Abstract: A microfluidic device for obtaining a homogenous plasma-reagent mixture includes a collection module for blood plasma arranged to passively separate the blood plasma from a drop of blood taken, a capillary channel in fluidic connection with said collection module and a storage reservoir for a reagent in fluidic connection with said capillary channel. The device also contains a mixing chamber in fluidic connection with said capillary channel equipped with a flow outlet. The volume of said storage reservoir for reagent being greater than the sum of the volumes of said capillary channel and of said mixing chamber, setting the reagent in motion, after saturation of said capillary channel with blood plasma, induces a flow of the homogenous plasma-reagent mixture from the flow outlet.

Abstract: The present invention relates to a biological material extraction apparatus. According to the present invention, a tube in which a solution for use in extracting a biological material is contained is rotated to directly mix the solution, and cells where stirring is being conducted in each step are sealed to fundamentally block stirring-induced pollution between cells, thereby improving an extraction efficiency.

Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.

Abstract: Systems and methods of the present disclosure enable automated nucleic acid extraction using components including a rotating platform and a magnetic extractor. A controller controls the components to identify a program associated with a well plate kit based on a well plate kit indicator, where each well plate in the well plate kit is associated with a step for extracting nucleic acid from a sample, and each well plate is loaded with a particular substance for processing each step. Positions on the rotating platform associated with each well plate in the well plate kit are determined. Using the positions and the program, the controller performs each step by determining a particular position for particular well plate of a particular step, controlling the rotating platform to position the particular well plate under the magnetic extractor, and controlling magnetic rods of the magnetic extractor according to the program.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

Abstract: A sample analysis substrate in which transfer of a liquid is effected through rotational motions, including: a substrate having a rotation axis; a first retention chamber being located in the substrate and retaining a diluent; a measurement chamber being located in the substrate; at least one reagent; a reagent chamber being located in the substrate and having the at least one reagent disposed therein, the reagent chamber being connected to the measurement chamber; and a first diluent path being located in the substrate, and connecting the first retention chamber and the measurement chamber or reagent chamber.

Abstract: A micro-bioelectrochemical cell (?-BEC) device is disclosed that includes from 4 to 96 microfluidically connected of chambers, in which each chamber encloses a volume of about 1 ?L to 2 ?L. A working electrode, reference electrode, and counting electrode contacts each volume. The ?-BEC device includes a support layer coated with a working electrode layer, a microfluidics layer containing a plurality of wells, and an electrical layer containing the reference and counter electrodes. Methods of using the ?-BEC device to perform bioelectrochemical measurements of cells are also disclosed.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: Blood samples are maintained in a modified atmosphere sealed environment, where moisture is reduced using a desiccant and oxygen is removed using a deoxygenation compound, thus resulting in the preservation of numerous blood analytes, for delayed (e.g., 14 days from collection) blood testing, such as for enzymatic activity, concentration of protein and measurement of other blood components in human and veterinary blood test applications.

Abstract: Provided is a genome extraction device to which a dual chamber structure of an outer chamber and a bead chamber is applied, more particularly a genome extraction device to which the above-described dual chamber structure is applied so that the performance of dry beads vulnerable to moisture can be maintained for a long time.

Abstract: A fluid vapor distillation system. The system includes a control system for controlling a fluid vapor distillation apparatus including a blow down controller for controlling a blow down valve, a source flow controller for controlling a source flow valve, and a blow down level sensor in communication with a blow down controller and a source flow controller, the blow down level sensor sends signals related to the blow down level to the blow down controller and the source flow controller indicative of the blow down level, wherein the source flow controller actuates the source flow valve based at least on the blow down level sensor signals, and wherein the blow down controller actuates the blow down valve based at least on the blow down level sensor signals, whereby the blow down level and the source flow level are maintained using the blow down level sensor signals as input.

