Patents Examined by Natalia Harkaway
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Patent number: 4160841Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles, useful as antifungal and antibacterial agents.Type: GrantFiled: November 21, 1977Date of Patent: July 10, 1979Assignee: Janssen Pharmaceutica, N.V.Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
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Patent number: 4160097Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups.Type: GrantFiled: December 8, 1977Date of Patent: July 3, 1979Assignee: Westwind Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4160098Abstract: Pyrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable nontoxic salts thereof wherein R is hydrogen, trifluoromethyl or alkyl;R.sup.1 is hydrogen or alkyl;R.sup.2 is alkyl;R.sup.3 is an unsubstituted or substituted aryl moiety;R.sup.3 is naphthyl or pyridyl; andR.sup.4 is R.sup.5 CO wherein R.sup.5 is alkyl unsubstituted or substituted by 1, 2 or 3 halogen moieties, by alkoxy, or by mono- or dialkylamino; lower alkoxy; dialkylamino; thiophene; phenyl unsubstituted or substituted by 1 or 2 alkyl, trifluoromethyl, alkoxy, nitro or halogen moieties; or a 5- to 7-membered heterocycle unsubstituted or substituted by 1 or 2 halogen, alkyl or nitro moieties; orR.sup.4 is Z-SO.sub.2 wherein Z is alkyl, phenyl or phenyl substituted by 1 or 2 alkyl, halogen, nitro, trifluoromethyl or trifluoromethylsulphonyl moieties; or dichloroquinoxalinyl.The pyrazole derivatives and their salts are useful as diuretics, saluretics and antihypertensives.Type: GrantFiled: April 28, 1977Date of Patent: July 3, 1979Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4159380Abstract: Imidazolylethoxy derivatives of pyrazolo-[3,4-b]pyridine-5-methanols having the general formula ##STR1## and their acid addition salts are useful as antifungal and antibacterial agents.Type: GrantFiled: July 10, 1978Date of Patent: June 26, 1979Assignee: E. R. Squibb & Sons, Inc.Inventor: Hans Hoehn
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Patent number: 4154846Abstract: Benzimidazole carbamate derivatives are provided having the structure ##STR1## wherein R is lower alkyl, lower alkenylalkyl, lower alkynylalkyl, phenyl, substituted phenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or phenylalkyl, R.sup.1 is lower alkyl, phenylalkyl or di-lower alkylaminoalkyl, Z is a single bond or a straight or branched chain alkylene group, and n is 0, 1 or 2. These compounds are useful as anthelmintic agents administered orally or parenterally.Type: GrantFiled: June 16, 1978Date of Patent: May 15, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Rudiger D. Haugwitz, Frank L. Weisenborn, Peter C. Wade, Thomas P. Kissick
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Patent number: 4153712Abstract: Amino aceto anilides of the formula I shown hereinafter are effective microbicides. They may be used to control fungi on plants or parts of plants or to protect them from fungi attack.Type: GrantFiled: May 12, 1978Date of Patent: May 8, 1979Assignee: Ciba-Geigy CorporationInventors: Adolf Hubele, Walter Kunz, Wolfgang Eckhardt
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Patent number: 4153710Abstract: N-{4-[2-(Pyrazole-1-carbonamide)-ethyl]-benzenesulphonyl}-ureas of the formula 1 ##STR1## wherein R, R.sub.2 are a hydrogen atom or lower alkyl of up to 4 carbon atoms, R.sub.1 is a hydrogen, chlorine or lower alkyl atom containing up to 4 carbon atoms and R.sub.3 is an alkyl of 2 to 5 carbon atoms or cycloalkyl of 5 to 6 carbon atoms, and their method of preparation is described, said compounds possessing biological properties, capable of decreasing the sugar level in blood.Type: GrantFiled: December 20, 1977Date of Patent: May 8, 1979Assignees: Starogardzkie Zaklady Farmaceutyczne POLFA, Akademia MedyczncInventors: Zdzislaw Brzozowski, Stanislaw Magielka, Stefan Angielski, Stanislaw Janicki, Czeslaw Wojcikowski, Zenon Jakubowski
