Patents Examined by R. Clarke
  • Patent number: 11448644
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: September 20, 2022
    Assignee: Northwestern University
    Inventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt
  • Patent number: 11434466
    Abstract: The present invention provides a process of cultivating microalgae and a joint method of same jointed with denitration. During the microalgae cultivation, EM bacteria is added into the microalgae suspension. In the nutrient stream for cultivating microalgae, at least one of the nitrogen source, phosphorus source and carbon source is provided in the form of a nutrient salt. During the cultivation, the pH of the microalgae suspension is adjusted with nitric acid and/or nitrous acid. The joint method includes (1) a step of cultivating microalgae; (2) a separation step of separating a microalgae suspension obtained from step (1) into a wet microalgae (microalgae biomass) and a residual cultivation solution; and (3) a NOx absorbing/immobilizing step of denitrating an industrial waste gas with the residual cultivation solution obtained from step (2). The nutrient stream absorbed with NOx obtained from step (3) is used to provide nitrogen source to the microalgae cultivation of step (1).
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: September 6, 2022
    Inventors: Junfeng Rong, Xuhua Zhou, Lin Cheng, Junying Zhu, Xugeng Huang, Baoning Zong
  • Patent number: 11433108
    Abstract: Therapeutic methods for administering gut microbiota and oncolytic viruses to a subject are provided. The gut microbiota serve to pre-condition, the subject's immune system to antitumor responses and augments anticancer activity of the oncolytic vims. Combinations of the gut. microbiota and viruses and uses thereof for treating and preventing cancer are provided. The present disclosure also provides methods for building elite responder selection platforms through hierarchical clustering analysis of genomic profiles for human gut microbiome.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: September 6, 2022
    Inventors: Minjie Hu, Yu Li, Xiaoling Liu, Rebecca Hu
  • Patent number: 11389565
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: July 19, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
  • Patent number: 11332768
    Abstract: A method for producing a partially hydrolysed lignocellulosic material is provided including treating a lignocellulosic material with an acid and/or an alkali and then a polyol. Also provided are methods of producing a fermentable sugar, or a fermentable sugar and a fermentation product from said partially hydrolysed lignocellulosic material. A partially hydrolysed lignocellulosic material, a fermentable sugar, and fermentation product produced by such methods are also provided. Also provided is an apparatus for producing a partially hydrolysed lignocellulosic material, such as by the aforementioned method.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 17, 2022
    Inventors: Alex Baker, Leslie Alan Edye
  • Patent number: 11332771
    Abstract: The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine can be added to serum-free media or chemically defined media to improve viable cell density, to reduce cell doubling time, and to increase the production of a protein of interest.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: May 17, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shadia Abike Oshodi, Amy S. Johnson, Shawn M. Lawrence
  • Patent number: 11291686
    Abstract: The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: April 5, 2022
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Suzanne T. Ildstad, Mary Jane Elliott
  • Patent number: 11291161
    Abstract: Systems and methods for growing vegetation are provided. The disclosed systems (100) and methods (1100, 1200) use rotating growth mats (102) and a cutting device (112). The rotating growth mats and cutting device can be coupled to an anaerobic digester (402) to generated methane gas using vegetation grown on the growth mats. The systems and methods may further use C artificial light sources (108) and a nutrients delivery system (110) to assist growth.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: April 5, 2022
    Inventors: Christopher Mann, Michael Bennett, Derek William Kenneth Jenkins, Thomas William Bradshaw, Matthew Charles Seabrook Heritage
  • Patent number: 11274277
    Abstract: The present invention provides a production method of a cell aggregate containing an anterior eye segment tissue or a partial structure thereof, or a precursor tissue thereof, including culturing pluripotent stem cell aggregates in suspension in the presence of a bone morphogenic factor signal transduction pathway activating substance to induce self-organization of an anterior eye segment tissue or a partial structure thereof, or a precursor tissue thereof. In one embodiment, the bone morphogenic factor signal transduction pathway activating substance is BMP4. In one embodiment, the suspension culture is performed entirely or partially in the presence of a fibroblast growth factor. The produced cell aggregate can further contain a neural retinal tissue.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: March 15, 2022
    Assignees: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki Sasai, Chikafumi Ozone, Yuko Maruyama
  • Patent number: 11253818
    Abstract: A method of producing cellulase includes steps (1) to (3): (1) subjecting an aqueous solution of cellulase derived from filamentous fungi to filtration through an ultrafiltration membrane with a molecular weight cut off of 100,000 to 200,000 to obtain a filtrate and concurrently obtain a concentrated enzyme liquid as a retentate; (2) further subjecting the filtrate obtained in step (1) to filtration through a second ultrafiltration membrane with a molecular weight cut off of 5,000 to 50,000 to obtain a second concentrated enzyme liquid as a retentate; and (3) mixing the concentrated enzyme liquid obtained in steps (1) and (2) to obtain cellulase derived from filamentous fungi.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: February 22, 2022
    Assignee: Toray Industries, Inc.
