Abstract: Fluorosilicone fluids useful as high-density fluid ocular tamponades and methods of producing, purifying and using the fluorosilicone fluids in an ocular surgical procedure for retinal treatment.
Type:
Grant
Filed:
September 19, 2002
Date of Patent:
March 9, 2004
Assignee:
Bausch & Lomb Incorporated
Inventors:
Jay F. Kunzler, Richard M. Ozark, Joseph C. Salamone
Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders
Type:
Grant
Filed:
November 15, 2002
Date of Patent:
March 9, 2004
Assignee:
Eli Lilly and Company
Inventors:
James Allen Knobelsdorf, Timothy Alan Shepherd, Eric George Tromiczak, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
Abstract: A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
Type:
Grant
Filed:
July 8, 2002
Date of Patent:
February 24, 2004
Assignee:
The Ohio State University Research Foundation
Inventors:
Robert W. Curley, Jr., Serena M. Mershon
Abstract: Compounds of formula (I)
are novel P2X3 and P2X2/P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.
Type:
Grant
Filed:
July 26, 2002
Date of Patent:
February 17, 2004
Assignee:
Abbott Laboratories
Inventors:
Chih-Hung Lee, Meiqun Jiang, Richard A. Perner, Arthur Gomtsyan, Erol K. Bayburt, Guo Zhu Zheng
Abstract: The invention provides a novel method for synthesizing Morphine-6-Glucuronide comprising the step of reacting 3-O-pivaloyloxymorphine and methyl 1&agr;,2-ethylorthopivalate-3,4-di-O-pivaloylglucouronate.
Type:
Grant
Filed:
October 4, 2002
Date of Patent:
February 17, 2004
Assignee:
Cenes Limited
Inventors:
Philip James Parsons, Richard Andrew Ewin
Abstract: The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Type:
Grant
Filed:
January 23, 2001
Date of Patent:
February 17, 2004
Assignee:
Eli Lilly and Company
Inventors:
Macklin Brian Arnold, David Michael Bender, Buddy Eugene Cantrell, Winton Dennis Jones, Paul Leslie Ornstein, Richard Lee Simon, Edward C. R. Smith, Eric George Tromiczak, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
Abstract: A method of reducing adhesion at a site of trauma includes forming a film from an alginate solution, contacting the film with a cross-linking solution to form a cross-linked mechanically stable sheet, and placing at least a portion of the sheet at the site of trauma. An anti-adhesion barrier includes a sheet of ionically cross-linked alginate having a thickness in a range of 0.25 mm to 10 mm. The sheet has a tear strength sufficient for suturing and repositioning. A drug delivery device includes a cross-linked alginate container that can be filled with a drug.
Type:
Grant
Filed:
January 10, 2003
Date of Patent:
February 17, 2004
Assignee:
SciMed Life Systems, Inc.
Inventors:
Jianmin Li, Weenna Bucay-Couto, Timothy P. Harrah
Abstract: Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A1), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and <1% of a compound of formula (1b)(A2); and then subjecting the sertraline-imine isomeric mixture obtained according to reaction route (A1) or (A2), in a suitable solvent, to recrystallisation (B), in accordance with scheme (I) wherein in formula (1a), R1, R2 and R3 are each independently of the others
Type:
Grant
Filed:
September 20, 2002
Date of Patent:
February 17, 2004
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Marc Thommen, Andreas Hafner, Roman Kolly, Hans-Jörg Kirner, Frédéric Brunner
Abstract: A method for producing biphenols by oxidative coupling of dialkylphenols which proceeds in two stages using a copper amine complex which is catalytically effective in each stage is disclosed. A novel copper amine complex is also disclosed wherein the complex exhibits high catalytic activity for the oxidative coupling of substituted phenols under mild conditions, has dual (two stage) activity and can be readily recycled and reused.
Abstract: An integrated process for preparing &agr;-(2,4-disulfophenyl)-N-tert-butylnitrone and its salts is disclosed in which N-tert-butylhydroxylamine acid addition salt is incompletely neutralised so as to leave catalytic amounts of acid and the neutralisation product is condensed with an appropriate aldehyde.
Type:
Grant
Filed:
April 5, 2001
Date of Patent:
February 10, 2004
Assignees:
Centaur Pharmaceuticals, Inc., AstraZeneca AB
Inventors:
Henry Kruk, John McGinley, Sergei Pouhov, John Vajda, Allan Wilcox, Jörgen Blixt, Ulf Larsson
Abstract: A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.
