monitor is configured to obtain a first set of physical activity data over a first time period, for example during the day, and a second set of physical activity data over a second time period, for example during the night. A processor processes the data obtained by the activity monitor to calculate a physical activity ratio which is the ratio of the physical activity measured during the first time period to the physical activity measured in the second time period. The processor also calculates a first overall value which represents an activity level of the subject during the first time period. The physical activity ratio together with the first overall value may be used to assess the severity of symptoms of COPD displayed by a subject or to identify respiratory disease comorbidity information for example psychological issues such as low motivation, or sleep quality issues displayed by the subject.

Abstract: An analyte monitoring system may include one or more sensors, one or more transceivers, one or more primary display devices, a remote computing device, and one or more secondary display devices. Each sensor may be in communication with a respective transceiver, and each transceiver may be in communication with a respective primary display device. A patient application may be stored as computer readable instructions in a storage medium of a primary display device, and an observer application is stored as computer readable instructions in a storage medium of a secondary display device. The patient application may be configured to allow a user of the primary display device to share analyte information with a secondary display device. The observer application may be configured to allow a user of the secondary display device to receive and display the shared analyte information.

Abstract: A method of monitoring changes in oxygen saturation of a subject by analysing a three colour channel video image of the exposed skin of the subject. Within each colour channel a normalised signal obtained by dividing the intensity signal by its mean value, and the normalised signals are averaged across plural regions of interest within the exposed skin area image of the subject. Regions of interest are selected on the basis of the signal-to-noise ratios for the heart rate and breathing rate components. A single representative waveform for each colour channel is obtained by signal averaging and the ratio of the amplitudes of the representative waveforms from two different colour channels, e.g. blue and red, is taken. The changes in the ratio of amplitudes is output as a measure of changes in blood oxygen saturation.