Patents Examined by Matthew D Krcha
  • Patent number: 11156545
    Abstract: An enrichment system for enrichment of a sample comprising one or more microscopic particles of interest in a fluid carrier is disclosed. The enrichment system comprises a flow cell configured to receive a portion of the sample, a plurality of sample holding chambers and a waste, each connected to a flow cell, an imaging sensor configured to obtain an image of the microscopic particles in the fluid carrier in the flow cell and a controller configured to direct passage of the portion of the fluid sample in the flow cell, in dependence on the image obtained by the imaging sensor, to one of the holding chambers or to the waste.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 26, 2021
    Assignee: See-Through Scientific Limited
    Inventors: Oliver Harriman, Irwin Zaid
  • Patent number: 11154860
    Abstract: The present invention relates to a centrifugal force-based nanoparticle separation apparatus and method. Specifically, the present invention is based on having a low centrifugal force and a small size, and may thus separate nanovesicles unrelated to antibody specificity in a short time and without using an ultracentrifuge. Further, the present invention requires no additional professional personnel and enables accurate fluid measurement by integrating and automating all processes after sample injection, and may thus reduce the loss of nanovesicles.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 26, 2021
    Assignee: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE & TECHNOLOGY)
    Inventors: Yoon-Kyoung Cho, Hyun-Kyung Woo, Ja-Ryoung Han, Tae-Hyeong Kim, Yoon-Keun Kim
  • Patent number: 11154857
    Abstract: A single-channel, chemical-immunological hybrid biosensor is disclosed. According to an embodiment, the hybrid biosensor includes a reaction strip 100 in the form of a porous membrane through which a sample 1 moves by capillary action. the reaction strip 100 is in the form of a porous membrane through which the sample 1 moves by capillary action. Biomarkers in the sample 1 are independently detected based on a chemical reaction and binding reactions on the reaction strip 100.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: October 26, 2021
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
    Inventor: Se-Hwan Paek
  • Patent number: 11148134
    Abstract: An assay device for use with samples of biological fluid, the assay device comprising: a physical detection unit for measuring a viscosity of a biological fluid sample; and a biomarker detection unit for detecting and/or measuring a biomarker in the biological fluid sample, wherein the physical detection unit and the biomarker detection unit act together as part of an assay process.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: October 19, 2021
    Assignee: SEPSENSE LIMITED
    Inventors: Peter Hull, Jimish Patel
  • Patent number: 11148132
    Abstract: The manual dosing device (1) comprises the main body (3) that can be screwed to the fluid discharge unit (4), the detent connection (10) being provided alongside the screw connection (6) for removably connecting the main body (3) to the fluid discharge unit (4), which detent connection is locked by connecting the main body (3) and the fluid discharge unit (4) together (cf. FIG. 5).
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 19, 2021
    Assignee: IKA-Werke GmbH & Co. KG
    Inventor: Philip Döbele
  • Patent number: 11147897
    Abstract: A sterilization process challenge device configured to test the efficacy of a sterilization process includes a tubular body for containing at least one sterilization indicator and a filter assembly including at least one filter member. The only flow path into the interior of the tubular body containing at least one sterilization indicator is provided through the filter assembly to control and restrict flow of a gaseous sterilization medium from an external environment.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: October 19, 2021
    Assignee: American Sterilizer Company
    Inventor: Harry Bala
  • Patent number: 11148131
    Abstract: A dropper includes a bulb, a pipette coupled to the bulb, and a cap coupled to the bulb. The dropper is composed entirely of recyclable material having a same recycle code. The dropper has a length of greater than 2 inches. The dropper is recyclable as a single unit. In one embodiment, the pipette includes an undercut on an inside of the pipette nearest the bulb.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: October 19, 2021
    Assignee: APC Packaging, LLC.
    Inventor: Robert John Bulla
  • Patent number: 11134875
    Abstract: A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: October 5, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Milan Ivosevic, Bradley M. Wilkinson, C. Mark Newby, Kishore K. Bokka Srinivasa Rao
  • Patent number: 11136623
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: October 5, 2021
    Assignee: Oxford Nanopore Technologies Limited
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • Patent number: 11137337
    Abstract: Flow cytometry investigation and flow cytometry result analysis to determine an optimized dilution factor range for flow cytometry investigation of a target sample fluid stock using a flow cytometer. The optimized dilution factor range may be determined using a screening assay module of a flow cytometry system to analyze flow cytometry results determined to fall within a dynamic range of a flow cytometer to determine the optimized dilution factor range for a given flow cytometer to investigate a given target sample fluid stock. In turn, a titer assay module may be executed to prepare particle titer results based on optimized target fluid samples provided within the optimized dilution factor range. The screening assay module and/or the titer assay module may provide automated data processing with data notifications and confirmations to provide robust data analysis.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: October 5, 2021
    Assignee: Essen Instruments, Inc.
