Patents Examined by Natalia Harkaway
  • Alkylation of aniline with a lactone in the presence of a base
    Patent number: 4203904
    Abstract: A process for producing a lactone-substituted aniline wherein a 3-halo-tetrahydro-2-oxofuran is reacted with an aniline in the presence of water and a base at a temperature between 80.degree. and 160.degree. C. and wherein the base is added at a sufficiently slow rate so that the pH does not exceed about 7.5.
    Type: Grant
    Filed: July 27, 1978
    Date of Patent: May 20, 1980
    Assignee: Chevron Research Company
    Inventor: Richard N. Reynolds, Jr.
  • D-Homopregnanes
    Patent number: 4202823
    Abstract: D-Homopregnanes of the formula ##STR1## wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond; R.sup.6 is hydrogen, R.sup.7 is hydrogen, lower alkanoylthio or aroylthio, or R.sup.6 and R.sup.7 taken together denote a carbon to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bondor a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy having diuretic activity are disclosed.
    Type: Grant
    Filed: June 30, 1978
    Date of Patent: May 13, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Peter Keller, Marcel Muller
  • 2-Hydro xy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives
    Patent number: 4200755
    Abstract: Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]ben zoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: April 29, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • Water-soluble fluorescing and lasing dyes
    Patent number: 4200753
    Abstract: Compounds having the structures: ##STR1## wherein R is CH.sub.3 or CF.sub.3 and wherein R.sup.1 is H or CH.sub.3. compounds are prepared by a four step method involving (1) the formation of a benzylaminophenol or benzylaminohydroxypyridine, (2) the formation of a coumarin or azacoumarin, (3) sulfonation of the coumarin or azacoumarin and (4) neutralization of the sulfonate with sodium bicarbonate. The compounds are useful as water-soluble lasing dyes.
    Type: Grant
    Filed: November 17, 1978
    Date of Patent: April 29, 1980
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Ronald A. Henry
  • Preparation of imidazo[2,1-a]isoindole compounds
    Patent number: 4200759
    Abstract: The present invention relates to a process for the preparation of certain known imidazo[2,1-a]isoindoles of the general formula I: ##STR1## wherein X represents a hydrogen atom, a halogen atom or a lower alkoxy group. The said isoindoles, which may be prepared from novel lactams, have been shown to have utility as psychic energizers and anorectics.
    Type: Grant
    Filed: July 20, 1978
    Date of Patent: April 29, 1980
    Assignee: Delmar Chemicals, Limited
    Inventor: Robert A. Dickinson
  • Methyl 3-(3-ethylureido)-1,2,5,6-tetrahydro-2-oxopyridine-4-carboxylate
    Patent number: 4200756
    Abstract: Methyl 3-(3-ethylureido)-1,2,5,6-tetrahydro-2-oxopyridine-4-carboxylate is useful as a muscle relaxant.
    Type: Grant
    Filed: December 7, 1978
    Date of Patent: April 29, 1980
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Ronald E. White
  • Antiinflammatory 4,5-diaryl-2-nitroimidazoles
    Patent number: 4199592
    Abstract: Antiinflammatory 4,5-diaryl-2-nitroimidazoles, such as 4,5-bis(4-fluorophenyl)-2-nitroimidazole, useful for treating arthritis and related diseases.
    Type: Grant
    Filed: March 6, 1979
    Date of Patent: April 22, 1980
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Saul C. Cherkofsky
  • Piperidenylmethylidene phosphonylamidines
    Patent number: 4198510
    Abstract: A process for the preparation of carboxylic acids represented by a formula ##STR1## wherein R.sub.1 represents hydrogen atom or a lower alkyl radical, R.sub.2 represents hydrogen atom, lower alkyl or allyl radical and R.sub.3 represents phenyl, substituted phenyl, substituted naphthyl, dibenzofuranyl or substituted biphenyl. Following novel enamine and amidine compounds as intermediates for manufacturing the carboxylic acids and processes for the manufacture of said enamine and amidine compounds ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 represent the meanings as referred to and R.sub.4 represents dimethylamino, pyrrolidyl, piperidyl or morpholyl.
    Type: Grant
    Filed: July 7, 1978
    Date of Patent: April 15, 1980
    Assignees: Sanwa Kagaku Kenkyusho Co., Ltd., Takayuki Shioiri
    Inventors: Takayuki Shioiri, Nobutaka Kawai, Masatoshi Ban
  • Process for the production of 3-substituted pyrazolanthrones
    Patent number: 4198518
    Abstract: A process for the production of 3-substituted pyrazolanthrones of the formula ##STR1## wherein X is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or a group --COR, in which R is hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxyl, C.sub.1 -C.sub.6 alkoxy, --NH.sub.2, --NH--C.sub.1 -C.sub.6 alkyl or --NR.sub.1 R.sub.2, in which R.sub.1 and R.sub.2, each independently of the other, are C.sub.1 -C.sub.6 alkyl, which comprises reacting 1-nitroanthraquinones of the formula ##STR2## wherein X is as defined in formula (1), in aprotic dipolar solvents, with hydrazine or hydrazine hydrate, at normal or slightly elevated temperature, to give 3-substituted pyrazolanthrones of the formula (1).
