Patents Examined by Natasha Patel
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Patent number: 11247054Abstract: The present invention relates to the medical field, in particular to the enhancement of brain performances and to the treatment of pathological stress. More specifically the present invention relates to a nanoparticle or nanoparticles' aggregate for use in enhancing brain performances or in prevention or treatment of pathological stress in a subject when the nanoparticle and/or nanoparticles' aggregate is exposed to an electric field, wherein the nanoparticle's or nanoparticles' aggregate's material is selected from a conductor material, a semiconductor material, an insulator material with a dielectric constant ?ijk equal to or above 200, and an insulator material with a dielectric constant ?ijk equal to or below 100. It further relates to compositions and kits comprising such nanoparticles and/or nanoparticles' aggregates as well as to uses thereof.Type: GrantFiled: December 19, 2017Date of Patent: February 15, 2022Assignee: NANOBIOTIX S.A.Inventors: Laurent Levy, Marie-Edith Meyre, Agnès Pottier
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Patent number: 11241572Abstract: Method and systems control a rotational speed of a blood pump during ventricular diastole. A method includes controlling a blood pump in accordance with a first segment operational mode. A controller monitors the blood flow rate through the blood pump. The controller determines, based on the blood flow rate, whether continued controlling of the blood pump per the first segment operational mode would result in the blood flow rate through the blood pump being less than a target minimum blood flow rate. In response to a determination that continued controlling of the blood pump per the first segment operational mode would result in the blood flow rate through the blood pump being less than the target minimum blood flow rate, the controller controls the rotational speed of the blood pump so that the blood flow rate through the blood pump is approximate to the target minimum blood flow rate.Type: GrantFiled: August 27, 2019Date of Patent: February 8, 2022Assignee: TC1 LLCInventors: Charles Dague, Dan Harjes
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Patent number: 11234594Abstract: According to an aspect of some embodiments of the present invention there is provided a method of dynamically adapting a facial treatment based on a current facial skin profile, comprising: using at least one sensor for measuring at least one current value of at least one variable skin characteristic of facial skin of a patient; acquiring at least one personal skin characteristic of facial skin of the patient; calculating a current facial skin status of the patient according to the at least one personal skin characteristic and the at least one current value; determining instructions to operate a treatment applicator according to the current facial skin status; and instructing the treatment applicator according to the instructions.Type: GrantFiled: May 19, 2016Date of Patent: February 1, 2022Assignee: E.S.I Novel Ltd.Inventors: Haim Amir, Arie Wainberg, Anat Kaphan
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Patent number: 11229399Abstract: A receiver apparatus is configured to receive a first and second signal from one or more sensors, the first signal comprising a measure of one or more exercise parameters of the user at a first time period of an exercise session, and the second signal comprising a measure of the one or more exercise parameters at a second time period. A processor is configured to store the first and second signals in a memory, generate a fatigue signal based on a comparison of the measured one or more exercise parameters of the first signal to the respective measured one or more exercise parameters of the second signal, generate an exercise efficiency signal based on a comparison of the measured one or more exercise parameters of the second signal to an a priori exercise parameter threshold, and cause the exercise efficiency signal and the fatigue signal to be simultaneously displayed.Type: GrantFiled: February 13, 2019Date of Patent: January 25, 2022Assignee: Under Armour, Inc.Inventors: Mark A. Oleson, F. Grant Kovach, Nathan Dau, Angela Nelligan
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Patent number: 11224718Abstract: Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs.Type: GrantFiled: September 13, 2019Date of Patent: January 18, 2022Assignee: Native Cardio, Inc.Inventors: Young D. Kim, Joseph V. Pergolizzi, Scot Johnson
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Patent number: 11219759Abstract: A medical device kit includes a tunneling tool configured to form a tunnel through patient tissue for receiving an electrical stimulation lead. The tunneling tool includes a tunneling-tool body having an elongated shape with a proximal portion and a distal portion. The tunneling-tool body is formed from a material configured to be manually bent prior to insertion into patient tissue to conform to an anatomical contour through which the tunnel is to extend. A blunt tip is disposed at the distal portion. The blunt tip is configured to tunnel through patient tissue. A tunneling-tool suture-receiving element is disposed along the proximal portion of the tunneling-tool body. The tunneling-tool suture-receiving element is configured to receive a suture extendable along the tunnel formed by the tunneling tool.Type: GrantFiled: August 27, 2018Date of Patent: January 11, 2022Assignee: Boston Scientific Neuromodulation CorporationInventors: Jacob B. Leven, Kevin Peng Wang, Rhys Wheatley
