Patents Examined by Mark R Luderer
  • Patent number: 10647652
    Abstract: A process for the production of organic acids having at least three carbon atoms comprises the steps of forming an amount of carbon monoxide and reacting the amount of carbon monoxide with an amount of an unsaturated hydrocarbon. The reaction is preferably carried out in the presence of a supported palladium catalyst, a strong acid, and a phosphine. In some embodiments, the unsaturated hydrocarbon is one of acetylene and methylacetylene, and the organic acid is one of acrylic acid and methyl acrylic acid. The reacting step is preferably performed with carbon monoxide produced from carbon dioxide.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: May 12, 2020
    Assignee: Dioxide Materials, Inc.
    Inventors: Richard I. Masel, Zheng Richard Ni, Qingmei Chen, Brian A. Rosen
  • Patent number: 10576467
    Abstract: Described herein are processes and apparatus for the high purity and high concentration recovery of multivalent products via continuous ion exchange from aqueous solutions for further down-stream purification.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: March 3, 2020
    Assignee: INVISTA North America S.a.r.l.
    Inventors: Mariusz Kamionka, Alex Conradie
  • Patent number: 10544072
    Abstract: Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 28, 2020
    Assignee: Iowa Corn Promotion Board
    Inventors: David James Schreck, Ray Chrisman, Brooke Albin, Nye Clinton, Marion McKinley Bradford, Donald Bunning
  • Patent number: 10501406
    Abstract: The invention relates to polyphenyl polymethylene polyisocyanates having an NCO number of at least 29% comprising less than 2% by weight ureas, less than 8% by weight carbodiimides or uretonimines and less than 1000 ppm organic chlorine compounds. The polyphenyl polymethylene polyisocyanates can be prepared according to the invention by reacting (i) polyphenyl polymethylene polyamines with organic carbonates to give the corresponding polyphenyl polymethylene polycarbamates, (ii) by thermally cleaving the polyphenyl polymethylene polycarbamates to give the polyphenyl polymethylene polyisocyanates, wherein, prior to the thermal cleavage, the free amino groups or urea groups present in the carhamate crude mixture comprising the polyphenyl polymethylene polycarbamates are reacted with a derivatizing reagent to give amide groups or urethane groups.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: December 10, 2019
    Assignee: BASF SE
    Inventors: Michael Lorenz, Axel Franzke, Robert Baumann, Michael Bock, Geert Janssens
  • Patent number: 10472310
    Abstract: Continuous processes for making propylene glycol from ketose-yielding carbohydrates are disclosed which enhance the selectivity to propylene glycol.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 12, 2019
    Assignee: Iowa Corn Promotion Board
    Inventors: David James Schreck, Ray Chrisman, Brooke Albin, Nye Clinton, Marion McKinley Bradford, Donald Bunning
  • Patent number: 10435416
    Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: October 8, 2019
    Assignee: University of South Florida
    Inventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
  • Patent number: 10428012
    Abstract: The present invention relates to a preparation method of 4-isopropylamino-1-butanol, in which using cheap and readily available tetrahydrofuran and acetic acid solution of hydrogen bromide as starting materials to prepare a novel intermediate of 4-isopropylamino-1-acetoxyl butane and further obtain the target product. The present invention has advantages of convenient process operations, mild reaction conditions, economical and environment-friendly benefits, and suitability for industrial production to obtain the product with high purity and high yield.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: October 1, 2019
    Inventors: Fanghui Tang, Chi Ma, Qiang Jia
  • Patent number: 10428010
    Abstract: The present invention relates to a process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound comprises a primary amine, a cyclic secondary amine or a tertiary bicyclic amine.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 1, 2019
    Assignee: Nouryon Chemicals International B.V.
    Inventors: Rolf Krister Edvinsson, Eike Nicolas Kantzer, Per Fredrik Olmo Larsson, Karl Fredrik Lake, Antoon Jacob Berend Ten Kate, Ulf Schröder, Johan Salman Malmberg
  • Patent number: 10421712
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 24, 2019
    Assignee: AbbVie Inc.
