Patents Examined by Michael B. Hydorn
  • Patent number: 5243088
    Abstract: Dibromonaphthalene compounds having the formula (1): ##STR1## are 1-monodebrominated by reacting same, neat or in an acid organic solvent, with molecular hydrogen or a compound that generates nascent hydrogen, in situ, in the medium of reaction, in the presence of a catalytically effective amount of a hydrodebromination catalyst.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: September 7, 1993
    Assignee: Potasse et Produits Chimiques
    Inventors: Roland Jacquot, Francoise Truchet
  • Patent number: 5243094
    Abstract: Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.
    Type: Grant
    Filed: July 11, 1991
    Date of Patent: September 7, 1993
    Assignee: Medafor
    Inventor: Jacques Borg
  • Patent number: 5242925
    Abstract: Piperazinylbenzodioxane derivatives of formula I ##STR1## wherein B is an indol-3-yl or benzimidazol-1-yl radical which is unsubstituted or monosubstituted by CN, CO--R.sup.1, C.sub.n H.sub.2n --R.sup.1, Hal, OH, OA, O--C.sub.n H.sub.2n --CO--R.sup.1, or NHR.sup.2, and Q is C.sub.n H.sub.2n, or a physiologically acceptable salt thereof. The derivatives are active in the central nervous system, especially as serotonin agonists and antagonists.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: September 7, 1993
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Boettcher, Christoph Seyfried, Hartmut Greiner, Gerd Bartoszyk
  • Patent number: 5241121
    Abstract: A process for preparing 4,4'-dihydroxydiphenylsulfone, the process including heating 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone in the presence of an acid catalyst to isomerize the 2,4'-dihydroxydiphenylsulfone into 4,4'-dihydroxydiphenylsulfone, the process being characterized in that a suspension of 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone in a liquid dispersing medium is heated for isomerization while the liquid portion is distilled off or a crystal mixture of 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone is heated for isomerization to produce 4,4'-dihydroxydiphenylsulfone in the form of crystal powder.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: August 31, 1993
    Assignee: Konishi Chemical Ind. Co., Ltd.
    Inventors: Eiji Ogata, Nobuyuki Nate, Kazuo Hamano
  • Patent number: 5241062
    Abstract: The hydroxyl group in a pyrrolic compound having in the 2-position thereof a group having the formula R(OH)CH--R is hydrocarbyl or substituted hydrocarbyl, is replaced by a group, for example a p-nitrobenzoate group, having better leaving properties than those of hydroxyl for a subsequent self-condensation and cyclization of the pyrrolic compound to form a meso-hydrocarbyl or meso-substituted hydrocarbyl porphyrin.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: August 31, 1993
    Assignee: Sun Company, Inc. (R&M)
    Inventors: Tilak P. Wijesekera, Richard W. Wagner
  • Patent number: 5238959
    Abstract: The present invention provides 3-(4-substitutedphenoxy)-3-phenyl propanamines capable of inhibiting the uptake of serotonin. These compounds are useful for treating many pharmacological disorders, including depression and obesity. These compounds can also be used to reduce the desire to smoke and consume alcohol.
