Patents Examined by Michael Paul Shimek
  • Patent number: 10794896
    Abstract: Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample. The blood coagulation system examination module includes a thrombin potential examination unit configured to examine thrombin potential on the basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: October 6, 2020
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marcaurele Brun, Shinji Omori
  • Patent number: 10758877
    Abstract: Disclosed are a sample pretreatment module and a sample pretreatment method using the same. The sample pretreatment module including: a body having a chamber for accommodating a sample therein; a cap coupled to one end of the body; a dotting substrate provided to have at least some portion of it dotted with the reagent and be inserted into the chamber; a discharge tip movably coupled to the other end of the body for discharging a sample accommodated in the chamber; a permanent magnet provided to be inserted in the chamber and mix the sample by rotating owing to a magnetic force acting in accordance with a change in a magnetic field externally applied; and a moving unit movably provided in the cap and pressing the sample in the chamber according to the movement to discharge the sample to the outside.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: September 1, 2020
    Assignee: NANOENTEK, INC.
    Inventor: Yu-Rae Kim
  • Patent number: 10758905
    Abstract: The present invention relates to the use of acoustic waves for the manipulation and sorting of particles and cells. In an embodiment, there is provided a microfluidic device for manipulating a particle in a fluid suspension, the device comprising: (a) a substrate; (b) a channel defined in the substrate, the channel having an inlet for receiving the fluid suspension and an outlet for discharging the fluid suspension; and (c) an acoustic source configured to deliver a travelling surface acoustic wave transverse the flow of the fluid suspension in the channel, wherein the acoustic source is an interdigital transducer (IDT), the IDT comprises a plurality of concentric circular arcs having a tapered end directed at the channel, and the tapered end has an aperture of between 4 ?m and 150 ?m. In an alternative embodiment, the device comprises a second channel disposed intermediate the first channel and the acoustic source wherein the first and second channels are connected by a pumping channel.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: September 1, 2020
    Assignee: Singapore University of Technology and Design
    Inventors: Ye Ai, David John Collins
  • Patent number: 10751717
    Abstract: A microfluidic chip for collecting dielectric particles in a fluid sample to be tested includes an insulating substrate, a first interdigitated electrode, a second interdigitated electrode, and a dielectric layer. The dielectric layer is formed on the first and second interdigitated electrodes and is made from a semiconductive inorganic material having a dielectric constant of from 3.7 F/m to 80 F/m.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 25, 2020
    Assignee: National Cheng Kung University
    Inventors: Hsien-Chang Chang, Tien-Chun Tsai, Yen-Liang Cho, Zong-Zhan Wu, Peng-Ting Chen
  • Patent number: 10753950
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: August 25, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 10753853
    Abstract: A method of evaluating the corrosion resistance of a coated metal substrate, the method including putting a liquid composition into contact with a corrosion protection coating present on the surface of a metal substrate, the liquid composition including water, a gelling agent, corrosion-catalyst ions, and a color pH indicator; gelling the liquid composition in order to form a corrosion-accelerator gel in contact with the coating; performing a corrosion test during which the gel that has formed is left in contact with the corrosion protection coating; and evaluating the corrosion resistance of the substrate coated by the corrosion protection coating by observing the color of the color pH indicator present in the gel after performing the corrosion test.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 25, 2020
    Inventors: Marie Betaille-Francoual, Loïc Oger, Anaïs Lecaplain
  • Patent number: 10746725
    Abstract: Endotoxin is detected by electrochemical measurement. A detection device 15 of endotoxin detects endotoxin contained in a fluid to be tested (for example, a dialysate) specifically in the following manner. First, the fluid to be tested is brought into contact with an adsorbent 17 that adsorbs endotoxin to cause the adsorbent 17 to adsorb the endotoxin. Then, a basic solution is brought into contact with the adsorbent 17 to desorb the endotoxin. Electrochemical measurement of the basic solution containing the desorbed endotoxin is performed. The endotoxin can be detected by the electrochemical measurement with high sensitivity at low cost.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 18, 2020
    Inventors: Jiye Jin, Nobuyuki Kurashina, Junichiro Soejima, Toshiharu Sawada
  • Patent number: 10737233
