Patents Examined by P. Ponnaluri
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Patent number: 6015877Abstract: Compounds used to treat cancer which inhibit carboxy terminal proteolysis of proteins having a carboxyl-terminal -CAAX motif (C=cysteine, A=aliphatic amino acid, and X=any amino acid). The compounds have the formula W--Y--CH.sub.2 --Q, where:1) W is a substituted or unsubstituted farnesyl group, a substituted or unsubstituted geranylgeranyl group, or a lipophilic alkyl, alkenyl, aryl or arylalkyl hydrocarbon group;2) Y is: ##STR1## wherein T.sub.1 is: --H, --CH.sub.3, --F, or --(CH.sub.2).sub.n --X.sub.1 ; in which n is an integer <20; and X.sub.1 is: --SH, --COOH, or --CONH.sub.2 ;T.sub.2 is: --N-benzxyloxycarbonyl (Boc), N--.phi.--, in which .phi. is an amino acid or a polypeptide reside; and ##STR2## wherein X.sub.2 is a peptide residue linked to carbon via the amino terminal nitrogen; and X.sub.3 is a peptide residue linked via an alpha carbon of the peptide; n is an integer <20, X.sub.4 is a halide and .beta. is an amino acid residue.Type: GrantFiled: March 14, 1996Date of Patent: January 18, 2000Assignee: President and Fellows of Harvard CollegeInventor: Robert R. Rando
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Patent number: 6013458Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: April 30, 1997Date of Patent: January 11, 2000Assignee: Molecumetics, Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim
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Patent number: 6008057Abstract: Disclosed is a method of assaying, in assay apparatus, for at least the ligand intended to be used to assay analyte in a sample, with which analyte the ligand will specifically bind. The method provides a product in which a ligand is labeled with a detectable tag and is immobilized on an appropriate substrate. An assay is made to measure the immobilized, labeled ligand by detecting the tag labeling the latter. The product can then be used to assay for the analyte by contacting the latter so as to form a complex. The extent and rate of specific binding of the analyte in the complex is identifiable, either by competition assay or sandwich assay as a rate of change, so the relative proportions of analyte and ligand are readily determinable.Type: GrantFiled: March 17, 1995Date of Patent: December 28, 1999Assignee: Roche Diagnostics CorporationInventors: Thomas R. Glass, Myron J. Block
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Patent number: 6008005Abstract: A method for estimation of change in bone mineral density or a method for diagnosis of osteoporosis, comprising the step of measuring change in a concentration of soluble interleukin-6 receptor in a blood sample, by for example, sandwich assay or competition assay; and a kit for carrying out said methods, comprising:(1) an anti-sIL-6R antibody immobilized to a solid carrier, and(2) an anti-sIL-6R antibody is bound to a detectable marker or capable of binding to a detectable marker.Type: GrantFiled: February 20, 1996Date of Patent: December 28, 1999Assignee: Tosoh CorporationInventors: Masataka Shiraki, Jui-Tung Chen, Ikuo Morita, Naoko Maruo
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Patent number: 5998580Abstract: Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including a photolabile molecule; and (b) incorporating the amino acid into a peptide during synthesis, wherein incorporation of the amino acid into the peptide produces a photosensitive peptide. Also disclosed is a method of introducing a photosensitive cleavage site into a synthetic peptide, including synthesizing a synthetic peptide having at least one photolabile amino acid, wherein the photolabile amino acid is positioned within the synthetic peptide so that upon irradiation the synthetic peptide is cleaved.Type: GrantFiled: October 13, 1995Date of Patent: December 7, 1999Inventors: Frederick F. Fay, Robert Carraway, Mitsuo Ikebe, Jeffrey Walker
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Patent number: 5989453Abstract: A process for the manufacture of pigments comprising a colored composition incorporated in a polycondensation resin, wherein the reactants for the formation of the polycondensation resin and the colored composition are introduced continuously into an extruder, preferably at a temperature of between 100.degree. C. and 280.degree. C., the mixture is caused to travel forward in the extruder, at the end of reaction the mixture is withdrawn continuously from the extruder, and is deposited continuously onto a conveyor belt, broken up into thermoset flakes, and cooled, the conveyor belt having means for cooling and means for detaching the flakes from the belt. The process is particularly suitable for the preparation of fluorescence pigments. Also disclosed are compositions comprising diketo-pyrrolo-pyrrole colorants and certain polyester or polyamide resins as well as a process for the preparation of the compositions.Type: GrantFiled: March 7, 1994Date of Patent: November 23, 1999Assignees: Societe Nouvelle de Chimie Industrielle S.A., Ciba Specialty Chemicals Holding, Inc.Inventors: Michel Jean Marcq, Martin Tanner