    Type: Grant
    Filed: April 20, 1992
    Date of Patent: August 24, 1993
    Assignee: Eli Lilly and Company
    Inventors: David W. Robertson, David T. Wong
  • Patent number: 5237067
    Abstract: This application is directed to optoelectronic materials which are bistable organic tautomeric compositions of dithio or diseleno carbamate esters of cyclic 1,3-dithia or -diselena-2-iminium salts. Specifically, it is concerned with compounds having the formula: ##STR1## Wherein X is S or Se; wherein R or R.sub.1 are alkyl, or alkyl that together form a ring of carbon atoms; wherein An is the anion of a strong acid. These molecules are in themselves molecular-sized optoelectric switching devices.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: August 17, 1993
    Inventor: Robert R. Schumaker
  • Patent number: 5237111
    Abstract: A process for the etherification and separation of C.sub.3 -C.sub.5 hydrocarbons is improved by the advantageous integration of an oxygenate recovery unit having a 3-bed arrangement into the etherification separation section. A feedstream including C.sub.3 hydrocarbons and isobutene are reacted with methanol in an etherification to produce an etherification effluent that is separated in a first separator into a bottoms stream of MTBE product and an overhead stream of unreacted isobutane, methanol, other oxygenate compounds and C.sub.3 -hydrocarbons. After recovery of methanol, in an adsorptive separation process, the methanol deficient overhead stream enters a second separation zone in the form of depropanizer for the separation of isobutane and higher boiling hydrocarbons from the C.sub.3 hydrocarbons. Any oxygenate compounds that are carried from the bottom of the column with the C.sub.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: August 17, 1993
    Assignee: UOP
    Inventors: Carmen M. Yon, John P. Brady, Joe Quock
  • Patent number: 5237106
    Abstract: A process for improving the catalytic activity of a partially deactivated solubilized rhodium-tertiary organophosphine complex hydroformylation catalyst by treating it with propargyl alcohol and a carboxylic acid.
    Type: Grant
    Filed: January 24, 1992
    Date of Patent: August 17, 1993
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: James E. Babin, David R. Bryant, Arnold M. Harrison, David J. Miller
  • Patent number: 5235056
    Abstract: 1-Hydroxy-2,6-diaryl-4-piperidone ketal derivatives, such as the compound of formula I ##STR1## wherein Ar.sub.1 and Ar.sub.2 are each phenyl, R.sub.1 to R.sub.6 are all hydrogen, X.sub.1 and X.sub.2 are each --O-- and T is a direct bond, are novel compounds and are effective process stabilizers, such as polypropylene, for polymers processed at elevated tempertures providing both good melt flow stabilization and good resistance against discoloration during said processing.
    Type: Grant
    Filed: April 22, 1992
    Date of Patent: August 10, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Glen T. Cunkle, Donald J. Sabrsula
  • Patent number: 5235054
    Abstract: The following 3-carboxaldehyde quinolines and naphthyridines have antibacterial activity ##STR1## wherein A, Y, R, and R.sub.2 are as defined herein. These compounds are particularly suitable for administration by injection. A specific example of such compound is 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-y l]-4-oxo-1,4-dihydroquinoline-3-carboxaldehyde.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: August 10, 1993
    Assignee: Pfizer Inc.
    Inventor: Martin R. Jefson
  • Patent number: 5232951
    Abstract: A continuous flow method and system is provided for converting environmentally pollutant by-product waste gases emitted during the manufacture of silicon carbide in a first manufacturing plant to methanol in a second manufacturing plant such that release of the gases into the atmosphere may be prevented.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: August 3, 1993
    Assignees: Exolon-ESK Company, Elektroschmelzwerk Kempten GmbH
    Inventors: Hans Pfingstl, Walter Martyniuk, Armand Ladage, Tom McNally, Robert Myers, Ludwig Eberle
  • Patent number: 5231223
    Abstract: Substituted olefins of the formula (I) ##STR1## are prepared by reaction of a compound of the formula (II) ##STR2## with a compound of the formula (III)R--CH--CH.sub.2in the presence of an organic and/or inorganic palladium salt as a catalyst using water and/or an alcohol as a solvent, the substituents and indices being defined in the disclosure.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: July 27, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Axel Bader, Dieter Arlt, Dietmar Fiedel, Stefan Meier
  • Patent number: 5229136
    Abstract: The present invention provides an enteral product for providing nutritional requirements to a patient comprising: a caloric content of less than 1.00 Kcal/ml;. an osmolality of less than 300 mOsm; and a fiber content of preferably greater than 15 gms/liter. Additionally, the present invention provides a method of providing nutrition to a patient through a tube-fed enteral product and reducing the risk of diarrhea comprising the steps of: providing a sterile enteral product, that does not require diluting, having an osmolality of less than 300 mOsm and a caloric content of less than 1.0 Kcal/ml, but, having a fiber content of greater than 15 gms/liter; and enterally administering the product to a patient.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: July 20, 1993
    Assignee: Clintec Nutrition Co.
