Abstract: A method of atraumatic medication pellet delivery using an atraumatic trocar apparatus is described. The atraumatic trocar apparatus includes a cannula and an obturator. The method includes receiving the obturator by the cannula, wherein the obturator passes through the interior passage and exits through the anterior cannula opening so that the obturator anterior rounded tip extends past the anterior cannula end and at least one opening proximate to the anterior rounded tip also extends past the anterior cannula end. The method includes inserting the atraumatic trocar through an incision into subcutaneous tissue along an insertion path to an insertion length. Additionally, the method includes inserting one or more medication pellet into the medication slot of the inserted cannula and delivering the medication pellet(s) through the interior passage of the cannula to a subcutaneous delivery site by inserting the obturator into the posterior opening of the cannula.

Abstract: A delivery system and methods are disclosed for delivering a material to a target site. A delivery instrument is coupled to a robotic manipulator and comprises a delivery device having a distal tip comprising an opening deliver the material to the target site through the opening. A navigation system tracks the delivery device and the target site and generates position signals. One or more controllers are in communication with the robotic manipulator and the navigation system and define a virtual boundary associated with the target site, wherein the virtual boundary is utilized to constrain movement of the delivery device. The one or more controllers control one or more joint motors of the robotic manipulator to move the distal tip of the delivery device with respect to the virtual boundary based on the position signals from the navigation system.

Abstract: Constriction valves for catheters and method of using constriction valves are presented. The catheter valve has a conduit comprising mesh defining a lumen. The catheter also has a biasing member that is configured to bias the lumen from an open position to a closed position by altering an effective length of the conduit or altering the circumference of the conduit. The biasing member is further configured to change its configuration by changes of intraluminal pressure of the valve. A user can insert a tool into a catheter having a valve by manipulating the valve to expand a substantially closed lumen by compressing the biasing member, twisting the biasing member, or pulling on a cord coupled with the valve.

Abstract: Priming systems and infusion assemblies are provided. For example, a priming system comprises a priming conduit having a priming portion and a pressure portion. The priming portion is in fluid communication with a first fluid source, with an inlet and an outlet for ingress and egress of a first fluid from the first fluid source. The pressure portion is in fluid communication with a second fluid source connected by a connector. Disposed within the priming conduit are a biasing member and a valve having an open position and a closed position. The biasing member is in operable communication with the valve to urge the valve into the closed position such that the valve defaults to the closed position. The open position allows the first fluid to flow from the inlet to the outlet and the closed position prevents the first fluid from flowing from the inlet to the outlet.

Abstract: A guidewire retraction device having a first support structure located opposite a second support structure. The first support structure has a primary bore traversing the length of the first support structure. The first support structure has a first opening bordering a first ramp. The first ramp is connected to the primary bore. A second support structure has a secondary bore traversing the length of the second support structure. The second support structure has a second opening bordering a second ramp. The second ramp is connected to the secondary bore. The first ramp of the first support structure and the second ramp of the second support structure are configured to receive a guidewire. A rotation element is rotated in a first direction to orient the guidewire in a retracted orientation. The rotation element is rotated in a second direction to orient the guidewire in an advanced orientation.

Abstract: Systems and methods are disclosed for providing recommended doses and instructions for pharmaceutical treatments by measuring physiological and/or electrophysiological signals from a subject and providing recommended doses and instructions of pharmaceuticals based at least in part on the measured signals. Further, the recommended doses and instructions are based at least in part on a subject's disease(s), disorder(s), or injuries and/or symptom(s) of such, and/or side effects of medications or treatments the subject is receiving. The recommended doses and instructions are personally tailored to the subject to precisely and personally address the subject's needs, and may be based in part on correlation with database(s) comprising historical data of the subject and/or other subjects to treat the subject's movement disorders, injuries to the body or brain, cognitive diseases and disorders, sleep diseases and disorders, chronic pain, or other conditions.

Abstract: An external catheter stabilizer device for stabilizing and retaining a catheter tube includes a base portion configured to adhesively attach at a patient, a retaining element configured to retain a catheter tube thereat, and a pivot element that pivotally attaches the retaining element to the base portion so as to allow for pivotal movement of the retaining element about a pivot axis generally normal to the patient where the base portion is attached. The retaining element includes a guide pin protruding therefrom and spaced from the pivot element. Pivotal movement of the retaining element relative to the base portion is limited to a selected range via engagement of the guide pin of the retaining element with an arcuate slot at the base portion.

Abstract: An automatic injection device includes an injection syringe for injecting liquid provided with a syringe body carrying an injection needle and a piston rod mounted to be able to move inside this syringe body to cover an injection stroke during which the liquid is injected, an external casing and a positioning control member that are telescopic, the relative movement of which controls the operation of the automatic injection device, and control members arranged to selectively control the movement of the syringe body and the movement of the piston inside the positioning control member in order to automatically inject the liquid present in the injection syringe, the automatic injection device further comprising a device for generating sound signals activated during the automatic injection of the liquid present in the injection syringe so as to generate a series of sound signals from the start to the end of the injection.

