Patents Examined by Peter O'Sullivan
  • Method of producing nitroguanidine- and nitroenamine derivatives
    Patent number: 6747146
    Abstract: Method of producing compounds of formula wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical —N(R3)R4; or R2 and R6 together are —CH2—CH2—S—; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a radical —CH2B; R6 is hydrogen, C1-C8-alkyl, aryl or benzyl; or R3 and R6 together are —CH2—CH2—, —CH2—CH2—CH2—, —CH2—O—CH2—, —CH2—S—CH2— or —CH2—N(R5)—CH2—; X is CH—CN; CH—NO2 or N—NO2; A is an optionally substituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is optionally substituted phenyl, 3-pyridyl or thiazolyl; characterised in that a compound of formula wherein R2, R6 and X have the same significance as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of f
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: June 8, 2004
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Gottfried Seifert, Thomas Rapold, Verena Gisin
  • Thiol sulfonamide metalloprotease inhibitors
    Patent number: 6747027
    Abstract: This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: June 8, 2004
    Assignee: Pharmacia Corporation
    Inventors: Gary DeCrescenzo, Zaheer S. Abbas, John N. Freskos, Daniel P. Getman, Robert M. Heintz, Brent V. Mischke, Joseph J. McDonald
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6743929
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 1, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Process for the preparation of ruthenium compounds
    Patent number: 6743935
    Abstract: A process for the preparation of ruthenium compounds of the formula {Ru(dienyl)2} wherein “dienyl” represents a substituted pentadienyl or cycloheptadienyl group by reacting dichloro(2,7-dimethylocta-2,6-dien-1,8-diyl)-ruthenium with an appropriate diene in the presence of a primary or secondary alcohol capable of reducing Ru(IV) to Ru(II); and a carbonate of an alkaline material. These ruthenium compounds are useful as precursors of Ru catalysts.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: June 1, 2004
    Assignee: Firmenich SA
    Inventors: Albrecht Kurt Lutz Salzer, Frank Peter Herbert Podewils, Stefan Geyser
  • Electrochemically stable onium salts and electrolytes containing such for electrochemical capacitors
    Patent number: 6743947
    Abstract: Based on the discovery that the melting point and solubility of onium salts are affected by the asymmetry of the substitution on cation, and that the branched substituents effectively shield onium cations from electrochemical reduction, new onium salts are synthesized and high performance electrolytes based on these salts for electrochemical capacitor are provided. The composition of the new electrolyte comprises an onium salt or mixture of such onium salts dissolved in aprotic, non-aqueous solvents or mixture of such solvents. The electrolyte is able to perform at high rate of charge/discharge, at low ambient temperatures, and within wide operating voltage, due to the high solubility, low melting temperature, and the improved reduction stability of the new onium cations, respectively.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: June 1, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kang Xu, Shengping Ding, T. Richard Jow
  • 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines, process for preparation thereof and use thereof as hypoglycemic agents
    Patent number: 6730704
    Abstract: The present invention relates to 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines useful as hypoglycemic agents, and to a process for synthesis thereof. The present invention also relates to the synthesis of 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines as new hypoglycemic agents which may be useful in the treatment of diabetes.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: May 4, 2004
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ramalingam Thallapalli, Venkata Durga Nageswar Yadavalli, Ramakrishna Sistla, Adari Bhaskar Rao, Prakash Vamanrao Diwan, Jhillu Singh Yadav, Kondapuram Vijaya Raghavan
  • Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors
    Patent number: 6730783
    Abstract: Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: May 4, 2004
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Bruce E. Tomczuk, Richard M. Soll, Tianbao Lu, Cynthia L. Fedde, Carl R. Illig, Thomas P. Markotan
  • Process for the preparation of urea
    Patent number: 6730811
    Abstract: The invention relates to a process for the preparation of urea from ammonia and carbon dioxide in which the low-pressure carbamate stream formed in the further upgrading of the urea synthesis solution is stripped in a CO2-carbamate stripper in countercurrent contact with CO2, which results in the formation of a gas mixture consisting substantially of ammonia and carbon dioxide. This gas mixture is preferably subsequently condensed in a high-pressure carbamate condenser and then returned to the synthesis zone.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: May 4, 2004
    Assignee: DSM N.V.
