Abstract: A process for the production of organic acids having at least three carbon atoms comprises the steps of forming an amount of carbon monoxide and reacting the amount of carbon monoxide with an amount of an unsaturated hydrocarbon. The reaction is preferably carried out in the presence of a supported palladium catalyst, a strong acid, and a phosphine. In some embodiments, the unsaturated hydrocarbon is one of acetylene and methylacetylene, and the organic acid is one of acrylic acid and methyl acrylic acid. The reacting step is preferably performed with carbon monoxide produced from carbon dioxide.
Type:
Grant
Filed:
August 21, 2018
Date of Patent:
May 12, 2020
Assignee:
Dioxide Materials, Inc.
Inventors:
Richard I. Masel, Zheng Richard Ni, Qingmei Chen, Brian A. Rosen
Abstract: Described herein are processes and apparatus for the high purity and high concentration recovery of multivalent products via continuous ion exchange from aqueous solutions for further down-stream purification.
Abstract: Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol.
Type:
Grant
Filed:
June 2, 2017
Date of Patent:
January 28, 2020
Assignee:
Iowa Corn Promotion Board
Inventors:
David James Schreck, Ray Chrisman, Brooke Albin, Nye Clinton, Marion McKinley Bradford, Donald Bunning
Abstract: The invention relates to polyphenyl polymethylene polyisocyanates having an NCO number of at least 29% comprising less than 2% by weight ureas, less than 8% by weight carbodiimides or uretonimines and less than 1000 ppm organic chlorine compounds. The polyphenyl polymethylene polyisocyanates can be prepared according to the invention by reacting (i) polyphenyl polymethylene polyamines with organic carbonates to give the corresponding polyphenyl polymethylene polycarbamates, (ii) by thermally cleaving the polyphenyl polymethylene polycarbamates to give the polyphenyl polymethylene polyisocyanates, wherein, prior to the thermal cleavage, the free amino groups or urea groups present in the carhamate crude mixture comprising the polyphenyl polymethylene polycarbamates are reacted with a derivatizing reagent to give amide groups or urethane groups.
Type:
Grant
Filed:
January 22, 2016
Date of Patent:
December 10, 2019
Assignee:
BASF SE
Inventors:
Michael Lorenz, Axel Franzke, Robert Baumann, Michael Bock, Geert Janssens
Abstract: Continuous processes for making propylene glycol from ketose-yielding carbohydrates are disclosed which enhance the selectivity to propylene glycol.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
November 12, 2019
Assignee:
Iowa Corn Promotion Board
Inventors:
David James Schreck, Ray Chrisman, Brooke Albin, Nye Clinton, Marion McKinley Bradford, Donald Bunning
Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.
Type:
Grant
Filed:
October 25, 2017
Date of Patent:
October 8, 2019
Assignee:
University of South Florida
Inventors:
Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
Abstract: The present invention relates to a preparation method of 4-isopropylamino-1-butanol, in which using cheap and readily available tetrahydrofuran and acetic acid solution of hydrogen bromide as starting materials to prepare a novel intermediate of 4-isopropylamino-1-acetoxyl butane and further obtain the target product. The present invention has advantages of convenient process operations, mild reaction conditions, economical and environment-friendly benefits, and suitability for industrial production to obtain the product with high purity and high yield.
Abstract: The present invention relates to a process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound comprises a primary amine, a cyclic secondary amine or a tertiary bicyclic amine.
Type:
Grant
Filed:
February 10, 2017
Date of Patent:
October 1, 2019
Assignee:
Nouryon Chemicals International B.V.
Inventors:
Rolf Krister Edvinsson, Eike Nicolas Kantzer, Per Fredrik Olmo Larsson, Karl Fredrik Lake, Antoon Jacob Berend Ten Kate, Ulf Schröder, Johan Salman Malmberg
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
Type:
Grant
Filed:
October 20, 2017
Date of Patent:
September 24, 2019
Assignee:
AbbVie Inc.
Inventors:
Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
Abstract: A process for producing a polyetheramine by reacting a polyether alcohol, previously synthesized in the presence of a basic potassium or sodium compound as catalyst, with ammonia in the presence of hydrogen and a catalyst in one reactor or a plurality of reactors, wherein the employed polyether alcohol when previously synthesized in the presence of a basic potassium compound as catalyst has a content of potassium ions of less than 50 wppm and when previously synthesized in the presence of a basic sodium compound as catalyst has a content of sodium ions of less than 50 wppm.
Type:
Grant
Filed:
December 1, 2015
Date of Patent:
September 17, 2019
Assignee:
BASF SE
Inventors:
Christof Wilhelm Wigbers, Wolfgang Mägerlein, Thomas Krug, Johann-Peter Melder
Abstract: The present invention provides a method for isomerizing a cyclohexanediamine, which simply and highly actively realizes an isomerization reaction of a cyclohexanediamine, without passing through a high-pressure reaction and a complicated multi-stage process. The isomerization method has an isomerization step of isomerizing a cyclohexanediamine in the presence of a compound represented by the following formula (1) and at least one selected from the group consisting of an alkali metal, an alkali metal-containing compound, an alkaline earth metal or an alkaline earth metal-containing compound.
