Patents Examined by Nghi Nguyen
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Patent number: 8669086Abstract: Disclosed herein is a structure having: a porous polymeric film permeated by a first extracellular matrix material; and a topcoat layer comprising a second extracellular matrix gel disposed on the film. Also disclosed herein is a method of: providing a porous polymeric film; permeating the film with a first extracellular matrix material; and applying a topcoat layer of a second extracellular matrix material to the film. Also disclosed herein is a method of: laser-machining holes through a film comprising collagen to form a web-like structure.Type: GrantFiled: April 29, 2011Date of Patent: March 11, 2014Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Bradley R Ringeisen, Russell K. Pirlo, Peter K Wu
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Patent number: 8642310Abstract: A hydrolytic enzyme is to be stabilized in a liquid surfactant preparation. This is achieved by using a component that stabilizes the hydrolytic enzyme and encompasses a phthaloylglutamic acid and/or a phthaloylaspartic acid.Type: GrantFiled: January 25, 2013Date of Patent: February 4, 2014Assignee: Henkel AG & Co. KGaAInventors: Petra Siegert, Marion Merkel, Hendrik Hellmuth, Timothy O'Connell, Karl-Heinz Maurer
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Patent number: 8633004Abstract: A method for extracting fuel gases from an underwater plume emitted from an underwater hydrothermal vent includes the step of collecting via an underwater fluid collector an underwater plume emitted from the hydrothermal vent. The underwater plume includes methane and hydrogen. The method further includes a step of directing a first fluid containing the underwater plume into a first inlet of a first underwater heat exchanger and a second fluid into a second inlet of the first underwater heat exchanger. The second fluid at the second inlet is at a temperature sufficiently lower than the temperature of the first fluid to transfer sufficient heat therebetween to form methane hydrate and hydrogen-methane hydrate in the first fluid. The method further includes the step of conveying the methane hydrate and hydrogen-methane hydrate to the surface of the water body via a duct connected to a first outlet of the first heat exchanger.Type: GrantFiled: April 18, 2011Date of Patent: January 21, 2014Assignee: Lockheed Martin CorporationInventors: John W. Rapp, Stephanie S. Groves, Nicholas J. Nagurny
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Patent number: 8628763Abstract: The present invention relates to a method for the preparation of a fermented milk product comprising Bifidobacteria in combination with lactic acid bacteria of the species Lactococcus lactis, Sterptococcus thermophilus, and/or Lactobacillus bulgaricus. The problem to be solved is to provide a method to improve growth of Bifidobacteria population in milk during the fermentation process for making fermented milk products (e.g. a yogurt) in order to obtain a high cell count of Bifidobacteria in the final product.Type: GrantFiled: August 28, 2009Date of Patent: January 14, 2014Assignee: CHR-Hansen A/SInventors: Ditte Marie Folkenberg, Cecile Seimandi
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Patent number: 8586331Abstract: The present invention pertains to a method to produce RTX-toxin Apxl by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, to which medium a calcium salt is added to form calcium ions in the medium, wherein the culturing medium contains borogluconate to form a calcium borogluconate complex in the medium.Type: GrantFiled: November 25, 2009Date of Patent: November 19, 2013Assignee: Intervet International B.V.Inventors: Simen-Jan Slagman, Christian Theodoor Gerardus Smits, Bayram Bulut
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Patent number: 8574873Abstract: A process for the preparation of aqueous solutions of glucans having a ?-1,3-glycosidically-linked main chain and side groups having a ?-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the fermentation broth is effected using asymmetrical filter membranes.Type: GrantFiled: December 14, 2010Date of Patent: November 5, 2013Assignee: Wintershall Holding GmbHInventors: Jörg Therre, Hartwig Voβ, Julia Kristiane Schmidt, Tillmann Faust, Rajan Hollmann
