Patents Examined by Nam P Nguyen
  • Patent number: 11116848
    Abstract: A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: September 14, 2021
    Assignee: University of Notre Dame du Lac
    Inventors: Zihni Basar Bilgicer, Nathan J. Alves
  • Patent number: 11119097
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 14, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ye Lu, Joseph J. Mitala, Bohdana Discher, Brett R. Goldsmith
  • Patent number: 11105807
    Abstract: Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for ?-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-?-N-acetylgalactosamine antibody, to the prostate-specific antigen.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 31, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tomonori Kaneko, Takatoshi Kaya
  • Patent number: 11092604
    Abstract: The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 17, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Nicholas Paul Barwell, Tony James
  • Patent number: 11085920
    Abstract: Nanodiamond particles and related devices and methods, such as nanodiamond particles for the detection and/or quantification of analytes, are generally described. In some embodiments, the device comprises a plurality of nanodiamond particles and a species bound to the nanodiamond particles. In certain embodiments, the plurality of nanodiamond particles may be exposed to a sample suspected of containing an analyte. In some cases, the analyte may bind to the species such that the presence of the analyte in the sample may be detected. In some embodiments, the devices, systems, and methods described herein are useful for the detection of an analyte in a sample obtained from a subject for, for example, diagnostic purposes. In some cases, the systems, devices, and methods described herein may be useful for diagnosing, prevent, treating, and/or managing a disease or bodily condition.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: August 10, 2021
    Assignee: Debina Diagnostics, Inc.
    Inventors: Giora Z. Feuerstein, Mark E. Sternberg
  • Patent number: 11085929
    Abstract: Certain embodiments of the invention provide TiO2 nanoshell particles, methods of fabricating TiO2 nanoshell particles, and methods of enriching peptides in a sample using TiO2 nanoshell particles.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: August 10, 2021
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, THE METHODIST HOSPITAL
    Inventors: Ye Hu, Yang Bu
  • Patent number: 11079377
    Abstract: A process for monitoring binding events, a coating compound, and a device for monitoring binding events are disclosed. The process includes providing two reservoirs that contain an electrically conductive fluid, wherein the reservoirs are separated by a membrane having a nanopore. The process also includes selecting a target compound, selecting a ligand based on the selection of the target compound, and preparing a coating that includes the coating compound, wherein the coating compound includes the ligand and a moiety that immobilizes the ligand. Additionally, the process includes applying the coating to the inner surface of the nanopore, adding the target compound to a conductive liquid in the first chamber, establishing a voltage gradient across the membrane, and electrically monitoring translocation of the target molecule. The device includes the reservoirs and the membrane having the coated nanopore.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: August 3, 2021
    Assignee: International Business Machines Corporation
    Inventors: Priscilla Racquel Rogers, Stefan Harrer, Ali Afzali-Ardakani, Jose Miguel Lobez Comeras, Sung Cheol Kim, Natalie J. Gunn
  • Patent number: 11067581
    Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: July 20, 2021
    Assignees: NSPC TECHNOLOGIES, LLC, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, William J. Sonstein, Fuming Zhang
  • Patent number: 11054417
    Abstract: For fluorescent nanoparticles having a zeta potential of ?10 mV to ?60 mV at pH 7.0 or a zeta potential of 0 mV to ?10 mV in a buffer of pH 6.0 to 8.0, an appropriate electrical repulsive force can be generated between biomolecules that are generally negatively charged and the fluorescent nanoparticles. As a result, non-specific binding between the fluorescent nanoparticles and the biomolecules is suppressed and the fluorescent nanoparticles are specifically bound to a biomolecule to be stained through interaction stronger than the electrical repulsive force, so that the visibility of the specific biomolecule to be stained can be improved. Further, since an appropriate electrical repulsive force is also generated between the fluorescent nanoparticles themselves, aggregation of the fluorescent nanoparticles can be inhibited and the dispersibility in a staining solution can thereby be maintained.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: July 6, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Masaru Takahashi, Kensaku Takanashi, Fuminori Okada
  • Patent number: 11047851
    Abstract: Nanodiamond particles and related devices and methods, such as nanodiamond particles for the detection and/or quantification of analytes, are generally described. In some embodiments, the device comprises a plurality of nanodiamond particles and a species bound to the nanodiamond particles. In certain embodiments, the plurality of nanodiamond particles may be exposed to a sample suspected of containing an analyte. In some cases, the analyte may bind to the species such that the presence of the analyte in the sample may be detected. In some embodiments, the devices, systems, and methods described herein are useful for the detection of an analyte in a sample obtained from a subject for, for example, diagnostic purposes. In some cases, the systems, devices, and methods described herein may be useful for diagnosing, prevent, treating, and/or managing a disease or bodily condition.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: June 29, 2021
    Assignee: Debina Diagnostics, Inc.
