Abstract: The method and the apparatus serve for non-invasively determining the blood pressure of a patient. An electrical cardiac potential measurement signal and a pulse-pressure-wave measurement signal are detected which, starting from the heart, propagate within the blood vessels as far as to a pulse-feeling location. A pulse-pressure-wave propagating time between the heart and the pulse-feeling location is determined, based on the electrical measurement signal and the pulse measurement signal. The blood pressure is determined by the aid of a function interrelationship on the basis of the propagating time, with the function interrelationship comprising a first portion that specifies the active elasticity behaviour of the blood vessels, and a second portion that specifies the passive electricity behaviour of the blood vessels. In this way, especially accurate blood pressure determination is rendered possible.

Abstract: The present invention includes a method for assessing the fitness of an individual. In one embodiment, the method comprises providing a physical fitness value of an individual by measuring a first trial of an activity conducted by the individual to provide a first measured component. The method further comprises measuring a second trial of an activity conducted by the individual to provide a second measured component. In addition, the method comprises determining the physical fitness values from the first and second measured components. In some embodiments, the method comprises estimating speed or mechanical power output values for the individual over a desired duration. In other embodiments, the method comprises determining the VO2 max of the individual.

Abstract: A method of measuring blood clotting ability of a patient. A known volume of blood is dispensed on a reference disc of blotter paper, such that at least one reference blotch is formed on the reference disc. The surface area of the reference blotch formed on the reference disc, such that a relationship between the volume of blood and the surface area of the reference blotch can be obtained. An incision is made at the patient. A piece of blotter paper to the incision is applied to the incision to collect blood flowing therefrom, such that at least one blotch is formed on the piece of blotter paper. The surface area of the blotch formed on the piece of blotter paper is measured. The volume of the blood absorbed blood by the blotter paper is calculated according to the relationship between the blood volume and the surface area of the blotch.

Abstract: Patients are evaluated in terms of various physiological parameters such as hemodynamic parameters. Covariate information indicative of the patient's individual characteristics may also be determined. A state variable indicative of the patient's characteristics is determined. This state variable is used to compare the patient to other patients in the database. The other patients in the database are evaluated in terms of similar parameters and their probability of survival as well as different treatments and the probability of survival based on those different treatments. The patient may be simply evaluated based on the database or a proper course of treatments may be determined based on the database.

Abstract: The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.

Abstract: A suction adapter for use with first and second medical devices capable of accommodating suction, the adapter including a manifold having at least three ports and a flexible flow valve. The ports may include: a suction port configured for connecting to a suction source; a first device port configured for accommodating a first medical device, preferably an endoscope; and a second device port configured for accommodating a second medical device, preferably a suction biopsy device. The flexible flow valve has at least one opening and may be located between the first device port and both the second device port and the suction port.

Abstract: Methods and apparatus of the present invention provide viscoelastic barrier materials for use as barriers in devices such as pressure measurement catheters. Improved barrier materials sometimes include at least one barrier material precursor combined with an amount of a softener. In other embodiments, two barrier material precursor components are combined without a softener to provide a fully cross-linked barrier material having certain softness characteristics. In various embodiments, a softener may be dimethyl silicone oil and may be combined with a barrier material precursor in an amount of between about 25% and about 45% by weight, relative to the final barrier material. Once a viscoelastic barrier material is prepared, it may be placed in a pressure transmission catheter or similar device, for example by injecting the gel into a lumen of the catheter via a syringe.

Abstract: The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.

Abstract: A system and method for assessing pulmonary performance through transthoracic impedance monitoring is described. Transthoracic impedance measures are directly collected through an implantable medical device. The transthoracic impedance measures are correlated to pulmonary functional measures relative to performance of at least one respiration cycle. The transthoracic impedance measures are grouped into at least one measures set corresponding to one of an inspiratory phase and an expiratory phase. The at least one transthoracic impedance measures set are evaluated to identify a respiratory pattern relative to the inspiratory phase or the expiratory phase to represent pulmonary performance.

Abstract: The preferred embodiment of the present invention comprises a single microprocessor-based interface that connects between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor or module. The interface effectively emulates an IBP transducer in such a way that the IBP monitor sees the interface as if it were a regular IBP transducer from a fluid-filled blood pressure monitoring line. It receives the signal from an NIBP sensor and determines the blood pressure corresponding to the signal. It accepts the excitation voltage provided by the IBP monitor. From the excitation voltage and a known transducer sensitivity which the IBP monitor is configured to work with, the interface emulates the IBP transducer output signal corresponding to the blood pressure. The interface also emulates the input and output impedances of the IBP transducer which the IBP monitor is configured to work with.

