Abstract: A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

Abstract: An injector device includes a housing for receiving a medicament cartridge; a needle unit comprising a needle; and a first sleeve slideable along a longitudinal axis of the housing from a first position, in which the first sleeve conceals the needle, to a second position, in which the needle is exposed from an end of the first sleeve, the first sleeve configured to engage the needle unit so that, during use, movement of the first sleeve from the first position to the second position moves the needle unit from a primary position to a secondary position, in which secondary position the needle unit locates over an end of a medicament cartridge, wherein the device further comprises a second sleeve arranged to move telescopically with respect to the first sleeve, the first sleeve extending from the second sleeve when the first sleeve is in the first position.

Abstract: A drug-delivery device for vessels comprising a catheter body, an elongate ultrasound transmission member, an inflatable balloon, and a plurality of support wires. The catheter body has at least one lumen extending longitudinally therethrough. The elongate ultrasound transmission member extends longitudinally through the lumen. The elongate ultrasound transmission member has a distal portion and a proximal end configured to be coupled to an ultrasound transducer. The inflatable balloon, having an exterior surface, is coupled to the distal portion. The plurality of support wires are connected to the elongate ultrasound transmission member at two locations. A coating of at least one drug is on the exterior surface of the inflatable balloon. The elongate ultrasound transmission member is configured to transmit longitudinal vibrations to the inflatable balloon such that the inflatable balloon is longitudinally vibrated. The coating is removed by mechanical vibration of the inflatable balloon.

Abstract: An ultrasonic surgical handpiece includes a motor having a transducer assembly along a central axis of the surgical handpiece. The motor is configured for operative connection to a power source. A surgical attachment has a proximal end detachably connected to the motor and a distal end defining a working plane for engagement with biological tissue. A housing has a housing distal end, a housing proximal end, and a cavity configured to receive the motor and the surgical attachment. An irrigation path of the housing is configured to communicate irrigation fluid. The irrigation path has an inlet proximate the housing proximal end operatively connected to an irrigation fluid source, and an outlet proximate to the working plane. The irrigation path is separated from the housing cavity to prevent contact between the irrigation fluid and an operational portion of the surgical attachment.

Abstract: The present invention relates to peripheral intravenous catheters, and in particular to an integrated peripheral intravenous catheter having a low profile securement platform, a needle hub having an interior compartment and further comprising a paddle grip, and an extension tube coupled to the catheter and stored within the interior compartment of the needle hub prior to catheterization.

Abstract: A method and apparatus to direct a drug directly at the point needed for a specific duration for dialysis catheters which are made in standard sizes. Disclosed is a combination of a rate and duration-controlled infusion pump and reservoir and a pre-measured infusion catheter with a radiopaque distal tip. Along the length of the infusion catheter there is a luer lock connector and anti-leak valve. The invention is inserted into a dialysis catheter where the preset marking is aligned with the catheter hub and the distal infusion tip rest at or near the end of the dialysis catheter. The infusion unit is then activated, and the drug is delivered at the distal tip of the catheter, at or in the fibrin for maximum effect. The method of use and device saves time and resources as it can be deployed without the need for a surgical suite or heath care team.

Abstract: A guiding sheath has a braided layer for improved deflection characteristics and ring electrodes for electrical sensing, mapping and visualization, wherein lead wires for the ring electrodes are passed through lumened tubing position under the braided layer in a proximal portion of the guiding sheath shaft and above the braided layer in a distal portion of the guiding sheath shaft. Moreover, the hemostatic valve includes an improved friction ring with air vents to reduce the risk of air being introduced into the valve.

Abstract: An autoinjector having a reservoir (100) containing fluid and a piston; a needle; a driver (200) having a body; a piston rod (210) movable between a rest position and an injection position; an injection spring (220); and a force control mechanism (280, 290) for causing the force exerted by the injection spring to vary in predetermined manner during injection, and a lever (280) and a cam (290), the lever (280) pivotally mounted on the piston rod, being connected to the injection spring (220), and co-operating with the cam; and an interface module (300) fastened to the driver that receives a reservoir (100) before each actuation. The interface module having a selector ring (310) mounted to turn on the driver module, and pivot elements (320) fastening the reservoir module in the interface module.

Abstract: A medicament delivery device extends along a longitudinal axis and includes: a generally tubular elongated housing having a proximal and a distal end, where the generally tubular elongated housing is arranged to accommodate a medicament container; a drive unit comprising a drive element and plunger rod operably arranged to act on the medicament container; a tubular element rotatably arranged in relation to the housing and operably arranged to the plunger rod, where the plunger rod includes at least one holding member and where the tubular element includes at least one arm extending generally transversal to the longitudinal axis of the device, wherein the at least one arm is arranged to engage the at least one holding member on the plunger rod to releasable hold the drive unit in an energy accumulated state.

