Patents Examined by Nghi Nguyen
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Patent number: 9044444Abstract: A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein the peripheral monocytes are induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and an interleukin relative to GCSF.Type: GrantFiled: June 20, 2012Date of Patent: June 2, 2015Assignee: CHINA MEDICAL UNIVERSITYInventors: Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou, Po-Cheng Lin, Hen-Yi Chu
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Patent number: 9029079Abstract: A method of biotechnological production of a bovine hemoderivative comprising the steps of: freshly acquired animal blood matter is first fermented in several phases, the blood fermentation product obtained is dried, the dried fermentation product is separated, which is followed by ethanol extraction of the blood fermentation product in several phases, the blood fermentation product is then subjected to vacuum inspissation with subsequent stabilization after undesirable substances have been removed. The condensed extract is processed with etheric preparation during which the condensed blood fermentation product is subjected to ether precipitation, and the precipitate, thus obtained is separated from the solution of undesirable substances soluble in ether.Type: GrantFiled: February 26, 2010Date of Patent: May 12, 2015Assignee: SVUS Pharma a.s.Inventor: Du{hacek over (s)}an Trávní{hacek over (c)}ek
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Patent number: 8999710Abstract: In a process for preparing disinfected preparations from mammalian tissues, mammalian tissue is perfused at one step with an enzyme-free liquid antibiotic composition that includes at least one antibiotic and is contained in at least one perfusion buffer. In a step occurring after such one step, enzymatic antibiotic-free treatment of the tissue is carried out to obtain a single-cell suspension. In another step disinfected preparations are obtained.Type: GrantFiled: July 30, 2011Date of Patent: April 7, 2015Assignee: Cytonet GmbH & Co. KGInventors: Krasimira Aleksandrova, Marc Barthold, Lubomir Arseniev, Carsten Griesel, Christoph Priesner
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Patent number: 8921088Abstract: The present invention includes a method for harvesting or separating one or more biological cells from an aqueous feed, a stream, a suspension, or any combinations thereof by providing the aqueous feed, the stream, or the suspension comprising the one or more biological cells in a tank or a vessel; providing one or more ion-exchange resins, wherein the ion-exchange resin is an anion-exchange resin; contacting the anion-exchange resin with the aqueous feed; binding the one or more biological cells to the anion-exchange resin; releasing or eluting the bound one or more biological cells by changing the pH; and collecting the released one or more biological cells to obtain a concentrated slurry or suspension of the one or more biological cells.Type: GrantFiled: October 3, 2012Date of Patent: December 30, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Martin Poenie, Jessica Jones
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Patent number: 8858932Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1+ multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.Type: GrantFiled: June 25, 2009Date of Patent: October 14, 2014Assignee: Mesoblast, Inc.Inventor: Peter Ghosh
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Patent number: 8846339Abstract: The presently disclosed subject matter relates to Managed Ecosystem Fermentation (MEF) which is a continuous microbial process utilizing a managed ecosystem approach employing dozens to thousands of species of microorganisms, occurring in a controlled artificial environment and consuming organic materials without benefit of sterilization. The process of utilizing this fermentation for the consumption of organic materials on a continuous basis is within the scope of this disclosed subject matter. The process of separating chemicals as industrial chemicals from this fermentation on a continuous basis is within the scope of this disclosed subject matter. The process of separating biomass useful as high protein animal feed or fertilizer from this fermentation on a continuous (or semi-continuous) basis is within the scope of this disclosed subject matter.Type: GrantFiled: October 14, 2013Date of Patent: September 30, 2014Assignee: Integrated BioChem, LLCInventors: Edward Arthur Calt, Jr., Herbert Graham Tull, IV, Stanley Sylvester Toporek
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Patent number: 8828725Abstract: A culture medium is used for culturing neural cells. Each neural cell includes a neural cell body and at least one neurite branched from the neural cell body. The culture medium includes a substrate and a carbon nanotube structure located on the substrate. The carbon nanotube structure includes a number of carbon nanotube wires spaced apart from each other. A distance between adjacent carbon nanotube wires is greater than or equal to diameters of the neural cell bodies. The carbon nanotube wires are capable of guiding extending directions of the neurites.Type: GrantFiled: August 1, 2012Date of Patent: September 9, 2014Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.Inventors: Li Fan, Chen Feng, Wen-Mei Zhao
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Patent number: 8822176Abstract: Provided are methods for preparing chemically modified lipids. The lipids are obtained from heterotrophically cultured microalgae and are subjected to a transesterification or interesterification reaction. The microalgae include those from the genus Parachlorella, Prototheca, Chlorella, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to a Parachlorella, Prototheca, or Chlorella strain that are cultured in a bioreactor substantially in the absence of light.Type: GrantFiled: May 7, 2013Date of Patent: September 2, 2014Assignee: Solazyme, Inc.Inventors: Anthony G. Day, Geoffrey Brooks, Scott Franklin
