Patents Examined by Qing Xu
  • Patent number: 11951138
    Abstract: A method of mimicking a phenotype of a first ruminating animal in a second ruminating animal is disclosed. The method comprises administering to the second ruminating animal a microbial composition comprising a plurality of microbes having a signature which is statistically significantly similar to the microbial signature of a rumen microbiome of the first ruminating animal, wherein the first and the second ruminating animal are of identical species, thereby mimicking the phenotype of the first ruminating animal in the second ruminating animal.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: April 9, 2024
    Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)
    Inventors: Itzhak Mizrahi, Elie Jami
  • Patent number: 11930824
    Abstract: The present algae extracts are used for biocontrol of insects. Specifically, the present extracts are obtained from Cystoseria muricatum using a polysolvent system. Once obtained, the extracts can be applied to plants to repel insects and/or to facilitate fertilization of the plants.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: March 19, 2024
    Inventor: Nermin Adel El Semary
  • Patent number: 11932846
    Abstract: A system for expressing a chloramphenicol split protein is disclosed. Uses thereof are also disclosed.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: March 19, 2024
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventor: Gali Prag
  • Patent number: 11905315
    Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: February 20, 2024
    Inventors: Brian Thompson, Ashley Siegel
  • Patent number: 11905539
    Abstract: A novel modified polypeptide having an isopropylmalate synthase activity, a polynucleotide encoding the same, a microorganism including the polypeptide, and a method of producing L-leucine by culturing the microorganism.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: February 20, 2024
    Assignee: CJ Cheiljedang Corporation
    Inventors: Ji Hye Lee, Byeong Cheol Song, Ae Ji Jeon, Jong Hyun Kim, Hye Won Kim
  • Patent number: 11875298
    Abstract: An NADP(H) nanosensor has i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: January 16, 2024
    Assignee: Forschungszentrum Julich GMBH
    Inventors: Solvej Siedler, Georg Schendzielorz, Stephan Binder, Lothar Eggeling, Stephanie Bringer-Meyer, Michael Bott
  • Patent number: 11850451
    Abstract: The invention relates to the use of an agent and a composition, respectively, comprising the following active ingredients: a) an aromatase inhibitor and/or a 5-?-reductase inhibitor, b) an antioxidant, and c) hyaluronic acid for cosmetic purposes.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: December 26, 2023
    Assignee: Lucolas-M.D. Ltd.
    Inventor: Alfred Schmidt
  • Patent number: 11845927
    Abstract: Certain disclosed embodiments concern a bioremediation composition comprising microbial cells, at least one co-metabolism substrate to induce selected enzyme production by the microbial cells, and a bead or gel encapsulating the microbial cells, such as bacterial or fungi cells, and the at least one co-metabolism substrate. For certain embodiments, the substrate is a slow release compound, such as an orthosilicate that hydrolyzes to produce an alcohol growth substrate. Embodiments of a method for using the composition to transform contaminants of concern also are disclosed.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: December 19, 2023
    Assignees: Oregon State University, North Carolina State University
    Inventors: Lewis Semprini, Mitchell Rasmussen, Michael R. Hyman
  • Patent number: 11846640
    Abstract: The present invention is directed to a novel method of determining inhibitors of proteolytically active coagulation factors, referred to herein as anticoagulants, in a sample, in particular the qualitative detection of direct thrombin and factor Xa inhibitors in a sample. The method of the present invention allows a qualitative determination of the nature anticoagulants present in a sample. This can be achieved with only one coagulation-based test. The method can be used in a test kit, including a point-of-care (POC) system.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: December 19, 2023
    Assignee: PENTAPHARM AG
    Inventors: Abel Ferrandez, Anne Brisset
  • Patent number: 11839634
    Abstract: The present invention relates to the use of a composition comprising bacteria to increase the intestinal production of butyric acid, folic acid or niacin and/or to decrease the intestinal production of succinic acid. Moreover, the present invention relates to the use of said composition for the treatment and/or prevention of an intestinal butyrate- and/or succinate-dependent pathological condition. In particular, for the treatment and/or the prevention of intestinal inflammation, diarrhoea, ulcerative colitis or intestinal colopathies.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: December 12, 2023
    Assignee: ALFASIGMA S.P.A.
    Inventors: Simone Domenico Guglielmetti, Ruggero Rossi, Walter Fiore, Andrea Biffi
  • Patent number: 11834698
    Abstract: Methods and materials for specific imaging of active enzyme in a live or intact cell are disclosed. The enzyme of interest tagged to reporter protein (donor) is exogenously expressed in a cell. The conversion of proenzyme to active enzyme (containing reporter protein) is achieved upon applying an appropriate stimulus to the target cells. The activated enzyme is labelled with an activity-based probe carrying a fluorophore (acceptor). The covalent labelling of active enzyme by the activity-based probe creates a FRET pair which provides the opportunity to exquisitely image the function of an “active enzyme”. This method is used for specific imaging of the function of active caspase-3,-7,-8,-9 and cathepsin-B and also for profiling of inhibitors of caspases and cathepsin B.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: December 5, 2023
    Inventors: Sandanaraj Selvaraj Britto, Punita Bathla
  • Patent number: 11819844
    Abstract: A process for evaluating efficacy of a deodorant product includes: introducing sweat into a main channel formed in a fluidic device satisfying particular requirements; measuring a flow rate of the sweat in the main channel and transmitting the flow rate to a controller; imposing a pressure set point on the pressure actuator by closed-loop control so the flow rate of the sweat in the main channel is controllable; contacting the sweat and a deodorant product and reacting the sweat and the deodorant product with each other, the deodorant product being provided in a particular manner, wherein while the sweat and the deodorant product react with each other, the flow rate of the sweat in the main channel is maintained at substantially zero; and determining at least one of a physicochemical parameter and a biological parameter of a product of the reaction between the sweat and a the deodorant product.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: November 21, 2023
    Assignee: MICROFACTORY
    Inventors: Jules Dupire, Fabrice Monti, Patrick Tabeling
  • Patent number: 11805774
    Abstract: Described herein are methods and compositions for improving plant growth and other properties. The methods and compositions utilize bacteria and bacterial exudates incorporated into plant seeds for improvement of plant growth and other properties.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: November 7, 2023
    Assignee: ANDES AG, INC.
