Patents Examined by Matthew D Krcha
  • Patent number: 11504708
    Abstract: A pipetting apparatus and method for pulsed dispensing of small metered-liquid doses of no more than 1 ?l. The apparatus includes a pipetting conduit at least partly filled with working gas, a pressure-modifying apparatus for modifying the pressure of the working gas, and a control apparatus for applying control to the pressure-modifying apparatus. The control apparatus can control the pressure-modifying apparatus so as to generate in the pipetting conduit, with respect to a reference holding pressure in the pipetting conduit which is necessary for immovable holding of the metered-liquid quantity, an overpressure pulse having a pulse duration of no more than 40 ms.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: November 22, 2022
    Inventors: Hanspeter Romer, Reto Ettinger, Fridolin Gysel, Jürg Rast, Jonas Hilti
  • Patent number: 11493526
    Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: November 8, 2022
    Inventors: Eliodor Ghenciu, Theodore E. Straub, Evan W. Foster, Michael C. Pallas
  • Patent number: 11493474
    Abstract: This invention relates to a handheld mobile device which can analyze and measure whole blood, serum, urine or analytes which contain target agents such as mycotoxin, aflatoxin or cholera etc. with a easy to use reusable cartridge consisting of a cartridge head and cartridge body. The cartridge comprises four syringes, one of which being detachable. A waste reservoir is integrated with the syringes.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: November 8, 2022
    Assignee: TUBITAK
    Inventors: Yildiz Uludağ, Mehmet Yağmur Gök, Serkan Barut, Veysi Cansu
  • Patent number: 11491487
    Abstract: Devices and methods for measuring analytes and target particles in a sample are disclosed. In some embodiments, the disclosure provides a cartridge device. In other embodiments, the disclosure provides a method of using a cartridge device as disclosed herein for analyzing analytes and target particles in a sample. In further embodiments, the disclosure provides an analyzer including a cartridge device and a control unit device. The control unit device is configured to receive, operate, and/or actuate the cartridge device. In some embodiments, the disclosure provides a method of using an analyzer as disclosed herein for analyzing analytes and target particles in a sample.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 8, 2022
    Assignee: CytoChip Inc.
    Inventors: Wendian Shi, Yuzhe Ding, Yuan Gao
  • Patent number: 11484876
    Abstract: A system for testing for an analyte includes a test strip. The test strip includes a first flow path. The test strip further includes a heating element in communication with a heating area of the first flow path, for heating a sample in the first flow path. The test strip further includes an e-gate, the e-gate in the first flow path, the e-gate separating the heating area from a detection area of the first flow path.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: November 1, 2022
    Inventors: Joseph P. Joyce, Matthew Musho
  • Patent number: 11480584
    Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: October 25, 2022
    Inventors: Kuan Moon Boo, Wei Fuh Teo, Zeqi Tan, Soo Yong Lau, Ming Tiong Sia, Woon Liang Soh, Ching Yee Lam, Shan Hua Dong, Marc Haberstroh, Michael C. Pallas, Hardeep Sangha
  • Patent number: 11478796
    Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: October 25, 2022
    Inventors: Per Augustsson, Pelle Daniel Ohlsson, Ola Jakobsson, Klara Andersson, Gert Blankenstein, Josef Kerimo, Ethan Schonbrun
  • Patent number: 11471878
    Abstract: Described are exemplary embodiments of a handheld, powered positive displacement pipette having unique mechanisms for the retention, identification and ejection of associated pipette syringes.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: October 18, 2022
    Assignee: Mettler-Toledo Rainin, LLC
    Inventors: Richard Hill, Michael McNaul, Stephen Grimwade, Thomas James McPherson
  • Patent number: 11471881
    Abstract: The disclosure describes methods and devices with which to process and analyze difficult chemical, biological, environmental samples including but not limited to those containing bulk solids or particulates. The disclosure includes a cartridge which contains a separation tube as well as one or more valves and cavities for receiving raw sample materials and for directing and containing various fluids or samples. The cartridge may contain a separation fluid or density medium of defined density, and structures which direct particulates toward defined regions of the cartridge. Embodiments can include a rotational device for rotating the cartridge at defined rotational rates for defined time intervals. Embodiments allowing multiple assays from a single sample are also disclosed. In some embodiments, this device is used for direct processing and chemical analysis of food, soil, blood, stool, motor oil, semen, and other samples of interest.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: October 18, 2022
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Ulrich Schaff, Christopher Tomkins-Tinch, Jason Sauers, Greg Sommer
  • Patent number: 11474034
    Abstract: A lateral flow test system having an optical reader, a lateral flow cartridge and a computer system is provided. The lateral flow cartridge includes a porous test strip with a reading window into the porous test strip exposing an exposed zone of the porous strip. The optical reader has a reader housing and a slot for inserting the cartridge into the reader housing. The optical reader has an illumination arrangement adapted for illuminating the exposed zone of the porous strip when the cartridge is inserted into the slot. The optical reader further has a video camera configured for acquiring a series of digital images comprising the exposed zone of the porous strip. The computer system receives sets of pixel data representing the plurality of consecutive digital images and calculates wetting progress along the length of the exposed zone of the porous strip based on the sets of pixels data.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: October 18, 2022
    Assignee: Zoetis Services LLC
    Inventors: Carl Esben Poulsen, Johan Eriksen, Martin Heller, Niels Kristian Bau-Madsen
  • Patent number: 11465144
    Abstract: In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: October 11, 2022
    Inventors: David K. Schaffer, Dmitry A. Markov, Ronald S. Reiserer, Lisa McCawley, Michael Geuy, Clayton M. Britt, John P. Wikswo
  • Patent number: 11466239
    Abstract: A biological material manufacturing device according to an embodiment of the inventive concept includes a main body and a head unit that is rotatable on the main body. The main body includes a main groove and a first container groove connected to the main groove. The head unit includes a pillar provided in the main groove and a protruding part that protrudes from the pillar.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: October 11, 2022
    Assignee: VIEA Logis Co., Ltd.