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Patent number: 4153800Abstract: Isoindolinone pigments of the formula ##STR1## wherein R represents an aliphatic or cycloaliphatic radical, a cycloaliphatic, aromatic or heterocyclic radical to which the oxygen atoms are attached through alkyl or alkoxy groups, V.sub.1 and V.sub.2 represent hydrogen or halogen atoms, alkyl or alkoxy groups of 1 to 4 carbon atoms, X represents a halogen atom, Y and Z represent halogen atoms, alkoxy or alkylmercapto groups of 1 to 6 carbon atoms, cycloalkoxy groups of 5 to 6 carbon atoms, aralkoxy, aryloxy or arylmercapto groups, and n is an integer from 2 to 6, are valuable pigments coloring plastics, lacquers and printing inks in various yellow shades of excellent fastness properties and high color strength.Type: GrantFiled: November 10, 1977Date of Patent: May 8, 1979Assignee: Ciba-Geigy CorporationInventor: Ernst Model
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Patent number: 4152445Abstract: A compound of formula (I) ##STR1## wherein: X is O or S;n is 1 to 8;R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms;R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl-C.sub.1-6 -alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof; has useful pharmacological activity.Type: GrantFiled: June 14, 1978Date of Patent: May 1, 1979Assignee: Beecham Group LimitedInventor: Gordon Wootton
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Patent number: 4151293Abstract: Compounds of the formula ##STR1## wherein R is phenyl, benzyl, 1-isopropylbenzyl wherein each of said aromatic rings may carry a chlorine substituent, ##STR2## R' is H, --C.tbd.N or --C.tbd.CH; R" is chlorine, bromine, fluorine or methyl; X and Y both but independently are H or loweralkyl; and Z is phenyl or benzyl which may carry an optional aromatic chlorine substituent, have been found to be excellent insecticides, ovicides and/or miticides.Type: GrantFiled: October 23, 1978Date of Patent: April 24, 1979Assignee: Abbott LaboratoriesInventor: Robert G. Stein
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Patent number: 4151289Abstract: The compunds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.Type: GrantFiled: September 8, 1977Date of Patent: April 24, 1979Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Charon R. Ganellin
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Patent number: 4149005Abstract: 1-PHENYL-3-AMINO-2-PYRAZOLINES ARE CATALYTICALLY OXIDIZED TO 1-PHENYL-3-AMINOPYRAZOLES, USING OXYGEN AND/OR AIR AS THE OXIDIZING AGENT AND IN THE PRESENCE OF COPPER SALTS, OPTIONALLY ASSOCIATED WITH METALLIC COPPER AND/OR AN AROMATIC, HETEROCYCLIC ORGANIC BASE SELECTED FROM N-dialkyl anilines, pyridines, piperidine, and ethanolamine, or equivalents thereof, in an inert reaction medium and at a temperature of from about 20.degree. C. to about 40.degree. C.Type: GrantFiled: June 24, 1977Date of Patent: April 10, 1979Assignee: Montedison S.p.A.Inventors: Ruggero Battisti, Luigi Cassar, Nicola Mazzaferro
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Patent number: 4147797Abstract: Novel spiro-furanohydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The compounds include 2-methyl-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-fluoro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-chloro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-bromo-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione and spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione.Type: GrantFiled: August 11, 1978Date of Patent: April 3, 1979Assignee: Pfizer Inc.Inventors: Paul R. Kelbaugh, Reinhard Sarges
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Patent number: 4147796Abstract: A compound of formula (I): ##STR1## wherein: X is O or S;n is 1 to 8;R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms;R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl;R.sub.3 is hydroxy or protected hydroxy,R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cyclo alkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl-C.sub.1-6 -alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group;R.sub.5 is C.sub.1-6 alkyl, C.sub.1-6 alkyl substituted by a nitro, hydroxy, C.sub.1-6 alkoxy, CO.sub.2 A, (CO.sub.2 A).sub.2, CN or halogen group, C.sub.5-8 cycloalkyl, phenyl, phenyl, phenyl-C.sub.1-6 alkyl, phenyl-C.sub.Type: GrantFiled: June 14, 1978Date of Patent: April 3, 1979Assignee: Beecham Group LimitedInventor: Gordon Wootton
