Patents Examined by Mark R Luderer
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Patent number: 10233138Abstract: Ethylene glycol is prepared from a carbohydrate source in a process, wherein hydrogen, the carbohydrate source, a liquid diluent and a catalyst system are provided as reactants into a reaction zone; wherein the catalyst system comprises a tungsten compound and at least one hydrogenolysis metal selected from the noble metals Pd, Pt, Ru, Rh, Ir and combinations thereof; wherein the carbohydrate source is introduced into the reaction zone such that in the reaction zone the concentration of the carbohydrate source in the diluent is at least 4% wt, calculated as weight of carbohydrate source per weight of diluent; wherein the amount of the at least one hydrogenolysis metal selected from the noble metals Pd, Pt, Ru, Rh, Ir and combinations thereof ranges from 0.2 to 1.Type: GrantFiled: January 13, 2016Date of Patent: March 19, 2019Assignee: AVANTIUM KNOWLEDGE CENTRE B.V.Inventors: Jan Cornelis Van Der Waal, Gerardus Johannes Maria Gruter, Paula Claassens-Dekker
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Patent number: 10232353Abstract: Catalysts for oxidative esterification can be used, for example, for converting (meth)acrolein to methyl (meth)acrylate. The catalysts are especially notable for high mechanical and chemical stability even over very long time periods, including activity and/or selectivity relatively in continuous operation in media having even a small water content.Type: GrantFiled: December 29, 2015Date of Patent: March 19, 2019Assignee: Evonik Röhm GmbHInventors: Alexander Lygin, Steffen Krill, Matthias Groemping, Andreas Tepperis
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Patent number: 10233144Abstract: The present disclosure relates to a novel crystalline form of a compound of formula (I), preparation method and use thereof. The novel crystalline form in the present disclosure has good stability, low hygroscopicity, and remarkable purification effect in process. The novel crystalline form of the compound of formula (I) provided by the present disclosure can be used for the preparation of the drug for treating heart failure.Type: GrantFiled: March 18, 2016Date of Patent: March 19, 2019Assignee: Crystal Pharmatech Co., Ltd.Inventors: Minhua Chen, Yanfeng Zhang, Chaohui Yang, Shu Yu, Xiaoyu Zhang, Liang Zhang
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Patent number: 10214761Abstract: There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.Type: GrantFiled: June 1, 2017Date of Patent: February 26, 2019Assignee: MEDIMMUNE LIMITEDInventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
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Patent number: 10196344Abstract: Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e.g.Type: GrantFiled: December 17, 2015Date of Patent: February 5, 2019Assignee: SUZHOU PHARMAVAN CANCER RESEARCH CENTER CO., LTD.Inventors: Haimei Feng, Rensen Zhou, Xiang Chen, Yunhui Yu, Qian Liu, Yong Li, Shiping Deng, Chuangliang Jiang
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Patent number: 10189778Abstract: A process for the preparation of methionine a-hydroxy analogue and derivatives thereof comprising contacting one or more sugars or derivatives thereof with a metallo-silicate composition in the presence of a compound comprising sulphur and a solvent.Type: GrantFiled: April 29, 2016Date of Patent: January 29, 2019Assignee: Haldor Topsoe A/SInventors: Irantzu Sadaba Zubiri, Esben Taarning, Despina Tzoulaki
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Patent number: 10189769Abstract: The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.Type: GrantFiled: November 26, 2014Date of Patent: January 29, 2019Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Jie Zhang, Liang Zhang, Wang Huang
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Patent number: 10183905Abstract: A method produces acetic acid and includes a reaction step, a first purification step, a second purification step, and a third purification step. In the reaction step, a material mixture including methanol, carbon monoxide, a catalyst, and an iodide is subjected to a methanol carbonylation reaction in a reactor (1) to form acetic acid. In the first purification step, a crude acetic acid stream including acetic acid formed in the reaction step is subjected to distillation in a distillation column (3) to give a first acetic acid stream enriched with acetic acid. In the second purification step, the first acetic acid stream is subjected to distillation in a distillation column (5) to give a second acetic acid stream further enriched with acetic acid. In the third purification step, an acetic acid stream is subjected to purification in an additional purification unit (e.g.Type: GrantFiled: September 20, 2016Date of Patent: January 22, 2019Assignee: DAICEL CORPORATIONInventors: Masahiko Shimizu, Nobuyuki Hirabayashi, Yoshihisa Mizutani