    Abstract: The invention relates to a flow element for transferring fluids comprising a capillary cartridge (1) having an integrated capillary line (3). The capillary cartridge according to the invention (1) has a ring-shaped channel (8) and securing grooves (6, 6?), wherein the flow element is characterized in that the capillary line (3) is arranged in the ring-shaped channel (8). The ends of the capillary lines (3) are connected to connection elements (9) in which securing grooves (6, 6?) are secured in a positive locking manner. The flow elements according to the invention contribute toward improved manageability and effectiveness of components. In a preferred embodiment, the flow elements are used as a distribution system in the form of a plurality of capillary cartridges (1-1, 1-2, . . . ). Such distribution systems are of technical importance in the field of catalyst testing apparatuses with reactors arranged in parallel.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: August 11, 2020
    Assignee: hte GmbH the high throughput experimentation company
    Inventors: Armin Brenner, Oliver Koechel, Sebastian Keim, Frank Guellich, Joerg Braschkat
  • Patent number: 10732154
    Abstract: A two-dimensional liquid chromatography (2D-LC) apparatus and method of its use, the apparatus constructed with (1) a first dimension (first-D) having at least one first chromatography column, (2) at least one multi-port stream selector in fluid communication with the at least one first chromatography column for receiving an effluent therefrom, and (3) a second dimension (second-D) having a plurality of second chromatography columns, each second chromatography column in fluid communication with a corresponding port of the at least one multi-port stream selector for receiving an effluent fraction of the effluent from the at least one first chromatography column, thereby enabling simultaneous chromatographic separation by the plurality of second chromatography columns of a set of multiple effluent fractions outputted from the at least one first chromatography column.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 4, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Shaorong Liu, Zaifang Zhu
  • Patent number: 10725011
    Abstract: A chemical oxygen demand (COD) of a sample including water is determined. At least two test specimens are obtained. Each of the test specimens include a mixture of the sample and a standard solution including potassium hydrogen phthalate (KHP) in a known concentration. Each of the specimens include a same amount of the sample. Each of the specimens include different amounts of the standard solution. Each of the specimens is diluted with water. A COD of each of the specimens is measured. A COD of the sample is determined based on the measured CODs of the specimens.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 28, 2020
    Assignee: Saudi Arabian Oil Company
    Inventors: Nasir Ullattumpoyil, Abdulaziz M. Rueshed
  • Patent number: 10718760
    Abstract: A method of determining the specific binding of ligand reversibly binding to a binding site in a sample using displacement competitive inhibition. The method comprising incubating the ligand (unlabeled) in the absence of a labeled ligand on a first tissue specimen, incubating the ligand (unlabeled) in the presence of a labeled ligand on a second tissue specimen, the first and the second tissue specimens being adjacent sections of specimen. MALDI imaging mass spectrometry is used to subsequently visualizing bound ligand localization, using in the first and second tissue specimen, respectively.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 21, 2020
    Assignee: TREAT4LIFE AB
    Inventors: Gyorgy Marko-Varga, Thomas Fehniger, Yutaka Sugihara
  • Patent number: 10690680
    Abstract: A method to analyze the activity of an ion channel comprising: providing in a hydrophobic medium a first droplet of an aqueous solution AS1 comprising a concentration q of an ion I with c1?0, wherein the droplet is surrounded by a monolayer of amphiphilic molecules; providing in the hydrophobic medium a second droplet of an aqueous solution AS2 comprising a concentration c2 of the ion I with c2?0, and c2?c1, wherein the second droplet is surrounded by a monolayer of amphiphilic molecules further comprising the ion channels to an analyzed; bringing the first droplet and the second droplet into contact so as to form a bilayer of amphiphilic molecules, wherein the bilayer further comprises ion channels to be analyzed, and measuring the radius of the two droplets when they are brought into contact referred to as initial state; and maintaining the first droplet and the second droplet in contact until equilibrium is reached and measuring the radius of the two contacted droplets or determining the number of resultin
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 23, 2020
    Assignees: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Abdou Rachid Thiam, Béatrice Schaack
  • Patent number: 10684277
    Abstract: A method for colorimetric detection of cholesterol in a sample is disclosed. The method includes adding beta-cyclodextrin and cholesterol to a phenolphthalein indicator solution in the presence of a phosphate buffer solution to create a solution medium and quantifying the cholesterol as a function of a complexed beta-cyclodextrin in the solution medium.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: June 16, 2020
    Assignee: COMSATS Institute of Information Technology
    Inventors: Akhtar Hayat, Muhammad Azhar Hayat Nawaz