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Patent number: 8574870Abstract: The presently disclosed subject matter relates to Managed Ecosystem Fermentation (MEF) which is a continuous microbial process utilizing a managed ecosystem approach employing dozens to thousands of species of microorganisms, occurring in a controlled artificial environment and consuming organic materials without benefit of sterilization. The process of utilizing this fermentation for the consumption of organic materials on a continuous basis is within the scope of this disclosed subject matter. The process of separating chemicals as industrial chemicals from this fermentation on a continuous basis is within the scope of this disclosed subject matter. The process of separating biomass useful as high protein animal feed or fertilizer from this fermentation on a continuous (or semi-continuous) basis is within the scope of this disclosed subject matter.Type: GrantFiled: January 9, 2013Date of Patent: November 5, 2013Assignee: Integrated BioChem, LLCInventors: Edward Arthur Calt, Jr., Herbert Graham Tull, IV, Stanley Sylvester Toporek
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Patent number: 8563296Abstract: Embodiments of a process for discharging amine byproducts formed in an amine-based solvent are provided. The process comprises the steps of contacting the amine-based solvent with flue gas comprising carbon dioxide, oxygen, nitrogen, NOx, SOx, or mixtures thereof to form a carbon dioxide-laden amine-based solvent that contains the amine byproducts. Carbon dioxide is separated from the carbon dioxide-laden amine-based solvent to form a carbon dioxide-depleted amine-based solvent. The amine byproducts from the carbon dioxide-depleted amine-based solvent are fed to an algae source.Type: GrantFiled: November 24, 2010Date of Patent: October 22, 2013Assignee: UOP LLCInventors: David W. Greer, Graham Ellis, Edward Zbacnik, Lubo Zhou
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Patent number: 8562973Abstract: Methods of treating individuals having sarcoidosis or a sarcoidosis-related disease or disorder using placental cells are described. Also describe are kits comprising placental stem cells or a composition thereof that can be used in methods of treating sarcoidosis or a sarcoidosis-related disease or disorder.Type: GrantFiled: April 6, 2011Date of Patent: October 22, 2013Assignee: Anthrogenesis CorporationInventors: James W. Edinger, Steven Alan Fischkoff, Aleksandar Francki, Vladimir Jankovic, Bitao Liang, Philippe Martin, Cynthia Ray, Xiaokui Zhang
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Patent number: 8551745Abstract: A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 ?m and less than 1 ?m, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.Type: GrantFiled: February 3, 2009Date of Patent: October 8, 2013Assignee: Toray Industries, Inc.Inventors: Nanami Sasaki, Ken Morita, Takashi Mimitsuka, Hideki Sawai, Katsushige Yamada
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Patent number: 8524223Abstract: A microorganism inhibits the growth of various plant pathogens, and is not reduced in its efficacy even when the microorganism is used in combination with a chemical pesticide. The microorganism is Bacillus subtilis KS1 strain (NITE BP-569). The plant disease control agent comprises a culture of the microorganism as an active ingredient.Type: GrantFiled: July 3, 2009Date of Patent: September 3, 2013Assignee: University of YamanashiInventors: Tsutomu Takayanagi, Shunji Suzuki, Seiichi Furuya
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Patent number: 8497086Abstract: A reaction medium for detecting and/or identifying methicillin-resistant Staphylococcus aureus (MRSA) bacteria includes a chromogenic substrate, a first antibiotic that belongs to the cephalosporin family and a second antibiotic that belongs to the aminoglycoside family.Type: GrantFiled: July 20, 2010Date of Patent: July 30, 2013Assignee: BiomereuxInventors: Jean-Marc Roche, Gilles Zambardi
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Patent number: 8470600Abstract: A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.Type: GrantFiled: May 27, 2009Date of Patent: June 25, 2013Assignee: Aarhus UniversitetInventors: Mogens Ryttergård Duch, Lotte Markert, Jette Lovmand, Annette Christine Füchtbauer, Ernst Martin Füchtbauer, Morten Foss, Flemming Besenbacher, Finn Skou Pedersen
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Patent number: 8450083Abstract: Methods for modifying a microalgal lipid by subjecting the lipid to a chemical reaction are provided, the lipid containing no more than 500 ppm color-generating impurities and obtained from Parachlorella, Prototheca, or Chlorella microalgal strains, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to such strains grown under heterotrophic conditions.Type: GrantFiled: August 31, 2012Date of Patent: May 28, 2013Assignee: Solazyme, Inc.Inventors: Anthony G. Day, Geoffrey Brooks, Scott Franklin