Abstract: Traditional cuffs for measuring blood pressure use an air chamber enclosed in a non-stretchable fabric to occlude an artery in a limb when supplied with pressurised air. A stethoscope used on the limb is used to monitor blood flow. Application of the cuff is inconvenient and correct placement of the stethoscope chestpiece requires skill. According to the invention blood pressure measurement is facilitated by having the air chamber enclosed in a pre-formed shell-like structure being flexible around the limb and stiff along the limb and by using a linear array of microphones to detect the blood flow noises, the best signal from one of the microphones being automatically selected. Furthermore, the invention provides a facility for correcting the reading in dependence of the amount of wrap of the limb.

Abstract: A blood pressure monitor includes a main unit casing placed on a table, a living body insert portion casing of an approximately cylindrical shape, positioned on the main unit casing in a non-use state and having a cuff arranged on its inner peripheral surface, the cuff having a hollow portion to which an upper arm of a subject is inserted, and a connection mechanism for connecting the living body insert portion casing with the main unit casing in a movable manner such that, upon application of the cuff to the subject, the living body insert portion casing can move to come closer to the subject than the main unit casing. Thus, a blood pressure monitor provided with an automatic cuff winding mechanism enabling measurement of blood pressure with high accuracy, not giving unnecessary pain to the subject, and allowing measurement with an unconstrained posture can be provided.

Abstract: The wearable heartbeat measuring device is accomplished by wearing a wrist-watch-like heart monitor device on the wrist. The heart monitor is worn on the top of the wrist with a strap around the wrist. The strap has an inflexible extending portion that extends from the heart monitor at a predetermined angle and a predetermined width with respect to the wrist so that a predetermined space is maintained between the top portion of the wrist and the strap for promoting the transfer efficiency of the pulsation force that is initially experienced at a part of the strap at the bottom of the wrist. The strap also has a flexible portion. A predetermined angle and a predetermined width of the extended portion also facilitate the flexible portion to form a flat area where the wrist contacts the strap. In the prefer embodiments, the width of the strap exceeds the width of the wrist when it is worn.

Abstract: An apparatus that continuously monitors the arterial pressure measured by a pressure sensor in an artery, which pressure is regarded as the reading Pao that approximately corresponds to the aortal pressure. In principle, the arterial pressure can be measured in the aorta, near the aorta, or in the arterial tree. To provide a second reading, the apparatus, via the input channel, continuously monitors the central venous pressure (CVP), which is regarded as the reading PIT that approximately corresponds to the intrathoracic pressure (ITP). The third reading is provided via the input channel as a reading Z which expresses the thoracic compliance.

Abstract: Inflatable blood pressure cuff assemblies include an inflatable elongate cuff member having opposing long edges and opposing short edge portions with a fluid chamber therein and a resilient support sleeve with at least one rib support member, the sleeve attached to a respective one of the opposing short edge portions of the inflatable elongate cuff member. The sleeve may be configured with a sensor chamber and a cable routing channel. Related systems and methods of fabricating cuff assemblies and resilient support sleeves are also described.

Abstract: A breath monitor includes: a plurality of sensors for detecting a load derived from a human lying on a bed and for outputting a sensor signal corresponding to the load; and breath signal computation means. The sensors are disposed under the human with a predetermined arrangement. The breath signal computation means converts each sensor signal to a frequency domain so that a spectrum of each sensor signal is obtained, selects the sensors on the basis of the converted sensor signals, and computes a breath signal on the basis of the sensor signals outputted from the selected sensors.

Abstract: Methods and apparatus for the analysis of exhaled breath by spectroscopy are disclosed. An optical cavity containing the exhaled breath, typically comprising a pair of opposing high reflectivity mirrors, is used to implement a cavity enhanced absorbtion technique. Pairs of 12CO2 and 13CO2 absorbtion lines suitable for use in spectroscopic breath analysis are also disclosed.

Abstract: Methods, systems, and computer program products for transmitting neural signal information. Methods, systems, and computer programs products are disclosed for neural channel selection in a multi-channel system. A method according to one embodiment can include a step for receiving a plurality of neural signals on a first plurality of channels. The method can also include a step for calculating criterion variable value for the neural signal on each of the channels. In addition, the method can include a step for ranking the channels by the criterion variable value. The method can also include a step for calculating mutual information between a measured output and a total population activity for the first plurality of channels. Further, the method can include a step for determining a second plurality of channels that encodes a predetermined amount of the mutual information.

Abstract: Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder.

Abstract: An analyte test device is constructed as an integrated, single-use, disposable cartridge which can be releasably installed into a compatible analyte test monitor. In use, the device can be used in conjunction with the monitor to lance the skin of a patient to create a blood sample and, in turn, calculate the concentration of a particular analyte in the expressed blood sample. In one embodiment, the device includes a base and a cover which are affixed together to create a test cartridge which has a substantially flat and low profile design. A lancet carrier is disposed between the base and the cover and includes a anchor fixedly mounted on the base and a lancet support member which is slidably mounted on the base, the anchor and the lancet support member being connected by a spring. A lancet is removably mounted on the lancet support member is disposed directly beneath an analyte test strip which secured to the underside of the cover.