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Patent number: 4146726Abstract: Herbicidal compositions containing as an active ingredient one or more of the pyrazole compounds having the formula ##STR1## (wherein R.sub.1 represents hydrogen atom or a lower alkyl group, R.sub.2 represents a lower alkyl group or a lower alkenyl group, X represents a halogen atom, nitro group, a lower alkyl group, a halogenated lower alkyl group, a lower alkoxy group, a lower alkanesulfonyl group, cyano group, a lower alkylthio group or an aliphatic acyl group and n is an integer of 1 to 4 and when n is 2, 3 or 4, X's may be the same or different), salts thereof and organic acid esters thereof, as well as new pyrazole compounds having herbicidal activities and the formula ##STR2## (wherein R.sub.1 represents hydrogen atom or a lower alkyl group, R.sub.Type: GrantFiled: September 30, 1977Date of Patent: March 27, 1979Assignee: Sankyo Company LimitedInventors: Takuo Konotsune, Katsuhiko Kawakubo
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Patent number: 4146632Abstract: N,N-dimethyl-O-[3-tert.-butylpyrazol-5-yl]-carbamic acid esters of the formula ##STR1## in which R represents hydrogen, alkyl or cyanoalkyl andR.sup.1 represents hydrogen, halogen or alkyl which possess arthropodicidal and nematicidal properties.Type: GrantFiled: September 16, 1977Date of Patent: March 27, 1979Assignee: Bayer AktiengesellschaftInventors: Wolfgang Hofer, Fritz Maurer, Hans-Jochem Riebel, Rolf Schroder, Ingeborg Hammann, Wolfgang Behrenz, Bernhard Homeyer, Wilhelm Stendel
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Patent number: 4143149Abstract: New indazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; andR.sub.2 is straight-chain or branched lower alkyl which can be substituted by lower alkylthio;And the pharmacologically compatible salts thereof; are outstandingly effective adrenergic .beta.-receptor inhibitors and useful in the treatment or prevention of a recurrence of cardiac and circulatory diseases.Type: GrantFiled: April 25, 1977Date of Patent: March 6, 1979Assignee: Boehringer Mannheim GmbHInventors: Fritz Wiedemann, Wolfgang Kampe, Max Thiel, Wolfgang Bartsch, Egon Roesch
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Patent number: 4142886Abstract: 1,2-Di-lower alkyl-5-branched chain alkyl benzimidazoles and their use as selective herbicides.Type: GrantFiled: June 17, 1977Date of Patent: March 6, 1979Assignee: United States Borax & Chemical CorporationInventors: Don L. Hunter, Wayne S. Belles
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Patent number: 4143228Abstract: Dyestuffs of the formula ##STR1## WHEREIN R.sub.1 denotes halogen, alkyl, cycloalkyl, aralkyl, nitro, cyano, acyl, acylamino, amino, aminocarbonyl, aminosulphonyl, arylsulphonyl, alkylsulphonyl, alkoxy, aryloxy, aralkoxy, carboxyl, alkoxycarbonyl, aryloxycarbonyl or aralkoxycarbonyl or arylazo,R.sub.2 denotes alkyl, alkenyl, cycloalkyl, aryl or aralkyl,R.sub.3 denotes alkyl, cycloalkyl or aralkyl,R.sub.4 denotes alkyl, cycloalkyl or aralkyl,R.sub.5, r.sub.6, r.sub.7 and R.sub.8 denote hydrogen, alkyl, cycloalkyl, aralkyl or aryl and R.sub.6 and R.sub.7 conjointly can form a fused cycloaliphatic ring,R.sub.9 denotes chlorine, bromine, nitro, cyano, C.sub.1 -C.sub.4 -alkyl, phenyl, benzyl, C.sub.1 -C.sub.4 -alkoxy, phenoxy, benzyloxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, phenoxycarbonyl, benzyloxycarbonyl, carboxyl, C.sub.1 -C.sub.4 -alkylsulphonyl, phenylsulphonyl, benzylsulphonyl, C.sub.1 -C.sub.4 -alkoxysulphonyl, phenoxysulphonyl, benzyloxysulphonyl, aminocarbonyl, mono- or di- C.sub.1 -C.sub.Type: GrantFiled: August 23, 1977Date of Patent: March 6, 1979Assignee: Bayer AktiengesellschaftInventors: Hubertus Psaar, Winfried Kruckenberg
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Patent number: 4140792Abstract: 1-(Substituted-phenylcarbamoyl)-3-halophenyl-2-pyrazolines of the forumla ##STR1## in which R represents hydrogen or alkyl,R.sup.1 represents hydrogen or halogenophenyl,R.sup.2 represents hydrogen, halogenoalkoxy or halogenoalkylthio,R.sup.3 represents hydrogen, halogen, halogenoalkoxy or halogenoalkylthio andR.sup.4 represents halogen,With the proviso that one of the radicals R.sup.2 and R.sup.3 must represent halogenoalkoxy or halogenoalkylthio, which possess arthropodicidal properties.Type: GrantFiled: December 15, 1977Date of Patent: February 20, 1979Assignee: Bayer AktiengesellschaftInventors: Wilhelm Sirrenberg, Erich Klauke, Ingeborg Hammann, Wilhelm Stendel