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Patent number: 5989551Abstract: The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to GAD.sub.65, IA-2 and a previously unidentified antigen termed IA-2.beta. herein, the method provides a chemical assay which has improved reliability. In addition, these antigens may be employed in therapeutic regimens aimed at achieving amelioration of the clinical condition.Type: GrantFiled: October 25, 1995Date of Patent: November 23, 1999Assignees: The United States of America as represented by the Department of Health and Human Services, The University of FloridaInventors: Noel K. Maclaren, Abner L. Notkins, Michael S. Lan, Qing Li
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Patent number: 5989918Abstract: A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4) disrupting the emulsion, and (5) analyzing the aqueous phase of the perfusate for the concentration of test compounds.Type: GrantFiled: August 28, 1997Date of Patent: November 23, 1999Assignee: Chiron CorporationInventors: Corine M. Dietz, Jacqueline A. Gibbons, Eric W. Taylor
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Patent number: 5985957Abstract: A corrosion preventive material contains zinc and is applied to the surface of a metal product for preventing corrosion of the product. The material consists essentially of a base material of synthetic resin and 65% or more zinc powder by weight dispersed in the base material, the zinc powder containing 25% or more zinc powder by weight having a grain diameter of or above 150 .mu.m. Alternatively, the corrosion preventive material consists essentially of a base material of synthetic resin and 45% or more zinc powder by weight dispersed in the base material, the zinc powder containing 90% or more zinc powder by weight having a grain diameter of or above 150 .mu.m.Type: GrantFiled: January 31, 1997Date of Patent: November 16, 1999Assignees: Togo Seisakusyo Corporation, Nitto Denko CorporationInventors: Kazutoshi Sakakibara, Minoru Kaneko, Kazumasa Asano
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Patent number: 5981286Abstract: The present invention concerns new hydrophilic metal complexes and their use as luminescent marker groups in immunoassays.Type: GrantFiled: January 16, 1997Date of Patent: November 9, 1999Assignee: Roche Diagnostics, GmbHInventors: Rupert Herrmann, Hans-Peter Josel, Gunter Pappert, Fritz Vogtle, Bruno Frommberger, Jorg Issberner
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Patent number: 5980017Abstract: A process for producing a liquid jet recording head, comprising the steps of: providing a substrate for a liquid jet recording head, which is provided with a heat generating resistor; forming a thermoplastic resin layer capable of being solubilized on the substrate; subjecting the thermoplastic resin layer on the substrate to patterning treatment to form an ink pathway pattern in a state that the heat generating resistor is positioned at the bottom of the ink pathway pattern while being covered by the ink pathway pattern; subjecting the ink pathway pattern to heat treatment at a higher temperature than the melting point of the thermoplastic resin layer constituting the ink pathway pattern to round corners of the ink pathway pattern into a rounded ink pathway pattern; forming a resin coat layer on the substrate having the rounded ink pathway pattern thereon; forming an ink discharge outlet at a portion of the resin coat layer which is situated right above the heat generating resistor; and eluting the rounded iType: GrantFiled: January 10, 1997Date of Patent: November 9, 1999Assignee: Canon Kabushiki KaishaInventor: Tamaki Sato
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Patent number: 5976492Abstract: .sup.32 P- and .sup.33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking .sup.32 P- or .sup.33 P-containing molecules to targeting proteins in such a way that the targeting protein retains the ability to bind to a cellular target. Methods for preparing the labeled proteins and their use in methods of radiotherapy are described.Type: GrantFiled: November 26, 1997Date of Patent: November 2, 1999Assignee: Immunomedics, Inc.Inventors: Gary L. Griffiths, Hans J. Hansen, Habibe Karacay
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Patent number: 5962338Abstract: A method of using a reaction plenum in the presence or absence of paramagnetic beads to perform chemical syntheses resulting in separation and recovery of a final desired reaction product is provided. The reaction plenum comprises a reaction plate, a reaction vessel for mounting in the reaction plate, a reaction plate holder, a screw-like rod, a mounting block attached to the reaction plate holder for operably receiving the screw-like rod, a motor, a sonication region in a temperature controllable water bath and a magnetic separation region in the water bath. Paramagnetic beads having reaction sites are introduced into the reaction vessels along with the appropriate solvent and one or more reactants. The contents of the reaction vessel are sonicated, then moved to the magnetic separation region where the paramagnetic beads are tightly held against the reaction vessel while the solvent is aspirated off. Once the desired reaction product is attained, the reaction product is cleaved off the paramagnetic bead.Type: GrantFiled: May 29, 1998Date of Patent: October 5, 1999Assignee: Solid Phase Sciences Corp.Inventor: Irving Sucholeiki
