Patents Examined by Mark V Stevens
  • Preparation of microparticulate methylprednisolone acetate suspension
    Patent number: 11433084
    Abstract: The present invention relates to a process for preparation of a water-insoluble steroid composition by moist heat sterilization. The invention particularly relates to a process for preparation of a water-insoluble steroid composition comprising moist heat sterilization or autoclaving of an aqueous slurry of methylprednisolone acetate in the presence of a specified quantity of polysorbate. The suspensions prepared by using the current invention exhibited good physical and chemical stability. Compositions related thereto are also disclosed.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: September 6, 2022
    Assignee: Somerset Therapeutics LLC
    Inventors: Rahul Kalhapure, Prem Sagar Akasapu, Veerappan Subramanian, Ilango Subramanian
  • Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
    Patent number: 11426345
    Abstract: Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CRC) under isotonic conditions. The hypo tonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectal at its CRC will form a “plug” of gel in the lumen.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: August 30, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Katharina Maisel, Laura Ensign, Justin Hanes, Richard Cone
  • Isotonic crystalloid aqueous solution
    Patent number: 11426427
    Abstract: The invention relates to an isotonic crystalloid aqueous solution of the type containing Na+, K+ and Cl?, and to the use thereof as a vasodilator.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: August 30, 2022
    Inventor: Lara Oller Duque
  • Personal care composition
    Patent number: 11419801
    Abstract: The invention relates to a personal care composition, more particularly to a composition for application to a topical surface that prevents or reduces inflammation. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or ester thereof selected from docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), DHA-ethyl ester, EPA-ethyl ester, DHA-triglyceride, EPA-triglyceride, dihomogamma-Linolenic Acid (DGLA), DGLA-ethyl ester, DGLA-triglyceride or combinations thereof and a 4-substituted resorcinol compound, wherein the mole ratio of the PUFA or ester thereof to the 4-substituted resorcinol compound is 5:1 to 1:5.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 23, 2022
    Assignee: CONOPCO, INC.
    Inventors: Chenliang Guo, Nan Huang, Sheila Alves Rocha
  • Stabilized tacrolimus composition
    Patent number: 11419823
    Abstract: The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: August 23, 2022
    Assignee: VELOXIS PHARMACEUTICALS, INC.
    Inventors: Nikolaj Skak, Per Holm
  • Nanoparticle delivery systems
    Patent number: 11413253
    Abstract: Nanoparticle compositions described herein comprise combinations of prodrugs of therapeutic agents that achieve enhanced therapeutic effects as compared to those observed when combinations of free forms of these therapeutic agents are administered.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: August 16, 2022
    Assignee: Celator Pharmaceuticals, Inc.
    Inventors: Leon Wan, Winnie Lui, Paul Tardi, Lawrence Mayer
  • Misoprostol dispersible tablet
    Patent number: 11406615
    Abstract: The present invention relates to a solid pharmaceutical formulation comprising misoprostol or a pharmaceutically acceptable salt thereof. In particular, the invention relates to a dispersible tablet comprising misoprostol or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: August 9, 2022
    Assignee: Azanta Danmark A/S
    Inventors: Selvaraj Sekar, Elumalai Baskar, Arunachalam Malaiarasan, Venugopal Prabhakaran
  • Ophthalmic drug delivery
    Patent number: 11398306
    Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: July 26, 2022
    Assignee: Eyenovia, Inc.
    Inventors: Bernard L. Ballou, Jr., Mark Packer, Russell John Mumper, Tsontcho Ianchulev
  • Compositions and methods for nasal administration of drugs to brain and for systemic effect
    Patent number: 11389404
    Abstract: The invention relates to a nasally administrable composition comprising at least one active substance in magnesium-containing vesicular carrier, said carrier comprising glycol, phospholipids, water and at least one magnesium source. Methods for nasal administration of the composition, for example, for pain relief, are also provided.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: July 19, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Elka Touitou, Hiba Natsheh
  • Deodorant comprising a zinc carboxylate salt and aluminum chlorohydrate
    Patent number: 11389380
    Abstract: An advantageous deodorizing composition comprising at least one zinc carboxylate salt and aluminium chlorohydrate is provided, as well as a deodorant consumer product comprising the same. Furthermore, a method of suspending aluminium chlorohydrate in an at least essentially anhydrous solvent is provided, as well as a method of preventing clumping of aluminium chlorohydrate in a deodorizing composition or a deodorant consumer product and a method of preventing clogging of a nozzle of a deodorant spray containing a deodorizing composition.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: July 19, 2022
    Assignee: GIVAUDAN SA
    Inventor: Matthew Peter Brooks
  • Compositions and methods to treat disease
    Patent number: 11382929
    Abstract: Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: July 12, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Chun Wang, Samuel Hanson
  • Compositions and methods for improving the appearance of the skin
    Patent number: 11382855
    Abstract: The disclosure relates to compositions and methods for improving the appearance of the skin. Compositions comprise at least one thermoplastic elastomer, at least one adhesive polymer, and at least one filler. Methods comprise applying the compositions to the skin to tighten the skin or hide skin imperfections by forming a film on the skin.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: July 12, 2022
