Abstract: Succinimides of aminoaryl sulfonic acid salts provide exceptional detergency, viscosity control and anticorrosion properties to lubricants and greases and to other fluid compositions useful in hydraulic systems. Ammonium, alkylammonium, alkali metal, alkaline earth metal and groups IB, IIB, VIB, VIIB, VIII metal salts of aminoaryl sulfonic acid salts, and the salts of sulfanilic acid in particular, can be reacted with alkenyl or alkylsuccinic anhydride, acid or ester, in which the alkenyl or alkyl group may contain from 8 to about 500 carbon atoms, to yield the products of this invention. These products are understood to be novel. Suitable modifications of the aforementioned are the succinimides of di(aminoaryl sulfonic acid) salts, aniline disulfonic acid salts and corresponding aminonaphthalene sulfonate salts which are also useful in the compositions of this invention.

Abstract: The invention relates to physiologically active compounds which are coupling products between an N-acyl aspartic acid and a biologically active amine such as dopamine or serotonin.

Abstract: 1-(Phenylamino)pyrrole, useful as a urinary antiseptic, hypotensive and hypoglycemic agent, is prepared by reaction of an N-benzoylphenylhydrazine or N-lower-alkanoylphenylhydrazine or a lower-alkanealdehyde N-benzoylphenylhydrazone or N-lower-alkanoylphenylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran followed by hydrolytic removal of the benzoyl or lower-alkanoyl group from the resulting N-benzoyl-1-(phenylamino)pyrrole or N-lower-alkanoyl-1-(phenylamino)pyrrole.

Abstract: Selenium compounds, and a method of their preparation, are disclosed which have a structure that renders the compounds useful in immunoassays or in competitive protein binding assays wherein either radio-labeled selenium compounds or nonradioactive selenium compounds are used respectively, with radiologic or fluorometric analysis. One class of these compounds have the generalized structural formula of: ##STR1## wherein: X is hydrogen or oxo;R.sub.1 and R.sub.2, together, are ethylene, trimethylene, or 5,6-phenylene;R.sub.3 is alkylene of 1 to 6 carbons;R.sub.4 is alkyl or isoalkyl of 1 to 6 carbons, phenyl or benzyl; orR.sub.3 and R.sub.4 together are 1,2,3-propanetriyl;And n is 1 or 2. The compounds in the aforementioned structure are N-pyrrolidine derivatives wherein R.sub.1 and R.sub.2 together are ethylene; N-succinimdyl derivatives when R.sub.1 and R.sub.2 together are ethylene and the X groups are oxo groups; N-phthalimidyl derivatives when R.sub.1 and R.sub.

Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.

Abstract: Antibiotic N-acetyl-dehydro-thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces in suitable fermentation media.

Abstract: The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.

Abstract: Novel substituted N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide comnds and derivatives thereof are disclosed. The compounds have psychotropic properties and may be used in pharmaceutical compositions as behavior modifiers.

Abstract: In a process for treating 2-(beta-cyanoethyl)-cyclohexanones with a dehydrogenation catalyst to produce the corresponding quinolines, the improvement comprising passing the 2-(beta-cyanoethyl)-cyclohexanone over a dehydrogenation catalyst at temperatures below 230.degree. C. and thereafter contacting the resulting reaction product, in the gaseous state and in the presence of hydrogen, at a temperature of over 230.degree. C.

Abstract: Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia in animals.

Abstract: New phosphonoacyl prolines and related compounds have the general formula ##STR1## wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, unsustituted or substituted phenyl-lower alkyl, or a metal ion;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN is 0 or 1.These compounds are useful as hypotensive agents.

Abstract: The present invention relates to novel bioprecursors for prostaglandin analogs of the formula ##STR1## These bioprecursors are useful for the same pharmacological purposes as the corresponding prostaglandin analogs, being hydrolyzable thereto in vivo.

