Patents Examined by Mary C. Cebulak
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Patent number: 5391766Abstract: Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.Type: GrantFiled: May 5, 1993Date of Patent: February 21, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Michael Klaus, Peter Mohr
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Patent number: 5391727Abstract: This invention provides gold(I) complexes comprising sulfur- and selenium-substituted macrocyclic polyether ligands, photographic elements containing the compounds, and emulsions containing the compounds. The compounds include monomers and dimers having the following formulas, respectively:[AuL].sup.+ X.sup.- or [AuL].sub.2.sup.2+ 2X.sup.-wherein X.sup.- is any suitable anion such as tetrafluoroborate, nitrate, etc., and wherein L is a macrocyclic ligand containing at least two thioether and/or selenoether linkages and comprising from about 12 to about 30 members in the ring. The general structural formula for the macrocyclic compounds L may be represented as follows: ##STR1## wherein Q.sub.1 and Q.sub.2 are each independently sulfur or selenium, and R.sub.1 and R.sub.Type: GrantFiled: August 13, 1993Date of Patent: February 21, 1995Assignee: Eastman Kodak CompanyInventor: Joseph C. Deaton
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Patent number: 5389277Abstract: The present invention relates to a powdered detergent composition comprising from about 2 percent by weight to about 30 percent by weight, basis the total weight of the composition, of one or more secondary alkyl sulfate compounds and from about 30 percent by weight to about 85 percent by weight, basis the total weight of the composition, of one or more builders, from about 0.1 percent by weight to about 48 percent by weight, basis the total weight of the composition, of one or more fillers, and from about 0 percent by weight to about 12 percent by weight, basis the total weight of the composition, of one or more bleach compounds.Type: GrantFiled: September 30, 1993Date of Patent: February 14, 1995Assignee: Shell Oil CompanyInventor: Nelson E. Prieto
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Patent number: 5382376Abstract: Detergent compositions with excellent spotting/filming characteristics comprising propylene glycol/ethylene glycol block copolymer nonionic detergent surfactant, preferably in a surfactant mixture with a nonionic detergent surfactant having a conventional hydrocarbon hydrophobic group and a mixed propylene glycol/ethylene glycol hydrophilic group; optional hydrophobic cleaning solvent; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.Type: GrantFiled: August 17, 1993Date of Patent: January 17, 1995Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, Michael S. Maile
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Patent number: 5380748Abstract: A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents lower alkyl;R.sup.3, R.sup.4 and R.sup.5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen;R.sup.6 and R.sup.7 may be the same or different from each other and each represents hydrogen or lower alkyl;R.sup.8 represents hydrogen, lower alkyl, lower alkoxy or halogen;X represents oxygen, sulfur, --CH.dbd.N-- or --CH.dbd.CH--;Y represents oxygen, sulfur, methylene, N--R.sup.11 (wherein R.sup.11 represents lower alkyl), SO or SO.sub.2 ;Z represents --OCO(CH.sub.2).sub.p .about. or --OCH.sub.2 (CH.sub.2).sub.p .about. (wherein p represents a number of 0 to 4 and symbol .about.Type: GrantFiled: August 30, 1993Date of Patent: January 10, 1995Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Yoshiaki Muto, Hiromi Ichikawa, Kuniyoshi Ogura, Kyoji Chaki, Masao Seiki, Toshihiko Takemasa
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Patent number: 5380519Abstract: Gas or air filled microbubble suspensions in aqueous phase usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: GrantFiled: September 29, 1993Date of Patent: January 10, 1995Assignee: Bracco International B.V.Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl-Sutherland
