Abstract: Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

Abstract: A pulsatile blood pump including a chamber having an upstream portion, a downstream portion, and a wall coupling the upstream portion to the downstream portion, the upstream portion defining an inlet sized to fit within a ventricle of a heart, the downstream portion defining an outlet, and the wall defining a bore; a piston disposed within the bore of the wall, the piston including a first side in continuous fluid communication with the ventricle of the heart when the inlet is within the ventricle of the heart and defining a travel path within the bore including an upstream direction toward the inlet and a downstream direction toward the outlet; and a valve coupled to the piston and defining a one-way fluid flow path within the chamber through the first side of the piston in the downstream direction.

Abstract: A prosthetic heart valve includes a support frame and a plurality of leaflets disposed inside the support frame. The support frame extends between an inflow end and an outflow end and includes a leaflet frame and a plurality of positioning members coupled to the leaflet frame. The leaflet frame has an undulating shape at the outflow end of the support frame and includes a plurality of commissure regions spaced apart from each other. The positioning members are disposed between the commissure regions of the leaflet frame and extend radially outwardly relative to the leaflet frame. The positioning members are configured to contact native tissue and anchor the support frame relative to the native tissue. The leaflets are coupled to the commissure regions of the leaflet frame. The leaflets are configured to allow flow in a first direction and to substantially block flow in an opposite direction.

Abstract: Provided is an intraocular lens including a lens body having a back surface disposed on a retinal side and a front surface disposed on a corneal side, wherein an entire back surface is shaped in such a way as to protrude from a peripheral edge of the back surface toward the retinal side in a direction of an optical axis, in a shape of a truncated cone, and the front surface has any of the following shapes (i) to (iii); (i) the front surface is shaped in such a way as to start to be recessed toward the retinal side in the direction of the optical axis when viewed toward a center from a peripheral edge of the front surface, (ii) the front surface is shaped in such a way that an initial part from the peripheral edge of the front surface toward the center is flat, (iii) the front surface is shaped in such a way as to start to protrude toward the corneal side in the direction of the optical axis when viewed toward the center from the peripheral edge of the front surface, but a rate of rise of a protrusion from

Abstract: In certain aspects, the invention relates to a method for generating a mitral repair ring for a corresponding mitral valve, comprising the steps of generating (S1) a reference circumference (13) indicative of said valve ring (110); generating (S2) a reference grid (2); inscribing (S3) said reference circumference (13) in said reference grid (2); combining (S4) said reference circumference (13) with a plurality of characteristic measures (15, 16, 17, r1-r6) of said mitral valve (100); generating (S5) a three-dimensional reference grid (250); identifying (S6) on said three-dimensional reference grid (250) a plurality of deformation points (300-302) of said reference circumference (13); deforming said reference circumference (13) at said deformation points (300-303) so as to obtain a geometric model (10) of said mitral repair ring (10?); and generating said mitral repair ring (10?) from said obtained geometric model (10).

Abstract: A buoy system for treating cardiac valve regurgitation comprising a movable plug having atrial and ventricular ends, wherein a through-hole passes from the atrial to the ventricular end, wherein during systole, the plug travels toward a cardiac atrium, wherein during diastole, the plug travels into a cardiac ventricle; a tether having atrial and ventricular ends, wherein the tether passes through the through-hole of the moving plug, wherein the atrial end of the tether projects into an atrium, wherein the atrial end of the tether includes a cap to engage a delivery tool; at least one distal anchor located in the ventricle, wherein the distal anchor is coupled to the ventricular end of the tether, and wherein the system is percutaneously delivered and optionally recaptured via catheter and recapture tool at the cap of the tether, respectively.

Abstract: Described here are prosthetic systems, devices, and methods of use therefor. Generally, a prosthesis may be configured to set a resistance to rotation of a prosthetic joint based on a phase of gait. The prosthesis may include a first cylinder, a first piston slidable within the first cylinder, a fluid sump, and a fluid circuit. The fluid circuit may include a plurality of interconnected fluid channels having a unidirectional variable-resistance valve and a set of check valves that are configured to provide unidirectional flow through the valve during piston compression and extension.

Abstract: The invention is a prosthetic device for improving function of a mitral valve. The device includes a sealing member configured for positioning between mitral valve leaflets. The device also includes an expandable anchor frame configured to be positioned within one or more heart chambers, for maintaining the sealing member at a desired position between valve leaflets. The sealing member reduces mitral regurgitation be filling the gap that can occur between opposing leaflets of a damaged mitral valve, thus restoring proper mitral valve closure.

Abstract: Accommodating intraocular lenses and methods of use. The accommodating intraocular lenses include peripheral regions that are adapted to be more responsive to certain types of forces than to other types of forces. For example, the accommodating intraocular lenses can include haptics that are stiffer in an anterior-to-posterior direction than in a radial direction.