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Patent number: 8822142Abstract: An analysis of type, state or other distinguishing features of individual cells from body fluids, smears or tissues includes the steps of depositing the cells, with a minimum possible overlap, on a mass spectrometric sample support, determining the coordinates of the cells, coating the sample support with a layer of small crystals of a matrix substance, positioning the cells, inside a mass spectrometer, according to their known coordinates with a movement device into the position of the laser focus, acquiring mass spectra of the individual cells with ionization of the cell components by matrix assisted laser desorption, and using the mass spectra for an analysis of type, state or other distinguishing features of the cells.Type: GrantFiled: December 9, 2008Date of Patent: September 2, 2014Assignee: Bruker Daltonik GmbHInventor: Sören-Oliver Deininger
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Patent number: 8822177Abstract: Provided are methods for preparing chemically modified lipids. The lipids are obtained from heterotrophically cultured microalgae and are subjected to an epoxidation reaction. The microalgae include those from the genus Parachlorella, Prototheca, Chlorella, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to a Parachlorella, Prototheca, or Chlorella strain that are cultured in a bioreactor substantially in the absence of light.Type: GrantFiled: May 7, 2013Date of Patent: September 2, 2014Assignee: Solazyme, Inc.Inventors: Anthony G. Day, Geoffrey Brooks, Scott Franklin
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Patent number: 8815565Abstract: Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.Type: GrantFiled: November 24, 2010Date of Patent: August 26, 2014Assignee: Cellsafe Co., Ltd.Inventor: Jae-Jin Han
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Patent number: 8809034Abstract: Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.Type: GrantFiled: November 26, 2013Date of Patent: August 19, 2014Assignee: Cellsafe Co., Ltd.Inventor: Jae-Jin Han
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Patent number: 8809015Abstract: Methods and systems for the production of hydrocarbon products, including providing a substrate comprising CO to a bioreactor containing a culture of one or more micro-organisms; and fermenting the culture in the bioreactor to produce one or more hydrocarbon products. The substrate comprising CO is derived from an industrial process selected from the group comprising steam reforming processes, refinery processes, steam cracking processes, and reverse water gas shift processes.Type: GrantFiled: October 21, 2011Date of Patent: August 19, 2014Assignee: LanzaTech New Zealand LimitedInventors: Michael Anthony Schultz, James Obern, Sean Dennis Simpson
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Patent number: 8802433Abstract: Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.Type: GrantFiled: December 3, 2010Date of Patent: August 12, 2014Assignee: Aureo Co., Ltd.Inventors: Naoyuki Moriya, Yukiko Moriya, Yasuhiro Nikawa, Yukitoshi Nagahara, Hidekazu Tamegai, Tadaaki Miyazaki
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Patent number: 8785195Abstract: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.Type: GrantFiled: October 12, 2010Date of Patent: July 22, 2014Assignee: The University of TokyoInventors: Shoji Takeuchi, Hiroaki Onoe, Yukiko Matsunaga, Daisuke Kiriya, Riho Gojo, Midori Negishi
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Patent number: 8765405Abstract: A sugar liquid containing only very small amounts of fermentation-inhibiting substances is produced by a method for producing a sugar liquid using a cellulose-containing biomass as a raw material, the method including: (1) a step of hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution; and (2) a step of filtering the obtained aqueous sugar solution through a nanofiltration membrane and/or reverse osmosis membrane to collect a purified sugar liquid from the feed side, while removing fermentation-inhibiting substances from the permeate side.Type: GrantFiled: December 8, 2009Date of Patent: July 1, 2014Assignee: Toray Industries, Inc.Inventors: Hiroyuki Kurihara, Atsushi Minamino, Masateru Ito, Hideki Sawai, Masayuki Hanakawa, Shin-ichi Minegishi, Katsushige Yamada
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Patent number: 8753853Abstract: This invention provides a process of making a linear dicarboxylic acid of C10, C12, C14, C16 or C18 chain length, the process comprising providing a feed which is a renewable resource, contacting the feed with a catalyst in the presence of hydrogen and at a temperature of about 250° C. to about 425° C. and at a pressure of about 500 psig to about 2500 psig (3450 kPa to about 17,250 kPa) to produce a hydrocarbon product having at least a 5:1 ratio of even-numbered alkanes to odd-numbered alkanes and comprising a linear alkane of Cn chain length; and fermenting at least a portion of the linear alkane of Cn chain length to a linear dicarboxylic acid of Cn chain length, wherein n=10, 12, 14, 16 or 18. The catalyst comprises an oxide, molybdenum, and one or more active metals selected from the group consisting of nickel, cobalt, and mixtures thereof and the catalyst is in sulfided form.Type: GrantFiled: December 11, 2009Date of Patent: June 17, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Joachim C. Ritter, Sourav Kumar Sengupta, Hasan Dindi, Robert D. Fallon, Ekaterini Korovessi, Andrew C. Eliot, John Joseph Hagedorn
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Patent number: 8741597Abstract: A reaction medium for detecting and/or identifying Staphylococcus aureus bacteria, comprising a combination of two enzymatic substrates for alpha-glucosidase.Type: GrantFiled: October 7, 2009Date of Patent: June 3, 2014Assignee: BiomérieuxInventors: Sylvain Orenga, Denis Robichon
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Patent number: 8709784Abstract: A method for liver protection of a mammal is provided and includes administering an effective amount of isolated Lactobacillus plantarum CMU995 thereto. Providing a new use of Lactobacillus plantarum CMU995, which is deposited at the Food Industry Research and Development Institute (FIRDI) in Taiwan under accession number BCRC 910472 and in the German Collection of Microorganisms and Cell Cultures (DSMZ) under accession number DSM 23780.Type: GrantFiled: January 8, 2013Date of Patent: April 29, 2014Assignee: China Medical UniversityInventors: Wen-Hsin Lin, Chi-Rei Wu
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Patent number: 8668899Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.Type: GrantFiled: November 15, 2010Date of Patent: March 11, 2014Assignee: University of Maryland, College ParkInventors: Matthew Dowling, Srinivasa Raghavan