Patents Examined by Paul D. Pyla
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Patent number: 11078461Abstract: The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.Type: GrantFiled: October 27, 2017Date of Patent: August 3, 2021Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Zayna Nahas, Jennifer H. Elisseeff, Iwen Wu
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Patent number: 11058734Abstract: The invention relates to a probiotic strain selected from Lactobacillus reuteri V340 with accession number CECT and Bifidobacterium breve BT820 with accession number CECT 8606, or a variant of said probiotic strain having cholesterol-absorbing capacity, and to methods and therapeutic uses thereof. The invention also relates to compositions, pharmaceutical compositions, feeds or nutritional products comprising a probiotic strain selected from Lactobacillus reuteri V3401 with accession number CECT 8605 and Bifidobacterium breve BT820 with accession number CECT 8606, or a variant of said probiotic strain having cholesterol-absorbing capacity.Type: GrantFiled: December 10, 2015Date of Patent: July 13, 2021Assignee: BIOSEARCH, S.A.Inventors: Ana Isabel Sañudo Otero, Raquel Criado García, Alba Rodríguez Nogales, Alberto Garach Domech, Mónica Olivares Martín, Julio Juan Gálvez Peralta, Santiago De La Escalera Huerso, Juan Manuel Duarte Pérez, Antonio Zarzuelo Zurita, Óscar Bañuelos Hortigüela
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Patent number: 11053474Abstract: The invention concerns novel Lactobacillus strains and the uses thereof, in particular for preserving foods, animal feedstuff, pharmaceutical compositions and/or cosmetic compositions.Type: GrantFiled: March 12, 2014Date of Patent: July 6, 2021Assignee: Novozymes A/SInventors: Detlef Goelling, Andreas Heilmann, Christine Lang
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Patent number: 10983104Abstract: The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like.Type: GrantFiled: December 13, 2013Date of Patent: April 20, 2021Assignee: Advanced Animal Diagnostics, Inc.Inventors: Rodolfo R. Rodriguez, Charles F. Galanaugh
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Patent number: 10982849Abstract: The invention provides a process for the conversion of biomass into a biomass product which is suitable for use as a fuel. The biomass is of plant origin and comprises microorganisms naturally occurring in the biomass. The process comprises—preparing a slurry by dispersing the biomass comprising the naturally occurring microorganisms in an aqueous liquid, maintaining the slurry at conditions suitable for aerobic digestion by the microorganisms to obtain a slurry comprising the biomass product as a dispersed solid phase, and—recovering the biomass product. The recovering comprises washing and drying the biomass product. The invention also provides a combustion process.Type: GrantFiled: December 13, 2018Date of Patent: April 20, 2021Assignee: NEWFOSS HOLDING B.V.Inventors: Dirk Jan Vos, Simon Rustenburg
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Patent number: 10952441Abstract: The present disclosure provides a novel endophyte, Serendipita vermifera ssp. bescii (“S. bescii”), uses thereof and methods incorporating the use thereof for enhancement of plant performance. The present disclosure also provides methods for detecting the presence of and identifying S. bescii.Type: GrantFiled: June 19, 2017Date of Patent: March 23, 2021Assignee: NOBLE RESEARCH INSTITUTE, LLCInventors: Kelly Craven, Prasun Ray
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Patent number: 10954532Abstract: The invention relates to a process for the production of biogas from biomass, in particular from lignocellulose-containing biomass. According to the invention bio gas is produced from lignocellulose-containing biomass in a process, wherein the cellulose and hemicellulose in the lignocellulose are made accessible for bioconversion.Type: GrantFiled: October 10, 2007Date of Patent: March 23, 2021Assignee: STICHTING WAGENINGEN RESEARCHInventors: Johannes Wouterus Van Groenestijn, Gijsbert Maurits Bos
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Patent number: 10954571Abstract: The present invention provides methods and compositions involving microbiome signatures and their association with oral complications of cancer therapy.Type: GrantFiled: June 23, 2017Date of Patent: March 23, 2021Assignee: The Charlotte-Mecklenburg Hospital AuthorityInventors: Farah K. B. Mougeot, Jean-Luc C. Mougeot