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Patent number: 8445235Abstract: The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterized in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level to increase RTX-toxin production during the production phase of the RTX-toxins.Type: GrantFiled: November 25, 2009Date of Patent: May 21, 2013Assignee: Intervet International B.V.Inventors: Simen-Jan Slagman, Christian Theodoor Gerardus Smits
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Patent number: 8444968Abstract: The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.Type: GrantFiled: December 7, 2006Date of Patent: May 21, 2013Assignee: Isto Technologies, Inc.Inventors: Mitchell S. Seyedin, Matthew Matava
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Patent number: 8415115Abstract: A reaction medium for detecting and/or identifying Methicillin-resistant Staphylococcus aureus (MRSA) bacteria, comprising a predetermined combination of two antibiotics, a first antibiotic which belongs to the cephalosporin family and a second antibiotic, said first and second antibiotics each being at a sub-inhibitory concentration.Type: GrantFiled: October 7, 2009Date of Patent: April 9, 2013Assignee: BiomerieuxInventors: Sylvain Orenga, Denis Robichon, Gilles Zambardi
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Patent number: 8399253Abstract: A three-dimensional cell culture method for increasing cell proliferation efficiency by suitably regulating the proliferation-inducing and proliferation-inhibitory signals between cells is provided. The method includes repeatedly performing any one or both of the following processes a) and b) so as to regulate proliferation-inducing and proliferation-inhibitory signals between the cells: a) a process of gradually adding the micro-scaffolds, in which a small amount of the micro-scaffolds are used in an initial stage in order to maintain a suitable distance between the cells, and the amount of the micro-scaffolds is then increased slowly according to cell proliferation rate; and b) a periodic shaking process, in which shaking is performed in order to separate connected cells from each other by a physical force, after the cells are incubated for more than a given period of time.Type: GrantFiled: April 28, 2007Date of Patent: March 19, 2013Inventor: Hyunjin Yang
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Patent number: 8367372Abstract: The presently disclosed subject matter relates to Managed Ecosystem Fermentation (MEF) which is a continuous microbial process utilizing a managed ecosystem approach employing dozens to thousands of species of microorganisms, occurring in a controlled artificial environment and consuming organic materials without benefit of sterilization. The process of utilizing this fermentation for the consumption of organic materials on a continuous basis is within the scope of this disclosed subject matter. The process of separating chemicals as industrial chemicals from this fermentation on a continuous basis is within the scope of this disclosed subject matter. The process of separating biomass useful as high protein animal feed or fertilizer from this fermentation on a continuous (or semi-continuous) basis is within the scope of this disclosed subject matter.Type: GrantFiled: June 11, 2012Date of Patent: February 5, 2013Assignee: Integrated BioChem, LLCInventors: Edward Arthur Calt, Jr., Herbert Graham Tull, IV, Stanley Sylvester Toporek
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Patent number: 8354257Abstract: A process for producing alcohol from syngas integrates the alcohol recovery with the removal of CO2 from syngas. A syngas feed containing CO, H2, and CO2 contacts an aqueous alcohol stream to remove CO2 from the syngas that then passes to bioreactor containing microorganisms for conversion to alcohol and other liquid products. Flashing of the scrubbing liquid releases the CO2 and simultaneously concentrates alcohol in the overhead flash vapor. Condensation of the flash vapor provides an enriched alcohol stream for enhanced recovery of the ethanol product in a product separation zone. The remainder of the scrubbing liquid along with make-up alcohol and water from the process gets returned for continued contact with the syngas feed.Type: GrantFiled: January 8, 2010Date of Patent: January 15, 2013Assignee: Coskata, Inc.Inventors: Rathin Datta, Ralph Corley