Abstract: Systems and methods are provided for operating a physiological monitoring system that comprises a distributed algorithm. The physiological monitoring system ma comprise a sensor and a physiological monitor that may be communicatively coupled with the sensor. The sensor may store a first executable code segment and the physiological monitor may store a second executable code segment. The physiological monitor may be configured to receive the first executable code segment and execute the first and second executable code segments to determine at least one physiological parameter of a subject based on physiological signal provided by the sensor. The physiological monitor may be configured to delete or deactivate the first executable code segment. The physiological monitor may also store a configurable algorithm stage that may be configured based on algorithm configuration data received from the sensor.

Abstract: A mobile device, having a processor, includes an accelerometer configured to generate acceleration data, the acceleration data including a plurality of acceleration measurements. The mobile device also includes a memory having embodied thereon computer-executable instructions that are configured to, when executed by the processor, cause the processor to: obtain the acceleration data from the accelerometer; and generate, based on the acceleration data, heart sound data, the heart sound data including data associated with one or more heart sounds.

Abstract: An interferential current therapy kit for treatment of a patient following an orthopedic shoulder surgery includes, within a container for facilitating the distribution and transport of the kit, a first plurality of electrodes, a second plurality of electrodes and an interferential current therapy control unit. The interferential current therapy control unit is configured to supply interferential current electrical impulses, via the electrodes, so as to give rise to at least one first beat impulse acting on the suprascapular nerve of the patient and so as to give rise to the at least one second beat impulse acting on at least one of an axillary nerve and a supraclavicular nerve of the patient.

Abstract: Methods and devices for long term, cuffless, and continuous arterial blood pressure estimation using an end-to-end deep learning approach are provided. A deep learning system comprises three modules: a deep convolutional neural network (CNN) module for learning powerful features; a one- or multi-layer recurrent neural network (RNN) module for modeling the temporal dependencies in blood pressure dynamics; and a mixture density network (MDN) module for predicting final blood pressure value. This system takes raw physiological signals, such as photoplethysmogram and/or electrocardiography signals, as inputs and yields arterial blood pressure readings in real time.

Abstract: The device includes an energy harvesting module with a pendular unit formed of an elastically deformable piezoelectric beam associated with an inertial mass. A multifunction part includes an axial through-recess with inner bearing surfaces opposite respective outer faces of the beam. These bearing surfaces having an increasing transverse spacing, such as, during an oscillation cycle, the beam comes into contact with one of the bearing surfaces, hence reducing the free length of the beam as the bending of the latter goes along. The multifunction part also allows rationalizing the manufacturing and the assembly of the capsule, with high-level integration of the inner components of the implant.

Abstract: Evaluating health of a user can include providing an equilibrium envelope for a user, wherein the equilibrium envelope includes a range for each of a plurality of vital signs, and detecting, using a processor, a current metric. The current metric corresponds to an exit condition for the equilibrium envelope determined based upon sensor data or a re-entry condition for the equilibrium envelope determined based upon the sensor data. A health status for the user can be determined, using the processor, based upon a comparison of the current metric with a historical metric for the user.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.

Abstract: The present invention relates to an apparatus for strengthening pelvic floor muscles which can be used even when a user wears clothes and thus can be used comfortably without psychological burden; can be cleanly used without the remains of foreign matter around the urethra and the anus or on the exterior of the apparatus after use; can perform treatment in a state in which an electrode portion is pressed in close contact with the bladder and the pelvic floor muscles through a height adjustment means; and can perform both an active exercise through low-frequency pulses and a passive exercise through a muscular strength sensing means.

Abstract: A method for processing ECG records from multiple patients for clinician overreading includes identifying an unread group of current ECG records from multiple patients awaiting clinician overreading. Each ECG record in the ungroup includes at least a current ECG data, a current waveform measurement, a current interpretative statement, and a serial comparison statement. A set of prioritization rules is applied with a processor to prioritize the current ECG records in the unread group into a prioritized order for clinician overreading based on at least one of the current waveform measurements, the current interpretive statements, and the serial comparison statements. The current ECG records are then presented in the prioritized order for clinician overreading.

