Patents Examined by Mary Vaughn
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Patent number: 4111953Abstract: A process is disclosed for preparing 5-sulfamoylbenzoic acids substituted in 4-position by various substituents and in 3-position by a cyclic amino group having sali-diuretic properties. Novel intermediate compounds are also disclosed.Type: GrantFiled: December 6, 1976Date of Patent: September 5, 1978Assignee: Hoechst AktiengesellschaftInventors: Dieter Bormann, Wulf Merkel, Dieter Mania
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Patent number: 4111951Abstract: L-3,4-dehydroproline is produced in good yield from D,L-3,4-dehydroproline by resolution via the tartaric acid salt and thermal racemization of the D-3,4-dehydroproline tartaric acid salt containing mother liquors.Type: GrantFiled: January 17, 1977Date of Patent: September 5, 1978Assignee: Hoffmann-La Roche Inc.Inventor: Urs Oskar Hengartner
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Patent number: 4110533Abstract: The invention concerns a process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolysing the enamino group in the resulting 7.beta.-acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.Type: GrantFiled: February 10, 1976Date of Patent: August 29, 1978Assignee: Ciba-Geigy CorporationInventors: Robert B. Woodward, Hans Bickel
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Patent number: 4107165Abstract: Novel alkylenetris- and alkylenetetrakis-[1,2,3,4-tetrahydroisoquinoline] and -[3,4-dihydroisoquinoline] compounds, the pharmaceutically acceptable acid addition salts thereof and compositions containing such substances have been found useful for inhibiting the formation of blood clots in mammals and/or dissolving blood clots in mammals after they have been formed.Type: GrantFiled: September 15, 1976Date of Patent: August 15, 1978Assignee: Endo LaboratoriesInventors: Parthasarathi Rajagopalan, Irwin J. Pachter
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Patent number: 4107174Abstract: The imidyl compounds, according to the invention, of the formula I are suitable for the manufacture of polymers which can be crosslinked by light, which polymers can be, for example, polyesters, polyamides, polyamide-imides, polyimides, polyester-polyamides, polyester-amide-imides, polyethers, polyamines, polysaccharides and polysiloxanes. Polymers of this type are suitable for carrying out photochemical processes. Compared with known polymers, the polymers based on the imidyl compounds according to the invention have the advantage that they are photochemically substantially more sensitive. In addition, this sensitivity can also be further increased effectively by a combination with sensitizers.Type: GrantFiled: June 15, 1976Date of Patent: August 15, 1978Assignee: Ciba-Geigy CorporationInventors: Marcus Baumann, Vratislav Kvita, Martin Roth, John Sidney Waterhouse
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Patent number: 4105776Abstract: New proline derivatives and related compounds which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.Type: GrantFiled: December 22, 1976Date of Patent: August 8, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Miguel Angel Ondetti, David W. Cushman
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Patent number: 4103019Abstract: Glycyrrhetinic acid esters of the formula: ##STR1## wherein R is hydrogen or an acyl radical of 2 to 20 carbon atoms and R.sub.1 is a lower alkyl of 1 to 4 carbon atoms and the haloacid or alkylsulfate quaternary ammonium salts thereof as well as a process for preparing same are provided. The compounds of the invention display anti-inflammatory, antihistaminic, and anti-ulcer pharmacological activity.Type: GrantFiled: October 7, 1975Date of Patent: July 25, 1978Assignee: Laboratorios Landerlan, S. A.Inventor: Jose E. Acosta Mira
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Patent number: 4101553Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.Type: GrantFiled: November 4, 1974Date of Patent: July 18, 1978Assignee: Sandoz, Inc.Inventor: William J. Houlihan
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Patent number: 4100166Abstract: Cis-1-cyclopropylmethyl-3a-(substituted-phenyl) decahydroisoquinoline, useful as analgetic agonist and analgetic antagonist.Type: GrantFiled: October 22, 1976Date of Patent: July 11, 1978Assignee: Eli Lilly and CompanyInventors: Dennis M. Zimmerman, Winston S. Marshall
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Patent number: 4100165Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and anti-depressants, e.g. 5-(2-thienyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol, are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.Type: GrantFiled: July 22, 1976Date of Patent: July 11, 1978Assignee: Sandoz, Inc.Inventor: William J. Houlihan
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Patent number: 4098790Abstract: Ergolines are chlorinated with SO.sub.2 Cl.sub.2 /BF.sub.3 .multidot.etherate, preferentially in the 2 position.Type: GrantFiled: September 15, 1976Date of Patent: July 4, 1978Assignee: Eli Lilly and CompanyInventor: Nicholas J. Bach
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Patent number: 4097490Abstract: Process for resolving enantiomers of 1-t-butylamino-2,3-dihydroxypropane using a pyroglutamic acid or a tartaric acid as resolving agent. The enantiomers of 1-t-butylamino-2,3-dihydroxypropane are useful in preparing .beta.-adrenergic blocking agents.Type: GrantFiled: February 9, 1977Date of Patent: June 27, 1978Assignee: Merck & Co., Inc.Inventor: Donald F. Reinhold