    Inventor: Johannes H. Mennen
  • Aromatic imide and aromatic methylidynetrissulfonyl compounds and method of making
    Patent number: 6727386
    Abstract: A method is provided for making aromatic-imide and aromatic-methylidynetrissulfonyl species by reaction of aromatic species with a reactant according to formula (I): (X—SO2—)m—QH—(—SO2—R1)n  (I) wherein Q is C or N; wherein each X is independently selected from the group consisting of halogens, typically F or Cl; wherein each R1 is independently selected from the group consisting of aliphatic and aromatic groups, which may or may not be saturated, unsaturated, straight-chain, branched, cyclic, heteroatomic, polymeric, halogenated, fluorinated or substituted; wherein m is greater than 0; wherein m+n=2 when Q is N; and wherein m+n=3 when Q is C. Ar may be derived from an aromatic polymeric compound.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: April 27, 2004
    Assignee: 3M Innovative Properties Company
    Inventor: Steven Joseph Hamrock
  • Preparation of organohalosilanes
    Patent number: 6727376
    Abstract: In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphonium compound having on the molecule at least one group of the formula: [R2R3R4P—]+Y− wherein R2, R3 and R4 each are a monovalent hydrocarbon group and Y is a halogen atom or acid group. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: April 27, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Tetsuya Inukai, Hajime Ishizaka
  • Crystalline forms of the sodium salt of 5-chloro-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonylpenyl)ethyl)benzamide
    Patent number: 6723751
    Abstract: The present invention relates to crystalline forms of the sodium salt of 5-chloro-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonylphenyl)ethyl)benzamide, processes for their preparation, their use, and pharmaceutical preparations comprising them.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 20, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinrich Christian Englert, Uwe Gerlach, Harald Schneider, Tobias Metzenthin
  • Method for producing anthracenes
    Patent number: 6723870
    Abstract: Disclosed is a method for producing anthracene of formula (II) below by mixing a reaction mixture with a primary alcohol, wherein the reaction mixture is a reaction mixture obtained by reacting a metal hydride with an anthraquinone of formula (I):
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: April 20, 2004
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takashi Kamikawa, Junji Morimoto
  • Siloxane bischloroformates
    Patent number: 6723864
    Abstract: Siloxane bischloroformates are prepared in a continuous process by phosgenating siloxane bisphenols in a flow reactor using a substantial excess of phosgene and sodium hydroxide. While very high levels (>95%) of conversion of the siloxane bisphenol to the corresponding siloxane bischloroformate are achieved using a flow reactor according to the method of the invention, only more modest conversion (˜90%) of the siloxane bisphenol to the corresponding siloxane bischloroformate is attained when analogous batch processes are employed. The process holds promise for use in the manufacture of silicone-containing copolycarbonates which requires high purity siloxane bischloroformate intermediates.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: April 20, 2004
    Assignee: General Electric Company
    Inventors: James Manio Silva, David Michel Dardaris, Gary Charles Davis
  • Sulfonamide derivatives
    Patent number: 6720357
    Abstract: The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: April 13, 2004
    Assignee: Eli Lilly and Company
    Inventors: Paul Leslie Ornstein, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
  • Method for producing N-methyl-N?-nitroguanidine
    Patent number: 6720451
    Abstract: The present invention relates to a novel process for the preparation of N-methyl-N′-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: April 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Kai van Laak, Wolfram Sirges
  • Process for the chlorination of methylsilanes
    Patent number: 6720440
    Abstract: The invention relates to a process for the chlorination of methylsilanes, which comprises reacting methylsilanes with chlorine in the presence of at least 0.1% by weight of hydrogen chloride, based on the weight of methylsilane of the formula (II), under the action of electromagnetic radiation which induces chlorination, chlorine being used in a substoichiometric amount based on the methylsilane of the formula (II), and the reaction being carried out at temperatures below the boiling point of the methylsilane of the formula (II). The invention further relates to an apparatus suitable for carrying out the chlorination of an industrial scale.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 13, 2004
    Assignee: Wacker-Chemie GmbH
    Inventors: Helmut Hollfelder, Siegfried Pflaum, Franz Riener
  • Carbanilides used as pesticides
    Patent number: 6716881
    Abstract: The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with methods of using the compounds to control microorganisms in crops and in the protection of materials. The compounds of the present invention also find use in controlling animal pests.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: April 6, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Bernd-Wieland Krüger, Robert Markert, Ralf Tiemann, Dietmar Kuhnt, Stefan Dutzmann, Klaus Stenzel, Christoph Erdelen, Martin Kugler, Hans-Ulrich Buschhaus
  • Hydrosilation with platinum free neat copper containing catalyst
    Patent number: 6713644
    Abstract: Chloropropylsilanes are prepared via hydrosilation of olefinic halides with organosilicon hydrides, in the presence of neat platinum free copper containing catalysts. Organosilicon hydrides such as triethylsilane, olefinic halides such as allyl chloride, and catalysts such as copper acetate, copper chloride, copper sulphate, copper hydroxide, copper nitrate, and copper cyanide, can be used in the process.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: March 30, 2004
    Assignee: Dow Corning Corporation
    Inventor: Binh Thanh Nguyen
  • Process for the preparation of cell proliferation inhibitors
    Patent number: 6710185
    Abstract: The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: March 23, 2004
    Assignee: Abbott Laboratories
    Inventors: Ashok K. Gupta, Steven A. King, Elaine C. Lee, Howard E. Morton, Daniel J. Plata, Yu-Ming Pu, Padam N. Sharma
  • Aminoguanidines and alkoxyguanidines as protease inhibitors
    Patent number: 6706765
    Abstract: Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: March 16, 2004
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Bruce E. Tomczuk, Richard M. Soll, Tianbao Lu, Cynthia L. Fedde, Carl R. Illig, Thomas P. Markotan, Thomas P. Stagnaro