    Inventors: David A. Mark, Lance Stalker
  • Patent number: 5229416
    Abstract: Avermectin derivatives are disclosed which incorporate two fluorine atoms at the 4' monosaccharide position, the 4" disaccharide position or the 23 position. Avermectin aglycone derivatives are also disclosed which incorporate two fluorine atoms at position 13 or 23. These difluoro avermectin analogs are derived from corresponding ketones and enones which in turn are prepared by chemical modification of naturally occurring avermectins. These compounds are used as antiparisitic, insecticidal and antihelmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Peter T. Meinke, Helmut Mrozik, Michael H. Fisher
  • Patent number: 5225438
    Abstract: The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X.sup.1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X.sup.1 is a group of the formula--X.sup.4 --CR.sub.2 -- or --CR.sub.2 --X.sup.4 --whereinX.sup.4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl;each of Ar.sup.2 and Ar.sup.3 is optionally substituted phenylene;X.sup.2 is oxy, thio, sulphinyl or sulphonyl;R.sup.1 is (1-4C)alkyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.1 --X.sup.3 --A.sup.2 -- which together with the carbon atom to which A.sup.1 and A.sup.2 are attached define a ring having 5 to 7 ring atoms, wherein each of A.sup.1 and A.sup.2 is (1-3C)alkylene and X.sup.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: July 6, 1993
    Assignees: Imperial Chemical Industries PLC, I.C.I.-Pharma
    Inventors: Robert I. Dowell, Philip N. Edwards, Keith Oldham
  • Patent number: 5219867
    Abstract: The present invention relates to substantially pure stereoisomers of a compound of the formula: ##STR1## wherein n.sub.1 and n.sub.2 are the same or different and are 1 or 2; X is alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10) or aralkyl (C.sub.7 -C.sub.12); and wherein R, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are chosen from H, alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10), aralkyl (C.sub.7 -C.sub.12), or a heterocyclic group, and addition salts thereof with pharmaceutically acceptable acids. The invention also relates to a method for the inhibition of blood platelet aggregation in a blood supply comprising administering to said blood supply a blood platelet aggregation inhibiting amount of the compounds of the present invention.
    Type: Grant
    Filed: August 10, 1992
    Date of Patent: June 15, 1993
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Ramachander Gollamudi, Zixia Feng
  • Patent number: 5214180
    Abstract: Phosphatidylinositol of high purity useful for the treatment of central nervous system disorders, prepared from vegetal substances containing it by treating them with reagents suitable for the functionalization of the inositol hydroxy group with protective groups, separating the thus protected phosphatidylinositol by solvent extraction or chromatography, and finally removing said protective groups under conditions which do not modify the phosphatidyl group.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: May 25, 1993
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Enrico Ferrari, Pier Giuseppe Pagella, Stefano Maiorana, Mario Brufani
  • Patent number: 5210195
    Abstract: Polyoxyalkylene diamines react with excess acrylate to form diesters which react with 2,2',6,6'-tetramethyl-4-aminopiperidines to give a product of formula 1, useful as photostabilizer for photosensitive materials.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: May 11, 1993
    Assignee: Texaco Chemical Co.
    Inventors: Jiang-Jen Lin, George P. Speranza
  • Patent number: 5210258
    Abstract: Optically active naphthyl alpha-substituted alkyl ketones, are a class of ketones useful as intermediates in the production of optically active alpha-naphthylalkanoic acids which exhibit anti-inflammatory, analgesic and anti-pyretic activity.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: May 11, 1993
    Assignee: Syntex Pharmaceuticals International Ltd.
    Inventor: George C. Schloemer