Abstract: A connector is disclosed that attaches an irrigation catheter to tubing of an anal or stomal irrigation system. The connector has a housing, a pressure control device retained within the housing, and a restriction element. The pressure control device has an inlet channel on a distal side of the pressure control device communicating along an irrigation flow path with an outlet channel on a proximal side of the pressure control device, and a secondary outlet located between the inlet channel and the outlet channel and in communication with the irrigation flow path. The restriction element is inserted into the secondary outlet.

Abstract: Systems and methods for providing recommended doses and instructions for pharmaceutical treatments, and more particularly systems and methods for measuring physiological and/or electrophysiological signals from a subject and providing recommended doses and instructions of pharmaceuticals based at least in part on the measured signals are described. Further, the recommended doses and instructions are based at least in part on a subject's disease(s), disorder(s), or injuries and/or symptom(s) of such, and/or side effects of medications or treatments the subject is receiving. The recommended doses and instructions are personally tailored to the subject to precisely and personally address the subject's needs, and may be based in part on correlation with database(s) comprising historical data of the subject and/or other subjects to treat the subject's movement disorders, injuries to the body or brain, cognitive diseases and disorders, sleep diseases and disorders, chronic pain, or other conditions.

Abstract: An external catheter stabilizer device includes a base portion that attaches at a patient, a retaining element that retains a catheter tube, and a pivot element that pivotally attaches the retaining element to the base portion. The pivot element includes a shaft and a larger diameter head at an end of the shaft. The housing includes a key hole having a wider portion and a narrower portion. The housing is positioned at the base portion by receiving the head of the pivot element through the wider portion of the key hole and moving the shaft of the pivot element along the key hole to position the shaft of the pivot element at the narrower portion of the key hole. With the pivot element positioned at the narrower portion of the key hole, the housing maintains the pivot element at the narrower portion when the housing is closed.

Abstract: There is provided an IV flow regulator, which includes an upper lever; a lower lever which is disposed below the upper lever and regulates the flow rate of the IV by a regulation operation of rotating by facing the upper lever; a cover fastened to the lower lever; and switching restraint unit which switches a restraint state in which the cover and the lower lever are mutually restrained to enable the regulation operation and a free state in which the cover and the lower lever are not mutually restrained to disable the regulation operation, according to a relative position of the cover and the lower lever.

Abstract: A flow control device includes a housing having a primary valve body defining a primary inlet and an outlet, a secondary valve body defining a secondary inlet and a chamber defined by an inner circumferential surface of the housing and fluidly connecting the primary and secondary inlets with the outlet. The primary and secondary inlets share a common central axis perpendicularly disposed to a central axis of the outlet. A valve member is reciprocally mounted in the chamber to block fluid communication between the secondary inlet and the outlet when fluid pressure into the primary inlet is higher than fluid pressure into the secondary inlet, and block fluid communication between the primary inlet and the outlet when fluid pressure into the secondary inlet is higher than fluid pressure into the primary inlet.

Abstract: A drug delivery device includes a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger. The feedback mechanism comprises a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position The plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Abstract: A connector for connecting a container containing a medical fluid to a vascular access device may include an upper housing defining a first internal chamber, and a lower housing coupled to the upper housing and defining a second internal chamber for circulation of the medical fluid into the outlet. The connector may further include a slider disposed at least partially in the first and second internal chambers, and a plug coupled to a distal end of the slider. The slider may be reciprocally movable between (i) an open position, where the plug is spaced apart from a floor of the internal chamber to allow the medical fluid to flow through the outlet, and (ii) a closed position where the plug abuts the floor of the second internal chamber to block the medical fluid from flowing through the outlet.

