Abstract: An aqueous topical composition with low pH comprising an acidic anti-acne agent and a water soluble glycol ether. The composition is useful for exfoliation and prevention or treatment of acne. In one preferred embodiment of the present invention, the composition further comprises a nonionic surfactant and a silicone copolymer.

Abstract: A process for preparing defined molecular weight polymers, particularly polyquaternary ammonium compounds, is disclosed. As the molecular weights of these compounds can be absolutely defined, rather than defined merely in terms of "number average molecular weight," these compounds are particularly useful as identification standards for other polymers which are made using conventional polymerization processes. The polyquaternary ammonium compounds described are further suitable for use as antimicrobial agents, particularly in ophthalmic compositions.

Abstract: A method for producing a sterile packaged adhesive hydrogel product by preparing an aqueous mixture of water, a polymer which can be cross-linked by radiation to form a hydrogel, and a cross-linking inhibitor in an amount sufficient to retard the cross-linking of the polymer when the mixture is exposed to radiation; providing the mixture in a predetermined shape or configuration representative of a hydrogel product; enclosing the shaped mixture in a sealed package; and subjecting the package to a dose of radiation sufficient to simultaneously cross-link and sterilize the mixture to provide a sterile packaged adhesive hydrogel product. The invention also is directed to the sterile packaged adhesive hydrogel product formed by this method, as well as the packaged product prior to sterilization.

Abstract: Copolymers of the formula: ##STR1## wherein the bonds between the glucoside units are .beta. (1.fwdarw.4), the degree of polymerization referred to a single glucoside unit varies from about 50 to 50,000, R is a free or esterified carboxy group and S is an amino or acylamino group. The part designated by x may vary between about 5% and 100% and that designated by y may vary between about 95% and 0%. At least a part of the R groups are esterified carboxy groups, and at least a part of the S groups are acylamino groups. Salts of these copolymers are also disclosed. The products of the invention are particularly useful in the cosmetic field.

Abstract: A method for suppressing the viscosity of a calcium exotoxin slurry is disclosed. The method comprises adding to the slurry a viscosity-suppressing amount of a copolymer of a vinyl-based monomer and 2-acrylamide-2-methylpropane sulfonic acid or its sodium salt. The copolymer has a weight average molecular weight of from about 1,000 to about 10,000. A slurry comprising calcium exotoxin and about 0.25 to about 2.5 percent by weight of such copolymer is also disclosed.

Abstract: Disclosed is a process of preparing an ion exchange membrane which comprises adding a highly hydrophilic solvent into a solution of an ion exchange resin containing an ion exchange group on the polymer chain, placing the solution into a membrane-forming vessel and forming a membrane by removing the solvent.The ion exchange membrane prepared in accordance with the present invention exhibits the high degree of orientation so that the ionic conductivity can be elevated to provide the satisfactory cell performance.

Abstract: PEO-containing quaternary ammonium compounds have good broad spectrum antimicrobial activity. These compounds are useful in pharmaceutical compositions as preservatives and in contact lens care compositions as preservatives and/or disinfectants.

Abstract: There is provided an EW pesticidal formulation comprising:(a) 190 g/l to 350 g/l of at least one pesticide selected from the group consisting of chlorpyrifos, endosulfan, and imazalil.(b) 150 g/l to 400 g/l of the methyl ester of rosin.(c) 30 g/l to 200 g/l of at least one surfactant.(d) water to make up to one liter, but not less than 200 g/l;and optionally containing a polar solvent completely or partially soluble in water. This affords formulations which have low irritations and surprisingly improved biological activity to target species.

Abstract: In accordance with the present invention, an ion-exchange composition has been formed which comprises synthetic resin support particles, dispersant capable of suspending the support particles in an aqueous medium to inhibit or prevent agglomeration, and fine synthetic resin layering particles. In a preferred embodiment, the complex can be formed by contacting a suitable dispersant with monomer in an aqueous solution in which the monomer is insoluble. Under suitable conditions for suspension polymerization, the monomer will polymerize to form resin support particles having dispersant irreversibly attached to those particles. The dispersant is irreversibly attached to the synthetic resin support particles, either by covalent bonding or permanent physical entanglement. The dispersant is also attached to the fine layering particles, either by covalent bonding or electrostatic forces. The result is formation of a support particle-dispersant-layering particle complex.

Abstract: A composition containing an antimicrobial and a silicone-based emulsion is disclosed for treating heat exchange surfaces. The liquid formulation retards microbial growth and prevents debris from adhering to the surfaces, thus minimizing fouling. The composition does not form a film on the treated surfaces, but rather clings via ionic interaction; thus the heat transfer characteristics of the system are not substantially altered. In addition, the composition does not contain any volatile organic compounds, which can be harmful to a building's occupants. An application method is further disclosed that entails spraying the composition into the cooling coils to be treated, drawing the composition across the heat exchange surfaces in an air stream, and drying the surfaces. This method results in the formation of a low-friction antimicrobial deposit that will resist fouling and microbial growth.