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Patent number: 5378681Abstract: The invention relates to new substituted triazolinones of the general formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, halogenoalkyl or halogenoalkoxy,R.sup.2 represents hydrogen, alkyl or halogenoalkyl,R.sup.3 represents hydrogen or halogen,R.sup.4 represents hydrogen, cyano, halogen or a radical of the formula --O--R.sup.6, --S--R.sup.6, --C(O)--O--R.sup.6, --C(O)--S--R.sup.6, --NR.sup.6 R.sup.7 or --C(O)--NR.sup.6 R.sup.7,R.sup.5 represents cyano or nitro andX represents oxygen or sulphur, whereR.sup.6 and R.sup.7 independently of one another in each case represent hydrogen or in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, cycloalkoxycarbonyl, aryl or arylalkyl,to a plurality of processes for their preparation, and to their use as herbicides.Type: GrantFiled: November 16, 1993Date of Patent: January 3, 1995Assignee: Bayer AktiengesellschaftInventors: Otto Schallner, Wilhelm Haas, Karl-Heinz Linker, Kurt Findeisen, Klaus Konig, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt
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Patent number: 5376298Abstract: Detergent compositions with excellent spotting/filming characteristics comprising nonionic detergent surfactant, preferably having a conventional hydrocarbon hydrophobic group and polyalkoxylate hydrophilic group; polyalkoxylate polycarboxylate surfactant/builder containing hydrocarbon hydrophobic group, polyalkoxylate moiety, and polyanionic moieties that are carboxyl groups except for one optional sulfate or sulfonate group; optional hydrophobic cleaning solvent and/or polycarboxylate detergent builder; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.Type: GrantFiled: July 29, 1993Date of Patent: December 27, 1994Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5376675Abstract: The use of the compound 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) ##STR1## or an acid addition salt thereof in controlling diseases caused by parasitic nematodes in plants or mammals.Type: GrantFiled: August 30, 1993Date of Patent: December 27, 1994Assignee: British Technology Group LimitedInventors: Thomas J. W. Alphey, Andrew N. E. Birch, Linda E. Fellows, Walter M. Robertson
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Patent number: 5374643Abstract: Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.Type: GrantFiled: August 12, 1993Date of Patent: December 20, 1994Assignee: E. R. Squibb & Sons, Inc.Inventors: Karnail S. Atwal, George C. Rovnyak
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Patent number: 5371064Abstract: 4-Benzoylisoxazole derivatives of formula (I): ##STR1## wherein: R represents hydrogen or --CO.sub.2 R.sup.4 ;R.sup.1 represents alkyl, haloalkyl or optionally substituted cycloalkyl;R.sup.2 represents halogen, alkyl, haloalkyl or alkyl substituted by --OR.sup.5, or a group selected from nitro, cyano, --CO.sub.2 R.sup.4, --S(O).sub.p R.sup.6, --O(CH.sub.2).sub.r OR.sup.5 and --OR.sup.5 ;R.sup.3 represents optionally substituted phenyl;X represents oxygen or --S(O)--.sub.q ;n represents zero or an integer from one to four;R.sup.4 and R.sup.5 independently represent alkyl or haloalkyl;R.sup.6 represents alkyl, haloalkyl or optionally substituted phenyl;R.sup.7 represents halogen, alkyl or haloalkyl or a group selected from nitro, cyano, --OR.sup.5 and --S(O).sub.p R.sup.6 ;p represents 0, 1 or 2; q represents 0, 1 or 2;r represents 1, 2 or 3;the herbicidal properties of these derivatives and their application to crop protection are described.Type: GrantFiled: July 22, 1993Date of Patent: December 6, 1994Assignee: Rhone-Poulenc Agriculture Ltd.Inventors: Susan M. Cramp, Claude Lambert, John Morris
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Patent number: 5369100Abstract: The present invention is directed to an insecticidal composition including irregularly shaped to spherically shaped particles prepared by compaction, in the absence of a binder, of an admixture including ammonium sulfate and at least one insecticidal compound of the formula: ##STR1## wherein R and R.sup.1 individually are an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms, R.sup.2 is hydrogen, an alkyl group containing 1 to 18 carbon atoms, a cycloalkyl group containing 3 to 8 carbon atoms, an alkenyl group containing 2 to 18 carbon atoms or an alkynyl group containing 3 to 18 carbon atoms, R.sup.3 is hydrogen or an alkyl group containing 1 to 6 carbon atoms, and Y is oxygen or sulfur. The present invention is also directed to methods for manufacturing such particles and for killing insects with such particles.Type: GrantFiled: September 24, 1992Date of Patent: November 29, 1994Assignee: Valent U.S.A. CorporationInventor: Gary L. Cummings
