Patents Examined by Melanie Yu Brown
-
Patent number: 10024855Abstract: The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.Type: GrantFiled: August 7, 2017Date of Patent: July 17, 2018Assignee: LEUKODX LTD.Inventors: Harvey Lee Kasdan, Julien Meissonnier, Yoav Zuta, Micha Rosen, Yael Himmel, Yehoshua Broder, Bruce Davis, Bruce Goldman, Boaz Giron, Zion Botesazan, Ellezer Blasberg, Ilan Semmel, Jacques Aschkenasy
-
Patent number: 10022109Abstract: The present invention refers to a detection device for the in vivo and/or in vitro enrichment of sample material, the detection device comprising a functional surface equipped with detection receptors. To further improve the enrichment of sample material by using a detection device of the aforementioned type, it is provided according to the invention that the functional surface has a three-dimensional structure with mutually facing functional sections which form spaces that can be filled with a sample liquid. Furthermore, the present invention provides for a use and for a method for the use of the detection device.Type: GrantFiled: June 17, 2010Date of Patent: July 17, 2018Assignee: GILUPI GMBHInventors: Klaus Lücke, Andreas Bollmann, Steffi Mewes, Robert Niestroj
-
Patent number: 10024850Abstract: The present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metallized particles thereby enhancing the signal. Importantly, these plasmonic emissions emitted from metallic particles generated without an external excitation source but instead from induced electronically excited states caused by the bioluminescent chemical reaction.Type: GrantFiled: February 17, 2010Date of Patent: July 17, 2018Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTYInventor: Chris D. Geddes
-
Patent number: 10018632Abstract: Methods and systems for selectively capturing analytes, such as cells, e.g., circulating tumor cells (CTCs), from fluid samples are disclosed. The methods include contacting the sample with an analyte binding moiety that selectively binds to the analytes; optionally separating first components of the sample including a majority of the analytes bound to the binding moieties from second components of the sample using size-based separation, e.g.Type: GrantFiled: April 10, 2015Date of Patent: July 10, 2018Assignee: The General Hospital CorporationInventors: Thomas A. Barber, Ajay Shah, John Walsh, Mehmet Toner, Ravi Kapur, Shannon Stott
-
Patent number: 10012645Abstract: The subject invention provides materials and methods for detecting Zika virus. Specific embodiments provide an electrochemical immunosensing device and the methods of making and using the same for detecting Zika virus with exceptionally low detection limit. In some embodiments, the immunosensing device is capable of detecting picomolar (pM) level of Zika virus present in a sample by employing immunosensors functionalized with Zika virus binding ligands such as monoclonal Zika virus antibodies and Zika non-structural proteins. In an exemplary embodiment, the immunosensing device can be integrated with microelectronics to be adopted as point-of-care sensing systems. Advantageously, technologies provided herein offer rapid, on-site biosensing methods for the accurate detection of diseases caused by Zika virus.Type: GrantFiled: August 24, 2016Date of Patent: July 3, 2018Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Ajeet Kaushik, Madhavan Nair
-
Patent number: 10012644Abstract: In an aspect, a sensor includes a combining portion that combines with a second substance having a molecular weight larger than a molecular weight of a first substance. Further, in an aspect, the sensor includes a substrate including a surface on which the combining portion is disposed. The combining portion detects whether or not the first substance is included in an analyte that has come into contact with both an aptamer and the second substance. The aptamer includes a first combining part for the first substance and a second combining part for the second substance and is combined with either of the first substance and the second substance.Type: GrantFiled: March 29, 2013Date of Patent: July 3, 2018Assignees: KYOCERA Corporation, Kyushu University, National University CorporationInventors: Shinsuke Sando, Hideharu Kurioka
-
Patent number: 10006902Abstract: The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.Type: GrantFiled: June 23, 2014Date of Patent: June 26, 2018Assignee: SOPHION BIOSCIENCE A/SInventors: David Geraint Owen, Nicholas Gerard Byrne
-
Patent number: 10000788Abstract: The invention features methods for rapidly and sensitively identifying molecular targets in medical, industrial, and environmental samples. The invention labels target molecules and then images them using large area imaging. Diagnostic tests based on the invention can be rapid, ultrasensitive, quantitative, multiplexed, and automated. A broad range of infectious agents (e.g., bacteria, viruses, fungi, and parasites) and molecules (e.g., proteins, DNA, RNA, hormones, and drugs) can be detected by the methods. The invention enables rapid, ultra-sensitive, cost-effective, and portable assays. The ability of the invention to detect low levels of target molecules rapidly and cost-effectively results from the combination of high intensity labeling, formats that facilitate rapid reaction kinetics, and large area imaging based using either instrumentation made from off-the-shelf commercial components or no instrumentation at all.Type: GrantFiled: September 6, 2002Date of Patent: June 19, 2018Assignee: First Light Biosciences, Inc.Inventor: Don Straus
-