Abstract: A system and method for monitoring the pressure of an injection site, utilizing a fluid operating in the laminar regime flowing through a calibrated tube, and measuring a pressure at one end of the calibrated tube with a pressure sensor, as well as a fluid velocity with a flow sensor, such as an elastic filament velocimeter, that comprises a nano-scale sensing element. Additional elements may be utilized, including the use of data acquisition units, processors, user interfaces, pumps, syringes, and control loops.

Abstract: A method for controlling gas composition in a surgical cavity during an endoscopic surgical procedure includes monitoring for a plurality of gas species in a gas flow from a surgical cavity of a patient. The method includes measuring the plurality of gas species in the gas flow from the surgical cavity and determining if the gas species measured in the gas flow from the surgical cavity are each present and/or within a respective desired range. The method includes adding gas into the surgical cavity if one or more gas species in the plurality of gas species is outside of the respective desired range so as to bring a composition of gas species in the surgical cavity within the respective desired range.

Abstract: A system for monitoring upstream flow characteristics for a pump is provided. The system may receive one or more outputs from a fluid level sensor coupled with a pump. The system may detect based on at least the one or more outputs, an abnormal upstream flow condition in the pump, such as a full upstream occlusion in the tube, a partial upstream occlusion in the tube, an empty reservoir, and/or a backflow of the fluid into the drip chamber. The system may adjust, based on the detection of an abnormal upstream flow condition in the pump, operation of the pump.

Abstract: Disclosed herein is a catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the catheter having a distal tube and a proximal shaft coupled to a proximal portion of the distal tubular member. The distal tube can have a tubular wall, a tube lumen defined within the tube by the tubular wall, a proximal opening sized to allow a medical device to be positioned therethrough, and at least one opening defined within the tubular wall along a length of the distal tube.

Abstract: A penis erection stimulation system comprises an implantable drug delivery device for delivering a drug to a penis to achieve erection of the penis. An infusion needle of the device is placed outside a left or a right corpus cavernosum in close proximity thereto and advanced into and retracted from, as well as deliver a drug when advanced into, at least one of: the left or right corpus cavernosum, one or two of deep arteries thereof, muscle tissue regulating blood flow through the right, left or both corpus cavernosum and tissue in close proximity to the left, right or both corpus cavernosum. The at least one infusion needle fits in a position in between the left and right corpus cavernosum at a base of the penile tissue placed inside a patient's body where the left and right corpus cavernosum are deviating away from each other.

Abstract: Provided is a cap for an injector comprising a syringe with a needle cover. The cap comprises a first cap body part in the form of a sleeve having forward and rear openings; a second cap body part in the form of a plug arranged for receipt by said forward opening of said sleeve form first cap body part, wherein said plug form second body part defines a plug top and an inner plug body, and wherein said inner plug body defines a protruding pocket; and arranged for receipt within said protruding pocket of the inner plug body, a metal connector defining plural needle cover gripping elements arranged around a central hub, wherein each gripping element is provided with one or more barbs for gripping the needle cover. The first cap body part, second cap body part and connector are provided as separate parts.

Abstract: An irrigation system for anal or stomal irrigation includes a tubing system attachable between a reservoir and a catheter. The tubing system has a proximal portion attachable to the reservoir and a distal portion including a distal end that is attachable to the catheter, with the tubing system providing an irrigation flow path from the proximal portion attachable to the reservoir through the distal end attachable to the catheter. A pump is operable to move the liquid through the irrigation flow path to provide the anal or stomal irrigation out of the catheter. A pressure control device is attachable to the distal portion of the tubing system and communicates with the catheter. The pressure control device has a valve that is adapted to limit an irrigation pressure for the anal or stomal irrigation out of the catheter to a value less than a pre-determined pressure threshold.

Abstract: A medical tube holding system for holding tubes extending from the mouth of a patient. Embodiments of the system comprise a rim or mask shaped and sized to be supported on the face of a patient, a lower support surface comprising various shapes and openings, and a tube holding device comprising at least one opening for receiving a medical tube and comprising a first adjusting component and a second adjusting component. Embodiments of the system include various features, including adjusting mechanisms in various dimensions, tube clamps, cushioning and straps.

Abstract: An automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the insertion needle, and a drive system configured to cause linear movement of the plunger to force the pharmaceutical product into the fluid path. The passive drive system has a movable element. The movable element has a shape memory alloy and is configured to change shape to move the plunger.

Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.

Abstract: A gear-driven infusion assembly is provided which has a housing, a gear assembly coupled to the housing, a shuttle assembly slidably coupled to the housing and operably coupled to the gear assembly, and a tube enclosure connected to the housing. The tube enclosure is configured to house a primary drug closure such as a syringe. The gear assembly includes a spool assembly having a pinion gear and a drive spool. When the spring rotates the drive spool, the drive spool drives the pinion gear, and the gear assembly drives the shuttle assembly. When the gear assembly drives the shuttle assembly, the shuttle assembly slides longitudinally along the housing. The gear assembly may be spring driven such that a spring rotates the pinion gear about the drive spool. An overspeed protection device is also provided which has a spool assembly including a drive spool.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.