Patents Examined by Mary C. Cebulak
  • Patent number: 5391766
    Abstract: Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: February 21, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Klaus, Peter Mohr
  • Patent number: 5391727
    Abstract: This invention provides gold(I) complexes comprising sulfur- and selenium-substituted macrocyclic polyether ligands, photographic elements containing the compounds, and emulsions containing the compounds. The compounds include monomers and dimers having the following formulas, respectively:[AuL].sup.+ X.sup.- or [AuL].sub.2.sup.2+ 2X.sup.-wherein X.sup.- is any suitable anion such as tetrafluoroborate, nitrate, etc., and wherein L is a macrocyclic ligand containing at least two thioether and/or selenoether linkages and comprising from about 12 to about 30 members in the ring. The general structural formula for the macrocyclic compounds L may be represented as follows: ##STR1## wherein Q.sub.1 and Q.sub.2 are each independently sulfur or selenium, and R.sub.1 and R.sub.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: February 21, 1995
    Assignee: Eastman Kodak Company
    Inventor: Joseph C. Deaton
  • Patent number: 5389277
    Abstract: The present invention relates to a powdered detergent composition comprising from about 2 percent by weight to about 30 percent by weight, basis the total weight of the composition, of one or more secondary alkyl sulfate compounds and from about 30 percent by weight to about 85 percent by weight, basis the total weight of the composition, of one or more builders, from about 0.1 percent by weight to about 48 percent by weight, basis the total weight of the composition, of one or more fillers, and from about 0 percent by weight to about 12 percent by weight, basis the total weight of the composition, of one or more bleach compounds.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: February 14, 1995
    Assignee: Shell Oil Company
    Inventor: Nelson E. Prieto
  • Patent number: 5382376
    Abstract: Detergent compositions with excellent spotting/filming characteristics comprising propylene glycol/ethylene glycol block copolymer nonionic detergent surfactant, preferably in a surfactant mixture with a nonionic detergent surfactant having a conventional hydrocarbon hydrophobic group and a mixed propylene glycol/ethylene glycol hydrophilic group; optional hydrophobic cleaning solvent; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.
    Type: Grant
    Filed: August 17, 1993
    Date of Patent: January 17, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Daniel W. Michael, Michael S. Maile
  • Patent number: 5380748
    Abstract: A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents lower alkyl;R.sup.3, R.sup.4 and R.sup.5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen;R.sup.6 and R.sup.7 may be the same or different from each other and each represents hydrogen or lower alkyl;R.sup.8 represents hydrogen, lower alkyl, lower alkoxy or halogen;X represents oxygen, sulfur, --CH.dbd.N-- or --CH.dbd.CH--;Y represents oxygen, sulfur, methylene, N--R.sup.11 (wherein R.sup.11 represents lower alkyl), SO or SO.sub.2 ;Z represents --OCO(CH.sub.2).sub.p .about. or --OCH.sub.2 (CH.sub.2).sub.p .about. (wherein p represents a number of 0 to 4 and symbol .about.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: January 10, 1995
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Yoshiaki Muto, Hiromi Ichikawa, Kuniyoshi Ogura, Kyoji Chaki, Masao Seiki, Toshihiko Takemasa
  • Patent number: 5380519
    Abstract: Gas or air filled microbubble suspensions in aqueous phase usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: January 10, 1995
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl-Sutherland
  • Patent number: 5378681
    Abstract: The invention relates to new substituted triazolinones of the general formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, halogenoalkyl or halogenoalkoxy,R.sup.2 represents hydrogen, alkyl or halogenoalkyl,R.sup.3 represents hydrogen or halogen,R.sup.4 represents hydrogen, cyano, halogen or a radical of the formula --O--R.sup.6, --S--R.sup.6, --C(O)--O--R.sup.6, --C(O)--S--R.sup.6, --NR.sup.6 R.sup.7 or --C(O)--NR.sup.6 R.sup.7,R.sup.5 represents cyano or nitro andX represents oxygen or sulphur, whereR.sup.6 and R.sup.7 independently of one another in each case represent hydrogen or in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, cycloalkoxycarbonyl, aryl or arylalkyl,to a plurality of processes for their preparation, and to their use as herbicides.
    Type: Grant
    Filed: November 16, 1993
    Date of Patent: January 3, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Otto Schallner, Wilhelm Haas, Karl-Heinz Linker, Kurt Findeisen, Klaus Konig, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 5376298
    Abstract: Detergent compositions with excellent spotting/filming characteristics comprising nonionic detergent surfactant, preferably having a conventional hydrocarbon hydrophobic group and polyalkoxylate hydrophilic group; polyalkoxylate polycarboxylate surfactant/builder containing hydrocarbon hydrophobic group, polyalkoxylate moiety, and polyanionic moieties that are carboxyl groups except for one optional sulfate or sulfonate group; optional hydrophobic cleaning solvent and/or polycarboxylate detergent builder; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: December 27, 1994
    Assignee: The Procter & Gamble Company
    Inventor: Daniel W. Michael
  • Patent number: 5376675
    Abstract: The use of the compound 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) ##STR1## or an acid addition salt thereof in controlling diseases caused by parasitic nematodes in plants or mammals.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: December 27, 1994
    Assignee: British Technology Group Limited
    Inventors: Thomas J. W. Alphey, Andrew N. E. Birch, Linda E. Fellows, Walter M. Robertson
  • Patent number: 5374643
    Abstract: Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, George C. Rovnyak
  • Patent number: 5371064
    Abstract: 4-Benzoylisoxazole derivatives of formula (I): ##STR1## wherein: R represents hydrogen or --CO.sub.2 R.sup.4 ;R.sup.1 represents alkyl, haloalkyl or optionally substituted cycloalkyl;R.sup.2 represents halogen, alkyl, haloalkyl or alkyl substituted by --OR.sup.5, or a group selected from nitro, cyano, --CO.sub.2 R.sup.4, --S(O).sub.p R.sup.6, --O(CH.sub.2).sub.r OR.sup.5 and --OR.sup.5 ;R.sup.3 represents optionally substituted phenyl;X represents oxygen or --S(O)--.sub.q ;n represents zero or an integer from one to four;R.sup.4 and R.sup.5 independently represent alkyl or haloalkyl;R.sup.6 represents alkyl, haloalkyl or optionally substituted phenyl;R.sup.7 represents halogen, alkyl or haloalkyl or a group selected from nitro, cyano, --OR.sup.5 and --S(O).sub.p R.sup.6 ;p represents 0, 1 or 2; q represents 0, 1 or 2;r represents 1, 2 or 3;the herbicidal properties of these derivatives and their application to crop protection are described.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: December 6, 1994
    Assignee: Rhone-Poulenc Agriculture Ltd.