Patent number: 9995744Abstract: The invention relates to compositions and methods for the immunoassay of an analyte of interest. The analyte is detected in an immunoassay using three or more antibodies, where in each antibody specifically binds to a different epitope on the analyte. When the analyte of interest in a clinical marker for an acute disease, the detection of the analyte by immunoassay is a diagnosis of the occurrence of the disease.Type: GrantFiled: January 13, 2016Date of Patent: June 12, 2018Assignee: Abbott Point of Care Inc.Inventors: John Lewis Emerson Campbell, Pamela Anne Frank, Meghan Elizabeth Hawkes, Shannon Reishma Lobin, Cary James Miller, Zhen Yang
-
Patent number: 9989523Abstract: The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.Type: GrantFiled: November 16, 2015Date of Patent: June 5, 2018Assignee: LEUKODX LTD.Inventors: Harvey Lee Kasdan, Julien Meissonnier, Yoav Zuta, Bruce Davis, Micha Rosen, Yael Himmel, Yehoshua Broder
-
Patent number: 9987633Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.Type: GrantFiled: June 8, 2015Date of Patent: June 5, 2018Assignee: 3M Innovative Properties CompanyInventors: Stephen B. Roscoe, Myungchan Kang, Evan D. Brutinel, Jesse D. Miller, Renee K. Cline, Minghua Dai, Hsi-Chou Liu
-
Patent number: 9989525Abstract: The present disclosure provides a diffraction based biosensor containing at least two diffraction gratings. The first grating is referred to as an in-coupling diffraction grating and the coherent light source (laser) is directed to illuminate the in-coupling grating, and the biosensor is configured such that a selected order of the light beam diffracted from the in-coupling diffraction grating illuminates a second biosensor grating coated with analyte-specific receptors which are selected to preferentially bind with analytes being tested for that may or may not be located in a sample being tested.Type: GrantFiled: March 15, 2013Date of Patent: June 5, 2018Assignee: AXELA INC.Inventors: Alexandre Izmailov, Paul Timothy Smith
-
Patent number: 9970897Abstract: A van der Pauw (VDP) sensor comprising an electronic circuit electrically coupled to a surface, the surface comprising a type III-V material, and the electronic circuit measuring a sheet resistivity of the surface using a VDP technique. The VDP sensor may further comprise a macromolecule, such as a porphyrin, an oligonucleotide, a protein, a polymer or a combination thereof in contact with the surface. The VDP sensors may be arranged in an array of similar or different sensors. An electronic circuit electrically coupled to a type III-V material having a two-dimensional electron gas, such as InAs or InN, the electronic circuit measuring an electrical property of the type III-V material having a two-dimensional electron gas.Type: GrantFiled: June 16, 2009Date of Patent: May 15, 2018Assignee: Duke UniversityInventors: Michael A. Garcia, Scott D. Wolter, April S. Brown, William V. Lampert
-
Patent number: 9964537Abstract: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.Type: GrantFiled: October 30, 2015Date of Patent: May 8, 2018Assignee: Abbott Point of Care Inc.Inventors: G. Bruce Collier, Cary James Miller
-
Patent number: 9956562Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: GrantFiled: November 2, 2015Date of Patent: May 1, 2018Assignees: The General Hospital Corporation, GPB Scientific, LLCInventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
-
Patent number: 9952169Abstract: A method of measuring biological sample properties and a biological sample property measuring apparatus is provided. A method of measuring biological sample properties includes disposing a biomaterial to contact a sensing unit, detecting a radio frequency (RF) signal flowing through the sensing unit, and obtaining an RF property indicator of the biomaterial based on the detected RF signal.Type: GrantFiled: October 13, 2015Date of Patent: April 24, 2018Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei UniversityInventors: Sang Uk Son, Duck Hwan Kim, In Sang Song, Seong Chan Jun, Ho Soo Park, Jea Shik Shin, Moon Chul Lee
-
Patent number: 9939385Abstract: Systems, methods, and test kits for monitoring and detecting variation in an analyte level in a fluid sample from an individual variation using a uniquely determined analyte threshold value. In one implementation, luteinizing hormone is the monitored analyte and is compared with the determined threshold value to predict the onset of ovulation for the individual.Type: GrantFiled: September 9, 2011Date of Patent: April 10, 2018Assignee: Church & Dwight Co., Inc.Inventors: Albert Nazareth, Andy Sturman, Benedict Zin, Yea-Shun Cheng, Henry Bell, Shang Li
-
Patent number: 9932635Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.Type: GrantFiled: May 24, 2012Date of Patent: April 3, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: David T. Wong, Fang Wei, Wei Liao
-
Patent number: 9931630Abstract: Aspects of the present disclosure relate to a capillary fluidic device comprising at least two inlets, a microfluidic channel and an outlet. The device allows for the autonomous and programmable sequential flow of the same or different fluids using capillary fluidics for autonomous pumping of liquids to other downstream fluidic structures. External pumping and valving systems are not required, thus reducing complexity and increasing portability of stand-alone microfluidic systems. Aspects of the present disclosure can be applied to other fluidic structures for performing analytical biological assays. The integration has at least one reaction chamber and at least one capillary pump. The device is integrated with at least one sensor for detection and quantification of the biological assay signals.Type: GrantFiled: June 5, 2013Date of Patent: April 3, 2018Assignee: INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS (INESC-MN)Inventors: Virginia Chu, Pedro José De Oliva Novo, João Pedro Estrela Rodrigues Conde, Francesca Volpetti
-
Patent number: 9933422Abstract: The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.Type: GrantFiled: May 1, 2015Date of Patent: April 3, 2018Assignee: Abbott Point of Care Inc.Inventors: Cary James Miller, Graham Davis, Michael Zelin