Patents Examined by Peter F. Kulkosky
  • Patent number: 5589072
    Abstract: An iodine capture system, and related method, comprising a biological liquid conduit and, disposed therein, a polyvinyl acetate-alcohol-acetal porous body, and methods of using the same are disclosed.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: December 31, 1996
    Inventor: Edward Shanbrom
  • Patent number: 5587143
    Abstract: This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: December 24, 1996
    Assignee: NanoSystems L.L.C.
    Inventor: Sui-Ming Wong
  • Patent number: 5585407
    Abstract: Water-based coatable compositions for application to a substrate to inhibit the growth of microbes for extended periods of time, durable removable biocidal polymeric coatings resulting from such coatable compositions, a method of protecting a substrate from the growth of microbes and substrates resistant to such growth are described. The coatable compositions comprise an acrylate emulsion polymer comprising the reaction product of one or more acrylate or methacrylate monomers and one or more carboxylic acid monomers, an organoalkoxysilane, an effective amount of biocide, plasticizer and water. The coatable composition may be applied to the surface of a substrate and allowed to dry to provide durable adherent polymeric coatings which slowly release biocide to the surrounding surface for extended periods of time.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: December 17, 1996
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Vinu Patel, Fidelis C. Onwumere
  • Patent number: 5580578
    Abstract: A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, overcoated with an aqueous dispersion of the plasticized water-insoluble acrylic polymer. The formulation provides a stable dissolution of the active agent which is unchanged after exposure to accelerated storage conditions.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: December 3, 1996
    Assignee: Euro-Celtique, S.A.
    Inventors: Benjamin Oshlack, Frank Pedi, Jr., Mark Chasin
  • Patent number: 5580548
    Abstract: A colorless or colored nail enamel contains a solvent system for enamels, nitrocellulose as a film forming substance, an arylsulfonamide formaldehyde resin or an alkyd resin, a plasticizing agent and an amino-silicone present in an amount ranging from 0.05 to 5 percent by weight based on the total weight of the nail enamel so as to improve the adherence of the enamel to the nail.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 3, 1996
    Assignee: L'Oreal
    Inventors: Myriam Mellul, Val erie de La Poterie
  • Patent number: 5580550
    Abstract: Cosmetic compositions comprising an emulsion, preferably an aqueous emulsion, including at least one cosmetic resin material, e.g. a hydrocarbon resin such as polyisobutylene, are made by direct emulsification of the resin without a solvent or carrier therefor. The direct emulsification may be achieved by a special mixing regime, with particular emulsifiers. The absence of solvent or carrier for the resin material avoids product thinning and gives several manufacturing and processing advantages.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: December 3, 1996
    Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.
    Inventors: Anthony D. Gough, Joanne M. De Groot, Jeffrey Price
  • Patent number: 5580544
    Abstract: Water-dispersible paste formulations used in connection with seed treatment and foliar treatment of plants provide excellent dust and rub-off control. The paste formulations comprise an active ingredient and a hydrocarbon oil carrier having a boiling point of at least 150.degree. C. The carrier is present in an amount that is effective for reducing dusting off of the plant leaf or seed. The paste formulations further include a surfactant and an effervescent comprising an alkaline carbonate and a solid and weak acid. The surfactant, the alkaline carbonate, and the solid and weak acid are respectively present in an amount that is effective for enabling the paste formulation to readily and quickly be dispersed in water. The paste formulations are especially suitable for containment in water soluble and/or water-dispersible bags or pouches, such use tending to render the active ingredient safer to handle and therefore better for consumers and the environment.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: December 3, 1996
    Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd/Ltee
    Inventors: Dong C. Dao, William L. Hallatt, Heather L. Hibbett, Colin H. Drennan
  • Patent number: 5576022
