Patents Examined by Qing Xu
  • Patent number: 11020442
    Abstract: The present invention relates to: Podoviridae bacteriophage Vib-PAP-2 (accession number KCTC 12910BP) which has the capability to specifically destroy Vibrio parahaemolyticus, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Vibrio parahaemolyticus infections, using a composition containing bacteriophage Vib-PAP-2 as an active ingredient.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: June 1, 2021
    Inventors: Seong Jun Yoon, Soo Youn Jun, An Sung Kwon, Soon Hye Hwang, Sang Hyeon Kang
  • Patent number: 11021586
    Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: June 1, 2021
    Assignee: Korea Institute of Science and Technology
    Inventors: Nakwon Choi, Sohyun Kim, Sohyeon Jeong, Eui Sung Yoon, Changjoon Justin Lee, Il-Joo Cho
  • Patent number: 11008264
    Abstract: Disclosed are methods and systems for the quantification of AngI and/or determination of plasma renin activity in a sample. The methods and systems disclosed herein can be useful for diagnosis of hypertension, aldosteronism and other abnormalities of the renin angiotensin aldosterone system (RAAS).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 18, 2021
    Assignee: Laboratory Corporation of America Holdings
    Inventors: William O. Slade, Jr., Russell Philip Grant, Christopher Michael Shuford
  • Patent number: 11000557
    Abstract: A composition comprising lactic bacteria for use in the preventive and/or curative treatment of bacterial infections, which cause urinary tract and/or bladder inflammations is described. The composition is in particular for the treatment of recurrent cystitis.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: May 11, 2021
    Assignee: PROBIOTICAL S.P.A.
    Inventor: Giovanni Mogna
  • Patent number: 10982242
    Abstract: The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: April 20, 2021
    Inventors: Hongwei Yu, Yong Lv, Yong Li, Jianbo Chen, Shaofeng Chen, Weifeng Li, Hongmei Zhang, Yongqiang Zhu
  • Patent number: 10920263
    Abstract: The invention relates to methods, compositions and kits for determining the cleanness of a surface. Described herein is a kit for determining the cleanness of a surface comprising an enzymatic solution comprising catalase; and a developer solution comprising hydrogen peroxide. Described also is a method for determining the cleanness of a surface comprising: applying on a zone of a surface to be cleaned an enzymatic solution comprising catalase and letting it dry; after cleaning said surface, applying on said zone a developer solution comprising hydrogen peroxide; and detecting a catalytic reaction between remaining catalase and hydrogen peroxide, wherein presence of a catalytic reaction is indicative of a surface not properly cleaned. Also provided are specific enzymatic solutions and developer solutions for the kits and methods.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: February 16, 2021
    Assignee: Sani-Marc Inc.
    Inventors: Dominic Desrosiers, Patrick Marchand
  • Patent number: 10920187
    Abstract: The present invention relates to a process of remediating wastewaters, preferably agricultural wastewaters resulting from animal production or contained animal feeding operation sites. The water is treated to promote assimilation of nutrients into algal biomass, which can be harvested and sold, and the resultant wastewater is then purified. According to the invention, short wavelength UV radiation (less than 280 nm wavelength) is used to pretreat wastewater, with the dose determined by absorbance of the water, not by bacterial load. Pretreated water exhibits changes in chromophoric dissolved organic matter that allows for improved and increased algae production by as much as 88%.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: February 16, 2021
    Assignee: Boise State University
    Inventors: Kevin Feris, Maxine Prior
  • Patent number: 10870733
    Abstract: A process for preparing an algal powder containing a reduced content of proteins, a bioplastic composition formed from such a powder, a process for manufacturing a plastic product obtained from such an algal powder and also the plastic product obtained in this way. Process for preparing an algal powder, especially intended for the manufacture of a plastic product, including the successive steps of: culturing and/or harvesting an algal biomass; reducing by at least 10% the intrinsic amount of proteins of the algae, by weight relative to the weight of proteins of the harvested biomass; drying; and reducing to give powder or granules.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 22, 2020
    Assignee: ERANOVA
    Inventors: Philippe Lavoisier, Ronan Pierre, Maud Benoit
  • Patent number: 10829833
    Abstract: The invention provides a process of isolating or enriching a heavy metal present in a liquid medium. The process comprising the following steps: (a) incubating a suspension containing (i) particulate scrap metal, household waste and/or industrial waste containing a heavy metal in elemental form and (ii) biomass comprising a bacterium, or a combination of two or more bacteria, capable of binding the heavy metal; (b) separating the biomass having bound heavy metal from the suspension of step (a); and (c) isolating the heavy metal from the biomass separated in step (b).