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Patent number: 10889793Abstract: A fermenter can have at least one hollow fluid conduit disposed at least partially within a vessel. An external circumference of the hollow fluid conduit and an interior circumference of the vessel can define a downward flow path through which a multi-phase mixture including a liquid media and compressed gas substrate bubbles flows. An interior circumference of the hollow fluid conduit can defined an upward flow path which is in fluid communication with the downward flow path. The multi-phase liquid can flow through the upward flow path and exit the fermenter. Cooling may be provided in the hollow fluid conduit or the vessel. One or more backpressor generators can be used to maintain a backpressure on the fermenter. One or more fluid movers can be used to variously create an induced and/or forced flow in the downward and upward flow paths.Type: GrantFiled: June 30, 2017Date of Patent: January 12, 2021Assignee: CALYSTA, INC.Inventors: Joshua A. Silverman, Sol M. Resnick, Drew D. Regitsky
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Patent number: 10869481Abstract: Plant propagation material expressing sugar beet cyst nematode resistance can be treated with a nematode-antagonistic biocontrol agent. Use of the nematode-antagonistic biocontrol agent can reduce the rate at which sugar beet cyst nematode (SBN) pests acquire tolerances to pesticidal activity of sugar beet plants expressing SBN resistance and pesticides, and can also increase yield and pesticidal activity.Type: GrantFiled: April 16, 2015Date of Patent: December 22, 2020Assignee: Syngenta Participations AGInventors: Palle Pedersen, Clifford George Watrin
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Patent number: 10864163Abstract: The invention relates to methods for attaching therapeutic agents to structures produced by thermally induced phase separation as well as methods for coating devices and producing multi-layered microspheres.Type: GrantFiled: December 22, 2014Date of Patent: December 15, 2020Assignee: UCL Business LTDInventor: Richard Michael Day
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Patent number: 10858682Abstract: The invention relates to a process for the hydrolysis of cellulose containing biomass which comprises a liquefaction step in which a first enzyme or first enzyme composition is added to liquefy at least part of the solids present in the biomass and to keep the viscosity of the cellulose containing biomass below 1000 cP, preferably below 800 cP, more preferably below 600 cP in the liquefaction step; followed by a saccharification step in which a second enzyme composition is added to form oligomeric and/or monomeric sugars; and whereby the first enzyme or first enzyme composition is different from the second enzyme composition; whereby the first enzyme or first enzyme composition comprises an endoglucanase; whereby the second enzyme composition comprises a cellulase; and whereby the first enzyme or first enzyme composition comprises more endoglucanase than the second enzyme composition (expressed in protein wt %).Type: GrantFiled: November 19, 2018Date of Patent: December 8, 2020Assignee: DSM IP ASSETS B.V.Inventors: Johannes Petrus Smits, Michael Petrus Jozef Berkhout, Bertus Noordam
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Patent number: 10842833Abstract: The present invention provides Lactobacillus plantarum CJLP133 KCTC 11403BP, a composition for treating intestinal diseases comprising the lactic acid bacteria, and a composition for enhancing immunity comprising the lactic acid bacteria.Type: GrantFiled: October 1, 2018Date of Patent: November 24, 2020Assignee: CJ CHEILJEDANG CORP.Inventors: Bong Joon Kim, Heon Woong Jung, Se Hee Hwang, Jin Hee Lee, Kang-Pyo Lee, Kwang Woo Hwang, Tae Joon Won
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Patent number: 10844443Abstract: Lactobacillus plantarum CJLP243 (KCTC 11045P), a composition for treating intestinal diseases comprising Lactobacillus plantarum CJLP243, and a composition for enhancing immune response comprising Lactobacillus plantarum CJLP243.Type: GrantFiled: August 28, 2018Date of Patent: November 24, 2020Assignee: CJ CHEILJEDANG CORP.Inventors: Bong Joon Kim, Heon Woong Jung, Kang Pyo Lee, Sae Hun Kim, Tae Hoon Chun, Kwang Woo Hwang, Tae Joon Won