Abstract: The electrochemical pump unit of mesh combined electrode of the present invention is connected to a drug injection container for operation, when it is connected to the power supply, the cathode (or anode) enters into electrochemical reaction with the electrolyte of the superabsorbent material layer through the mesh electrode to release a first gas, the first gas flows through the screen meshes of mesh electrode immediately without obstruction loss; the anode (or cathode) enters into electrochemical reaction with the electrolyte on the opposite side of superabsorbent material layer through the plane electrode to release a second gas, the second gas flows through the inter fibrous small space/channels of superabsorbent material layer and the screen meshes of mesh electrode; as the first gas and the second gas increase, the piston is pushed, and the medicament is pushed.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Abstract: An administration line for use with a fluid injector system includes a fluid verification module configured to be in operative communication with a housing of the fluid injector system such that the fluid injector system can determine a status of the administration line. The fluid verification module includes a body defining an inlet port, an outlet port, and a fluid channel extending from the inlet port to the outlet port; a first tubing section connected to the inlet port; and a second tubing section connected to the outlet port.

Abstract: Described herein is a dose monitoring device configured to couple with one or more medication delivery instruments to capture, record and/or process dosing events or events of delivering a medication dose. The dose monitoring device may include electronics such as a sensor, a clock module and a temperature module related to monitoring the time of dosing events.

Abstract: Some embodiments provide for humidifier control systems and methods configured to adjust power to a heater plate in a surgical humidifier to account for changes in flow rate to provide a consistent output, to provide functionality for different modes of use, and to provide accurate control over temperature and/or humidity at relatively low flows. The humidifier control system can receive a flow rate reading and determine a power requirement corresponding to the received flow rate reading, wherein the power requirement is one of a plurality of set points which correspond to ranges of flow rates. The humidifier control system can determine a mode of use based at least in part on the flow rate reading. The humidifier control system can provide electrical power to the heater plate according to the power requirement and/or the mode of use.

Abstract: A phototherapy face mask is provided for emitting therapeutic radiation towards the facial region of a user and aims to restore the youthful appearance of the user who is wearing the mask. The phototherapy mask comprises an outer surface and an inner surface, wherein the inner surface is aligned with the facial skin of the user. A flexible PCB layer is provided between the inner surface and the outer surface, on which a plurality of coherent light sources such as LEDs are mounted. The light sources are configured to emit radiation preferably in the visible and infrared range of the electromagnetic spectrum. The mask further includes a medicament chamber which is operably coupled to a piezoelectric pump that dispenses the medicament at regular intervals. The medicament is uniformly distributed all over the facial region of the user through a plurality of pores of the mask.

Abstract: In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors distributed pre-filled and with the springs tensed may be provided with a needle protecting cap to ensure sterility of the needle. When the needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container and needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve accommodating the active agent container. When the auto-injector is placed onto the skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange, thereby freeing the travel path for needle movement.

Abstract: A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

Abstract: An injector device includes a housing for receiving a medicament cartridge; a needle unit comprising a needle; and a first sleeve slideable along a longitudinal axis of the housing from a first position, in which the first sleeve conceals the needle, to a second position, in which the needle is exposed from an end of the first sleeve, the first sleeve configured to engage the needle unit so that, during use, movement of the first sleeve from the first position to the second position moves the needle unit from a primary position to a secondary position, in which secondary position the needle unit locates over an end of a medicament cartridge, wherein the device further comprises a second sleeve arranged to move telescopically with respect to the first sleeve, the first sleeve extending from the second sleeve when the first sleeve is in the first position.

Abstract: An ultrasonic surgical handpiece includes a motor having a transducer assembly along a central axis of the surgical handpiece. The motor is configured for operative connection to a power source. A surgical attachment has a proximal end detachably connected to the motor and a distal end defining a working plane for engagement with biological tissue. A housing has a housing distal end, a housing proximal end, and a cavity configured to receive the motor and the surgical attachment. An irrigation path of the housing is configured to communicate irrigation fluid. The irrigation path has an inlet proximate the housing proximal end operatively connected to an irrigation fluid source, and an outlet proximate to the working plane. The irrigation path is separated from the housing cavity to prevent contact between the irrigation fluid and an operational portion of the surgical attachment.