Abstract: Hypertension can be treated using compounds having the formula ##STR1## or a basic salt thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.5 is alkyl or aryl;R.sub.2 is hydrogen or alkyl;R.sub.3 is aryl;R.sub.4 is hydrogen, alkyl or arylalkyl andn is 0, 1 or 2.

Abstract: Anti-diabetic agents of the formula: ##STR1## wherein R is CHO or COOR.sub.1, where R.sub.1 is hydrogen or C.sub.1-6 alkyl,R.sub.o is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, bromo, chloro, fluoro, trifluoromethyl, nitro or ##STR2## where R.sub.2 is hydrogen or C.sub.1-4 alkyl, andn is 0 or 1,and the non-toxic, pharmaceutically acceptable salts thereof.

Abstract: Process for the stereoselective reduction of certain amino-substituted indoles and amino-substituted indole-containing structures to trans-dihydroindoles comprising the sequential steps of (1) reacting a strong acid addition salt of such an indole with a borohydride in an appropriate solvent in the absence of acid, and (2) acidifying the step (1) reaction product by which it is reduced and hydrolyzed to form the corresponding trans-dihydroindole. Many dihydroindoles so produced, for example, the trans-2-(adamantylemethyl)-=2,3,4,4a,5,9b-hexahydro-5-phenyl-1H-pyrido[4,3 -b]indole, are useful as pharmaceutical materials, such as tranquilizers.

Abstract: Certain thiazolinyl or thiazinyl ketobenzimidazole compounds and derivatives thereof are useful as antiviral agents.

Abstract: N,N-dimethyl-O-(3-substituted-pyrazol-5-yl)-carbamic acid esters of the formula ##STR1## in which R is hydrogen or optionally substituted alkyl,R.sup.1 is alkyl, andn is 1 or 2,which possess arthropodicidal properties.

Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.

Abstract: The compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy-2-pyridyl)methylthio)ethylamino]-2-nitroeth ylene.

Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N,N'-bis-[2-(2-pyridylmethylthioethyl]-N"-cyanoguanidine.

Abstract: New carbamates, a process for their manufacture by reaction of salts of pyrazolinediones with a carbamyl halide, and pesticides containing these new carbamates as active ingredients.The new carbamates may be used as insecticides and acaricides. They have an excellent action on sucking insects, especially aphids.

Abstract: Fungicidal 4- and 5-pyrazolecarboxamides of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is the group --CONHR.sup.5 in which R.sup.5 is phenyl optionally substituted with one, two or three substituents independently chosen from the group consisting of alkyl, alkoxy, halogen, trifluoromethyl, nitro and cyano; R.sup.3 is chosen from the group consisting of hydrogen, alkyl, hydroxyalkyl, phenyl and --CH.sub.2 COOR.sup.6 wherein R.sup.6 is alkyl; R.sup.4 and R.sup.1 or R.sup.2, whichever is not --CONHR.sup.5, are independently chosen from the group consisting of hydrogen, halogen, and alkyl; R.sup.2 and R.sup.4 are not both hydrogen when R.sup.1 is --CONHR.sup.5 ; R.sup.1 and R.sup.3 are not both hydrogen when R.sup.2 is --CONHR.sup.5 ; and R.sup.2, R.sup.3 and R.sup.4 are not each methyl when R.sup.1 is --CONHR.sup.5 and R.sup.5 is phenyl.

Abstract: New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.

Abstract: Bisamidines carrying one unsaturated nitrogen heterocycle-containing substituent, representative of which is 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methyl-g uanidino]octane, are histamine H.sub.2 -antagonists.

Abstract: 3-Pyrazolidinone carboxamides such as N(tertamyl)7[3-oxo-1(3-hydroxy-n-octyl)pyrazolidin-2-yl]-heptanamide exhibit prostaglandin antagonist activity.

Abstract: Hypertension can be treated using compounds having the formula or a basic salt thereof, whereinR.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR1## wherein R.sub.5 is alkyl or aryl;R.sub.2 is hydrogen or alkyl;R.sub.3 is aryl;R.sub.4 is hydrogen, alkyl or arylalkyl andn is 0, 1 or 2.

Abstract: A series of spiro-hydantoin compounds has been prepared by condensing the appropriate carbonyl ring compound, such as the corresponding 1-indanone, 1-tetralone, 4-chromanone, thiochroman-4-one, 7,8-dihydroquinolin-5(6H)-one, 6,7-dihydropyrindin-5(5H)-one, thiondane-3-one-1,1-dioxide and 4-oxoisothiochroman-2,2-dioxide, respectively, with potassium cyanide and ammonium carbonate. The resulting hydantoin derivatives are found to be useful in preventing or alleviating chronic diabetic complications. Preferred member compounds include spiro-[imidazolidine-4,1'-indan]-2,5-dione, 6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6-chloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,7-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,8-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6'-fluoro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione and 6',7'-dichloro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione.

Abstract: Quaternary N-alkyl pyrazole derivatives and their method of preparation are described. The pyrazole derivatives are useful as antimicrobial agents.

Abstract: Pyrazoles of the formula ##STR1## whereinR is hydrogen, alkyl, aryl, aralkyl, trifluoromethyl or a heterocycle;R.sup.1 is aryl or aralkyl unsubstituted or substituted by halo, trifluoromethyl, alkyl, alkoxy or nitro; or a halo-substituted alkylthio moiety;R.sup.2 is lower alkyl; phenyl; or benzyl;R.sup.3 is aryl unsubstituted or substituted by alkyl, alkenyl, alkoxy, cycloalkyl, cycloalkenyl, halo, trifluoromethyl, trifluoromethoxy, mono- or di-alkylamino, nitro, cyano, carboxamido, sulphonamido or SO.sub.n -alkyl; phenyl having fused thereto a 5- to 7-membered isocyclic or heterocyclic ring, said heterocyclic ring having 1 or 2 oxygen or sulphur heteroatoms; or pyridyl; andR.sup.4 is unsubstituted or substituted carboacyl or sulphonyl; are useful for their diuretic, saluretic, antihypertensive and antithrombotic properties.

Abstract: N-(4-Pyrazolidinyl)benzamides having the formula ##STR1## and their amino precursors are disclosed wherein R is lower alkyl, lower cycloalkyl or phenyllower-alkyl; R.sup.1 is lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R.sup.2 is hydrogen, lower alkyl or phenyl; R.sup.3 is hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulfamoyl or actamido, R.sup.3 can be the same radical or different radicals; n is an integer from zero to three inclusive, and pharmaceutically acceptable acid addition salts thereof. The compounds have anti-emetic and gastric emptying properties.

Abstract: There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: ##STR1## wherein R.sub.1 is hydrogen, a halogen atom, an alkyl mercapto group having 1 to 6 carbon atoms,R.sub.2 is hydrogen, an alkyl group with 1 to 6 carbon atoms,R.sub.3 is hydrogen or a halogen or a halogen atomthe structural part A-B is the group --CH.sub.2 .dbd.NH--and Y-Z is the group >C.dbd.N--, >C.dbd.N(.fwdarw.O), and Y-Z is the group >C.dbd.N--, their optical isomers and their pharmaceutically acceptable salts. The compounds have anticonvulsive properties.