Abstract: A medical system comprising: an analyte sensor for receiving an analyte signal corresponding to an analyte concentration of a user; a health monitor device comprising a display unit and in communication with the analyte sensor, the health monitor device comprising a processor and memory communicably coupled to the processor, the memory including instructions stored therein that, when executed by the processor, cause the processor to: receive the analyte signal from the analyte sensor; determine the analyte concentration based on the analyte signal; calculate a recommended medication dosage based on the analyte concentration; associate a current parameter type with the recommended medication dosage; associate the current parameter type to at least one corresponding stored historical parameter type associated with a historical medication dosage; and display, on the display unit, the recommended medication dosage and the historical medication dosage.

Abstract: An apparatus for preventing backflow. The apparatus includes a housing; a trap flow part forming a flow passage for a medical fluid, a discharge part provided on an lower portion of the housing and to receive the medical fluid from the trap flow part and to discharge the medical fluid; a backflow prevention chamber part provided between the trap flow part and the discharge part; and a plate-shaped backflow prevention member provided on one surface of the inner side of the backflow prevention chamber part connected to the trap flow part and in close contact with a periphery of the outlet opening, the plate-shaped backflow prevention member being provided to open or close the opening depending on forward flow and the backflow of the medical fluid.

Abstract: Methods and devices that provide enhanced delivery of a composition to a body region of a patient utilizing radiofrequency energy include directing a first electrode and a second electrode coupled to a radiofrequency energy source to a location proximate to the body region. Radiofrequency energy is provided in modulated pulses from the radiofrequency energy source to the body region from at least one of the first electrode and the second electrode to provide a delivery condition configured to enhance delivery of the composition. The composition is delivered proximate to the body region using a composition delivery element. Devices for enhance composition delivery are also disclosed.

Abstract: A safety needle system operable with a medical device includes: a housing with a needle mount having a needle; and a sheath telescopically engaged with the housing and surrounding the needle such that the sheath operates in a retracted position, in which the sheath exposes the needle, and an extended position, in which the sheath surrounds the needle. The sheath is coupleable to the medical device such that removal of the needle from the medical device draws the sheath over the needle, transitioning the sheath from the retracted position to the extended position. The system can include a slider engaged with the sheath and/or housing and including a restraint that engages and disengages the sheath to respectively reinforce and weaken the coupling of the sheath and medical device. The sheath can include a longitudinal track that slidingly engages a setting of the housing between sheath positions.

Abstract: An apparatus for capturing circulating tumor cells (CTCs) from blood. The apparatus includes a wearable device that receives fluid from vasculature of a subject through an input channel. A pump is coupled to the input channel the pump configured to receive blood at a first flow rate and to convert the flow of the blood to a second flow rate. The device further includes a replaceable candidate cell capture module having a microfluidic capture stage with herringbone channel structures configured to capture the candidate cells by antibodies. The device is further configured to provide the blood back to the vasculature of the subject.

Abstract: An atraumatic trocar apparatus, kit, and method of use are described. The atraumatic trocar includes a cannula and an obturator with an anterior rounded tip and an opening proximate to the anterior rounded tip. The atraumatic trocar is assembled by passing the obturator through an interior passage of a tubular cannula body of the cannula. The assembled atraumatic trocar is used to probe an incision, while delivering a hydrodissecting fluid through the opening to create a fluid channel, to reach a delivery site within subcutaneous tissue. The obturator is removed from the cannula and two or more medication pellets loaded within the interior passage. The obturator is used to push the medication pellets through the interior passage to the delivery site and deposit the medication pellets within the subcutaneous tissue.

Abstract: The embodiments presented herein relate to concepts designed to eliminate the gap between a catheter and guide wire that can otherwise contribute to a catheter getting stuck within the vasculature. In an example embodiment, a microcatheter with an enlarged distal section is described. The enlarged portion of the microcatheter may be located close to the inner diameter of the guide catheter in order to reduce any open space between the microcatheter and the guide catheter, and the guidewire can be placed through the microcatheter and used to guide the system. The microcatheter can include one or more marker bands to aid in aligning the microcatheter correctly relative to the guide catheter. After the guide catheter and microcatheter are tracked to the appropriate treatment site, the microcatheter can then be used to deploy various medical devices to treat a patient.

Abstract: A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. The limit of use is reached when at least one of a first criterion and a second criterion is met, wherein the first criterion is that the timer reaches or exceeds a time limit and wherein the second criterion is that at least one operation of a drive train of said medical device reaches or exceeds a limit.

Abstract: A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.

Abstract: Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.

Abstract: A flow selector valve assembly for an enteral feeding pump system (i.e., an enteral feeding pump system including a fluid delivery set with first and second feeding tubes, an enteral feeding pump and a pinching mechanism for regulating the flow of nutrient formula or water out of the first and second feeding tubes), and a twin port adapter for use in the valve assembly. The twin port adapter includes a body configured to receive the first and second feeding tubes therein, and a feeding tube guide rotatably connected to the body and configured to secure the first and second feeding tubes within the body.