Patents Examined by Natasha Patel
  • Patent number: 10799707
    Abstract: In an electrostimulator which applies electrical stimulation to patient tissue, measurements of lead impedance (tissue resistance), battery status, and like matters are used to format and/or truncate the ranges of programmable therapeutic output settings available for selection by a clinician. The clinician can therefore better tell whether chosen settings can actually be successfully implemented, and/or whether they may have adverse effects on device lifespan or patient safety.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: October 13, 2020
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Brian M. Taff, Kurt Swenson, Hannes Kraetschmer
  • Patent number: 10799695
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 13, 2020
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
  • Patent number: 10798504
    Abstract: A system includes a first device for neural stimulation of a patient's ipsilateral ear and a second hearing stimulation device, wherein the stimulation mode of the second stimulation device is different from that of the first stimulation device. The system further includes a fitting device for adjusting the first stimulation device and the second stimulation device. The fitting device includes a graphical user interface configured to present an acoustic level audiogram representation of aided acoustic and electric behavioral values for the first and second stimulation devices.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: October 6, 2020
    Assignee: Advanced Bionics AG
    Inventors: Josef Chalupper, Gunnar Geissler
  • Patent number: 10792499
    Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: October 6, 2020
    Assignee: Lungpacer Medical Inc.
    Inventor: Joaquin Andres Hoffer
  • Patent number: 10792483
    Abstract: The present invention relates to a vaccine composed of at least one immune stimulant and radiofrequency waves using capacitive coupling and to a method, especially an in-situ and in vivo vaccination method for treatment of primary cancer and its metastases even in disseminated cell-states, which cannot be detected by presently available imaging methods or for prevention of relapse of the cancer disease, and especially for enabling and supporting the patient's own immune system to recognize and kill the cancer cells and to build up a memory to prevent relapse of a cancer disease.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: October 6, 2020
    Assignee: XAX KFT.
    Inventors: Gabor Andocs, Oliver Szasz, Andras Szasz, Nora Iluri
  • Patent number: 10791940
    Abstract: A diagnosis assistance apparatus acquires a predetermined period's worth of biological information measured from a living body every heartbeat, from a storage unit storing the biological information, divides the biological information into multiple segments, generates fluctuating state information indicating the fluctuating state of the biological information in each segment, and displays a graph indicating the fluctuating state information of each segment on a display unit. Furthermore, if a certain piece of fluctuating state information is selected in the graph displayed on the display unit, the diagnosis assistance apparatus displays a graph indicating the biological information belonging to the segment corresponding to the selected piece of fluctuating state information on the display unit.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: October 6, 2020
    Inventors: Shingo Yamashita, Naoki Maeda
  • Patent number: 10780285
    Abstract: An implantable pulse generator (IPG) is disclosed having an improved ability to steer anodic and cathodic currents between the IPG's electrodes. Each electrode node has at least one PDAC/NDAC pair to source/sink or sink/source a stimulation current to an associated electrode node. Each PDAC and NDAC receives a current with a magnitude indicative of a total anodic and cathodic current, and data indicative of a percentage of that total that each PDAC and NDAC will produce in the patient's tissue at any given time, which activates a number of branches in each PDAC or NDAC. Each PDAC and NDAC may also receive one or more resolution control signals specifying an increment by which the stimulation current may be adjusted at each electrode. The current received by each PDAC and NDAC is generated by a master DAC, and is preferably distributed to the PDACs and NDACs by distribution circuitry.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 22, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pujitha Weerakoon, David M. Wagenbach, Philip L. Weiss, Goran N. Marnfeldt, Kiran K. Gururaj
  • Patent number: 10765875
    Abstract: An implantable cardioverter defibrillator (ICD) and methods of detection and treatment of dangerous and life-threatening heart rhythms by delivering real-time, customized low-energy pacing pulses to specific anatomy in the heart. The ICD includes a power source, a controller, powered by the power source, including an electronic processor, a memory, and a signal generator. The ICD also includes a lead coupled to the controller and an electrode that is in electrical communication with a His-bundle of a patient's heart. The ICD detects a ventricular arrhythmia of the patient's heart using the controller, and is configured to provide a pulsed defibrillation signal to the electrode to terminate the ventricular arrhythmia.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: September 8, 2020