Abstract: A particulate matter sensor device comprising an enclosure (21) that comprises a flow inlet (11), a flow outlet (12) and a flow channel (2) extending therebetween, a radiation source for emitting radiation into the flow channel (2) for interaction of the radiation with the particulate matter in the flow (20) of an aerosol sample when guided through the flow channel (2), a radiation detector (4) for detecting at least part of said radiation after interaction with the particulate matter. The sensor device comprises a flow modifying device (511) arranged upstream of the radiation detector (4) and/or of the radiation source (3) for modifying the flow (20) for reducing particulate matter precipitation onto the radiation detector (4) and/or onto the radiation source (3) and/or the channel wall sections in close proximity to the detector (4) and/or source (3). The invention also relates to a method of determining parameters of particulate matter in an aerosol sample by using such a particulate matter sensor device.

Abstract: Integrated cartridges for sample homogenization, nucleic acid fragmentation, and nucleic acid detection are disclosed herein. The integrated cartridges include a main housing having a sample well and a detection chamber and a sonication feature coupled to and extending outwardly from the main housing. The sonication feature includes a sonication chamber for receiving a sample fluid. A fluidic path directs the sample fluid from the sample well, to the sonication chamber, and to the detection chamber. Systems for use with the integrated cartridges can include sonotrodes with openings for positioning the sonication feature and/or temperature sensors for monitoring the temperature of the sonication feature. Methods include moving the sample fluid from the sample well to the sonication feature, transmitting ultrasonic energy into the sample fluid, moving the sample fluid from the sonication feature to the detection chamber, and performing a nucleic acid detection assay within the detection chamber.

Abstract: Disclosed are methods and devices for interfacing to or interacting with the flow of liquid passing into or through lateral-flow assays and related paper- or membrane-based in-vitro diagnostic testing platforms. This is done for the purpose of improving their performance, sensitivity, accuracy, repeatability, degree of multiplexing, and/or level of quantitation, and/or reducing their inherent limitations while maintaining, in large part, their simplicity, cost effectiveness, and ease of use. New methods are disclosed for pre-sample purification, aliquoting, sequential liquid delivery, flow control and other functions that are largely automatic and require no action on the part of the user.

Abstract: A fluid specimen collection receptacle includes a cup containing a chamber and an open end and a lid for connection with the cup open end and closing the cup chamber. A closure and a specimen collection needle are connected with the lid and a reservoir is arranged beneath the lid and connected with the closure for rotation relative to the lid between open and closed positions. The closure affords access to the needle when the closure is in the open position and prevents access to the needle when the closure is in the closed position. The reservoir includes a chamber closed by a portion of the lid when the closure is in the open position. When the closure is rotated to the closed position, the reservoir is opened for communication with the cup chamber to release an absorbent material from the reservoir chamber into the cup chamber to solidify any residual fluid specimen within the cup chamber.

Abstract: The present disclosure relates to retractable diagnostic devices, and hybrid diagnostic devices comprised of water-dispersible, flushable, biodegradable, or water-soluble material and non-water-dispersible, non-flushable, or non-water-soluble material.

Abstract: When an automatic analysis apparatus has a mechanism that performs an operation of an arcuate trajectory to access a plurality of positions arranged on a straight line, an arc and a straight line cannot coincide with each other. Thus position adjustment is required to minimize the deviation between the arc and the straight line. An automatic analysis apparatus according to the invention includes a reagent disk which accommodates a plurality of reagent bottles in each of which a plurality of suction ports are arranged along a center line, and which rotates around a central axis to transport a reagent bottle to a desired position; and a reagent dispensing mechanism which rotates around a rotation axis to suck a reagent from the reagent bottle at a predetermined suction position on the reagent disk, in which the reagent disk is provided with, at least one mounting position of the reagent bottle on the reagent disk, first and second marks sandwiching the mounting position of the reagent bottle.

Abstract: A pneumatic driver for a syringe is provided. The syringe has an elongated barrel with a cap secured to the proximal end that has a through bore. A filter is secured to the cap interior of the barrel that covers an opening in the through bore interior of the barrel. The pneumatic driver includes a source of pressurized air; a support for receiving and locating the syringe; and a supply block configured to receive pressurized air from the source and having an outlet for delivery of pressurized air. The supply block is movable between a first position spaced apart from the cap of the syringe and a second position in contact with the cap with fluid communication being established between the outlet of the supply block and the through-bore in the cap.

Abstract: A biological sample analysis device that is an easily portable free-standing device for determining the rate of deterioration of biological samples.