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Patent number: 10793892Abstract: The present invention relates to a method for detecting the presence of expanded-spectrum ß-lactamase (ß-lactamase hydrolyzing expanded-spectrum cephalosporin)-producing bacteria in a sample, said method comprising the steps of: a) performing cell lysis on a test sample in order to obtain an enzymatic suspension; b) reacting a fraction of the enzymatic suspension obtained in step a) with a reagent kit, said reagent kit comprising —expanded-spectrum ß-lactamase substrate selected from the group consisting of cephalosporins, aztreonam, and cephamycins, —a pH color indicator which will change color when the pH of the reaction mixture is comprised between 6.4 and 8.4, wherein a color change after step b) indicates the presence of expanded-spectrum ß-lactamase-producing bacteria in the test sample. The invention also relates to a reagent kit, to a microtiter plate and to their uses in detecting the presence of expanded-spectrum ß-lactamase producers in a test sample.Type: GrantFiled: November 16, 2012Date of Patent: October 6, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PARIS-SACLAY, ASSISTANTE PUBLIQUE HOPITAUX DE PARIS (APHP)Inventors: Patrice Nordmann, Laurent Dortet, Laurent Poirel
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Patent number: 10731192Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; d) fermentation of the hydrolysed ligno-cellulosic material to produce a fermentation product; and e) optionally recovery of a fermentation product; wherein before and/or during the enzymatic hydrolysis oxygen is added to the ligno-cellulosic material.Type: GrantFiled: November 14, 2017Date of Patent: August 4, 2020Assignee: DSM IP ASSETS B.V.Inventor: Bertus Noordam
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Patent number: 10724057Abstract: The invention relates to a process for the preparation of a sugar product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; and d) optionally recovery of a sugar product; wherein during part of the time of the enzymatic hydrolysis, oxygen is added to the ligno-cellulosic material and during part of the time of the enzymatic hydrolysis less oxygen is added to the ligno-cellulosic material compared to the other part of the time of the enzymatic hydrolysis, preferably no oxygen is added to the ligno-cellulosic material.Type: GrantFiled: March 23, 2018Date of Patent: July 28, 2020Assignee: DSM IP ASSETS B.V.Inventors: Bertus Noordam, Michael Petrus Jozef Berkhout, Aida Hiseni
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Patent number: 10717995Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; d) whereby less than 7.5 mg enzyme composition/g glucan (on dry matter and enzyme as protein) or less than 3.0 mg enzyme composition/g feedstock (on dry matter and enzyme as protein) is used; and e) fermentation of the hydrolysed ligno-cellulosic material to produce a fermentation product; and f) optionally recovery of a fermentation product; wherein before and/or during the enzymatic hydrolysis oxygen is added to the ligno-cellulosic material.Type: GrantFiled: October 4, 2018Date of Patent: July 21, 2020Assignee: DSM IP ASSETS B.V.Inventors: Bertus Noordam, Michael Petrus Jozef Berkhout
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Patent number: 10688128Abstract: A method for at least one of activating autoimmune system and treating cancer is provided. The method comprises administering to a subject in need an effective amount of Z-butylidenephthalide and an effective amount of mononuclear cells.Type: GrantFiled: May 16, 2017Date of Patent: June 23, 2020Assignee: EVERFRONT BIOTECH INC.Inventors: Hong-Lin Su, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Sheng-Feng Tsai
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Patent number: 10662447Abstract: A process for producing products from biomass comprising fermenting biomass to produce a first product stream comprising carboxylic acid salts; acidifying at least one of the first product stream and a second product stream to produce a third product stream comprising acids; extracting such acids from the third product stream with a solvent; separating the extracting solvent from the acids to produce the separated extracting solvent and a fourth product stream comprising acids; and processing the fourth product stream to produce a fifth product stream.Type: GrantFiled: December 19, 2013Date of Patent: May 26, 2020Inventors: Michael Kyle Ross, Cesar B. Granda