    Abstract: The present invention pertains to controlled release tacrine drug delivery systems comprising an immediate release composition and a sustained release composition wherein (1) the immediate release composition comprises in percentages by weight of the immediate release composition: (A) immediate release pellets comprising: (a) nonpareil seeds in an amount from about 25% to about 75%; (b) tacrine in an amount from about 10% to about 80%; and (c) a binding agent in an amount from about 1% to about 10%; and (B) a sealing layer over the immediate release pellets comprising: (a) a sealing agent in an amount up to about 6%, and (b) a first plasticizing agent in an amount up to about 5%; and (2) the sustained release composition comprises in percentages by weight of the sustained release composition; (A) the immediate release composition; and (B) a sustaining layer over the immediate release composition comprising; (a) a water-insoluble polymer in an amount from about 40% to about 90%; (b) a water-soluble polymer in
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: November 19, 1996
    Assignee: Warner Lambert Company
    Inventors: S. Shirley Yang, Wayne Boisvert, Nouman A. Muhammad, Jay Weiss
  • Patent number: 5575991
    Abstract: The aqueous or aqueous-alcoholic hair treatment composition contains:A) 0.1 to 10 percent by weight polyvinylpyrrolidone or polyvinylpyrrolidone-vinyl acetate-copolymer;B) 0.1 to 9 percent by weight of at least one amphoteric surfactant, preferably a fatty acid amidoalkylbetaine or a fatty acid amidoalkylsulfobetaine;C) 0.1 to 5 percent by weight of at least one cationic surfactant, advantageously cetyltrimethylammonium chloride or bromide; andD) 0.1 to 2.0 percent by weight of at least one organic acid, preferably tartaric acid, glyoxalic acid, lactic acid or formic acid.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: November 19, 1996
    Assignee: Wella Aktiengesellschaft
    Inventors: Karl-Heinz Kischka, Dietrich Hoch, Jurgen Schmenger, Ernst Flemming
  • Patent number: 5573782
    Abstract: An aigicidal composite sheet body suitable for use as a building material is described. The composite comprises a bituminous sheet material having a firmly adherent surfacing of granular material, the granular material comprising ceramic-coated base granules adhered to the bituminous sheet material by a composition containing calcium, the granular material and the composition forming an exterior surface on the composite sheet body, the composite sheet body exterior surface having an algicidal topical coating Thereon, wherein the algicidal topical coating comprises an organic oil and a tin-acrylate polymer dispersed therein, the tin-acrylate polymer being derived from a monomer composition comprising flee-radical polymerizable units. The organic oil is selected from the group consisting of slate oil, rock oil, coal oil, and seneca oil, and the tin-acrylate polymer is present at a weight percentage ranging from about 0.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: November 12, 1996
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: W. Stuart Bigham, Christine A. Sobon, Billy L. George
  • Patent number: 5571533
    Abstract: Disclosed are controlled-release mucoadhesive pharmaceutical compositions for the oral administration of furosemide. This composition comprises a multiplicity of microgranules of lipophilic material which are coated with a mucoadhesive coating. This invention reduced or eliminates the diuresis peak and reduces inter-subject response variability which normally accompany conventional treatment with this drug.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: November 5, 1996
    Assignee: Recordati, S.A., Chemical and Pharmaceutical Company
    Inventors: Giancarlo Santus, Giuseppe Bottoni, Caterina Lazzarini
  • Patent number: 5569720
    Abstract: A polymer conjugate consisting essentially of: from 90 to 99.9 mol % of units represented by the formula ##STR1## from 0.1 to 5 mol % of units represented by the formula ##STR2## wherein one of R.sub.1 and R.sub.2 is a copolymer residue of the formula ##STR3## and the other one is hydrogen atom; from 0 to 9.9 mol % of units represented by the formula ##STR4## wherein R is a phenyl or t-butoxy group, R.sub.3 is H or an acetyl group, A and A.sub.1 which may be the same or different, represent a chemical single bond, an amino acid residue or peptide spacer selected from .beta. Ala, Gly, Phe-Gly, Phe-Phe-, Leu-Gly, Val-Ala, Phe-Ala, Leu-Phe, Leu-Ala, Phe-Leu-Gly, Phe-Phe-Leu, Leu-Leu-Gly, Phe-Tyr-Ala, Phe-Gly-Phe, Phe-Phe-Gly, Phe-Leu-Gly-Phe, Gly-Phe-Leu-Gly-Phe,Gly-.beta.Ala, Phe-Gly-.beta.Ala, Phe-Phe-.beta.Ala, Leu-Gly-.beta.Ala, Val-Ala-.beta.Ala, Phe-Ala-.beta.Ala, Leu-Phe-.beta.Ala, Leu-Gly-.beta.Ala, Phe-Leu-Gly-.beta.Ala, Phe-Phe-Leu .beta.Ala, Leu-Leu-Gly-.beta.Ala, Phe-Tyr-Ala-.beta.Ala, Phe-Gly-Phe-.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: October 29, 1996
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Nicola Mongelli, Francesco Angelucci, Enrico Pesenti, Antonino Suarato, Giovanni Biasoli
  • Patent number: 5565193
