Patents Examined by Michael A Marcheschi
  • Patent number: 9933413
    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: April 3, 2018
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Patent number: 9868095
    Abstract: A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: January 16, 2018
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark Selker, Barbara Paldus
  • Patent number: 9480949
    Abstract: A process for desorbing CO2 gas from an ion-rich aqueous mixture comprising bicarbonate and hydrogen ions, includes providing micro-particles in the ion-rich aqueous mixture; and feeding the ion-rich aqueous mixture into a desorption reactor; the micro-particles comprising a support material and biocatalysts supported and stabilized by the support material and being sized and provided in a concentration in the desorption reactor such that the micro-particles are carried with the ion-rich aqueous mixture to promote transformation of the bicarbonate and hydrogen ions into CO2 gas and water, thereby producing a CO2 gas stream and an ion-depleted solution.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: November 1, 2016
    Assignee: CO2 Solutions Inc.
    Inventors: Sylvie Fradette, Julie Gingras, Norman Voyer, Jonathan Carley, Glenn R. Kelly, Olivera Ceperkovic
  • Patent number: 9464265
    Abstract: There is provided an incubator for an isolator, which is capable of reliably sterilizing a cultivation room of the incubator, a gas supply pipe and a sampling pipe. An incubator 1 for an isolator 40 includes a gas concentration control pipe 16 provided to communicate to a cultivation room 4 for control of concentration of cultivation gas in the cultivation room 4, a sterile gas circulation pipe 26 for circulating sterile gas from the cultivation room 4 to the gas concentration control pipe 16, and a circulation pump 24 provided in the sterile gas circulation pipe 26.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: October 11, 2016
    Inventors: Shinji Osawa, Tetsuya Miyoshi
  • Patent number: 9428734
    Abstract: A method and device for growing plant, animal or stem cells in a continuous manner.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: August 30, 2016
    Inventor: Eudes Francois Marie De Crecy
  • Patent number: 9347912
    Abstract: A sensor adapter is described for the noninvasive positioning of a sensor, especially of an electrochemical sensor, in a medium. The sensor adapter comprises an accommodating channel, in which the sensor can be positioned and the one end region of which is closed off by a semipermeable membrane. Moreover, the sensor adapter comprises a hollow cylindrical sealing structure, which is disposed within the accommodating channel coaxially with the longitudinal axis of the latter and with which the sensor can be disposed gas tight adjacent to the semipermeable membrane.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: May 24, 2016
    Assignee: Eppendorf AG
    Inventors: Jochen Beese, Sven Eikelmann, Jeff Watkins, Rafael Kopla
  • Patent number: 9339818
    Abstract: A device for isolating and cultivating live cells on a filter or for extracting the genetic material thereof includes: a filter holder (108) connected to a filter; a compartment (102) having an upper opening and a lower opening; and an element (110) that is mobile relative to the compartment for applying a force on the holder and releasing the holder. According to the embodiments, the filter holder is mechanically connected to the compartment or to the mobile element until the application of the force. Preferably, the device further includes a removable end piece (104) tightly and removably attached and adapted for preventing the relative movement of the mobile element and the compartment for applying the force and releasing the holder.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: May 17, 2016
    Assignee: SCREENCELL
    Inventor: Yvon Cayre
  • Patent number: 9321698
    Abstract: The method is for reaction treatment including: an organic waste in which oxygen is difficult to penetrate and in which a biochemical reaction by microbe is difficult to occur. This method includes: forcedly supplying oxygen to inner parts of the organic waste to elevate, by biochemical reactions, the temperature of the inner parts of the organic waste to which oxygen has been supplied; and maintaining the elevated temperature to continue the biochemical reactions and thereby compost the organic waste. Thereafter, the organic waste which has been composted is held in the presence of oxygen and carbon monoxide to cause an exothermic reaction and thereby reduce the volume of the organic waste or carbonize the waste.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: April 26, 2016
    Inventor: Kazunori Iwabuchi
  • Patent number: 9268346
    Abstract: Disclosed herein is a reactor including, a plurality of reaction regions, and a plurality of heaters, each arranged in each of the reaction regions, wherein the heater including a semiconductor heat generating element and a semiconductor temperature detecting element and being capable of independent temperature control, and the temperature detecting element having a heat conduction region of metal thin film in its surrounding region.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: February 23, 2016
    Assignee: Sony Corporation
    Inventors: Toshiki Moriwaki, Nobuhiro Kanai, Takanori Anaguchi
  • Patent number: 9261439
    Abstract: A system for depositing cells on an analysis plate, the cells being contained in a cell suspension including a fixing agent and the cells, included, for receiving the suspension, a chamber (5) which is positioned above the analysis plate and whose base is open and extends opposite a cell depositing zone of the plate and a material for absorbing the fixing agent placed around the chamber and the depositing zone of the plate. The chamber is mounted so as to be able to be moved between a first position in abutment against the analysis plate in order to allow the cells to be deposited on the depositing zone of the plate via decantation and a second position remote from this analysis plate in order to place the chamber in a fluid relationship with the absorption material in order to allow this material to absorb the fixing agent.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: February 16, 2016
    Assignee: NOVACYT
    Inventor: Eric Roger Louis Peltier
  • Patent number: 9260687
    Abstract: An apparatus for contacting a fluid stream with microorganisms is provided, the apparatus comprising a housing having a contacting chamber therein defined by a wall of the housing; a first inlet for the fluid stream to be treated; a first outlet for removing a liquid culture medium stream containing microorganisms; a rotor assembly comprising an impeller moveable within the contacting chamber to promote contact between the fluid stream being treated and the liquid culture medium within the contacting chamber; wherein at a least a portion of the wall of the housing defining the contacting chamber is transparent to light.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: February 16, 2016
    Inventor: Steven Skill
  • Patent number: 9260684
    Abstract: A cell culture device comprises a well. A plurality of microwells are within the well, and a first common fluid volume is within the well above the microwells. A set of sub-microwells are within each microwell, and a second common fluid volume is within each microwell above the set of sub-microwells.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: February 16, 2016
    Assignee: Stemcell Technologies Inc.