Abstract: Described herein are novel 1-aryl-3-(2-chloroalkanylureas derivatives. These derivatives are useful anticaner agents having excellent specifilty towards cell targets and potent antineoplastic activity without systemic toxicity derivatives mutagenicity. More specifically, the invention is directed to novel derivatives of the following formula:
wherein
R1 is C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, C1-C6 hydroxy alkyl, or C1-C6 halide;
R2 is H, C1-C6 alky, C3-C7 cycloalkyl, C1-C6 I alkoxy, C1-C6 hydroxy alkyl or C1-C6 halide, di-halide or tri-halide; R1 and R2 may also be part of cyclic structures.
Abstract: A method is provided for making aromatic-imide and aromatic-methylidynetrissulfonyl species by reaction of aromatic species with a reactant according to formula (I):
(X—SO2—)m—QH—(—SO2—R1)n (I)
wherein Q is C or N; wherein each X is independently selected from the group consisting of halogens, typically F or Cl; wherein each R1 is independently selected from the group consisting of aliphatic and aromatic groups, which may or may not be saturated, unsaturated, straight-chain, branched, cyclic, heteroatomic, polymeric, halogenated, fluorinated or substituted; wherein m is greater than 0; wherein m+n=2 when Q is N; and wherein m+n=3 when Q is C. Ar may be derived from an aromatic polymeric compound.
Abstract: This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Type:
Grant
Filed:
September 17, 2002
Date of Patent:
January 20, 2004
Assignee:
SmithKline Beecham Corporation
Inventors:
Michael R. Palovich, Katherine L. Widdowson, Hong Nie
Abstract: The invention relates to an installation for the preparation of urea from ammonia and carbon dioxide, the installation comprising two reactor sections in a vertically placed combined reactor and a high-pressure condenser section. The installation may comprise a vertically placed combined reactor, with the two reactor sections being separated by a high-pressure condenser section. In another embodiment the installation comprises a vertically placed combined reactor that comprises two reactor sections and a high-pressure condenser section placed outside the reactor. The invention also relates to a process for the preparation of urea in this installation. This involves feeding the gas stream leaving the stripper wholly or partly to the high-pressure condenser section of the installation. Preferably, a portion of the gas stream leaving the scrubber is fed to the second reactor section in the vertically placed combined reactor via an ammonia-driven ejector.
Abstract: A method of manufacturing (meth)acrylic acid includes:
a reaction step of carrying out a catalytic gas-phase oxidation reaction;
an absorbing step of absorbing (meth)acrylic acid from a (meth)acrylic-acid-containing mixed gas prepared in the reaction step;
a refinement step of separating, refining, and recovering (meth)acrylic acid from a (meth)acrylic-acid-containing liquid prepared in the absorbing step; and
a recirculation step of recirculating (meth)acrylic acid contained in a vent gas produced in the refinement step to the absorbing step and/or the refinement step.
Abstract: Oximes are prepared from ketones or aldehydes, hydrogen peroxide and ammonia. The reaction is carried out in a system of one aqueous phase and one phase of hydrocarbons inert under the reaction conditions in the presence of at least one interphase contactor and a catalyst system which consists of at least two components. A first component of the catalyst system is present in heterogeneous form and is based on titanium, silicon and oxygen and a second component is a homogeneously dissolved or suspended ammonium salt.
Type:
Grant
Filed:
November 14, 2002
Date of Patent:
December 16, 2003
Assignee:
Degussa AG
Inventors:
Juergen Herwig, Stefan Leininger, Georg Oenbrink, Thomas Schiffer
Abstract: The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.
Type:
Grant
Filed:
June 5, 2001
Date of Patent:
December 9, 2003
Assignee:
Magnolia Nutritionals, L.L.C.
Inventors:
Steven J. Catani, Stephen A. Roth, Edward J. McGuire, Juan L. Navia
Abstract: The present invention relates to compounds useful as catalysts in asymmetric synthesis of chiral compounds, methods for the synthesis of said catalysts, and methods for synthesizing chiral compounds with high enantioselectivity.
Type:
Grant
Filed:
March 14, 2003
Date of Patent:
December 9, 2003
Assignee:
The Trustees of the University of Pennsylvania
Abstract: A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol or a pharmacologically acceptable salt thereof, and pharmaceutical compositions.