    Inventors: Susan M. Cramp, Claude Lambert, John Morris
  • Patent number: 5369100
    Abstract: The present invention is directed to an insecticidal composition including irregularly shaped to spherically shaped particles prepared by compaction, in the absence of a binder, of an admixture including ammonium sulfate and at least one insecticidal compound of the formula: ##STR1## wherein R and R.sup.1 individually are an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms, R.sup.2 is hydrogen, an alkyl group containing 1 to 18 carbon atoms, a cycloalkyl group containing 3 to 8 carbon atoms, an alkenyl group containing 2 to 18 carbon atoms or an alkynyl group containing 3 to 18 carbon atoms, R.sup.3 is hydrogen or an alkyl group containing 1 to 6 carbon atoms, and Y is oxygen or sulfur. The present invention is also directed to methods for manufacturing such particles and for killing insects with such particles.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: November 29, 1994
    Assignee: Valent U.S.A. Corporation
    Inventor: Gary L. Cummings
  • Patent number: 5369124
    Abstract: Novel substituted thiophenecarboxamides of the formula (I), ##STR1## in which R represents hydrogen or alkyl,A represents doubly linked alkanediyl,Ar represents optionally substituted aryl andn represents a number 0 or 1,with the exception of the compounds 4,5-dibromo-thiophene-2-carboxylic acid N-(4-bromophenyl)-amide, 4,5-dibromo-thiophene-2-carboxylic acid N-(2,3-dichlorophenyl)-amide and 4,5-dibromo-thiophene-2-carboxylic acid N-[2-(3,4-dimethoxyphenyl)-ethyl]-amide, and their use for combating pests.The novel compounds are described by the formula (I) and they can be prepared by analogous processes, e.g. by reacting suitable thiophenecarbonyl halides with suitable amines.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: November 29, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Ralf Tiemann, Gerd Hanssler
  • Patent number: 5362886
    Abstract: This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: November 8, 1994
    Assignee: Eli Lilly and Company
    Inventor: Richard A. Berglund
  • Patent number: 5360815
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: November 1, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Rejean Fortin, Yves Girard, Erich Grimm, John Hutchinson, John Scheigetz
  • Patent number: 5358967
    Abstract: The present invention is a composition comprising an effective amount of an N'-alkyl-N'-(3,5-dimethylbenzoyl)-N-(substituted benzoyl)-hydrazine to treat wool for protection from keratin digesting insects, and an insect-proofing method using such compounds. The compositions and methods have particular application in treating wool.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: October 25, 1994
    Assignee: Rohm and Haas Company
    Inventor: Glenn R. Carlson
  • Patent number: 5358958
    Abstract: The present invention relates to a process for the control of fungal disease of plants by applying to the leaves of the plants:a) 2-(4-chlorobenzylidene)-5,5-diemthyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyc lopentanol;b) one or more fungicides suitable for protecting against the said fungal diseases and to compositions which may be used in the process.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: October 25, 1994
    Assignee: Rhone-Poulenc Secteur Agrochimie
    Inventors: Alfred Greiner, Jean Hutt, Jacques Mugnier, Regis Pepin
  • Patent number: 5348947
    Abstract: There are provided fungicidal diarylboron esters and thioesters having the structural formula ##STR1## Further provided are compositions and methods for the protection of plants from fungal infestation and disease.
    Type: Grant
    Filed: May 7, 1993
    Date of Patent: September 20, 1994
    Assignee: American Cyanamid Company
    Inventor: Bomi P. Patel
  • Patent number: 5348948
    Abstract: There are provided fungicidal 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene compounds having the structural formula ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from fungal infestation and disease.
    Type: Grant
    Filed: May 7, 1993
    Date of Patent: September 20, 1994
    Assignee: American Cyanamid Company
    Inventor: Bomi P. Patel
  • Patent number: 5346915
    Abstract: Novel compounds of the formula ##STR1## where X is S, O; R.sub.1 -R.sub.5 are hydrogen or lower alkyl; R.sub.6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds, (CH.sub.2).sub.n where n is 0-5; and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, COONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR", CR"(OR.sub.12).sub.2, or CR"OR.sub.13 O, where R" is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.
    Type: Grant
    Filed: January 6, 1993
    Date of Patent: September 13, 1994
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. S. Chandraratna