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Patent number: 5369124Abstract: Novel substituted thiophenecarboxamides of the formula (I), ##STR1## in which R represents hydrogen or alkyl,A represents doubly linked alkanediyl,Ar represents optionally substituted aryl andn represents a number 0 or 1,with the exception of the compounds 4,5-dibromo-thiophene-2-carboxylic acid N-(4-bromophenyl)-amide, 4,5-dibromo-thiophene-2-carboxylic acid N-(2,3-dichlorophenyl)-amide and 4,5-dibromo-thiophene-2-carboxylic acid N-[2-(3,4-dimethoxyphenyl)-ethyl]-amide, and their use for combating pests.The novel compounds are described by the formula (I) and they can be prepared by analogous processes, e.g. by reacting suitable thiophenecarbonyl halides with suitable amines.Type: GrantFiled: September 24, 1993Date of Patent: November 29, 1994Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Ralf Tiemann, Gerd Hanssler
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Patent number: 5362886Abstract: This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.Type: GrantFiled: October 12, 1993Date of Patent: November 8, 1994Assignee: Eli Lilly and CompanyInventor: Richard A. Berglund
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Patent number: 5360815Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.Type: GrantFiled: June 23, 1993Date of Patent: November 1, 1994Assignee: Merck Frosst Canada, Inc.Inventors: Rejean Fortin, Yves Girard, Erich Grimm, John Hutchinson, John Scheigetz
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Patent number: 5358967Abstract: The present invention is a composition comprising an effective amount of an N'-alkyl-N'-(3,5-dimethylbenzoyl)-N-(substituted benzoyl)-hydrazine to treat wool for protection from keratin digesting insects, and an insect-proofing method using such compounds. The compositions and methods have particular application in treating wool.Type: GrantFiled: July 6, 1993Date of Patent: October 25, 1994Assignee: Rohm and Haas CompanyInventor: Glenn R. Carlson
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Patent number: 5358958Abstract: The present invention relates to a process for the control of fungal disease of plants by applying to the leaves of the plants:a) 2-(4-chlorobenzylidene)-5,5-diemthyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyc lopentanol;b) one or more fungicides suitable for protecting against the said fungal diseases and to compositions which may be used in the process.Type: GrantFiled: June 10, 1993Date of Patent: October 25, 1994Assignee: Rhone-Poulenc Secteur AgrochimieInventors: Alfred Greiner, Jean Hutt, Jacques Mugnier, Regis Pepin
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Patent number: 5348947Abstract: There are provided fungicidal diarylboron esters and thioesters having the structural formula ##STR1## Further provided are compositions and methods for the protection of plants from fungal infestation and disease.Type: GrantFiled: May 7, 1993Date of Patent: September 20, 1994Assignee: American Cyanamid CompanyInventor: Bomi P. Patel
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Patent number: 5348948Abstract: There are provided fungicidal 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene compounds having the structural formula ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from fungal infestation and disease.Type: GrantFiled: May 7, 1993Date of Patent: September 20, 1994Assignee: American Cyanamid CompanyInventor: Bomi P. Patel
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Patent number: 5346915Abstract: Novel compounds of the formula ##STR1## where X is S, O; R.sub.1 -R.sub.5 are hydrogen or lower alkyl; R.sub.6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds, (CH.sub.2).sub.n where n is 0-5; and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, COONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR", CR"(OR.sub.12).sub.2, or CR"OR.sub.13 O, where R" is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.Type: GrantFiled: January 6, 1993Date of Patent: September 13, 1994Assignee: Allergan, Inc.Inventor: Roshantha A. S. Chandraratna