    Assignee: L'OREAL
    Inventors: Anne-Laure Suzanne Bernard, Yang Deng, Hy Si Bui, Laure Daubersies, Roshanak Debeaud
  • Skin whitening composition comprising cultured product of or extract thereof
    Patent number: 11376212
    Abstract: Disclosed in the present specification is a skin whitening composition comprising a Bacillus hwajinpoensis strain, a lysate thereof, a cultured product thereof or an extract of the strain, lysate or cultured product as an active ingredient. Disclosed in the present specification is a Bacillus hwajinpoensis strain SNC 135, having an accession number of KCCM12051P, which has a skin whitening function.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 5, 2022
    Assignee: Amorepacific Corporation
    Inventors: Kilsun Myoung, Jaeyoung Ko, Yong Jin Kim
  • Cosmetic compositions and methods
    Patent number: 11369562
    Abstract: The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of one or more of Butyrospermum parkii (shea butter), PEG-50 shea butter, glycerin, Helianthus annuus (sunflower) seed oil, Prunus armeniaca (apricot) kernel oil, acrylates copolymer, sodium lauryl sulfate, lauramidopropyl betaine, sodium methyl cocoyl taurate, glycerin, and polyquaternium-7.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 28, 2022
    Inventors: Michael Frushour, Lisha VanPelt, Kim Wilson, Geetha Kalahasti, Lee Vickers
  • De-colonization drug, preparation method therefor, and application thereof
    Patent number: 11351192
    Abstract: A decolonization drug, a preparation method thereof and an application thereof. The decolonization drug is non-antibiotic, simple and convenient to use, and can be used systemically, and has more types of sterilization; The decolonization drug involved in the invention contains added special components, which can improve the bactericidal performance of the drug through the activator effect; The decolonization drug is suitable for use in adults and sensitive populations, including the elderly, pregnant women, infants, children, etc.; especially as a mucosal drug for nasal mucosa, oral mucosa, ocular mucosa, abdominal mucosa, genital mucosa, etc., and can also be used as a bactericidal drug in other medical fields, including diabetic foot, burns, surgical site infections (SSIs), etc.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: June 7, 2022
    Assignee: BEIJING HYGIENE & HEALTHCARE INNOVATION TECHNOLOGY CO., LTD.
    Inventors: Zhengwang Wang, Gangyi Li
  • Glyceryl polyrhamnosides, process for the preparation thereof, and cosmetic and/or pharmaceutical composition comprising same
    Patent number: 11337911
    Abstract: Composition based on a polyol of formula HO—CH2-CHOH—CH2-OH and on alkyl polyrhamnosides of formula HO—CH2-CHOH—CH2-O-(Rham)x-H; process for preparing same, and cosmetic or pharmaceutical composition comprising same.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 24, 2022
    Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Georges Manuel Dacosta, Jérome Guilbot, Stéphane Dessilla, Laetitia Cattuzzato
  • Phenylquinoline compositions for treatment of ocular disorders and conditions
    Patent number: 11337968
    Abstract: Compositions containing a phenylquinoline derivative compound having peroxisome proliferator-activated receptor a (PPAR?) agonistic activity, and methods of their use in enhancing PPAR? activity in retinal cells, and in treating ocular disorders or conditions, such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 24, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jian-xing Ma, Elizabeth Moran, Guotao Deng, Adam S. Duerfeldt
  • Supramolecular alginate materials for biomedical applications
    Patent number: 11331415
    Abstract: The present invention relates to the unexpected discovery of novel hydrogel formulations that allow for the encapsulation and delivery of living cells and/or drugs to a subject in need thereof. In certain embodiments, the hydrogel compositions of the invention comprise bound bioactive molecules that promote long-term cell viability and allows for the development of vasculature. The invention further provides methods of delivering viable cells and/or drugs to a subject comprising administering the compositions of the invention to the subject in need thereof.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: May 17, 2022
    Assignee: UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
    Inventors: Rachael A. Oldinski, Jennifer N. Etter
  • Abuse-deterrent dosage forms containing esketamine
    Patent number: 11324707
    Abstract: Disclosed herein are immediate release oral dosage forms that contain abuse-deterrent and abuse-resistant features. In particular, the disclosed dosage forms can provide deterrence of abuse by ingestion of multiple individual doses. The disclosed dosage forms can likewise provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses. The dosage forms may also exhibit abuse resistant properties when physically manipulated, and also when physically manipulated and then administered in a manner not consistent with oral dosing. The dosage forms may also exhibit abuse resistant properties when administered in a manner intended to result in administration of the esketamine in a higher than therapeutic dose.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: May 10, 2022
    Assignee: CLEXIO BIOSCIENCES LTD.
    Inventors: Derek Moe, Randal Seburg, Sagar Rane
  • Method to prepare pharmaceutical compositions of suggamadex
    Patent number: 11324692
    Abstract: The present invention relates to a method to prepare pharmaceutical compositions of sugammadex, to pharmaceutical compositions of sugammadex and uniform pharmaceutical batches of said compositions.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: May 10, 2022
    Assignee: Galenicum Health S.L.U.
    Inventors: Luis Gomez Coello, Javier Torrejón Nieto