Abstract: There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.
Type:
Grant
Filed:
December 15, 2017
Date of Patent:
September 10, 2019
Assignee:
LIFE TECHNOLOLGIES CORPORATION
Inventors:
Zhiwei Yang, Parul Angrish, Xavier de Mollerat du Jeu, Kristin Wiederholt
Abstract: Disclosed is a supported catalyst for the preparation of vinyl acetate monomer (VAM), a process for preparing a catalyst comprising an extruded alumina support, and a catalytic process for the manufacturing vinyl acetate using the supported catalyst. Specifically, it is shown that for activated palladium-gold VAM catalysts prepared using extruded alumina supports, enhanced performance is demonstrated with increased pore volume of the support, and the gas hourly space velocity (GHSV, hr?1), which was found to significantly increase the space time yield as GHSV increased as compared to the non-extruded alumina supported catalysts.
Abstract: This invention relates to unsaturated polyol esters that can be used in hydraulic fluid applications, including fire-resistant hydraulic fluid applications, marine hydraulic fluid applications, metalworking fluid applications, food grade fluid applications, and transformer fluid applications, and methods for making the same.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
August 6, 2019
Assignee:
Elevance Renewable Science, Inc.
Inventors:
Paul A. Bertin, Courtnay Shaner, Na Liu, Monika Mujkic, Kristine Counter, Jonathan Brekan
Abstract: Provided is an ethyleneimine polymer which exhibits excellent close adhesion properties and adhesive properties and is unlikely to form a gel-like film, and a method for producing the same. An ethyleneimine polymer, wherein a number average molecular weight (Mn) of the ethyleneimine polymer measured by gel permeation chromatography in terms of pullulan is 13,000 or more, a degree of dispersion of the ethyleneimine polymer is greater than 3.0 and 5.0 or less, and a water content in the ethyleneimine polymer is from 3 to 35% by weight.
Abstract: Disclosed is a method for the production of urea allowing a substantial reduction, even down to zero, of the continuous emission of ammonia conventionally resulting from such a process. According to a preferred embodiment of the invention, the urea-forming reaction from carbon dioxide and ammonia is conducted in a synthesis section that does not require passivation by oxygen. As a result of the absence of oxygen, a hydrogen-rich gas stream results from the synthesis section, that can be used as a fuel in an incinerator. In the incinerator, ammonia-comprising gas streams from the urea production process are combusted.
Type:
Grant
Filed:
August 24, 2017
Date of Patent:
July 30, 2019
Assignee:
Stamicarbon B.V.
Inventors:
Johannes Henricus Mennen, Barbara Cucchiella
Abstract: Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
Type:
Grant
Filed:
November 18, 2015
Date of Patent:
July 9, 2019
Assignee:
Insmed Incorporated
Inventors:
Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
Abstract: N-hydroxyalkylated polyamines, methods of making N-hydroxyalkylated polyamines, and drilling fluids containing N-hydroxyalkylated polyamines are provided, in which the N-hydroxyalkylated polyamine includes Formula (I): where R1 and R2 are independently a —C or —CH group; R3 is an aliphatic hydrocarbyl; R4 and R5 are independently acyclic hydrocarbyls, or R1, R2, R4, and R5 are covalently connected to form a cyclic hydrocarbyl; and R6, R7, R8, and R9 are independently acyclic hydrocarbyls or acyclic heterohydrocarbyls.
Abstract: A process for preparing bis(2-hydroxyethyl) terephthalate, comprising a step of: subjecting ethylene oxide and terephthalic acid in a molar ratio of from 2:1 to 3:1 to a reaction at an elevated temperature in the presence of a solvent mixture containing water and a C6-C8 hydrocarbon in a weight ratio of from 1:1 to 3:1.
Type:
Grant
Filed:
October 11, 2017
Date of Patent:
July 2, 2019
Assignee:
FAR EASTERN NEW CENTURY CORPORATION
Inventors:
Der-Ren Hwang, Cheng-Ting Wang, Hsiao-Chan Wang
Abstract: The inventive concepts disclosed and/or claimed herein relate generally to catalysts and, more particularly, but not by way of limitation, to a heterogeneous, metal-free hydrogenation catalyst containing frustrated Lewis pairs. In one non-limiting embodiment, the heterogeneous, metal-free catalyst comprises hexagonal boron nitride (h-BN) having frustrated Lewis pairs therein.
Type:
Grant
Filed:
August 7, 2017
Date of Patent:
June 25, 2019
Assignee:
University of Central Florida Research Foundation, Inc.