Abstract: An implantable intracardiac device to prevent systolic anterior motion of the anterior mitral valve leaflet into the left ventricular outflow tract is described. The device comprises a blocking member configured for implantation within the left ventricle of the heart and in-situ blocking of systolic anterior motion of the mitral valve into the left ventricular outflow tract when anchored into the left ventricle of the heart. The device may be configured for radial expansion from a contracted orientation suitable for transluminal delivery to the left ventricle of the heart within a suitable delivery vehicle and an expanded orientation suitable for deployment within the left ventricle of the heart. The device comprises anchors configured for anchoring the device in-situ within the left ventricle to a wall of the left ventricle.

Abstract: A stent is effective for anti-migration after operation of a lumen, and a first outer stent or a second outer stent is used to be integral to a cylindrical stent and an upper end part of each of the first outer stent or the second outer stent is connected to the cylindrical stent by sutures to have a space part between the cylindrical start, the first outer stent, and the second outer stent. The space part is provided such that the first outer stent or the second outer stent is freely moved or transformed by an external force, and a displacement part caused by the movement or a transformation part caused by the transformation further presses or moves into a lesion part or an inner surface of the lumen to be securely held thereon, whereby the stent is effectively prevented from deviating from the lesion part.

Abstract: Methods to produce thermoformed implants comprising poly-4-hydroxybutyrate homopolymer, copolymer, or blend thereof, including surgical meshes, have been developed. These thermoforms are preferably produced from porous substrates of poly-4-hydroxybutyrate homopolymer or copolymer thereof, such as surgical meshes, by vacuum membrane thermoforming. The porous thermoformed implant is formed by placing a porous substrate of poly-4-hydroxybutyrate homopolymer or copolymer thereof over a mold, covering the substrate and mold with a membrane, applying a vacuum to the membrane so that the membrane and substrate are drawn down on the mold and tension is applied to the substrate, and heating the substrate while it is under tension to form the thermoform.

Abstract: A method of altering a refractive property of a crosslinked acrylic polymer material by irradiating the material with a high energy pulsed laser beam to change its refractive index. The method is used to alter the refractive property, and hence the optical power, of an implantable intraocular lens after implantation in the patient's eye. In some examples, the wavelength of the laser beam is in the far red and near IR range and the light is absorbed by the crosslinked acrylic polymer via two-photon absorption at high laser pulse energy. The method also includes designing laser beam scan patterns that compensate for effects of multiphone absorption such as a shift in the depth of the laser pulse absorption location, and compensate for effects caused by high laser pulse energy such as thermal lensing. The method can be used to form a Fresnel lens in the optical zone.

Abstract: Disclosed herein are methods, implants and systems for treatment of mitral valve prolapse by subannular fixation of the prolapsed mitral valve. The disclosure relates generally to the field of heart valve repair devices, methods and kits and more specifically to trans catheter methods and devices for insertion of tethers and anchors to the mitral valve leaflets for reduction the prolapsed mitral valve and subannular fixation of the prolapsed leaflet to treat mitral valve regurgitation.

Abstract: The present invention relates to a transcatheter method for providing fluid communication between two anatomical compartments. The present invention also relates to a transcatheter system comprising an intracorporeal connector for fluid communication between two anatomical compartments through at least one anatomical wall, wherein said connector is adapted to receive a flow regulating device, a connector, a flow regulating device and an insertion device.

Abstract: A stent is formed from an at least partially cylindrical non-bioresorbable framework with a longitudinal zone of the stent that extends from the proximal end of the framework to the distal end and is defined by opposing longitudinal edges. A plurality of bioresorbable struts are secured to opposing longitudinal edges of the longitudinal zone. The bioresorbable struts hold the opposing longitudinal edges a first distance apart at an expanded deployed diameter to apposition the framework against a wall defining the vessel. After the stent is endothelialized, degradation of the bioresorbable struts causes the stent to contract to a reduced deployed diameter so that the opposing longitudinal edges are a second distance apart that is less than the first distance.

Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.

Abstract: Described herein are intraocular lenses and methods of implantation. In one aspect, the lens includes a shape changing optical element; a force translation element having a first end region coupled to the optical element and a second end region extending towards a ciliary structure, and an attachment portion coupled to the second end region of the force translation element and configured to contact the ciliary structure. The force translation element is configured to functionally transmit movements of the ciliary structure into a force exerted upon the optical element to effect an accommodating and a disaccommodating change of the optical element.

Abstract: A gradually-expandable stent includes a base ring completely encircling a central valve-accepting area. A plurality of uprights is provided. Each upright includes two longitudinally extending upright struts. Each upright strut has a strut base directly connected to the base ring and a strut tip directly attached to the other strut tip of the upright strut at a rounded upright apex. The upright apex is longitudinally spaced from the base ring. At least one expansion feature is associated with the base ring and gradually expands to enlarge the central valve-accepting area toward a maximum valve-accepting area responsive to growth of the patient over an extended dwell time.