Abstract: Disclosed are N-alkylated derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2): ##STR1## wherein n=1 or 2; and R.sup.5, R.sup.6, and R.sup.7 are, inter alia, hydrogen or alkyl. Such compounds the their pharmaceutically acceptable O- and carboxyl- derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.

Abstract: A dyestuff of the general formula (I) ##STR1## in which R represents alkyl, alkenyl, cycloalkyl, aralkyl, aryl or, preferably, hydrogen, M represents hydrogen or a cation, Y represents a free or modified carboxyl group, Z represents a non-ionic substituent, n represents 0, 1 or 2, A represents a heterocyclic radical or an aromatic radical having negative substituents and B and C can carry further non-ionic substituents. The dyestuffs give brilliant red and yellow shades on polyester fibers.

Abstract: The invention relates to compounds of the formula ##STR1## WHEREIN Z denotes OH or NR.sup.1 R.sup.2,R.sup.1 denotes hydrogen, alkyl, aralkyl, cycloalkyl or aryl,R.sup.2 denotes hydrogen or alkyl or, conjointly with R.sup.1, forms an alkylene chain.The dyestuffs are outstanding suitable for the dyeing of polyester fibres. The yellow and reddish dyeings are distinguished by good fastness to light.

Abstract: The present invention provides a novel cyclization process useful for the production of the peptide moiety of an ergotalkaloid.

Abstract: Cis- and trans-N-(2-aminocycloaliphatic)-2-arylacetamide derivative compounds of the formula ##STR1## e.g., N-?2-(N', N'-dimethylamino)cyclohexyl!-N-methyl-2-(4-bromophenyl)acetamide and trans-N-methyl-N-?2-(1-pyrrolidinyl)cyclohexyl!acetamide, 2-(3,4-dichlorophenyl) and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and the preferred compounds have in addition only low to moderate apparent physical dependence liability, compared to morphine and methadone. As analgesics they would be useful also as antitussives. Processes for preparation of these compounds are also disclosed. This invention also includes compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in humans and animals, as well as methods for alleviating pain in animals and humans with these compositions.

Abstract: Oxanilic acid derivatives having the formula: ##STR1## are disclosed wherein R is lower-alkyl, cycloalkyl, phenylalkyl or phenyl; R.sup.1 is hydrogen, lower-alkyl or phenyl; R.sup.2 is hydrogen, lower-alkyl, or lower-alkoxy; R.sup.3 is hydrogen, fluoro, chloro or bromo; X is oxygen or sulfur; and M is hydrogen, lower-alkyl or a physiologically acceptable cation. The compounds are useful for ameliorating and controlling symptoms associated with asthma.

Abstract: The invention concerns novel guanidine derivatives of the general formula (I) ##STR1## or pharmaceutically acceptable acid addition salts thereof, where.circle.Nrepresents ##STR2## wherein R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl, trifluoromethyl or halogen and R.sup.11 and R.sup.12 each represent hydrogen, lower alkyl, trifluoromethyl or halogen with the proviso that when one or both R.sup.11 or R.sup.12 groups represent halogen then R.sup.1 and R.sup.2 each represent lower alkyl, trifluoromethyl or halogen, R.sup.9 and R.sup.10 each represent hydrogen, lower alkyl or trifluoromethyl and R.sup.13 and R.sup.14 each represent hydrogen, lower alkyl, trifuoromethyl or halogen with the proviso that when one or both R.sup.13 and R.sup.14 groups represent halogen then R.sup.9 and R.sup.10 each represent lower alkyl or trifluoromethyl and R.sup.7 and R.sup.8 each represent hydrogen or lower alkyl and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each represent hydrogen or lower alkyl or R.sup.4 and R.sup.

Abstract: 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein Y is a moiety selected from the group consisting of ##STR2## in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring,R.sup.1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R.sup.1 substitution being at the ortho, meta or para positions of the aroyl group, andR.sup.2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, are prepared, by hydrolysis, from their corresponding nitriles.