Patents Examined by Mary Vaughn
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Patent number: 4087427Abstract: 2- AND 4-(5' NITROFURYL)QUINOLINE DERIVATIVES WHICH MAY BE VARIOUSLY SUBSTITUTED ON THE QUINOLINE NUCLEUS HAVE BEEN FOUND TO POSSESS EXCELLENT ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY. Procedures for their manufacture are disclosed.Type: GrantFiled: June 6, 1967Date of Patent: May 2, 1978Inventors: Raphael Ralph George Haber, Eva Schonberger
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Patent number: 4087539Abstract: Novel 5-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds represented by the formulas ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein X is oxygen or sulphur, R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms and R.sup.1 is hydrogen, methyl, chloro or bromo, the R.sup.1 substitution being at the 3, 4 or 5 positions of the furan or thiophene ring in the compounds of Formula (A), and process for the production thereof; 5-(2-thenoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylic acid and 5-(3-furoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid are representative of the class. These compounds, as the racemic mixture or the (1)-isomer, are useful as anti-inflammatory, analgesic and antipyretic agents and as smooth muscle relaxants.Type: GrantFiled: February 23, 1977Date of Patent: May 2, 1978Assignee: Syntex (U.S.A.) Inc.Inventors: Joseph M. Muchowski, Arthur F. Kluge
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Patent number: 4083851Abstract: A cis-2,5-dialkylpyrrolidine is produced from 2,5-dialkylpyrrole or 2,5-dialkyl-1-pyrroline by an improved hydrogenation process using a ruthenium metal catalyst on an alumina or titania support.Type: GrantFiled: June 16, 1975Date of Patent: April 11, 1978Assignee: Diamond Shamrock CorporationInventor: Alex Hlynsky
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Patent number: 4082753Abstract: Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.Type: GrantFiled: June 17, 1977Date of Patent: April 4, 1978Assignee: Eli Lilly and CompanyInventors: Edmund C. Kornfeld, Nicholas J. Bach
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Patent number: 4081456Abstract: Gamma-alkyl-gamma-butyrolactones having an alkyl substituent of at least 16 carbon atoms in length, preferably at least 25 carbon atoms, are formed by reacting a monoolefin with a carboxylic acid in the presence of a reducible metal ion of higher-valent form, such as the manganic ion, Mn.sup.+3. The resulting lactones are useful as antiwear agents and for improving the adherence of wax coatings of paper and, upon reaction with amines, polyalkylenepolyamines, for providing novel lactams and bislactams useful as multifunctional agents in lubricants, fuels, coolants and other organic fluids. Thus, the compounds of this invention are of the general structure ##STR1## the alkyl group being as defined above, X being oxygen, imino, alkylimino, polyalkylenepolyamino or lactam(polyalkylenepolyamino) and the dangling valences being hydrogen or lower alkyl (that is, no greater than 6 carbon atoms).Type: GrantFiled: February 20, 1976Date of Patent: March 28, 1978Assignee: Mobil Oil CorporationInventors: El Ahmadi I. Heiba, Ralph M. Dessau
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Patent number: 4081543Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of an atomic number from 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkynyl of 3 to 6 carbon atoms, in which the multiple bond is located in a position other than the .alpha.,.beta. position, hydroxyalkyl of 2 to 5 carbon atoms in which the hydroxy group is separated from the nitrogen atom of the tricyclic ring system by at least 2 carbon atoms, alkanoylalkyl of 3 to 5 carbon atoms, or phenylalkyl of 7 to 10 carbon atoms in which the phenyl ring is unsubstituted or mono-substituted by halogen of atomic number 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms, andEitherR.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms, or phenylalkyl of 7 to 10 carbon atoms in which the phenyl ring is unsubstituted or mono-substituted by halogen of atomic number from 9 to 35, or alkyl or alkoxy of 1 to 4 carbon atoms, andR.sub.4 is hydrogen,OrR.sub.3 and R.sub.Type: GrantFiled: June 7, 1976Date of Patent: March 28, 1978Assignee: Sandoz Ltd.Inventor: Jean-Michel Bastian
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Patent number: 4081447Abstract: A group of .beta.-blockers represented by the formula ##STR1## wherein R is ##STR2## or ##STR3## and the physiologically compatible acid addition salts thereof. These .beta.-blockers are .beta.-adrenergic receptor blocking agents which are useful in the treatment of angina pectoris, heart arrhythmia, and high blood pressure.Type: GrantFiled: April 9, 1975Date of Patent: March 28, 1978Assignee: Abbott LaboratoriesInventors: Raj Nandan Prasad, Herman Hal Stein, Karin Rosemarie Tietje
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Patent number: 4080331Abstract: The use of dyestuffs of the formula ##STR1## wherein R represents an alkyl, aralkyl, cycloalkyl or aryl radical, an alkylene radical bonded to the naphthalene ring, or hydrogen, andX represents an electron-attracting group for dyeing textiles by transfer printing.Type: GrantFiled: September 25, 1974Date of Patent: March 21, 1978Assignee: Bayer AktiengesellschaftInventor: Alfred Brack
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Patent number: 4079145Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.Type: GrantFiled: June 22, 1976Date of Patent: March 14, 1978Assignee: Hoechst AktiengesellschaftInventors: Dieter-Bernd Reuschling, Klaus Kuhlein, Bernward Scholkens, Rudolf Kunstmann, Ulrich Lerch, Wilhelm Bartmann, Hermann Teufel, Gerhard Beck