    Inventors: Hiroyuki Kurihara, Katsushige Yamada
  • Patent number: 11253554
    Abstract: Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 22, 2022
    Assignees: Virginia Commonwealth University, George Mason University
    Inventors: Jasmohan Bajaj, Patrick M. Gillevet
  • Patent number: 11241461
    Abstract: Provided herein are methods and compositions related to Blautia Strain A useful as therapeutic agents.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: February 8, 2022
    Assignee: Evelo Biosciences, Inc.
    Inventors: Brian Goodman, Peter Sandy, Jacqueline Papkoff, Humphrey Gardner, Holly Ponichtera
  • Patent number: 11220667
    Abstract: A Kurthia gibsonii strain EO-06 with Deposit Number of CGMCC No. 18436, a Clostridium kogasensis strain EO-08 with Deposit Number of CGMCC No. 18438 and a Clostridium acidisoli strain EO-09 with Deposit Number of CGMCC No. 18439 are provided. The above strains can be used to treat pollution, for example, to treat industrial gas or wastewater containing ethylene oxide, which greatly improves the decontamination disposal capacity of ethylene oxide in industrial production. The present disclosure also provides a degradation agent for degrading ethylene oxide and a method for biodegrading ethylene oxide.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: January 11, 2022
    Inventors: Shengwei Hu, Dongxin Hou, Jianlong Xue, Weiguo Wang, Yecheng He, Xiuling Zhong, Xin Yin, Liqing Zhu, Jiali Lin, Lixiong Feng
  • Patent number: 11186811
    Abstract: A process for fermenting syngas is provided which is effective for decreasing an amount of time needed to inoculate a main reactor. The process includes propagating a culture of acetogenic bacteria to provide an inoculum for a main reactor and fermenting syngas in the main reactor.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: November 30, 2021
    Inventors: Peter Simpson Bell, Ching-Whan Ko
  • Patent number: 11166992
    Abstract: The invention provides a composition for use in therapy of lactose intolerance or conditions arising from lactase deficiency, wherein the composition is a non-dairy solid dosage form comprising: (a) a lactase; and (b) one or more lactase-producing and/or lactase containing microorganisms selected from Lactobacillus delbrueckii ssp bulgaricus and Streptococcus thermophilus; wherein the lactase (a) is other than a lactase derived from the said one or more microorganisms (b); and wherein the one or more lactase-producing and/or lactase-containing microorganisms (b) are in dried form. Also provided are uncoated capsule and tablet compositions containing the lactase and the lactase-producing and/or lactase-containing microorganisms.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: November 9, 2021
    Assignee: Vitacare GmbH & Co. KG
    Inventors: Daniel Henry Wyrobnik, Isaac Harry Wyrobnik
  • Patent number: 11169140
    Abstract: An electrochemical device for diagnostic purposes, and particularly point-of-care diagnostic purposes, is capable of detecting quorum sensing molecules, such as AHL, within a biological sample with high precision. The device includes at least one reference electrode (RE), at least one counter electrode (CE), and two or more working electrodes (WEs). Each working electrode differs from the other working electrode(s) with respect to at least one of the following characteristics: surface area, size, material, and coating. The device also has a sample receiving area for receiving a biological sample, wherein the electrodes and the sample receiving area is fluidly connected, and a means for transferring the sample to the electrodes for measurement, and a means for displaying a result of the measurement.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: November 9, 2021
    Assignee: Danmarks Tekniske Universitet
    Inventors: Fatima Alzahra'a Alatraktchi, Winnie Edith Svendsen
  • Patent number: 11166991
    Abstract: The invention relates to a novel bacterial strain deposited with the CNCM under number 1-4969. This strain has properties that are useful in the treatment of respiratory disorders. The invention also relates to compositions and uses of said strain.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: November 9, 2021
    Assignee: Institut National De La Recherche Agronomique
    Inventors: Muriel Thomas, Aude Remot-Brizion, Philippe Langella
  • Patent number: 11155781
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: October 26, 2021
    Assignee: BIOLAMINA AB
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Patent number: 11154639
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 26, 2021
    Assignees: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 11119095
    Abstract: Provided is a method for measuring tyrosine phosphatase and tyrosine kinase activity, as a high-sensitivity measuring method, which is suitable for high throughput and which uses a compound represented by general formula (I) (in the formula, A represents a conjugated ring; L represents a linker or the like having a labeling substance at an end; R1 represents a hydrogen atom or the like; and R2 and R3 each represent a hydrogen atom, an alkyl group or the like).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: September 14, 2021
    Inventors: Shinichi Sato, Hiroyuki Nakamura, Hirofumi Nakano