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • Patent number: 10414716
    Abstract: A process for producing a polyetheramine by reacting a polyether alcohol, previously synthesized in the presence of a basic potassium or sodium compound as catalyst, with ammonia in the presence of hydrogen and a catalyst in one reactor or a plurality of reactors, wherein the employed polyether alcohol when previously synthesized in the presence of a basic potassium compound as catalyst has a content of potassium ions of less than 50 wppm and when previously synthesized in the presence of a basic sodium compound as catalyst has a content of sodium ions of less than 50 wppm.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: September 17, 2019
    Assignee: BASF SE
    Inventors: Christof Wilhelm Wigbers, Wolfgang Mägerlein, Thomas Krug, Johann-Peter Melder
  • Patent number: 10407380
    Abstract: The present invention provides a method for isomerizing a cyclohexanediamine, which simply and highly actively realizes an isomerization reaction of a cyclohexanediamine, without passing through a high-pressure reaction and a complicated multi-stage process. The isomerization method has an isomerization step of isomerizing a cyclohexanediamine in the presence of a compound represented by the following formula (1) and at least one selected from the group consisting of an alkali metal, an alkali metal-containing compound, an alkaline earth metal or an alkaline earth metal-containing compound.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: September 10, 2019
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yuko Shimizu, Yoshiaki Yamamoto
  • Patent number: 10406237
    Abstract: There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 10, 2019
    Inventors: Zhiwei Yang, Parul Angrish, Xavier de Mollerat du Jeu, Kristin Wiederholt
  • Patent number: 10399060
    Abstract: Disclosed is a supported catalyst for the preparation of vinyl acetate monomer (VAM), a process for preparing a catalyst comprising an extruded alumina support, and a catalytic process for the manufacturing vinyl acetate using the supported catalyst. Specifically, it is shown that for activated palladium-gold VAM catalysts prepared using extruded alumina supports, enhanced performance is demonstrated with increased pore volume of the support, and the gas hourly space velocity (GHSV, hr?1), which was found to significantly increase the space time yield as GHSV increased as compared to the non-extruded alumina supported catalysts.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: September 3, 2019
    Assignee: LyondellBasell Acetyls, LLC
    Inventors: Mure Te, Daniel F. White
  • Patent number: 10370494
    Abstract: Provided is an ethyleneimine polymer which exhibits excellent close adhesion properties and adhesive properties and is unlikely to form a gel-like film, and a method for producing the same. An ethyleneimine polymer, wherein a number average molecular weight (Mn) of the ethyleneimine polymer measured by gel permeation chromatography in terms of pullulan is 13,000 or more, a degree of dispersion of the ethyleneimine polymer is greater than 3.0 and 5.0 or less, and a water content in the ethyleneimine polymer is from 3 to 35% by weight.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: August 6, 2019
    Inventors: Seiichi Suzuki, Taisuke Kasahara
  • Patent number: 10370614
    Abstract: This invention relates to unsaturated polyol esters that can be used in hydraulic fluid applications, including fire-resistant hydraulic fluid applications, marine hydraulic fluid applications, metalworking fluid applications, food grade fluid applications, and transformer fluid applications, and methods for making the same.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: August 6, 2019
    Assignee: Elevance Renewable Science, Inc.
    Inventors: Paul A. Bertin, Courtnay Shaner, Na Liu, Monika Mujkic, Kristine Counter, Jonathan Brekan
  • Patent number: 10364215
    Abstract: Disclosed is a method for the production of urea allowing a substantial reduction, even down to zero, of the continuous emission of ammonia conventionally resulting from such a process. According to a preferred embodiment of the invention, the urea-forming reaction from carbon dioxide and ammonia is conducted in a synthesis section that does not require passivation by oxygen. As a result of the absence of oxygen, a hydrogen-rich gas stream results from the synthesis section, that can be used as a fuel in an incinerator. In the incinerator, ammonia-comprising gas streams from the urea production process are combusted.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: July 30, 2019
    Assignee: Stamicarbon B.V.
    Inventors: Johannes Henricus Mennen, Barbara Cucchiella
  • Patent number: 10343976
    Abstract: N-hydroxyalkylated polyamines, methods of making N-hydroxyalkylated polyamines, and drilling fluids containing N-hydroxyalkylated polyamines are provided, in which the N-hydroxyalkylated polyamine includes Formula (I): where R1 and R2 are independently a —C or —CH group; R3 is an aliphatic hydrocarbyl; R4 and R5 are independently acyclic hydrocarbyls, or R1, R2, R4, and R5 are covalently connected to form a cyclic hydrocarbyl; and R6, R7, R8, and R9 are independently acyclic hydrocarbyls or acyclic heterohydrocarbyls.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: July 9, 2019
    Assignee: Saudi Arabian Oil Company
    Inventors: Matthew Hilfiger, B. Raghava Reddy
  • Patent number: 10343979
    Abstract: Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 9, 2019
    Assignee: Insmed Incorporated
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
  • Patent number: 10336680
    Abstract: A process for preparing bis(2-hydroxyethyl) terephthalate, comprising a step of: subjecting ethylene oxide and terephthalic acid in a molar ratio of from 2:1 to 3:1 to a reaction at an elevated temperature in the presence of a solvent mixture containing water and a C6-C8 hydrocarbon in a weight ratio of from 1:1 to 3:1.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 2, 2019
    Inventors: Der-Ren Hwang, Cheng-Ting Wang, Hsiao-Chan Wang
  • Patent number: 10329228
    Abstract: A process for the production of saturated or unsaturated aliphatic alcohols and/or hydrocarbons includes condensing acetone and/or alcohol(s) to form one or more carbonyl compounds, and hydrogenating and/or hydrodeoxygenating at least one of the one or more carbonyl compounds to form the saturated or unsaturated alcohol(s) and/or hydrocarbons. In some embodiments, the condensation of acetone and/or alcohol(s) may be carried out in the presence of a solid acid catalyst and a transition metal catalyst. The saturated or unsaturated aliphatic alcohols and/or hydrocarbons may include one or more saturated linear C9 alcohols, C9 alkanes and/or one or more mono-unsaturated C9 alkenes.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: June 25, 2019
    Assignee: Triad National Security, LLC
    Inventors: Andrew Sutton, Cameron Moore, Rhodri Jenkins, Troy A. Semelsberger