    Inventors: Derek J. Dosdall, Ravi Ranjan
  • Patent number: 10758145
    Abstract: It relates to the field of displaying the heart-rate data collected in an exercise test, in particular to a method for achieving a panoramic display during Electrocardiogram Exercise Test by using a time axis, comprising following steps: (a) building a horizontal axis (X axis) in units of time as a time axis, and building a vertical axis (Y axis) in units of heart rate, therefore forming a two-dimensional tendency chart; (b) collecting and storing real-time 12-lead ECG raw data, acquiring and storing real-time heart rate data, (c) setting a time vernier, wherein in a default status, the time vernier is located at the current moment, and it is connected with 12-lead ECG raw data.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: September 1, 2020
    Assignee: Vales and Hills Biomedical Tech. Ltd.
    Inventors: Xiaodong Du, Yu Yang
  • Patent number: 10751003
    Abstract: Vital sign monitors are plagued by noisy photoplethysmography (PPG) data, making it difficult for the monitors to output consistently accurate readings. Noise in PPG signals is often caused by motion. The present disclosure provides improved techniques for reducing motion-related artifacts in optical/PPG measurements for vital signs monitoring. In general, techniques described herein are based on using measurements of reference sensors that include sensors other than optical sensors used for the optical measurements, e.g., biopotential sensors, bioimpedance sensors, and/or capacitive sensors. In particular, techniques described herein aim to filter PPG signals using substantially only the noise components of signals generated by reference sensors, by attenuating or altogether eliminating components of the signals generated by reference sensors which are indicative of the parameter the reference sensors are designed to measure.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: August 25, 2020
    Inventors: Roberto Munoz, Guillermo Serrano Leon, Carlos Millan Navarro
  • Patent number: 10751535
    Abstract: Systems and methods provide stimulation of peripheral targets such as targets in the lower limbs. Electrode arrays realized in circumferential or longitudinal embodiments have pads with horizontal and/or vertical offsets. Electrode array geometries are customizable and adaptable to individual users and treatment of different disorders. Novel systems of customization include software and hardware implemented solutions. A single device can provide treatment of two or more disorders or unwanted states using selected electrode geometries and stimulation protocols. Systems and methods for assessment of candidate stimulation sites and protocols use subjective or objective measures or both to determine which meet stimulation success criteria. Simulation is provided using transcutaneous, percutaneous, or implantable stimulators. A main advantage is the improved treatment of pelvic floor disorders, and especially overactive bladder (OAB).
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: August 25, 2020
    Assignee: EBT Medical, Inc.
    Inventors: Michael Sasha John, Paul B. Yoo
  • Patent number: 10744330
    Abstract: An external control device for use with a neurostimulation system having a plurality of electrodes capable of conveying an electrical stimulation field into tissue in which the electrodes are implanted is provided. The external control device comprises a user interface having one or more control elements, a processor configured for generating stimulation parameters designed to modify the electrical stimulation field relative to one or more neurostimulation lead carrying the electrodes. The external control device further comprises output circuitry configured for transmitting the stimulation parameters to the neurostimulation system.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: August 18, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, Sridhar Kothandaraman, James Carl Makous
  • Patent number: 10744245
    Abstract: A bearingless and sealless rotary blood pump is disclosed which provides multidirectional flow intended to provide low-pressure, high-volume right-sided partial assist circulatory support in a univentricular Fontan circulation on a permanent basis. The pump includes a housing and an impeller suspended in the center of the housing. The housing incorporates flow optimization features between inlet and outlet ends, as well as with the impeller surface. Large fluid gaps maintained between impeller and housing eliminate any potential for blood flow obstruction. The impeller contains some motor components. It includes a central stator and surrounding rotor. The motor includes a brushless DC outrunner electrical motor design. An electromagnetic stator core is surrounded by a circumferential passive magnetic ring. The rotor is further levitated about the stator spindle by a plurality of axially and radially located passive magnetic and hydrodynamic journal bearings on both ends of the spindle.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 18, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Mark D. Rodefeld
  • Patent number: 10737100
    Abstract: A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: August 11, 2020
    Assignee: Medtronic, Inc.
