Patents Examined by Qing Xu
  • Patent number: 10472664
    Abstract: Screening methods as well as systems and kits for identifying inhibitors of DNA-independent, histone H4-dependent activation of PARP-1 are provided. The methods comprise screening molecules for their capacity to inhibit the activation and/or biologic activity of PARP-1, as measured by poly(ADP)-ribose production from nicotinamide adenine dinucleotide. PARP-1 inhibitors identified through the screening methods may be used to treat cancer in which PARP-1 activation or biologic activity plays a role.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 12, 2019
    Assignee: Institute For Cancer Research
    Inventor: Alexei Tulin
  • Patent number: 10465209
    Abstract: The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurized pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurized pre-treatment over enzymatic hydrolysis and fermentation to sorting of fermentable and non-fermentable solids can be processed at a relatively high dry matter content in a single vessel or similar device using free fall mixing for the mechanical processing of the waste fraction.
    Type: Grant
    Filed: February 25, 2012
    Date of Patent: November 5, 2019
    Assignee: Renescience A/S
    Inventors: Nanna Dreyer Noerholm, Jan Larsen, Frank Krogh Iversen
  • Patent number: 10434150
    Abstract: Oral administration of ALV003 can protect celiac disease patients and patients otherwise suffering from gluten-intolerance from the harmful effects of ingesting food containing gluten.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: October 8, 2019
    Assignee: Immunogenics LLC
    Inventors: Bret Berner, Matthew John Siegel
  • Patent number: 10377649
    Abstract: The present invention relates to apparatus, methods, and applications for treating wastewater, and more particularly to biological processes for removing pollutants from wastewater. This invention further relates to apparatus and methods for growing microbes on-site at a wastewater treatment facility, and for economically inoculating sufficient microbes to solve various treatment problems rapidly.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: August 13, 2019
    Inventor: G. Robert Whiteman
  • Patent number: 10375955
    Abstract: Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain and at least one germinant. Methods for killing bacterial spores include contacting the spores with the formulation for a duration sufficient to initiate germination of the bacterial spores. The spores are then killed with the papain in the formulation, or are rendered by the papain susceptible to being killed by a reagent.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: August 13, 2019
    Assignee: Loyola University Chicago
    Inventor: Adam Driks
  • Patent number: 10316290
    Abstract: The invention relates to methods for directing differentiation of stem cells comprising graphene. In additional embodiments, the invention relates to methods for repairing and improving bone tissue functions comprising accelerating differentiation in stem cell growth by exposing stem cells to graphene and transplanting the graphene with the exposed stem cells in the tissue at the site of repair.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: June 11, 2019
    Assignee: National University of Singapore
    Inventors: Barbaros Oezyilmaz, Giorgia Pastorin, Henrik Andersen
  • Patent number: 10295536
    Abstract: Clostridium difficile disease involves a range of clinical presentations ranging from mild to self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of C. difficile are treated differently depending on severity of disease. Mild and moderate cases may be treated with metronidazole while moderate-to-severe and relapsing cases are often treated with vancomycin or fidaxomicin. The presence of C. difficile disease is detected using a biomarker panel that includes C. difficile antigen (GDH), toxins A and B, and fecal lactoferrin. In patients suspected of C. difficile disease, if GDH is detected indicating the presence of C. difficile, and then toxins A and/or B are detected to indicate toxigenic C. difficile and support a diagnosis of C. difficile-associated disease, fecal lactoferrin concentrations are measured to determine severity of the disease by indicating the amount of intestinal inflammation.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: May 21, 2019
    Assignee: TECHLAB, INC.
    Inventors: James Hunter Boone, David M. Lyerly, Tracy D. Wilkins, Robert J. Carman
  • Patent number: 10288603
    Abstract: Cells are grown in 3D culture and topological features obtained by photomicrography are correlated to cell viability and cell cell interactions.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: May 14, 2019
    Assignee: Greiner Bio-One North America, Inc.