    Inventors: Tyler Gates, Jeffrey Steaffens
  • Patent number: 11135593
    Abstract: A capillary connection unit for analysis devices and medical devices includes a capillary having at least one end section and a free end, at least one connection element arranged on the end section of the capillary, wherein the connection element has an axial guide-through for the capillary, a sealing element surrounding the capillary, and a metal sleeve element which radially externally surrounds the sealing element and which has a first end facing the connection element and a receiving region facing away from the connection element, wherein the connection element is configured to be detachably connected to a counter element and to exert an axial thrust force onto the sealing element.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: October 5, 2021
    Inventors: Frank Hirmer, Michael Frank
  • Patent number: 11123737
    Abstract: The invention relates to a closing element for closing a container for samples for analysis, particularly biological samples. The invention also relates to an assembly of a container and a closing element connected to the container. The invention also relates to a device for analysing samples, particularly biological samples, by making use of an assembly according to the invention. In addition, the invention relates to a method for analysing samples, particularly biological samples, by making use of an assembly according to the invention.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: September 21, 2021
    Assignee: eNose Holding B.V.
    Inventor: Albert Bos
  • Patent number: 11125762
    Abstract: Position adjustment of an analysis module in an automatic analyzer is performed where a position adjustment instruction and a position where the position adjustment is actually performed are separated from each other. Position adjustment of probe mechanisms is performed by operating probe position adjustment switches formed on a housing of an analysis module. Where interlocking covers (103 and 113) for the module are present, the probe mechanisms of the module are stopped when the closed covers are opened. The position adjustment switches (101A and 101B) and the position adjustment switch (104) are disposed to be separated from each other by a distance at which the switches cannot be operated by a single hand of an operator at the same time. Even when the cover (103) is opened by continuously pressing the position adjustment switch (104), the probe mechanisms of the module are in an operable state for the position adjustment.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: September 21, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventor: Tsuyoshi Yamamoto
  • Patent number: 11123730
    Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: September 21, 2021
    Assignees: Universite Laval, Meridian Bioscience Canada Inc.
    Inventors: Régis Peytavi, Sébastien Chapdelaine
  • Patent number: 11125730
    Abstract: A flow passage unit has a column for used in a liquid chromatograph and a support body that supports the column. The column has: a porous stationary phase; a porous pressure adjusting part disposed at least at the flow-in end of the stationary phase, a liquid entering the flow-in end, the pressure adjusting part being harder than the stationary phase; and a covering part that covers the stationary phase and pressure adjusting part. The support body has a first plate and a second plate that are mutually joined, the support body forming a column holding part and a liquid flow passage, the column holding part holding the column between the first plate and the second plate, the liquid flow passage communicating with the column holding part. Pressure applied from the first plate and second plate to the pressure adjusting part is higher than pressure applied to the stationary phase.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 21, 2021
    Assignee: ALPS ALPINE CO., LTD.
    Inventors: Yoshimune Suzuki, Setsuo Ishibashi, Yoshihiro Taguchi, Satoshi Kawamura, Junko Ito, Hiroyoshi Minaguchi
  • Patent number: 11125661
    Abstract: Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: September 21, 2021
    Assignee: Lucira Health. Inc.
    Inventors: Frank B. Myers, III, Wei Hsuan Ho, Debkishore Mitra, John Robert Waldeisen, Ivan Krastev Dimov, Ryan C. Griswold, Bruce Richardson
  • Patent number: 11117128
    Abstract: This disclosure provides, among other things, a filtration device comprising an open bottomed multi-well plate, a planar spacer that comprises apertures, and a porous capillary membrane. In the device, the planar spacer is sandwiched between the multi-well plate and the porous capillary membrane and the planar spacer is bonded to both the multi-well plate and the porous capillary membrane via an adhesive. Kits and methods of making the device are also provide.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 14, 2021
    Assignee: VANADIS DIAGNOSTICS AB
    Inventor: Mathias Howell
  • Patent number: 11119010
    Abstract: A closed and tamper-evident sealed container, including a fluid transport adapter. The adapter provides for sterile fluid communication between a fluid source outside the container and the container interior when adapter is open. The adapter is adjustable to a closed position wherein the fluid communication ceases. An alternative to the adapter utilizes a sampling attachment that fits into tight engagement with the lid which comprises at least one septum. Coupling the sampling attachment to the lid either causes sharps in the attachment to penetrate the at least one septum or to displace the edges of the septum inward to form a fluid communication with the container interior while the lid remains sealed closed. Other variations include a rotatable sampling attachment, a container with a displaceable bottom wall to act as a syringe and a large volume (e.g., 1500 mL) sealed ampoule which also uses a sampling attachment.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 14, 2021
    Assignee: CSP Technologies, Inc.
    Inventors: Jean-Pierre Giraud, Herve Pichot, Franklin Lee Lucas, Jr., Ethan Ross Perdue
  • Patent number: 11110464
    Abstract: A sample container carrier, a laboratory sample distribution system comprising such a sample container carrier and a laboratory automation system comprising such a laboratory sample distribution system are presented.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rudolf Durco, Marcel Kaeppeli
  • Patent number: 11110463
    Abstract: A sample container carrier, a laboratory sample distribution system comprising such a sample container carrier and a laboratory automation system comprising such a laboratory sample distribution system are presented.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Tobias Huber, Rudolf Durco