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: November 10, 2020
    Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
    Inventors: Stephen Gos, Andrea Christiansen, Xin Lu, Guido Meurer, Yvonne Tiffert, Esther Gabor, Benedikt Hoffmann, Martin Langer
  • Patent number: 10808214
    Abstract: A photobioreactor system and a process for its use is illustrated, whereby water and nutrients from multiple sources are balanced (mixed using aeration) to the specific requirements of the particular photosynthetic organism strain used, sterilized, further mixed to balance the system and seeded with the photosynthetic microorganism, e.g. microalgae (dilution of a concentrated stock or added to an existing algal biomass). In accordance with such an embodiment, the algal biomass is then grown for a most efficient number of hours in a totally controlled environment where temperature (using aeration, an internal coil cooling system, or a combination thereof), pH (via CO2 delivery) and light delivery (using internal lighting directly inside the algal biomass) are optimized to the algal strain grown.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: October 20, 2020
    Assignee: Avespa Corporation
    Inventors: David Punchard, Philippe Bois, Angela Cortina Burgueno
  • Patent number: 10633678
    Abstract: The present invention provides a process for the production of a microbial oil comprising culturing a micro-organism in a two stage fermentation process where, in a last stage that precedes the end of fermentation, the carbon source is: consumed by the micro-organisms at a rate greater than it is added to the medium; added at a rate #0.30 M carbon/kg medium; or is rate limiting on the growth of the micro-organism. The micro-organisms thus have the carbon source restricted so that they preferentially metabolise fats or lipids other than arachidonic acid (ARA), so increasing the proportion of ARA in the cells. A microbial oil is then recovered from the micro-organism, using hexane as a solvent, that has at least 50% ARA and at least 90% triglycerides.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: April 28, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Hugo Streekstra, Petrus Joseph Maria Brocken
  • Patent number: 10624335
    Abstract: The present invention relates to a device for cryopreservation of a cell or tissue, including a deposition part on which a cell or tissue is to be deposited, the deposition part having a layer containing a water-soluble polymeric compound on an outermost surface of the deposition part; and a method of cryopreservation using the device.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: April 21, 2020
    Inventors: Atsushi Matsuzawa, Katsumitsu Susaki, Yukio Tokunaga
  • Patent number: 10597629
    Abstract: There is disclosed a method for preparation of substrate for use in anaerobic digestion of organic waste. The method can be executed in a substrate pretreatment system, the method comprising: loading of a substrate into the substrate pretreatment system, mixing the substrate with liquid; heating the substrate and liquid to a pre-determined processing temperature; exposing the mixture to radiation; transferring the processed substrate to a bioreactor, during the heating, the method further comprises: degassing the mixture using vacuum extraction; and circulating the mixture past an ultrasonic hydrodynamic radiator.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 24, 2020
    Inventors: Aleksandr Andreevich Smotritckii, Andrey Vladimirovich Smotritskiy, Tatiana Andreevna Smotritskaya
  • Patent number: 10575516
    Abstract: Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula and being therein impregnated with a cryopreservation medium. The needle cannula or other device can be received in a capsule and/or other container, which in some forms can contain additional amounts of the cryopreservation medium occurring external of the lumen. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: March 3, 2020
    Assignee: Cook Biotech Incorporated
    Inventors: Umesh H. Patel, Michael L. Taylor, Claus Sondergaard, Cara McCammon, Rae Ritchie
  • Patent number: 10576110
    Abstract: The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicating L. johnsonii La1 NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: March 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Valerie Petit, Clara Garcia-Rodenas, Monique Julita, Guenolee Prioult, Annick Mercenier, Sophie Nutten
  • Patent number: 10564077
    Abstract: A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein to capture a desired fraction of the biological sample. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone multiple other positions adjacent various purification, protein analysis, separation and extraction zones. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the other zones to perform a multi-step assay on the isolated fraction within the device.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 18, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Joshua M. Lang, Benjamin P. Casavant, Scott M. Berry, Lindsay N. Strotman
  • Patent number: 10563167
    Abstract: Provided is a microorganism culture sheet having an excellent efficiency for collection of environmental microorganisms and a method for measuring the environmental microorganisms with an excellent collection efficiency. Provided is a microorganism culture sheet including a base sheet, a dry culture layer formed on the base sheet, and a cover sheet covering the dry culture layer, wherein an adhesive layer and a release film are laminated on the inner surface of the cover sheet. Because the environmental microorganisms are collected using the adhesive layer, an excellent collection efficiency is provided.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: February 18, 2020
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Shin-ichi Waku, Michiko Miyagi, Rui Saito, Tetsuji Ueki, Takuma Baba, Mai Kinoshita
  • Patent number: 10533194
    Abstract: A system and method for converting biomass with no chemical pretreatment is disclosed. Combination of a microbial system and the use of mechanical disruption during fermentation may help achieve high conversion rate without the extra cost and undesirable by-products typically associated with the pretreatment process.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: January 14, 2020
    Inventors: Lee R. Lynd, Julie M. D. Paye, Michael Balch
  • Patent number: 10487349
    Abstract: A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: November 26, 2019
    Assignee: GRADIENTECH AB
    Inventors: Johan Kreuger, Sara Thorslund, Zhigang Wu
  • Patent number: 10472664
    Abstract: Screening methods as well as systems and kits for identifying inhibitors of DNA-independent, histone H4-dependent activation of PARP-1 are provided. The methods comprise screening molecules for their capacity to inhibit the activation and/or biologic activity of PARP-1, as measured by poly(ADP)-ribose production from nicotinamide adenine dinucleotide. PARP-1 inhibitors identified through the screening methods may be used to treat cancer in which PARP-1 activation or biologic activity plays a role.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 12, 2019
    Assignee: Institute For Cancer Research
    Inventor: Alexei Tulin