Abstract: Proposed is a method for vascular embolization of the blood vessel of a patient by introducing an aqueous solution of a specific thermosensitive polymer, which is liquid at low temperatures but causes coagulation when heated up to the body temperature of the patient, into the blood vessel followed by in situ heating of the solution. The thermosensitive polymer found to be suitable for the purpose is a homopolymer or copolymer of an N-substituted (meth) acrylamide monomer having a specified intrinsic viscosity in tetrahydrofuran and gives an aqueous solution capable of exhibiting phase transition from a liquid to a coagulate at a transition temperature of 10.degree. to 37.degree..

Abstract: The invention provides a pretreatment method and primer that is applied directly to the hard tissue. The invention has particular utility for adhering to or coating sclerotic dentin and cervical enamel or for adhering to or coating hard tissue in a high humidity environment. The primer enables formation of extremely strong bonds to dentin. The method comprises the steps of:(a) applying to the hard tissue adhesively effective amounts of an acid and a water-dispersible film former comprising a polymer and(b) hardening the film former.Primer compositions are provided for use in this method, comprising a mixture of an acid and a film former comprising a polymer prior to hardening, the mixture being in the form of a film atop the hard tissue.

Abstract: A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

Abstract: Ion exchange resins are prepared by a process comprising functionalizing styrene-divinylbenzene copolymers, or other crosslinked vinyl copolymers, by sulfonation or chloromethylation and amination, and achieving high ion exchange capacity and a low degree of resin bead fragmentation, in the presence of hydrocarbon liquids, such as cyclohexane.

Abstract: An artificial human nail structure is described which is formed of polymerized alkyl methacrylate and hydroxyalkyl methacrylate in a weight ratio in the range of 1-50 parts of alkyl methacrylate per part of hydroxyethyl methacrylate, preferably a ratio of 2-20:1, and more preferably of 3-10:1, and wherein said alkyl moiety of either is any C.sub.1 -C.sub.4 alkyl, preferably ethyl. The artificial nail coating can be easily applied, polymerizes readily and rapidly without catastrophic crystallization and produces a transparent and easily shaped artificial nail structure. Also disclosed is an artificial human nail surface precursor having as its principal component a mixture of alkyl methacrylate and hydroxyalkyl methacrylate in the above mentioned weight ratio.

Abstract: The invention relates to new pharmaceutical compositions intended for administration by ocular route and to the process for obtaining them.A specific subject of the invention is a process for obtaining pharmaceutical compositions intended for ophthalmic route of which the active ingredient is bromocriptine, in which the active ingredient is dissolved in methanol then this solution is diluted with an aqueous solute containing a hydrosoluble inert filler, the mixture is lyophilized then the lyophilization deposit is redissolved at the time of use in an aqueous solute containing a preservative, a polyethylene glycol, physiological serum and an ethylenic acid.The solute obtained is a medicament for intra-ocular hypertension.

Abstract: This invention provides a composition, device and method for the removal of selected factors, such as cytokines or pharmaceuticals, from a substance such as whole blood or plasma. Advantageously, the invention provides for the treatment or prevention of septic shock syndrome or other conditions evidenced by the presence of cytokines in a patient by contacting the patient's whole blood with a composition comprising silica and a surface treatment material, such as heparin, but preferably human serum albumin (HSA). The treatment lowers the cytokine concentration of the blood. Pharmaceuticals can be removed from an individual's whole blood or plasma, such as for use in treating drug overdosage.

Abstract: A formulation is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein and a sponge of porous particulate polymer matrix. The sponge may be prepared by treating the porous particulate polymer matrix with a suitable fusing material such as ethanol and a surfactant such as a polysorbate.

Abstract: The disclosed invention pertains to a process for the preparation of a water-soluble, nitrogen-containing, epihalohydrin-based resin having a reduced content of total halogen, organic halogen, adsorbable organic halogen (AOX)and by-products. The process involves treatment of nitrogen-containing, epihalohydrin-based resins or intermediate reaction-products with a basic ion-exchanger. The invention also pertains to novel resins displaying such halogen contents far below the values known in the art. Subject resins are useful as wet-strength agents for paper and are preferably of the polyaminoamide-epihalohydrin type.

Abstract: Moulded plastics products are produced by in-mould copolymerization of methyl methacrylate with a polyurethane polyacrylate or polymethacrylate derived from a hydroxyalkyl acrylate or methacrylate by reaction of hydroxyl groups thereof with the isocyanate groups of a polyisocyanate or urethane polyisocyanate having isocyanate functionality greater than 2.0.