    Inventors: Erik J. Peterson, Mandla Shongwe
  • Patent number: 10729345
    Abstract: For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: August 4, 2020
    Inventors: Qing Lou, Jeffrey B. Adair, Qingguo Zeng, Ping Jia, Ryan Bokan, Connor Edel, Rahsean Ellis, Brian P. George, Raja Ghanem, Timothy G. Laske
  • Patent number: 10702696
    Abstract: Delivering stimulation includes delivering temporal patterns of stimulation pulses to respective transducers of an array of transducers, wherein the delivery of the pattern to a particular transducer of the array is different from at least some of the deliveries of the patterns to the other transducers of the array at least according to a time delay. The patterns delivered may include regular temporal patterns each having a respective constant inter-pulse interval. The constant inter-pulse intervals may be about the same. The patterns may be staggered. The transducers may deliver electrical, optical, acoustic, thermal or magnetic stimulation.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: July 7, 2020
    Assignee: Duke University
    Inventors: Warren M. Grill, Tianhe Zhang
  • Patent number: 10695477
    Abstract: A circulatory assist system is disclosed, the system including an implantable electrical device having an electric motor, an implantable controller connected to the implantable electrical device, and an implantable power source connected to the controller for supplying power to the controller. The controller is attachable to a first side of a percutaneous connector. A second side of the percutaneous connector, opposite to the first side, allows external connectivity to said controller.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: June 30, 2020
    Assignee: HeartWare, Inc.
    Inventors: Barry M. Yomtov, John Robert Batty, Jr., Daniel Tamez
  • Patent number: 10687726
    Abstract: A system for processing ECG recordings from multiple patients includes a preprocessing database containing unprocessed ECG records from multiple patients, a reporting database containing processed ECG records from multiple patients, a processor, and a triage module executable on the processor to assess each of the unprocessed ECG recordings from the multiple patients. The triage module is executable to detect a presence or absence of one or more known abnormalities and determines at least one abnormality identifier based on the detected known abnormality. One or more abnormality groups are then identified based on the abnormality identifiers. A normal group of ECG recordings from multiple patients is then identified from those ECG recordings that are not in the abnormality group. The normal group of ECG recordings is then stored in the reporting database then associated a normal identifier.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: June 23, 2020
    Assignee: General Electric Company
    Inventors: Joel Q. Xue, Mark Gilbert Langer
  • Patent number: 10674924
    Abstract: Systems and methods for mapping a cavernous nerve near an organ. The system includes: one or more processors; and a memory that is communicatively coupled to the one or more processors and stores one or more sequences of instructions, which when executed by one or more processors causes steps to be performed comprising: applying an excitation signal to an electrode at a tip of an laparoscope, the tip being configured to contact a point on a tissue near an organ; responsive to the excitation signal, measuring a change in a signal from a pair of electrodes configured to be installed on the penis, the change in the signal being associated with an erectile function of the penis; and based on the change in the signal from the pair of electrodes, determining a distance between the point on the tissue and a cavernous nerve near the organ.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: June 9, 2020
    Inventors: Chang Wook Jeong, Keewon Kim
  • Patent number: 10639489
    Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: May 5, 2020
    Inventors: Jeffrey P. Bodner, Randy Bierwerth