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Patent number: 11219754Abstract: Apparatus includes a flexible intraventricular receptacle that assumes a first volume upon passage of fluid that is not blood into the receptacle and a second, smaller volume upon passage of the fluid out of the receptacle. An expandable extracardiac receptacle expands upon transfer of the fluid into the extracardiac receptacle from the intraventricular receptacle and contracts upon passage of the fluid out of the extracardiac receptacle. A transmyocardial conduit allows passage of the fluid between the intraventricular receptacle and the extracardiac receptacle responsively to a cardiac cycle. During ventricular systole, a volume of fluid is expelled from the intraventricular receptacle, through the conduit, and into the extracardiac receptacle, producing a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle. Other embodiments are also described.Type: GrantFiled: May 20, 2020Date of Patent: January 11, 2022Assignee: RAINBOW MEDICAL LTD.Inventor: Yossi Gross
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Patent number: 11219763Abstract: The techniques of the disclosure describe example medical devices, systems, and methods for delivering stimulation therapy comprising a first set of a plurality of pulses having a first amplitude, and a second set of a plurality of pulses having a second amplitude greater than the first amplitude. The second amplitude is adjusted to an adjusted second amplitude based on second amplitude being less than or greater than activation threshold. The first amplitude is adjusted based on adjusted second amplitude, and therapy is delivered based at least one the adjusted first amplitude.Type: GrantFiled: October 5, 2017Date of Patent: January 11, 2022Assignee: MEDTRONIC, INC.Inventor: Nathan A. Torgerson
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Patent number: 11213675Abstract: Anchoring devices for affixing an implanted lead at a target location in a patient are provided herein. Such anchoring devices include a helical body having a plurality of tines extending laterally outward from the lead when deployed that engage tissue to inhibit axial movement of the implanted lead. The plurality of tines are biased towards the laterally extended deployed configuration and fold inward towards the lead to a delivery configuration to facilitate delivery of the lead through a sheath. The tines may be angled in a proximal direction or in both proximal and distal directions and may include various features to assist in visualization and delivery of the lead.Type: GrantFiled: October 9, 2019Date of Patent: January 4, 2022Assignee: AXONICS, INC.Inventors: Henry Lee, Alexander Hwu
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Patent number: 11202903Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissue-interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.Type: GrantFiled: May 17, 2019Date of Patent: December 21, 2021Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, David Dellal
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Patent number: 11202601Abstract: This document discusses, among other things, systems and methods for monitoring a patient at risk of epilepsy. A system comprises a sensor circuit that senses from the patient at least first and second physiological or functional signals. A wellness detector circuit can detect an epileptic event using the sensed physiological or functional signals, or additionally classify the epileptic event into one of epileptic seizure types. The system can generate a wellness indicator based on a trend of the physiological or functional signal during the detected epileptic event. The wellness indicator indicates an impact of the detected epileptic event on the health status of the patient. The system includes an output unit configured to output the detection of the epileptic event or the wellness indicator to a user or a process.Type: GrantFiled: November 28, 2017Date of Patent: December 21, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Pramodsingh Hirasingh Thakur, Qi An, Amy Jean Brisben, Stephen B. Ruble, Keith R. Maile
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Patent number: 11202899Abstract: Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.Type: GrantFiled: January 30, 2017Date of Patent: December 21, 2021Assignee: Mallinckrodt Pharmaceuticals Ireland LimitedInventors: Jim Potenziano, Douglas Alan Greene, Craig Flanagan
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Patent number: 11197998Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.Type: GrantFiled: August 8, 2019Date of Patent: December 14, 2021Assignee: ELECTROCORE, INC.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 11198012Abstract: Programming a stimulator device to deliver a stimulation therapy at high-density parameter settings using a cathode-minimized electrode configuration determined to induce paresthesia over a patient pain pattern at low-density parameter settings.Type: GrantFiled: August 22, 2017Date of Patent: December 14, 2021Assignee: Medtronic, Inc.Inventor: Hector Cantua
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Patent number: 11185285Abstract: Mouth guard that includes a flexible printed circuit board encapsulated within a base member is provided. The flexible printed circuit board includes multiple separate stiff sections spaced apart from each other within the base member. One or more electronic devices are disposed within the base member. In particular, the one or more electronics are disposed on the base member.Type: GrantFiled: December 26, 2018Date of Patent: November 30, 2021Assignee: INTEL CORPORATIONInventors: Braxton Lathrop, Cody Gabriel, James Hall, Michael Rosen, Nathan Stebor, Philip Muse, Rita Brugarolas Brufau, Shea Dillon, Stephanie Moyerman, Steven Xing, Tyler Fetters