    Inventors: Oliver Egeler, Steven Woodside
  • Patent number: 9260688
    Abstract: Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: February 16, 2016
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • Patent number: 9221055
    Abstract: Nucleic acid analysis apparatus includes a plurality of temperature adjustment apparatuses, a rotating mechanism, a delivery base and an ejection base, a delivery drive mechanism, an ejection drive mechanism, and a detection apparatus. The rotating mechanism can include a rotating shaft and a plurality of pressing portions that rotate around the rotating shaft. The reaction plate assembly can move over the temperature adjustment apparatuses along the circumferential direction in a state of being pressed onto the temperature adjustment apparatuses by the pressing portions. The delivery drive mechanism can cause the reaction plate assembly to be moved radially inward and delivered between the pressing portions and temperature adjustment apparatuses. The ejection drive mechanism can cause the reaction plate assembly to be moved radially outward and ejected from between the pressing portions and temperature adjustment apparatuses onto the ejection base.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: December 29, 2015
    Inventors: Yasunori Shoji, Muneo Maeshima, Chihiro Uematsu, Makiko Takahashi, Kyoko Imai
  • Patent number: 9174210
    Abstract: A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a macrofluidic component, including a chamber for receiving an unprocessed sample from a collection device and at least one filled liquid purification reagent storage reservoir; and (ii) a microfluidic component in communication with the macrofluidic component through at least one microfluidic element, the microfluidic component further comprising at least one nucleic acid purification matrix; and (iii) at least one interface port to a drive mechanism on the instrument for driving said liquid purification reagent, through the microfluidic element and the nucleic acid purification matrix, wherein the only inputs to the apparatus are through the chamber and the interface port to the drive mechanism.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: November 3, 2015
    Assignee: NetBio, Inc.
    Inventors: Richard F. Selden, Eugene Tan
  • Patent number: 9102574
    Abstract: A composting machine, particularly for vermicompost, is elongated in shape. Grates with openings are laid into a frame of the machine, onto cross beams which correctly locate the grates to be closely adjacent to one another except along a longitudinal center line of the machine, where the spaced-apart grates form a guiding channel through the length of the machine. Within this travels a downwardly extending keel of a carriage that is moved through the length of the machine when a bottom layer of finished compost is to be harvested from the bottom of the mass of compost material. To the carriage is attached a cutting blade extending the width of the machine, driven by longitudinal tension lines under the control of a driving motor. A tensioner maintains tension in the cable.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 11, 2015
    Inventors: Jack L. Chambers, Thomas R. Craig, David Zappetini
  • Patent number: 9055740
    Abstract: The invention provides, in various embodiments, systems and devices relating to a blood product heater for use in an ex-vivo organ care. In certain embodiments, the invention relates to maintaining a perfusion fluid flowing through the heater at near-physiologic conditions.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: June 16, 2015
    Assignee: TRANSMEDICS, INC.
    Inventors: Waleed Hassanein, Robert Fishman, Stanley Kyi, Scott Newell, Burt Ochs, Jonathan Rourke, Robert Havner
  • Patent number: 9057715
    Abstract: The present invention relates to a cell culture apparatus and a mass automatic cell culture device having it. There is provided a cell culture apparatus comprising a cylindrical cell culture flask which is air-tightly sealed and formed of a transparent material to observe an internal portion thereof, an injection unit for supplying the cell and the culture solution into the cell culture flask, a collection unit for discharging the cells and the culture solution from the cell culture flask, and a cell culture flask receiving part which is comprised of first and second vertical frames in which a plurality of injecting parts and collecting parts, and plate type connection parts which are respectively disposed between upper ends and lower ends of the two opposed vertical frames to be spaced apart from each other in regular intervals, and a mass automatic cell culture device having it.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: June 16, 2015
    Assignee: CORESTEM CO., LTD.
    Inventors: Kyung Suk Kim, Jai Jun Choung
  • Patent number: 9040288
    Abstract: This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 26, 2015
    Assignee: HandyLab, Inc.
    Inventors: Kalyan Handique, Sundaresh N. Brahmasandra, Karthik Ganesan, Betty Wu, Nikhil Phadke, Gene Parunak, Jeff Williams
  • Patent number: 9017997
    Abstract: The invention relates to a bioreactor for cultivating cells having a filter bag for separating culture fluid and cells, the filter medium of the filter bag having a degree of swelling of less than 1%. The bioreactor according to the invention is characterized by a high durability of the filter bag thereof.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: April 28, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Eberhard Wuenn, Gerhard Greller, Thorsten Adams