Patents Examined by Michael A Marcheschi
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Patent number: 12365857Abstract: A multi-layer culture vessel operation system capable of easily performing a multi-layer culture vessel handling operation is provided.Type: GrantFiled: December 21, 2018Date of Patent: July 22, 2025Assignee: SHIKOKU INSTRUMENTATION CO., LTD.Inventors: Toshiaki Mori, Hideki Takeda, Yasufumi Mishima, Shoji Matsuoka
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Patent number: 12356982Abstract: Disclosed is an oxygenator device for oxygenating a perfusate solution to be perfused through an organ or tissue. The device includes an inlet configured to receive oxygen from an oxygen supply; and tubing connected to the inlet, the tubing including a plurality of holes by which the received oxygen may exit the tubing.Type: GrantFiled: March 14, 2019Date of Patent: July 15, 2025Assignee: LIFELINE SCIENTIFIC, INC.Inventors: David Pettinato, Christopher P. Steinman, Alan K. Wu
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Patent number: 11882824Abstract: A vial sleeve for a cryogenic vial includes a cover portion including a side wall defining a cavity for receiving at least a portion of the vial, and a locking feature configured to operatively engage at least a portion of the vial for resisting movement of the vial relative to the vial sleeve. The vial sleeve may include a first label adhered to an exterior surface of the side wall and including a first set of indicia. The first set of indicia may be different from a second set of indicia included on a second label adhered to an exterior surface of the vial.Type: GrantFiled: July 31, 2019Date of Patent: January 30, 2024Assignee: Fisher BioServices Inc.Inventors: Abdul H. Ally, Bruce Simpson, Scott Hixon
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Patent number: 9933413Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.Type: GrantFiled: March 10, 2014Date of Patent: April 3, 2018Assignee: CFD Research CorporationInventors: Balabhaskar Prabhakarpandian, Kapil Pant
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Patent number: 9868095Abstract: A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.Type: GrantFiled: January 10, 2008Date of Patent: January 16, 2018Assignee: Finesse Solutions, Inc.Inventors: Mark Selker, Barbara Paldus
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Patent number: 8409331Abstract: The invention relates to auxiliary systems ensuring functioning of alkaline fuel cell (AFC), in particular to a method and device for sorptive purification of air used in an AFC of carbon dioxide. In accordance with the invention, in the method for purifying air for a fuel cell, the starting air is passed through an adsorber with an adsorbent of carbon dioxide, then the adsorbent is regenerated. After utilization the adsorbent comprising hydrated oxides of transition metals is regenerated at a temperature of 60-120° C. by the air spent in the fuel cell.Type: GrantFiled: November 4, 2003Date of Patent: April 2, 2013Assignee: Obschestvo S Ogranichennoi Otvetstvennostiyu “Intensis”Inventors: Ziya Ramizovich Karichev, Dmitry Alexandrovich Blatov, Stanislav Iliich Simanenkov, Valentina Nikolaevna Shubina
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Patent number: 8030087Abstract: The purpose of the present invention is to provide a method to more easily analyze the concentration of glue in an electrolyte solution, while suppressing the degradation of glue during the analysis. There is provided a method for analyzing the concentration of glue contained in an electrolyte solution containing the electrolyte components by using high performance liquid chromatography, where said method comprises a step wherein an electrolyte solution is added into the eluent pH of which has been adjusted equal to or less than 5 by adding acid to an aqueous solution of phosphate of alkaline metal or alkaline earth metal, a step wherein the eluent into which the electrolyte solution has been added is passed through a separation column the exclusion limit molecular weight of which is 4000-6000 for separating the glue and electrolyte components, and a step wherein the separated glue is detected by a detector.Type: GrantFiled: June 27, 2008Date of Patent: October 4, 2011Assignee: Pan Pacific Copper Co., Ltd.Inventors: Masayuki Takahira, Yozo Ishihara, Ikunobu Sumida
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Patent number: 8017080Abstract: A liquid state detecting apparatus including a detecting element having a heating resistor which generates heat when energized and being disposed in a liquid container for containing a liquid, the apparatus calculating a first difference between a first corresponding value corresponding to a first resistance of the heating resistor acquired after energization of the heating resistor is started and a second corresponding value corresponding to a second resistance of the heating resistor acquired after the heating resistor is energized for a predetermined detection time and obtaining a first concentration of a particular component included in the liquid, the first concentration being associated with the first difference, the apparatus including: an abnormality determination unit, a determination concentration acquiring unit, a concentration difference calculation unit, and a static state determination unit, all as defined herein.Type: GrantFiled: November 9, 2006Date of Patent: September 13, 2011Assignee: NGK Spark Plug Co., Ltd.Inventors: Takeo Sasanuma, Yoshikuni Sato