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Patent number: 10173965Abstract: The present invention provides a method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust pH; d) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.Type: GrantFiled: March 25, 2016Date of Patent: January 8, 2019Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.Inventors: Musong Liu, Wenling Zhang, Peng Wang
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Patent number: 10173212Abstract: The present invention relates to a method for regenerating a hydrogenation catalyst for a phthalate compound. More specifically, the present invention regenerates a hydrogenation catalyst for a phthalate compound by using an alcohol, and thereby provides a method for regenerating a hydrogenation catalyst for a phthalate compound that is capable of continuously hydrogenating a phthalate compound without replacing a catalyst in a catalytic reactor, and is also capable of improving operational stability and the lifetime of a catalyst and increasing economic efficiency.Type: GrantFiled: March 31, 2016Date of Patent: January 8, 2019Assignee: HANWHA CHEMICAL CORPORATIONInventors: Ki Taeg Jung, Kyong Jun Yoon, Hyo Suk Kim, Jang Young Kwak, Pil Je Seong, Kyoung Il Lee
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Patent number: 10173969Abstract: The invention relates to a method for producing aniline, comprising the steps of: a) providing o-aminobenzoate, wherein said o-aminobenzoate comprises anthranilate anion and a suitable cation, b) converting said anthranilate anion to aniline by thermal decarboxylation in the presence or absence of a catalyst, c) extracting the aniline produced in step b) in an organic solvent at least once, and d) purifying the aniline produced in steps b) and c) by distillation, wherein said distillation produces aniline and a water phase.Type: GrantFiled: February 19, 2015Date of Patent: January 8, 2019Assignee: COVESTRO DEUTSCHLAND AGInventors: Gernot Jaeger, Jorgen Magnus, Amgad Salah Moussa
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Patent number: 10173961Abstract: Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Pt, Rh, Ir, and Ru, and in absence of any catalytic amount of any second metal from the list consisting of Ag, Ni, Co, Sn, Bi, Cu, Au, and combinations thereof. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of active agrochemical compounds and microbicides of the methoximinophenylglyoxylic ester series.Type: GrantFiled: November 4, 2015Date of Patent: January 8, 2019Assignee: Taminco BVBAInventors: Kristof Moonen, Kim Dumoleijn, Laura Prati, Alberto Villa
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Patent number: 10166530Abstract: Disclosed is a method for reducing organic compounds using catalysts containing nickel (0) from metal hyperaccumulator plants. The method can be implemented in a green manner and is advantageous compared to methods using the known catalysts.Type: GrantFiled: July 15, 2015Date of Patent: January 1, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE MONTPELLIERInventors: Claude Grison, Vincent Escande
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Patent number: 10167246Abstract: A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), as represented by the following reaction scheme: wherein R1 is aryl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, thiadiazolyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl and hydrogen; R2 is alkoxycarbonyl, alkylaminocarbonyl, aminocarbonyl, alkylthiolcarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, aldehyde, carboxyl, nitro, alkyl and hydrogen; R3 is alkoxycarbonyl, alkyl amido carbonyl, aminocarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, carboxyl and nitro. The present invention has the following main benefits: cheap and readily available starting materials, safe processes, high yield, good quality, which facilitates industrial production.Type: GrantFiled: September 25, 2015Date of Patent: January 1, 2019Assignee: ZHEJIANG ZHUJI UNITED CHEMICALS CO., LTDInventors: Yehua Su, Jieping Shi, Jianxin Lu, Tianhao Zhang, Xiaohua Yu, Guoping Cai, Bangchi Chen
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Patent number: 10160713Abstract: The present invention describes a process for dehydrating alpha-substituted carboxylic acids in the presence of water at high pressures while avoiding by-products.Type: GrantFiled: June 24, 2015Date of Patent: December 25, 2018Assignee: Evonik Roehm GmbHInventors: Belaid Ait Aissa, Steffen Krill, Matthias Groemping