    Abstract: Provided hair styling compositions comprising: (a) from about 0.1% to about 15%, by weight, of a silicone grafted adhesive polymer, said polymer being characterized by an organic polymeric backbone having silicone macromers grafted to said backbone; (b) from about 0.5% to about 15%, by weight, of a hydrocarbon solvent selected from the group consisting of C.sub.10 -C.sub.14 branched chain hydrocarbons, and mixtures thereof; (c) a polar solvent phase comprising from about 80% to about 98.9%, by weight of the composition, of a polar solvent selected from the group consisting of water and C.sub.2 -C.sub.3 monohydric alcohols, and mixtures thereof, wherein said composition contains no more than about 15%, by weight, of C.sub.3 monohydric alcohol; wherein said organic polymer backbone is soluble in said polar solvent phase, and said silicone macromers of said hair setting polymer are soluble in said hydrocarbon solvent and insoluble in said polar solvent.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: October 15, 1996
    Assignee: Procter & Gamble
    Inventors: Sanjeev Midha, Peter M. Torgerson, Christine Hall
  • Patent number: 5562099
    Abstract: Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microparticles is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microparticles are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: October 8, 1996
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: Smadar Cohen, Alexander K. Andrianov, Margaret Wheatley, Harry R. Allcock, Robert S. Langer
  • Patent number: 5561945
    Abstract: A method of killing noxious insects with the use of either a shaped article having a projection previously coated with a particular active compound or a shaped article having a projection and provided with a spout for discharging said active compound. Pressure is applied from outside onto and around the stalks and/or stems of fruits, vegetables, flowers and ornamental plants, thereby forcibly making the surfaces of said stalks and/or stems absorb the active compound.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: October 8, 1996
    Assignee: Nihon Bayer Agrochem K.K.
    Inventors: Atsumi Kamochi, Nobuhiro Yamashita, Ikuya Saito
  • Patent number: 5558859
    Abstract: Compositions for the treatment and protection of the exoskeletal parts, in particular the hair and the eyelashes, characterized in that they contain, in a cosmetically acceptable medium, at least one ceramide and/or one glycoceramide and at least one vinylpyrrolidone polymer are disclosed. A process which uses these compositions for the nonwashing treatment of the exoskeletal parts, in particular of the hair and the eyelashes is also disclosed, as is a cosmetic treatment process making use of these compositions.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: September 24, 1996
    Assignee: L'Oreal
    Inventor: Isabelle Cretois
  • Patent number: 5556897
    Abstract: A primer solution composition to be applied to a tooth surface, which comprises (a) at least one metal compound selected from the group consisting of an iron compound, a copper compound and a cobalt compound, (b) a polymerizable monomer having an acidic group and (c) a polymerizable monomer having no acidic group, and which has adhesion properties to a tooth surface; and a method of forming an adhesive layer on a tooth surface, which comprises applying said primer solution composition comprising (a) to a tooth surface, and applying thereto a curing composition containing trialkylboron or its partial oxidate and a polymerizable monomer.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: September 17, 1996
    Assignee: Sun Medical Co., Ltd.
    Inventors: Narimichi Honda, Takashi Yamamoto, Masami Arata
  • Patent number: 5556618
    Abstract: An antibacterial electret material which consists of a synthesized organic polymer having a volume resistivity of not less than 10.sup.13 .OMEGA..multidot.cm and containing 0.01 to 2% by weight of one kind of electret stabilizer selected from the group composed of a hindered amine compound, a nitrogen-containing hindered phenol compound, a metallic salt hindered phenol compound, a phenol compound, a sulfur compound and a phosphorus compound and 0.1 to 4% by weight of metal ion-containing inorganic compound, and which has a surface density of charge of not less than 1.times.10.sup.-10 coulomb/cm.sup.2.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: September 17, 1996
    Assignee: Toray Industries, Inc.
    Inventors: Katsutoshi Ando, Masanori Takahashi, Goro Kondou
  • Patent number: 5556619
    Abstract: Disclosed are novel crosslinked polymeric ammonium salts wherein in said polymeric salt: about 25% or more of the segments which link ammonium nitrogen atoms are group Y wherein Y is an n-alkylene group or alkyl substituted n-alkylene group, wherein said n-alkylene group has 7 to about 20 carbon atoms; zero to about 75% of segments which link ammonium nitrogen atoms are group Z wherein Z is a hydrocarbylene radical containing 2 or more carbon atoms, said hydrocarbylene radical optionally containing one or more hydroxyl, ether, amino, thioether, keto, or silyl groups or heterocyclic rings; and about 25% or more of the ammonium atoms are secondary ammonium atoms.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: September 17, 1996
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Susan D. Royce, Garret D. Figuly, Nitya P. Khasat, Jose R. Matos
  • Patent number: 5552141
    Abstract: Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: September 3, 1996
    Inventor: Hans O. Ribi