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Patent number: 5958783Abstract: The present invention concerns new metal complexes with a charged linker and their use as luminescent marker groups in an immunoassay.Type: GrantFiled: June 20, 1996Date of Patent: September 28, 1999Assignee: Roche Diagnostics GmbHInventors: Hans-Peter Josel, Eva Hoss, Beatus Ofenloch-Hahnle, Christoph Seidel, Barbara Upmeier, Ursula-Henrike Wienhues
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Patent number: 5958413Abstract: A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1(5-oxo-hexyl)xanthine (known as Pentoxifylline or TRENTAL) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanized recombinant antibody or fragment.Type: GrantFiled: November 10, 1997Date of Patent: September 28, 1999Assignees: Celltech Limited, Hoechst AktiengesellschaftInventors: Hiristo Anagnostopulos, Ulrich Gebert, Heinz Hanel, Michael Limbert, Mark William Bodmer, Gerald Anthony Higgs
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Patent number: 5958757Abstract: Saturated aliphatic halocarbons, including environmental contaminants, are degraded to innocuous, environmentally acceptable compounds by contact, either in situ or in a bioreactor, with microorganisms that produce aromatic oxygenases, preferably with use of a co-substrate, for example, phenol, toluene, benzene, ethylbenzene and xylene, including the provision of novel bacteria that produce aromatic oxygenases, and new recombinant microorganisms that contain cloned aromatic oxygenase genes, examples of saturated aliphatic halocarbon that may be degraded to innocuous compounds being chloroform; bromoform; 1,2-dichloroethane; 1,2-dibromoethane; monochloroethane and monobromoethane.Type: GrantFiled: September 13, 1996Date of Patent: September 28, 1999Assignee: Envirogen, Inc.Inventors: Robert Jon Steffan, Kevin Rock McClay
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Patent number: 5958792Abstract: The invention relates to libraries of cyclic organic compounds and method of producing and assaying such libraries. According to the invention, each cyclic organic compound is constructed from a starting material in the form of a solid surface derivatized with a starting resin. Compounds are reacted with the resin to add or to form a cyclic group. The reactions are preferable carried out using a split resin procedure so that different compounds can be reacted with a plurality of subamounts so as to increase the size of the library. For example, compounds are reacted with a solid support bound starting resin to obtain a compound which includes an aldehyde functional group wherein the aldehyde compound or compounds reacted with it have substituents which are varied such that a mixture of products is obtained.Type: GrantFiled: June 7, 1995Date of Patent: September 28, 1999Assignee: Chiron CorporationInventors: Manoi C. Desai, John M. Nuss, Kerry L. Spear, Rajinder Singh, Paul A. Renhowe, Edward G. Brown, Lutz Richter, Barbara O. Scott
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Patent number: 5952182Abstract: Elevated levels of Inhibin-A in maternal serum or plasma have been shown to indicate the presence of Down's Syndrome. The assay method comprises the use of a monoclonal antibody specific for at least part of the inhibin-A .beta. sub-unit (.beta.A), and another monoclonal antibody specific for at least part of the Inhibin-A .alpha. sub-unit. The .beta.A antibody is used to capture Inhibin-A from the test sample, and the .alpha. sub-unit antibody is used as the detection antibody and is linked to a detectable marker. The method is carried out in the first or second trimester as a screening test to select patients for subsequent diagnostic testing.Type: GrantFiled: February 11, 1997Date of Patent: September 14, 1999Assignee: Oxford Brookes UniversityInventors: Nigel Patrick Groome, Euan Morrison Wallace
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Patent number: 5948696Abstract: Combinatorial chemical libraries of the Formula ?S!-C(O)-L'-Z containing biaryl amino acids are disclosed, in which ?S! represents a solid support and -L'-Z is a linker/compound residue. In these libraries, Z is --NR.sup.1 R.sup.2. R.sup.1 is chosen from H, C.sub.1 to C.sub.20 hydrocarbon, heteroaralkyl, heterocycloalkyl, substituted arylalkyl, alkoxyalkyl or alkyl-SO.sub.2 NH-alkyl and R.sup.4 is an acyl or sulfonyl residue. R.sup.2 is chosen from ##STR1## The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.Type: GrantFiled: June 16, 1997Date of Patent: September 7, 1999Assignee: Pharmacopeia, Inc.Inventors: Roland Ellwood Dolle, III, Brian Francis McGuinness, Zahid Hussain
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Patent number: 5948532Abstract: We disclose a bi-layer wear pad, for use in a slider/magnetic media interface, comprising a wear layer and an adhesion layer. The wear material is either carbon or a carbonaceous material. Typical carbonaceous materials useful for wear layers include elements such as hydrogen, fluorine, nitrogen, boron, and silicon dioxide. The adhesion layer is a thin cermet such as nichrome oxide (NiCrOx) or chromium silicon oxide (CrSiOx). Use of the cermet adhesion layer allows a relatively thick wear layer to be deposited with good adhesion and superior durability.Type: GrantFiled: December 10, 1996Date of Patent: September 7, 1999Assignee: International Business Machines CorporationInventors: Cherngye Hwang, Vedantham Raman, John Walter Raniseski