Abstract: A method for stimulating nerve fibers to treat a condition in a patient first involves identifying carotid sinus nerve afferent fibers in a first side of the patient's neck and identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck. The method further involves placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers. Finally, the method involves stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device. This method may be performed on a second side of the neck as well.

Abstract: Methods, systems and devices for providing cardiac resynchronization therapy (CRT) to a patient using a leadless cardiac pacemaker (LCP) implanted in or proximate the left ventricle of a patient. A setup phase is used to establish parameters in the therapy delivery. In operation, the method and/or device will sense at least one non-paced cardiac cycle to determine a native R-R interval, and then delivers a synchronization pace at an interval less than the native R-R interval followed by a plurality of pace therapies delivered at the R-R interval or a modification thereof.

Abstract: Apparatus is provided that includes an extracranial electrode, configured to be placed outside and in electrical contact with a skull of a subject identified as at risk of or suffering from a disease; and a cerebrospinal fluid (CSF) electrode, configured to be implanted in a ventricular system of a brain of the subject. Control circuitry is configured to drive the extracranial and the CSF electrodes to clear a substance from brain parenchyma of the subject into the ventricular system of the brain. Other embodiments are also described.

Abstract: An electrosurgical instrument includes jaws having an electrode configuration utilized to electrically modify tissue in contact with one or more electrodes. The instrument is removably connectable to an electrosurgical unit via an electrosurgical connector extending from the instrument and a receptacle on the electrosurgical unit. The electrosurgical instrument is rotatable without disrupting electrical connection to the electrodes of the jaws. One or more of the electrodes is retractable. The electrosurgical unit and instrument optimally seals and/or cuts tissue based on identifying the tissue and monitoring the modification of the tissue by the application of radio frequency energy.

Abstract: Examples are described for configuring cardiac pacing circuitry of an implantable medical device. Circuitry that is configurable to control delivery of therapy or sense signals in accordance with a plurality of vectors may determine that one or more pins, for therapy delivery or sensing in accordance with a first subset of vectors of the plurality of vectors, are in an electrically floating state. Circuitry may selectively close one or more switches to couple at least a subset of the one or more pins to one or more set voltage levels, and deliver therapy in accordance with a vector of a second subset of vectors of the plurality of vectors, wherein the second subset of vectors is different than the first subset of vectors.

Abstract: The proposed invention relates to a mobile device and methods for acquisition of biophysiological signals for the purpose of assessing mental states. The said mobile device is embedded into wireless headset that comprises headphones. The mobile device comprises sensors for biophysiological signal acquisition, including, but not limited to, electroencephalographic (EEG) signals, pulse oximetry, heart rate, body temperature and electrodermal activity. Furthermore, the device also measures environmental factors, including, but not limited to, ambient light and sound from the environment. The mobile device administers sound and visual stimuli to the user. The said biophysiological signals, after being processed, are used to assess mental states of the user (emotional states and cognitive processes). Furthermore, the intensity of the said mental states can be maintained at the same level, enhanced or weakened or fully modified using visual or sound stimuli.

Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic vagus, trigeminal, obturator or other nerves.

Abstract: Methods and systems are provided for detecting arrhythmias in cardiac activity. The methods and systems declare a current beat, from the CA signals, to be a candidate beat or an ineligible beat based on whether the current beat satisfies the rate based selection criteria. The determining and declaring operations are repeated for multiple beats to form an ensemble of candidate beats. The method and system calculate a P-wave segment ensemble from the ensemble of candidate beats, perform a morphology-based comparison between the P-wave segment ensemble and at least one of a monophasic or biphasic template, declare a valid P-wave to be present within the CA signals based on the morphology-based comparison, and utilize the valid P-wave in an arrhythmia detection process to determine at least one of an arrhythmia entry, arrhythmia presence or arrhythmia exit.

Abstract: A feedthrough for an implantable medical electronic device that has a housing and a header. The feedthrough having an insulator that has a housing-side surface and a header-side surface opposite it, a feedthrough flange surrounding the insulator, and at least one primary connection element penetrating the insulator and for connection of an electrical or electronic component of the device. This electrical or electronic component is arranged in the housing. The connection element is fastened by a hard solder connection, so that it is fluid-tight in a passage of the insulator. The primary connection element has a housing-side end that is essentially even with the housing-side surface of the insulator or is recessed into the insulator with respect to this surface.

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.