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Patent number: 8017091Abstract: A device consisting of a low-RPM motor wherein the motor spins a flat disk, a peg is attached to the disk, a stationary spring armature wherein the peg can activate the stationary spring armature as the disk rotates, and a tube containing beads in a fluid positioned in a top plate wherein the spring armature can contact the tube. This device can further include a soft closed-cell foam top mounted on the top plate wherein the tube is inserted and maintained by the foam in such a way as to allow for slight motion of the tube induced by the contact by the spring armature.Type: GrantFiled: November 20, 2006Date of Patent: September 13, 2011Assignee: The United States of America as represented by the Secretary of the NavyInventors: Turan A. Kayagil, Julie A. Richardson
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Patent number: 8017381Abstract: Electroporation on a plurality of samples of membranous structures is performed in an electroporation well plate that includes a frame that can hold a plurality of well strips to form a two-dimensional array of wells, and a set of well strips, the set containing strips that differ in the number of wells while having the same outer dimensions and hence being interchangeable, thereby allowing the user to select strips appropriate for a given electroporation procedure, and allowing the manufacturer to replace defective strips without rejecting an entire well plate when a small number of wells is found to be defective.Type: GrantFiled: March 8, 2007Date of Patent: September 13, 2011Assignee: Bio-Rad Laboratories, Inc.Inventors: Charles W. Ragsdale, John Morrill
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Patent number: 8012915Abstract: The present invention is a release oil of the general formulae: wherein (Z) is an amine. The solvent extracted portion of the release oil has a ratio of A:B less than 1:5. Less than 10% of the molecular weight distribution of the release oil is less than m/z 1000. The release oil preferably has a viscosity of between 200 and 500 centistokes.Type: GrantFiled: October 19, 2007Date of Patent: September 6, 2011Assignee: Eastman Kodak CompanyInventors: Wayne T. Ferrar, Jerry A. Pickering, David F. Cahill, Peter S. Alexandrovich, Andrew J. Hoteling
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Patent number: 8007744Abstract: The present invention relates to a sample container for analyses suitable for medical diagnostics comprising a platform plate having at least one reaction chamber. The reaction chamber has a bottom and a sidewall which form a three-dimensional chamber which is open in the upward direction. The ratio of the numerical value of the surface area of the bottom is relatively large relative to the height of the sidewall. The ratio may be greater than or equal to 30, 35, 40, 45, 50, 60, 70, 80, or 90. The reaction chamber further comprises a binding area on an internal surface of the reaction chamber which may be functionalized for binding at least one chemical entity for use in an assay.Type: GrantFiled: January 16, 2004Date of Patent: August 30, 2011Assignee: Greiner Bio-One GmbHInventors: Günther Knebel, Jörg Stappert, Heinrich Jehle, Joachim Kessler
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Patent number: 7985576Abstract: Systems and methods of treating flue gas and wastewater generated by treating the flue gas are disclosed and include introducing the flue gas, a flue gas treatment fluid that removes sulfur dioxide from the flue gas; and an organic acid conditioning agent into a wet-oxidation scrubber/absorber; introducing FGD scrubber wastewater generated by the wet-oxidation scrubber/absorber into an anoxic biological reactor to substantially denitrify the FGD scrubber wastewater; and introducing resulting substantially denitrified FGD scrubber wastewater into an anaerobic biological reactor to substantially reduce the amount of sulfate and/or selected heavy metals in the FGD scrubber wastewater.Type: GrantFiled: August 22, 2007Date of Patent: July 26, 2011Assignee: Infilco Degremont, Inc.Inventors: Robert F. Kelly, Michael Pudvay, Antonio Lau
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Patent number: 7981189Abstract: The invention has a captive tooless fastener for securing the engine intake air filter. The tooless fastener comprises shaft and associated bodies. The body has two arms oriented about 180 degrees apart. The shaft is threaded through a sealing washer and an aperture in a closed end cap of the air filter. The shaft is expanded so it cannot be removed from the end cap. The body's threaded inner diameter mates with a threaded portion of a central shaft in an air filter housing. The body's arms are rotated to screw the fastener and the shaft of the housing together. When tightened, the sealing washer closes the aperture. To remove the air filter, the fastener is unscrewed from the shaft of the housing and in the shaft floats in the aperture. A person in the field can remove the air filter by inserting fingers under the arms and pulling.Type: GrantFiled: August 29, 2005Date of Patent: July 19, 2011Assignee: Greenlees Filter LLCInventors: Ronald Troxell, Roy E. Greenlees, Kenneth S. Schultz