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Patent number: 10155707Abstract: A butanol production system and method for producing refined mixed butanols includes an internal baffle single pass reactor having an internal fluid conduit defined by an internal wall. The internal fluid conduit contains a process fluid comprising water, mixed butenes and mixed butanols, to form a crude product. Internal flow baffles are located along a length of the internal fluid conduit. Baffled cells are defined at an outer diameter by the internal wall and at ends by the internal flow baffles. A separation system separates water and mixed butenes from the crude product to produce refined mixed butanols. An oscillator assembly is coupled to the internal baffle single pass reactor and has a reciprocating oscillator head selectively movable in a back and forth linear motion, and in communication with the process fluid such that the process fluid undergoes a general sinusoidal movement along the internal baffle single pass reactor.Type: GrantFiled: October 9, 2015Date of Patent: December 18, 2018Assignee: Saudi Arabian Oil CompanyInventors: Abeer Arjah, Kareemuddin M. Shaik, Wei Xu
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Patent number: 10150096Abstract: A heteroatom (N,S,O)-rich porous organic polymer and a membrane-based separation system and process employing the polymer is provided that utilizes one of a number of the heteroatom-rich porous organic polymers which contain ultra-small pores in their structures. The polymers can be used in the membranes to form a simpler, easy to regenerate separation system and method that and does not involve phase changes in the operation of the system. The system with the functionalized nanoporous organic polymer(s) can be utilized as a nanoporous membrane composite(s) for CO2 gas separation, or in the formation of a heterogeneous catalyst to convert CO2 to useful chemicals.Type: GrantFiled: March 20, 2017Date of Patent: December 11, 2018Assignee: WISYS TECHNOLOGY FOUNDATION, INC.Inventor: Mohammad G. Rabbani
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Patent number: 10150726Abstract: Provided is a method for efficiently producing a levulinic acid ester from a cellulose-containing raw material or a carbohydrate-containing raw material in an alcohol solvent using an inexpensive, easily available catalytic system. In a method for producing a levulinic acid ester by reacting at least one of a cellulose-containing raw material and a carbohydrate-containing raw material in the presence of an alcohol and a catalyst, use is made of, as a catalyst, a combination of: at least one metal compound (exclusive of gallium acetylacetonate and indium acetylacetonate) selected from the group consisting of hydroxide salts, sulfates, nitrates, carboxylates, alkoxides, acetylacetonates, and oxides of at least one metal selected from the group consisting of metals belonging to Group XIII and Group XIV of the Periodic Table; and an organic sulfonic acid.Type: GrantFiled: February 1, 2016Date of Patent: December 11, 2018Assignees: UBE INDUSTRIES, LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Koji Nemoto, Kenichi Tominaga, Kazuhiko Sato, Atsushi Yamada, Yasushi Yamamoto
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Patent number: 10144701Abstract: The present invention relates to a preparation method of 4-isopropylamino-1-butanol, in which using cheap and readily available tetrahydrofuran and acetic acid solution of hydrogen bromide as starting materials to prepare a novel intermediate of 4-isopropylamino-1-acetoxyl butane and further obtain the target product. The present invention has advantages of convenient process operations, mild reaction conditions, economical and environment-friendly benefits, and suitability for industrial production to obtain the product with high purity and high yield.Type: GrantFiled: March 31, 2016Date of Patent: December 4, 2018Assignee: Seasons Biotechnology (Taizhou) Co., Ltd.Inventors: Fanghui Tang, Chi Ma, Qiang Jia
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Patent number: 10144702Abstract: A method for the manufacture of N,N-dialkyllactamide, whereby at least one of the compounds selected from the series made of alkyl lactate, lactide and polylactic acid is mixed with dialkylamine in order to form a reaction mixture, under conditions whereby aminolysis takes place in the reaction mixture. The method is characterized in that the reaction mixture further includes a Lewis acid. As a result of the method, N,N-dialkyllactamides can be manufactured in high yields and with high optical purity.Type: GrantFiled: October 1, 2015Date of Patent: December 4, 2018Assignee: PURAC BIOCHEM B.V.Inventors: Bastiaan Jeroen Victor Verkuijl, Jurgen Cornelis Henricus Maas