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Patent number: 4097579Abstract: Novel 5-(2-pyrroyl) and 5-(N-lower alkyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid compounds represented by the formula: ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein each of R and R.sup.1 is independently hydrogen or a lower alkyl group having from 1 to 4 carbon atoms and process for the production of such compounds; 5-(N-methyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid is representative of the class. These compounds are useful as anti-inflammatory analgesic and anti-pyretic agents and as smooth muscle relaxants.Type: GrantFiled: March 31, 1977Date of Patent: June 27, 1978Assignee: Syntex (U.S.A.) Inc.Inventors: Joseph Martin Muchowski, Arthur Frederick Kluge
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Patent number: 4097480Abstract: Compounds of the formula (I): ##STR1## and salts thereof wherein X is a group: ##STR2## R is hydrogen, methyl or ethyl; R.sub.1 is phenyl or naphthyl or phenyl substituted by fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl; R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen, methyl, ethyl or benzyl; R.sub.4 is hydrogen or methyl; and R.sub.5 is hydrogen or methyl; have been found to be mood modifying agents and anorexic agents.Type: GrantFiled: June 1, 1976Date of Patent: June 27, 1978Assignee: Beecham Group LimitedInventor: Derek Victor Gardner
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Patent number: 4097489Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen atom is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, smooth muscle stimulators, gastric antisecretory agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.Type: GrantFiled: June 17, 1977Date of Patent: June 27, 1978Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4096146Abstract: Quinine, quinidine, their antipodes or racemates and derivatives thereof, are prepared by (a) cyclizing the correspondingly substituted 4-[3-(1-chloro-3(R)-alkyl(or alkenyl)-4-(R)-piperidyl)-1-oxopropyl]quinolines, antipodes or racemates thereof, to the corresponding 4-[5(R)-alkyl(or alkenyl)-4-(S)-quinuclidin-2(S) or 2(R)-ylcarbonyl]quinolines, antipodes or racemates thereof; and (b) stereoselectively reducing the products of step (a) to .sup.a (S)-[5(R)-alkyl(or alkenyl)-4(S)-quinuclidin-2(R)-yl]-4-quinoline-methanols, antipodes or racemates thereof, and .alpha.(R)-[5(R)-alkyl(or alkenyl)-4(S)-quinuclidin-2(S)-yl]-4-quinolinemethanols, antipodes or racemates thereof. Various intermediates and the end products are useful antimalarial and antiarrhythmic agents.Type: GrantFiled: August 20, 1975Date of Patent: June 20, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Juerg Albert Walter Gutzwiller, Milan Radoje Uskokovic
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Patent number: 4092328Abstract: This invention relates to novel indolothiopyrones having the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or .omega.-substituted lower alkyl wherein the substituent is: ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R.sub.6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed.Type: GrantFiled: May 10, 1976Date of Patent: May 30, 1978Assignee: Warner-Lambert CompanyInventor: Richard E. Brown
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Patent number: 4091029Abstract: An N-perfluoroacyl-L-.alpha.-amino acid is converted to the corresponding acid halide which is useful as a resolving agent for the resolution of racemic amines.Type: GrantFiled: April 14, 1976Date of Patent: May 23, 1978Assignee: Eli Lilly and CompanyInventor: Rex W. Souter
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Patent number: 4089969Abstract: Novel 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R is hydrogen or a lower alkyl group containing from 1 to 4 carbon atoms and R.sup.1 is hydrogen, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group of 1 to 4 carbon atoms, chloro, fluoro or bromo, the R.sup.1 substitution being at the ortho, meta or para positions of the aroyl group and process for the production of such compounds; 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is representative of the class. These compounds, as the racemic mixture or the (1)-isomer, are useful as anti-inflammatory, analgesic and antipyretic agents and as smooth muscle relaxants.Type: GrantFiled: February 23, 1977Date of Patent: May 16, 1978Assignee: Syntex (U.S.A.) Inc.Inventors: Joseph M. Muchowski, Arthur F. Kluge
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Patent number: 4089862Abstract: A process is disclosed for the preparation of a compound of the formula I ##STR1## where R is hydrogen or methyl, X is sulphur or the NH group, Y is selected from the class consisting of methyl, methoxy, chlorine, bromine, iodine, nitro or cyano, m is 0, 1 or 2, and n is 1 or 2, characterized in that a compound of the formula II: ##STR2## where R and n have the above-mentioned meanings, is reacted in a suitable polar aprotic solvent, such as dimethylforamide or dimethylsulphoxide, under a nitrogen atmosphere and at a temperature between 50.degree. and 100.degree. C, with the sodium salt of an appropriate 2-aminopyridine or 2-mercaptopyridine to give, after evaporation of the solvent in vacuo, the desired compound of formula I which is then purified by methods known "per se".The invention also includes the compounds of general formula I, where R, X, Y, m and n have the same meanings, and their pharmaceutically acceptable salts.Type: GrantFiled: January 4, 1977Date of Patent: May 16, 1978Assignee: Societa' Farmaceutici Italia S.p.A.Inventors: Luigi Bernardi, Carlo Elli, Giovanni Falconi, Rosella Ferrari