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Patent number: 4077962Abstract: The invention relates to water-insoluble styryl dyestuffs of the formula ##STR1## in which A is arylB is an alkylene bridge,D denotes the remaining members of a heterocycleY denotes a non-ionic substituent,n is 0, 1, 2 or 3 andZ denotes a cyano group or a carboxylic acid ester group.The dyestuffs are outstanding suitable for the dyeing of synthetic fibre materials which are dyed in greenish-yellow shades with good fastness properties, especially good resistance to hydrolysis.Type: GrantFiled: September 24, 1975Date of Patent: March 7, 1978Assignee: Bayer AktiengesellschaftInventor: Hermann Beecken
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Patent number: 4077976Abstract: The enamines of this invention are useful in the preparation of certain benzamides employed in the treatment of emesis in mammals.Type: GrantFiled: June 11, 1976Date of Patent: March 7, 1978Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-FranceInventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
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Patent number: 4076716Abstract: Substituted 3-(2-pyridinyl)-4(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or --CH.sub.2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.Type: GrantFiled: June 25, 1976Date of Patent: February 28, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Patricia A. Young, Maximilian VON Strandtmann
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Patent number: 4076830Abstract: Certain 1-alkyl and 8-alkylmethanodibenzocycloheptapyrroles and their salts are useful as tranquilizers and analgesics.Type: GrantFiled: June 29, 1976Date of Patent: February 28, 1978Assignee: E. I. Du Pont de Nemours and CompanyInventor: Engelbert Ciganek
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Patent number: 4076715Abstract: The present invention concerns novel 13-bromo-lysergic acid compounds of formula I: ##STR1## wherein R.sub.2 is isopropyl, 1 or 2-methylpropyl or benzyl, useful as agents for the treatment of cerebral insufficiency.Type: GrantFiled: May 23, 1975Date of Patent: February 28, 1978Assignee: Sandoz Ltd.Inventors: Theodor Fehr, Hartmut Hauth
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Patent number: 4075212Abstract: 8,8-Disubstituted-6-methylergolines and 9-ergolenes, are prepared by alkylation of lysergic, or isolysergic acid or their 9,10-dihydro analogues.Type: GrantFiled: January 19, 1976Date of Patent: February 21, 1978Assignee: Eli Lilly and CompanyInventors: Nicholas J. Bach, Edmund C. Kornfeld
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Patent number: 4075213Abstract: 8-Aryl-9-ergolenes, .alpha.-blockers, serotonin inhibitors, prolactin inhibitors.Type: GrantFiled: March 2, 1977Date of Patent: February 21, 1978Assignee: Eli Lilly and CompanyInventors: Edmund C. Kornfeld, Nicholas J. Bach
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Patent number: 4075342Abstract: Novel tricyclic compounds containing two ring notrogen atoms and represented by the following formula I ##STR1## wherein: A is one of the groups --CH.sub.2 --; --CH.dbd.CH--; and --CH.sub.2 --CH.sub.2 --;R is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cyclo(C.sub.3-6 alkyl)oxy, hydroxy, benzyloxy, halo, sulfamoyl, cyano, trifluoromethyl or nitro; R.sub.1 is hydrogen, lower alkoxy or halo; or R and R.sub.1 taken together are methylenedioxy; the sequence ##STR2## is one of the following moieties: ##STR3## WHEREIN R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, methyl, carboxy, carbo(lower alkoxy), carbamyl, mono- or di-(lower alkyl) carbamyl or hydroxymethyl; provided that when the sequence ##STR4## is one of the moieties a) and b) wherein R.sub.2 is hydrogen or lower alkyl, A is not --CH.dbd.CH--; when the sequence ##STR5## is one of the moieties (a) and (b) wherein R.sub.2 is hydrogen, A is not --CH.sub.Type: GrantFiled: November 6, 1975Date of Patent: February 21, 1978Assignee: Gruppo Lepetit, S.p.A.Inventors: Amedeo Omodie Sale, Emilio Toia, Giulio Galliani, Leonard J. Lerner
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Patent number: 4073796Abstract: Novel N-(1-substituted-3-pyrrolidinyl)-1-naphthalene- and 4-quinolinecarboxamides of the formula: ##STR1## wherein R is lower cycloalkyl, R.sup.1 is hydrogen, lower alkyl or aryl, R.sup.2 is hydrogen, lower-alkyl, halogen, lower-alkoxy, amino or nitro, R.sup.3 is hydrogen, lower-alkyl, halogen, lower-alkoxy, amino or nitro, Y is carbon or nitrogen and pharmaceutically acceptable acid addition salts thereof having anti-emetic properties are disclosed.Type: GrantFiled: May 5, 1976Date of Patent: February 14, 1978Assignee: A. H. Robins Company, Inc.Inventor: Albert D. Cale, Jr.
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Patent number: 4072683Abstract: Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having .beta.-adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or aralkyl and R.sub.2 is C.sub.1 -C.sub.4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, ##STR2## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, ##STR3## wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula,R.sub.2 -- NH.sub.2wherein R.sub.2 is as defined above, and, if necessary, reducing the resulting product.Type: GrantFiled: November 10, 1975Date of Patent: February 7, 1978Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazuyuki Nakagawa, Minoru Uchida, Hiroaki Oka
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Patent number: 4070468Abstract: Anti-allergic 2-amino-quinolin-4-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of an organo-methane phosphate with a proton abstracting agent.Type: GrantFiled: March 1, 1976Date of Patent: January 24, 1978Assignee: Sandoz, Inc.Inventors: Goetz E. Hardtmann, Gary M. Coppola