    Inventors: Giora Z. Feuerstein, Mark E. Sternberg
  • Patent number: 11011603
    Abstract: Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: May 18, 2021
    Assignee: Life Technologies Corporation
    Inventors: Joseph Bartel, Yongfen Chen, Noah Lermer, Timothy Carter, Scott Sweeney, Chad Teters, Wenxi Huang
  • Patent number: 11002730
    Abstract: The compositions described herein include a substrate, wherein the substrate is a metal, metal oxide, metal nitride or a silicon containing material; a self-assembled monolayer (SAM) bonded to the substrate, wherein the self-assembled monolayer comprises: a surface binding unit bonded to the substrate, wherein the surface binding unit is selected from the group consisting of hydroxamates, phosphonates, catechols, halosilanes, alkoxysilanes, phosphonic acids, alkenes, alkynes, alcohols, 1,2-diols, and thiols; a separator unit bonded to the surface binding unit; a mass altering unit bonded to the separator unit; and a detector unit bonded to the separator unit.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: May 11, 2021
    Assignee: International Business Machines Corporation
    Inventors: Bharat Kumar, Sufi Zafar, Ali Afzali-Ardakani
  • Patent number: 11002736
    Abstract: SUSD2 protein is used as a marker in identification, selection or separation of pancreatic internal secretion precursor cells and/or newborn pancreatic internal secretion cells; and a use of an mRNA, for encoding the SUSD2 protein, of a precursor protein as the marker in identification of the pancreatic internal secretion precursor cells and/or the newborn pancreatic internal secretion cells. Analysis of gene expression of pancreatic endoderm cells sourced by induced directional differentiation of human pluripotent stem cells finds the enrichment expression of a SUSD2 gene in the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells. A protein encoded by the SUSD2 gene is a receptor protein on cell membranes. Using the protein as the marker, the identification, the selection or the separation of the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells can be conducted.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: May 11, 2021
    Assignees: PEKING UNIVERSITY, PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL, BEIJING RUIPU CHENCHUANG TECHNOLOGY CO., LTD.
    Inventors: Hongkui Deng, Haisong Liu, Dicong Zhu, Huan Yang, Zhen Liang
  • Patent number: 10976309
    Abstract: Provided herein are methods, compositions and kits for labeling of target proteins such as antibodies. The methods, compositions and kits are suited for labeling of such proteins that are mixed with other non-target molecules including BSA, gelatin, and other complex biological molecules.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: April 13, 2021
    Assignee: BIOTIUM, INC.
    Inventors: Fei Mao, Lori Michelle Roberts, Chingying Cheung
  • Patent number: 10968263
    Abstract: Problems to be Solved The present invention provides an affinity support capable of trapping a substance by cooperative binding that is less likely to cause dissociation even when the substance is a molecule other than an antibody, and a trapping method using the same. Means to Solve the Problems A method of trapping a substance comprising the step of contacting an objective to be trapped with an affinity support comprising a support, a spacer bound to the support and an affinity substance bound to the spacer, so as to bind the objective to be trapped to the affinity substance, wherein each one of the objective to be trapped has a plural of affinity sites and the affinity substance binds to at least two of the affinity sites simultaneously.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: April 6, 2021
    Assignee: BIOMOLECULAR HOLDINGS LLC
    Inventor: Daniel J. Capon
  • Patent number: 10962536
    Abstract: The invention is related to the field of biotechnology, specifically to the investigation of biomolecular interactions and sensing of biomolecules using a surface plasmon resonance. The biological sensor and a method of its production based on the thin films of graphene, graphene oxide, or single-walled or multi-walled carbon nanotubes are described. The technical results of the invention are a high sensitivity of the biosensor in combination with a high biospecificity; an expansion of the range of device applications; the protection of the metal film from an environmental exposure; the possibility to detect large biological objects.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: March 30, 2021
    Assignee: MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY (STATE UNIVERSITY)
    Inventors: Alexey Vladimirovich Arsenin, Yury Viktorovich Stebunov
  • Patent number: 10955419
    Abstract: Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: March 23, 2021
    Assignee: University of Washington
    Inventor: Daniel T. Chiu
  • Patent number: 10935545
    Abstract: The present invention relates to a simultaneous analysis method for a target using a plurality of metal nano-tags and, more particularly, to a simultaneous analysis method for a target using a plurality of metal nano-tags, wherein the method fuses a nano-particle technology on the basis of an antigen-antibody reaction, which is a conventional biological immune response, and simultaneously diagnoses a plurality of target materials by using a plurality of antigen-antibody reactions and a plurality of metal nano-tags, thereby enhancing diagnostic effect.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 2, 2021
    Inventors: Hae Ran Mun, Jong Su Kim, Inae Kim
  • Patent number: 10890586
    Abstract: A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts to the click chemistry moiety of the carbohydrate such that the label attaches to the carbohydrate to form a labeled proteoglycan; immobilizing the labeled proteoglycan on a multi-well plate, wherein the multi-well plate includes a specific anti-proteoglycan antibody for binding the labeled proteoglycan; treating the labeled proteoglycan with an endoglycosidase specific to the glycosaminoglycan chain; and detecting the labeled proteoglycan.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: January 12, 2021
    Assignee: BIO-TECHNE CORPORATION
    Inventors: Zhengliang L. Wu, Xinyi Huang, Cheryl M. Ethen
  • Patent number: 10890582
    Abstract: A sensor for detecting an analyte can include a photoluminescent nanostructure embedded in a sensor hydrogel. The sensor hydrogel can be supported by a substrate hydrogel.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: January 12, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nigel F. Reuel, Michael S. Strano