Abstract: Sensor arrangement having capture molecules immobilized on any of three sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules; a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes; a detection device, wherein in a first operating state a reference liquid is introduced into the sensor arrangement and a reference value of an electrical signal is detected at the selected sensor electrode, and in a second operating state an analyte possibly having molecules to be detected is introduced into the sensor arrangement and a sensor value of the electrical signal is detected at the selected sensor electrode; and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

Abstract: A method of and apparatus for monitoring and intervening in, in real time, a collaboration between a plurality of subjects comprising measuring indicia of physiological and cognitive states of each of the plurality of subjects, communicating the indicia to a monitoring computer system, with the monitoring computer system, comparing the indicia with one or more models of previous collaborative performance of one or more of the plurality of subjects, and with the monitoring computer system, employing the results of the comparison to communicate commands or suggestions to one or more of the plurality of subjects.

Abstract: A system and method for screening for coronary heart disease is provided. The method includes the steps of retrieving a test for assessing risk of coronary heart disease, the test including a plurality of data fields relating to coronary risk factors; accessing a database to populate the data fields with information of an individual patient; and calculating a risk assessment of the individual patient developing coronary heart disease. A system includes a first database including a plurality of structured computerized patient records; a second database including a knowledge base relating to coronary heart disease, the second database including at least one test for determining coronary heart disease risk; and a processor for retrieving the at least one test from the second database, populating the at least one test with patient information retrieved from the first database and calculating a risk assessment for at least one patient.

Abstract: A physiological sensor is located within the airway of the subject's body, such as for measuring barometric pressure and communicating this value to a blood pressure or other monitoring device, which can derive gauge pressure using the barometric pressure and a measured absolute pressure within the body. The physiological sensor may also detect one or more other physiological parameters such as air flow, sound, or a chemical property. It may be anchored within the airway with the ability to communicate wirelessly to one or more other medical devices, such as an implanted cardiac function management device. Methods of use are also described.

Abstract: A method and apparatus for monitoring changes in the intra-thoracic pressure of a patient due to the patient's respiratory activity or volumetric changes in the extra-thoracic arterial circulatory system due to cardiac function based on the changes in pressure in the patient's extra-thoracic arterial circulatory system as measured by a plethysmography sensor, such as an photoplethysmograph. A frequency spectrum is generated for the plethysmograph signal and the frequencies of interest is isolated from the frequency spectrum by setting appropriate cutoff frequencies for the frequency spectrum. This isolated frequency is used to filter the plethysmograph signal to provide a signal indicative of the patient's respiratory activity or cardiac function. For corrections for breathing frequency roll-off and deviations of the I:E ratio from 1:1.

Abstract: A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.

Abstract: Methods for covering an opening in an analyte meter are provided. Also provided are methods of determining analyte concentration.

Abstract: A method and apparatus are used for training adjustment in sports, particularly in running sports, in which light is radiated into the body tissue of a test person by at least one light source, the light intensity reflected in the body tissue is measured via at least one light sensor, a temporally oscillating measurement quantity is derived from the measured light intensity via an evaluator, a minima in the time curve of the measurement quantity are determined, and a performance rating from which the current metabolic state of the test person can be read out is generated via analysis of a plurality of temporally successive minima and displayed.

Abstract: Devices and methods for maintaining a medical device on-body are provided. Embodiments include medical device securement systems having first and second on-body securement elements. Also provided are systems and kits for use maintaining a medical device on-body.

Abstract: Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

Abstract: Method and apparatus for providing an introducer for transcutaneous placement of at least a portion of an analyte sensor through the skin of a patient is provided.

Abstract: An apparatus and method to detect a blood flow signal free from a motion artifact, and a stress test apparatus using the same, enhance data reliability of the blood flow signal by removing the motion artifact from the blood flow signal detected by photo-plethysmography. The apparatus to detect the blood flow signal includes a base pattern correlation coefficient calculating unit to determine peak points in the blood flow signal sensed from a body of an examinee using a blood flow sensing unit, and to calculate correlation coefficients of each peak point using a predetermined base pattern, and a motion artifact processing unit to determine the motion artifact using the calculated correlation coefficients and to remove the motion artifact from the blood flow signal. Thus, reliability of the blood flow signal is enhanced by effectively removing the motion artifact from the blood flow signal detected by the photo-plethysmography.

Abstract: The present invention provides systems and methods for monitoring subjects, especially during sleep. Respiratory and sound data are recorded and coughs arousal are recognized as joint events in both of these signals having selected characteristics. Further, cough-arousal events during sleep are recognized when a likely cough occurs in association with a recognized EEG arousal. Cough arousal events are combined into a cough arousal index that reflects disease severity and sleep disruption due to cough. The methods of this invention are computer-implemented and can be provided as a program product including a computer readable medium. Measurements and indices provided by this invention can be used to monitor and to treat respiratory diseases.

Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.

Abstract: The invention relates to a method and device for carrying out a signal-processing viewing of a measurement signal that is correlated with the respiratory activity of an individual, for example, of a measurement signal that is correlated with the respiratory gas. The aim of the invention is to provide solutions with which an improved electronic analysis of the signals that are representative with regard to respiratory activity can be achieved. To this end, the invention provides that viewing results are obtained within the scope of a signal-processing viewing of said measurement signal and make a differentiation between obstructive and central respiratory disorders possible. The viewing results are determined, in particular, while taking into account changes of selected breathing characteristics such as, for example, the change in the ratio of inhalation time to exhalation time.

Abstract: A blood pressure monitor includes a cuff having an air bag, a main-unit casing in which an inflation/deflation mechanism for inflating/deflating the air bag is provided, a flexible air tube connecting the air bag and the inflation/deflation mechanism, and a retractor unit capable of drawing in the air tube that is drawn out from the main-unit casing into an air tube housing provided in the main-unit casing. With this structure, the blood pressure monitor can be made superior in housing of the air tube connecting the cuff and the main-unit casing.

Abstract: The invention relates to a method and apparatus for measuring the responsiveness of a subject with lowered level of consciousness. Physiological signal data is obtained from the subject and a first measure indicative of the level of consciousness of the subject is derived from the physiological signal data. In order to obtain an objective measure of the responsiveness of the subject and to improve the specificity of patient monitoring, a sequence of the first measure is recorded without inducing arousals in the subject and a second measure indicative of a responsiveness of the subject is determined based on the recorded sequence. The determination of the second measure may be independent of the unintentional stimuli that cause arousals in the patient or the stimuli causing such arousals in the clinical environment may be detected to find out their effect on the first measure.

Abstract: A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump.

Abstract: A blood pressure measuring apparatus includes an inflatable sleeve socket that is capable of receiving an engagement portion of a compact gage housing having either a contained mechanical or an electronic pressure gauge. This coupling permits direct attachment to the sleeve and permitting fluid interconnection between the interior of the sleeve and the contained pressure gauge without requiring any hoses or tubing therebetween. The electronic pressure gauge is responsive to changes in pressure within the inflatable sleeve. The pressure changes can be processed and output to an integral display or can be wirelessly transmitted.

Abstract: This disclosure provides a method of indicating a subject's reaction to different agents administered to induce anesthesia. In particular, the subject's reaction can be assessed by receiving electrical signals from first and second electrodes spatially distributed on different regions of a subject's head, and by processing the electrical signals from the electrodes to provide a first indicator of the subject's reaction to a first of the agents and a second indicator of the subject's reaction to a second agent.