    Type: Grant
    Filed: August 25, 1978
    Date of Patent: April 15, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Athanassios Tzikas
  • Histidine derivatives
    Patent number: 4198517
    Abstract: New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: April 15, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel A. Ondetti
  • Pyrazole phosphates and phosphonates - insecticides
    Patent number: 4197295
    Abstract: Compounds having the formula ##STR1## wherein X is oxygen or sulfur, R is selected from the group consisting of alkyl and alkoxy, R.sub.1 is alkoxy, R.sub.2 is selected from the group consisting of hydrogen and methyl and R.sub.3 is selected from the group consisting of hydrogen, methyl and phenyl; these compounds are active as insecticides.
    Type: Grant
    Filed: October 2, 1978
    Date of Patent: April 8, 1980
    Assignee: Stauffer Chemical Company
    Inventor: Llewellyn W. Fancher
  • Potassium phthalocyanine complexes, method of preparation, and phthalocyanine purification processes
    Patent number: 4197242
    Abstract: The invention of this application is directed to dipotassium phthalocyanine glyme and crown ether complexes, such as for example dipotassium phthalocyanine bis (methoxy ethyl) ether and dipotassium phthalocyanine bis (18-crown-6) ether. Methods for obtaining these complexes by reacting metal free phthalocyanine with potassium hydroxide and the appropriate glyme or crown ethers in the presence of water is also described. Further methods for obtaining purified metal free phthalocyanines from the glyme and crown ether complexes are disclosed. These materials have many uses including pigments, electrophotographic photoreceptors and photoreceptor devices.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: April 8, 1980
    Assignee: Xerox Corporation
    Inventor: Wolfgang H. H. Gunther
  • 2-(Substituted amino)-N-(3-substituted phenyl)-2-imidazoline-1-carbothioamides
    Patent number: 4195092
    Abstract: 2-(Substituted amino)-N-(3-substituted phenyl)-2-imidazoline-1-carbothioamides, useful as insecticides.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: March 25, 1980
    Assignee: Eli Lilly and Company
    Inventor: Terry W. Balko
  • Imidazolyl alkylamino nitroethylene compounds
    Patent number: 4192879
    Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: March 11, 1980
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Geoffrey R. Owen, Rodney C. Young
  • Method of preparing a substituted butyrolactone acetic acid
    Patent number: 4190588
    Abstract: Metal salts and amides of alkyl-lactam acetic acids are prepared by reacting gamma-hydrocarbyl butyrolactone acetic acid compounds derived from alkenylsuccinic anhydrides with metal compounds and amines or amines alone. High molecular weight lactam acid salts and amides and metal complexes and metal carbamates thereof are useful as detergents or dispersants in organic industrial fluids. Another aspect of this invention is a method of preparing lactone acetic acids in yields up to 90% conversion from alkenylsuccinic anhydrides.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: February 26, 1980
    Assignee: Mobil Oil Corporation
    Inventors: El-Ahmadi I. Heiba, Albert L. Williams
  • N-heterocyclic derivatives of thienamycin
    Patent number: 4189493
    Abstract: Disclosed are N-derivatives of thienamycin having structures I and II. ##STR1## wherein: the bifunctional radical may contain additional unsaturation in the ring; and wherein n is an integer selected from 1-6; p is 0, 1 or 2; R.sup.1 is selected from hydrogen, alkyl having 1-6 carbon atoms, and aryl having 6-10 carbon atoms; and Z is imino (.dbd.NH), oxo (.dbd.O), hydrogen, amino, or alkyl having 1-6 carbon atoms. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: February 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, John Hannah, David H. Shih
  • Process for making imidazolines
    Patent number: 4189593
    Abstract: A process for making substituted imidazoline substantially completely free from diamide and preferably from byproduct ester. The process involves contacting an aminoethyl lower alkanol amine with a methyl carboxylate at elevated temperature and thereafter subjecting the reaction product to two successive heat treatments under specified conditions. A feature of the process is that it contains an optional step which can be employed to correct the formation of unwanted amounts of ester in the product. The product imidazoline is useful as a starting material for making amphoteric surfactants.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: February 19, 1980
    Inventors: Joseph R. Wechsler, Thomas G. Baker, George T. Battaglini, Frank L. Skradski
  • Semi-synthetic oleandomycin derivatives--C.sub.8 modifications
    Patent number: 4189590
    Abstract: The novel C.sub.8 modified oleandomycin compounds and the processes for their preparation are disclosed.
    Type: Grant
    Filed: January 4, 1979
    Date of Patent: February 19, 1980
    Assignee: Pfizer Inc.
    Inventor: Frank C. Sciavolino
  • Prostaglandin derivatives
    Patent number: 4188331
    Abstract: Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH or C.tbd.C; Y is CH.sub.2 or O; Z is OH, CH.sub.3 or CH.sub.2 OH, R" is H or loweralkyl and R is a linear, branched or cyclic alkyl group of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein R' is hydrogen, R and Z are the same as shown above, and P is a removable protective group. The new compounds are useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: February 12, 1980
    Assignee: Abbott Laboratories
    Inventors: Andre G. Pernet, Hiromasa Nakamoto, Naoyasu Ishizuka
  • 1-[p-(2-Trialkylammonium)propylsulfonylphenyl]-3-(phenyl)-pyrazoline salts
    Patent number: 4183853
    Abstract: Pyrazoline compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 denote hydrogen or chlorine,R.sub.3 denotes C.sub.1 -C.sub.4 -alkyl andX.sup..crclbar. denotes a colorless anion,are suitable for the whitening of polyacrylonitrile and wool.
    Type: Grant
    Filed: January 10, 1978
    Date of Patent: January 15, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Josef Schroeder, Carl-Wolfgang Schellhammer