    Inventor: Glauco R. Souza
  • Patent number: 10264796
    Abstract: A method for producing a seed of a plant resistant to seedling diseases is provided which includes contacting a non-pathogenic microbe corresponding to a seed-borne pathogen with a flower part of a host plant around the flowering time and collecting a seed of the host plant colonized by the non-pathogenic microbe obtained thereafter, and a method for controlling seedling diseases using the seed.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 23, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
    Inventors: Tsutomu Arie, Tohru Teraoka, Youko Nonaka, Akihiro Kato, Jun Tanaka, Tomomi Tokunaga, Kenichi Kurauchi, Tomotaka Suzuki
  • Patent number: 10238693
    Abstract: The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: March 26, 2019
    Assignee: Vivex Biomedical, Inc.
    Inventor: Harry Thomas Temple
  • Patent number: 10233477
    Abstract: The field of the invention is the analysis of target microorganisms in a complex sample. The present invention more particularly relates to a culture medium for the detection of at least one target microorganism including: at least one natural or synthetic fermentation or enzymatic activity substrate, and at least one selective agent, which inhibits non-target microorganisms, constituted by para-amino benzoic acid, one of its derivatives or one of their salts, at a concentration of between 0.05 and 1 g/L.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: March 19, 2019
    Assignee: BIOMERIEUX
    Inventor: Jean-Marc Roche
  • Patent number: 10227628
    Abstract: The present invention relates to a device for detecting a fungal contamination in an internal environment, to the use thereof and also to a method for detecting a fungal contamination in an internal environment using such a device.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: March 12, 2019
    Assignee: CENTRE SCIENTIFIQUE ET TECHNIQUE DU BATIMENT
    Inventors: Stephane Moularat, Yael Joblin, Enric Robine
  • Patent number: 10174360
    Abstract: The present disclosure provides a method for analyzing glyeart-derived monosaccharides in a sample. The present disclosure also provides a method for detecting or monitoring a disease or disorder in a patient. In addition, the present disclosure provides a method of determining aberrant glycotransferase activity. The present disclosure further provides a system for analyzing or comparing glycates in a sample.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 8, 2019
    Assignee: ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY
    Inventors: Chad Borges, Douglas Rehder
  • Patent number: 10093920
    Abstract: The present invention relates to methods for screening a polypeptide for desired activity against a target molecule In particular, the present invention relates to methods for screening a polypeptide for desired activity against a target molecule by expressing the polypeptide in a bacterial cell and permeabilizing the cell.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: October 9, 2018
    Assignee: AFFINITY BIOSCIENCES PTY LTD
    Inventors: Matthew Beasley, Ben Kiefel
  • Patent number: 10064900
    Abstract: Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore-forming bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 4, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: Geoffrey Von Maltzahn, Matthew R. Henn, David N. Cook, David Arthur Berry, Noubar B. Afeyan, Brian Goodman, Mary-Jane Lombardo McKenzie, Marin Vulic
  • Patent number: 10064896
    Abstract: The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: September 4, 2018
    Assignee: Vivex Biomedical, Inc.
    Inventor: Harry Thomas Temple
  • Patent number: 10028981
    Abstract: The present invention generally relates to the field of probiotic bacteria. In particular it relates to methods for treating functional GI disorders comprising administering Bifidobacterium longum, such as Bifidobacterium longum ATCC BAA-999.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: July 24, 2018
    Assignee: Nestec S.A.
    Inventors: Peter McLean, Gabriela Bergonzelli de Gonda, Stephen Michael Collins, Premysl Bercik, Elena Verdu de Bercik
  • Patent number: 10000786
    Abstract: By using the method and equipment according to this invention it is possible to analyze rapidly a large number of microbiological culture samples, or alternatively of liquid phase samples, based on the gases or gaseous compounds released by them. This invention exploits generally a sample line, along which the samples move, and it can be used for the microbial control tasks in hospitals, industry, hygiene and environmental fields. In this system gas is led into the culture vessels during the growth of the microbe, and gases released by the culture or liquids derived from them are collected into the chambers, capsules or equivalents.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: June 19, 2018
    Inventor: Eino Elias Hakalehto
  • Patent number: 9968642
    Abstract: The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: May 15, 2018
    Assignee: Northwestern University
    Inventors: Charles N. Rudick, David J. Klumpp, Anthony J. Schaeffer
  • Patent number: 9920301
    Abstract: Noncultured Wharton's Jelly stem cells and methods of their purification, storage and use are provided.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: March 20, 2018
    Assignee: Auxocell Laboratories, Inc.
    Inventor: Rouzbeh R. Taghizadeh