    Inventors: Chul-Hong Choi, Dong-Wook Shin, In-Sang Yoon, Jung-Min Kim
  • Patent number: 11458468
    Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: October 4, 2022
    Assignee: Arthrex, Inc.
    Inventors: Hannah McIntyre, Christopher Bare, Melissa Tucker, Andrea Matuska
  • Patent number: 11448571
    Abstract: Provided is a specimen collection tip having a novel structure, with which it is possible to collect a trace amount of a specimen with good quantitative precision. Also provided is a specimen preparation container having a novel structure, with which it is possible to dilute and prepare the specimen collected with the specimen collection tip with good quantitative precision. A specimen collection tip 10, wherein a specimen holding region 12 having a predetermined volume is provided inside the specimen collection tip 10, and in a distal end portion extending from a support part 15, there is formed a specimen collection hole 22 and an air vent hole 24 placing the specimen holding region 12 in communication with a surface 23. Also, a specimen preparation container 26 with a cap 30, wherein the specimen collection tip 10 is attached to the cap 30 at the support part 15.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: September 20, 2022
    Inventors: Toshiaki Baba, Koutarou Tanimura, Dosaku Tokudome, Yukihiro Yabe, Kanako Miura
  • Patent number: 11440014
    Abstract: A generic point of care based portable device and method thereof as a platform technology for detecting pathogenic infection via nucleic acid based testing achieving sample-to-result integration, comprising the following interconnected stand-alone modules: a thermal unit for executing piece-wise isothermal reactions in a pre-programmable concomitant fashion without necessitating in-between operative intervention; a colorimetric detection unit seamlessly interfaced with smartphone-app based analytics for detecting the target analyte.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: September 13, 2022
    Inventors: Nandita Kedia, Sujay Kumar Biswas, Saptarshi Banerjee, Aditya Bandopadhyay, Arindam Mondal, Suman Chakraborty
  • Patent number: 11433402
    Abstract: Magnetic assisted separation apparatuses for separating a target substance from a medium in which the target substance is suspended, and related methods, are provided. According to one aspect, a magnetic separator may include a frame having an opening configured to receive one or more containers containing the medium. Additionally, the magnetic separator may include first and second magnetic field generating elements mounted on opposing sides of the frame such that one or more containers can be positioned between the first and second magnetic field generating elements. According to another aspect, a workstation includes a work surface for receiving one or more containers containing the medium, a fluid transfer member, an automated manipulator configured to move the fluid transfer member, and a plurality magnetic field generating elements each being moveable between a position remote from the one or more containers and another position adjacent to the one or more containers.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: September 6, 2022
    Assignee: AMGEN INC.
    Inventors: Craig Michael Schulz, Justin James Provchy, John Kasajja Kawooya
  • Patent number: 11433390
    Abstract: Methods and systems are provided for a rotating capillary chamber. In one example, a system comprises a rotating capillary chamber arranged in a body of a fluid collection device, wherein the capillary chamber may rotate between two or more positions.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 6, 2022
    Assignee: ION LLC
    Inventors: James Thorne, Joshua King Hoyt
  • Patent number: 11435374
    Abstract: A sample collection and testing device for analyzing blood is provided that includes a controller, a fluid flow pathway, a pump configured to move fluid through the fluid pathway, and an optical fluid measurement element configured to measure a light intensity of the fluid in the fluid flow pathway. The controller is configured to: start the pump to move a blood sample in the fluid flow pathway, receive a signal from the optical fluid measurement element indicating a detection of a leading edge of the blood in the fluid flow pathway, stop the pump to stop the moving of the blood in the pathway, receive a plurality of light intensity measurements from the optical measurement element, each light intensity measurement measured at a corresponding point of time, and provide a mapping of the light intensity measurements into an indication of a coagulation of the blood sample over a time period.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: September 6, 2022
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian
  • Patent number: 11433389
    Abstract: Disclosed herein are fluid handling devices that include integrated card and pipette tip devices, for use with multichannel liquid dispensing devices.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: September 6, 2022
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Phillip Hairfield, Peter Paul Blaszcak
  • Patent number: 11428635
    Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 30, 2022
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence C. West, Michael Ferrigno, Paul E. Glenn, Anthony Bellofiore