    Inventors: Gonzalo Fuenzalida, Tania Timmermann, Roque Giordano, Veronica Morgante
  • Patent number: 11806462
    Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: November 7, 2023
    Assignee: Arthrex, Inc.
    Inventor: Christopher Bare
  • Patent number: 11759505
    Abstract: The present invention relates to a method for isolating Glu-plasminogen, said method comprising the anion exchange chromatography of blood plasma or a plasma fraction comprising Glu-plasminogen. Furthermore, the present invention relates to Glu-plasminogen obtainable from the method of the present invention and its use in a method for treating a patient suffering from or being at risk of developing a disorder selected from the group consisting of organ failure, a thrombotic event, arterial obstructive disease, microcirculation, disseminated intravascular coagulation (DIC), and a combination of two or more thereof.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: September 19, 2023
    Inventors: Ricarda Welz, Hanne Rieke Gerding, Marc Mazur, Stephan T. Kiessig, Hermann E. Karges
  • Patent number: 11718892
    Abstract: The invention provides an assay for identifying a bacterium capable of binding elemental heavy metal, comprising the following steps: cultivating a test bacterium in a suitable first culture medium; immersing at least a surface portion of a test tool into the first culture medium for a second predetermined period of time, said surface portion being coated by elemental heavy metal, respectively; removing said test tool from said first culture medium and optionally rinsing the test tool; contacting a second culture medium with the surface portion coated by elemental heavy metal of said test tool removed in the previous step; and identifying the test bacterium as being capable of binding elemental heavy metal from growth of the test bacterium in said second culture medium.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: August 8, 2023
    Assignee: CvPlus GmbH
    Inventors: Stephen Gos, Andrea Christiansen, Xin Lu, Guido Meurer, Yvonne Tiffert, Esther Gabor, Benedikt Hoffmann, Martin Langer
  • Patent number: 11680250
    Abstract: The present disclosure relates to a light-driven system which is able to chemically modify an organic substrate with high efficiency and in a cost-effective manner. Also provided are methods for chemically modifying an organic substrate using the present systems and methods for manufacturing such systems.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 20, 2023
    Assignee: University of Copenhagen
    Inventors: Claus Felby, David Cannella, Klaus Benedikt Möllers
  • Patent number: 11659839
    Abstract: Provided is a component having plant defense activity. A PR1 gene expression activator containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; A plant defense activator containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; A plant disease preventive or ameliorating agent containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; and a method of producing a plant defense activating component containing: cultivating a unicellular alga containing a green photosynthetic pigment under an aerobic condition to produce a culture containing an extracellular polysaccharide.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: May 30, 2023
    Inventors: Gouki Satou, Toshichika Ooki, Masahiro Koide, Hiroshi Sekiguchi
  • Patent number: 11583566
    Abstract: The invention discloses the use of the Schizochytrium limacinum and its preparation in improving the quality and yield of animal product. The deposit number of Schizochytrium limacinum in the present invention is CGMCC No. 13746 in the China General Microbiological Culture Collection Center. The Schizochytrium limacinum powder produced by the Schizochytrium limacinum may increase the DHA content in an animal product, reduce the cholesterol content in an animal product, and also improve the egg production performance of poultry. This animal product with high DHA content from natural sources is organic, safe, stable, and easy to be absorbed. It may be used as a safer and effective way for people to ingest natural DHA, and it may also cater to and meet consumer needs. Thus, Schizochytrium limacinum and Schizochytrium limacinum powder of the present application have a wide range of application in the field of general food and livestock breeding.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: February 21, 2023
    Inventors: Liyi Chen, Huichang Zhong, Shuirong Chen
  • Patent number: 11560580
    Abstract: A process for producing a solid material comprising isomaltulose crystals and trehalulose, including: A) contacting an enzyme complex with a sucrose-containing solution; B) isomerizing at least a part of the sucrose to isomaltulose and trehalulose; C) separating off the enzyme complex to obatin a solution including isomaltulose, trehalulose and water; D) partially removing the water by evaporation to obtain a concentrated solution; E) bringing the concentrated solution to a temperature range of 30° C. to 63° C. and subsequently inducing isomaltulose crystallization in this temperature range followed by cooling, thereby obtaining a solid material including isomaltulose crystals and trehalulose.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 24, 2023
    Assignee: Evonik Operations GmbH
    Inventors: Frank Hellmers, Sibylle Schlegel-Kachel, Johannes Oehrlein, Jan Wolter