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Patent number: 7981668Abstract: A method and system for culturing cells, having a substantially airtight enclosure configured to culture cells. The method and system also have a first conduit configured to provide a reduced pressure to the substantially airtight enclosure and a second conduit configured to provide a culture media to the substantially airtight enclosure.Type: GrantFiled: January 17, 2007Date of Patent: July 19, 2011Assignee: KCI Licensing Inc.Inventors: Robert P. Wilkes, Amy K. McNulty, Kristine Kieswetter, Teri D. Feeley, Marisa Schmidt
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Patent number: 7981686Abstract: A method of assessing body odor using as an index an indicator material comprising an alcohol compound having a mercapto group at the 3-position represented by the following formula (2) and/or a substance that is a derivative of an alcohol compound having a mercapto group at the 3-position, wherein an atom(s) or an atom group(s) is introduced to a mercapto group and/or a hydroxyl group of an alcohol compound having a mercapto group at the 3-position represented by the formula (2):Type: GrantFiled: March 30, 2010Date of Patent: July 19, 2011Assignee: Kao CorporationInventors: Masayuki Yabuki, Yoshihiro Hasegawa, Masamoto Matsukane
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Patent number: 7976589Abstract: Nanoscopic core-shell material additives for high temperature jet aviation fuels are disclosed. The nanometer dimensions of these core-shell material additives materials provide extremely large surface areas to promote chemical reactivity while permitting suspension in liquid fuels and providing unlimited access to all components of an aircraft fuel system. Core-shell technology involves additive encapsulation in a protective, fuel-mimicking shell material.Type: GrantFiled: May 4, 2006Date of Patent: July 12, 2011Assignee: United States of America as represented by the Secretary of the Air ForceInventor: Christopher E. Bunker
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Patent number: 7972841Abstract: The present invention relates to an exposure device for living cell cultures, the device having a medium chamber common to a plurality of cell culture chambers and medium directing means. The medium chamber, cell culture chambers and the medium directing means may be arranged so as to provide substantially contemporaneous medium exchange at the cell culture chambers.Type: GrantFiled: May 22, 2003Date of Patent: July 5, 2011Assignee: British American Tobacco (Investments) LimitedInventors: Elan David Massey, Justine Williamson, Jeremy Francis Neale Phillips
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Patent number: 7972839Abstract: The device and method invented provides a unique means to extract and multiply, by the millions, beneficial aerobic microbes found in compost and vermicompost to be applied to soil and plants in liquid form. Compared to many compost tea making devices being sold, the invented device is truly simple and can be dismantled and cleaned in under twenty minutes. Most of the parts are not glued and can be pulled apart. The device and method uses air pumps alone to actually circulate the water and can be used with or without a mesh extractor. This is achieved by the insertion of an air diffuser into the piping used, which infuses the water with oxygen while circulating the water, into either, an extractor containing compost or a body of water containing compost. Concurrently additional diffusers infuse the body of water with oxygen.Type: GrantFiled: January 19, 2009Date of Patent: July 5, 2011Inventor: Timothy James Wilson
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Patent number: 7968335Abstract: A cell culturing method employing biomechanical stimulation loading and a system for applying, in in vitro culture, stimulation similar to vertical weight load stimulation or sideward shear stress stimulation acting on tissues in an aboveground living body as repeated biomechanical stimulation to culture cells, culture tissues or a construct including the culture cells. The system includes a mechanical stimulation loading device and a culture receptacle that are placed in a carbon dioxide incubator, and a control computer. The device includes a weight loading piston, a piston raising and lowering stage supporting piston to allow vertical movement of a piston within a designated range, and a stage lifting and lowering mechanism for vertically moving the stage. A computer drives the mechanism in a specified cycle to effect the vertical movement of the stage. When the stage is lowered, a culture in the receptacle is weighted with the piston.Type: GrantFiled: June 16, 2005Date of Patent: June 28, 2011Inventor: Ken Nakata