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Patent number: 11185692Abstract: The present invention discloses a wireless and self-contained headset that delivers an electronic signal to a precise and self-locating position within bilateral conchae in both ears of a human user. The headset comprises an electronics housing that carries a specific waveform source. The waveform source generates the electronic signal, which is delivered simultaneously to both left and right ears of the human user. An array of silver electrodes housed within the bilateral earpieces cover with precision the location at the exact center of the relatively smooth plane of the conchae directly behind the external auditory meatus (ear opening/canal).Type: GrantFiled: December 10, 2019Date of Patent: November 30, 2021Inventor: Emily Ireland
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Patent number: 11185239Abstract: A system for determining reference signatures for use in assisting identification of a body state in a biological subject, the system including at least one processing device that obtains reference data for each of a plurality of reference individuals, the reference data including at least one reference impedance indicator obtained by performing at least one impedance measurement on the reference individual, a body state indication indicative of any body states associated with the reference individual and characteristic data indicative of one or more physical characteristics of the reference individual and analyses the reference data to establish one or more reference signatures, each reference signature being indicative of at least one reference impedance indicator associated with a respective body state for respective physical characteristics.Type: GrantFiled: February 15, 2017Date of Patent: November 30, 2021Assignee: IMPEDIMED LIMITEDInventors: Richard Roland Carreon, Jack Gerald Cosentino
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Patent number: 11185269Abstract: Optimizing psychiatric and physiologic monitoring of a patient having PTSD or anxiety-related mental health condition. According to an embodiment, one or more physiological variables are longitudinally measured; resting heart rate is measured from which a timeseries is constructed; outlier anomalous values are removed from the timeseries, it is de-trended and/or de-meaned; and a serial normal sinus rhythm beats (SDNN) and/or other parameters are determined. Fractal properties of the serial SDNN values are calculated, such as the Hurst exponent alpha via detrended fluctuation analysis (DFA) or spectral regression; and other measures of chaos and nonlinearity are calculated, such as the Shannon entropy of the SDNN or related timeseries. Where such measures indicate a statistically-significant transgression of a context-indexed reference range, a notification is provided to a case management clinician or caregiver so that appropriate additional evaluation and diagnosis and treatment may be undertaken.Type: GrantFiled: February 25, 2019Date of Patent: November 30, 2021Assignee: CERNER INNOVATION, INC.Inventor: Douglas S. McNair
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Patent number: 11179557Abstract: Modular mammalian body implantable fluid flow influencing device, comprising: docking unit having receiving surface, distal and proximal ends, proximal guide hole. Functional unit having docking surface shaped to mate with receiving surface, distal and proximal ends. Control wire extends from proximal end of functional unit then goes through guide hold then extends proximally away from docking unit. Functional and docking units are dimensioned and shaped to be deliverable to an implantation site via catheter. Functional unit has docked configuration in which docking surface mates with receiving surface of docking unit and undocked configuration in which docking surface is unmated with and spaced apart from receiving surface of docking unit. Functional unit moveable at implantation site between undocked and docked configurations via movement of control wire. Functional unit moveable into docked configuration by pulling control wire, and moveable from into undocked configuration by pushing control wire.Type: GrantFiled: May 4, 2020Date of Patent: November 23, 2021Assignee: PUZZLE MEDICAL DEVICES INC.Inventors: Gabriel Georges, François Trudeau, Jade Doucet-Martineau
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Patent number: 11172820Abstract: A physiological information processing method includes: acquiring electrocardiogram data from a subject; acquiring pulse wave data from the subject; measuring a plurality of RR intervals based on the acquired electrocardiogram data; measuring a plurality of pulse wave transit times based on the acquired electrocardiogram data and the acquired pulse wave data; calculating, based on the measured RR intervals and the measured pulse wave transit times during a given time period, a parameter related to correlation between the measured RR intervals and the measured pulse wave transit times; and outputting the calculated parameter.Type: GrantFiled: April 24, 2019Date of Patent: November 16, 2021Assignee: NIHON KOHDEN CORPORATIONInventors: Yoshihiro Sugo, Yoshiharu Harada, Tomoyuki Sakai, Mami Sakai